Welcome to Models of Cellular Processes¶

Course material for the lecture Models of Cellular Processes (Modelle zellulärer Prozesse WS19/20) at the Humboldt-University Berlin, Institute for Theoretical Biology (ITB) by Dr. Matthias König.

All code and material available from https://github.com/matthiaskoenig/mcp.

Course overview¶

Modelling overview
Boolean networks
Cellular automata
Finite difference equations
Ordinary differential equations (ODE)
Models of metabolism
Stoichiometric matrix
Constraint-based analysis (CBA)
Sensitivity & Metabolic Control Analysis (MCA)
Stochastic processes
Signalling pathways
Standard formats (reproducibility)
Parameter estimation
Biological databases
Course review

Contents:

01 Introduction modeling¶

Overview course¶

Kursziel

Verständnis der Modellierung zellulärer Prozesse

Methode

Mathematik & Computermodellierung

Themen (siehe

Boolesche Netzwerke
Differentialgleichungen & dynamische Systeme
Constraint-based models
Cellular networks
Stochastic systems
Parameter fitting
…

Anwendungen und Beispiele

Stoffwechsel/Metabolismus
Signaltransduktion
Genexpression
Cell cycle

Lernziele

wie modelliert man zelluläre Prozesse? Welche Methoden gibt es?
was ist ein dynamisches System?
was ist der Zustandsraum (state space), was sind Trajektorien?
was sind Feedback Loops?
was ist Stabilität?

Komplexität biologischer Systeme¶

incomplete knowledge
many components
roles of and interactions between components are often obscure and change over time
nonlinearities & feedbacks
multiple spatial scales - from organism to single molecule
different time-scales - from the human life span down to molecular kinetics, e.g. of enzyme catalysis in a fraction of a second
build via evolution
complex processes
- often not explained from first principle
- no understanding of behavior by intuition
- emergent properties (more than the sum of its parts)

⇒ requirement of abstract representation

Was ist ein Model?¶

A model is an artificial construct in the language of mathematics that represents biological phenomenon.

Gute Modelle

“essentially, all models are wrong, but some are useful” G. Box
enable **insights** into processes and systems (that we would not be able to gain otherwise)
repository of knowledge - make sense of large number of isolated facts and observations
allow to make **predictions** and **extrapolations** (which can be tested)
lead to the formulation of new hypotheses

Models can take any form

model can be intuitive or very abstract
minimal models vs. whole cell models

Wie konstruiert man ein Modell?¶

Abstraction steps

biological system
mental model
model scheme
process model
mathematical model
quantitative analysis

Modellierung ist Kunst

requires **technical expertise** and creativity
nicht zu kompliziert/nicht zu einfach → richtiger Abstraktionsgrad
conceptualizing in modules/components/processes
subjective and selective procedure
abhängig von Fragestellung

Modelling cycle - model predictions → experiments (validation) → refining models

Nichtlineare Dynamik¶

Dynamisches System: a function describes the time-dependence of a point in a state space.

state - Zustand
state space - Zustandsraum (all possible states)
function - rule how state is changing over time (depending on state and possible history)

Zustand

discrete / continuous
single state variable, or more often state vector (i.e. multiple variables define the concrete state, e.g., concentrations of metabolites)

Zustandsraum

entsprechend diskret/kontinuierlich
ein-dimensional / hoch-dimensional

Zeit/time

diskret/kontinuierlich

Function/rules

deterministisch, stochastisch
(description as state updates or changes in state over time)

Mögliche Fragen

time-evolution of the system (where do I end up depending on the start conditions)?
steady states (nothing is changing over time any more)?
which states are visited? periodic states (oscillations)?
stability & robustness ? (if I change a bit do I get similar results)
sensitivity (what is the effect of parameter changes and initial condition changes)

References¶

Herbert Sauro, Introduction to Pathway Modeling, First Edition; Chapter 4, Introduction to modelling
Eberhard O. Voit, A first course in Systems Biology, second edition; Chapter 1, Biological systems; Chapter 2, Introduction to mathematical modelling
Klipp, Liebermeister, Wierling, Kowald; Systems Biology - A Textbook, Second Edition; Part I, Introduction to Systems Biology

TODO add figures (coming soon)

TODO better formulations & English/German version

02 Boolean networks¶

Boolean networks code¶

Jupyter notebook available at docs/notebooks/01_boolean_networks.ipynb

Short introduction to python¶

Most of the examples will be based on python. A basic understanding of programming and the python language will be sufficient to follow the examples.

Many good basic python tutorials and introductions exist, for instance see

https://www.learnpython.org/ - interactive python tutorial
https://docs.python.org/3/tutorial/index.html - official tutorial, more in depth

This tutorial and all information related to it is available online at https://github.com/matthiaskoenig/mcp

To follow the tutorial a basic python3 installation with the packages listed in requirements.txt is needed.

If you have any questions or need help please contact konigmatt@googlemail.com

Boolean networks in a nutshell¶

A boolean network consists of nodes (which have a boolean state) and connections between the states (inputs for nodes).
The boolean states can be either 0 or 1.
Every node (state) in the boolean network has a rule which specifies the output of the node (state) for all possible combinations of inputs.
Based on the given rule for a node the node state is updated.
Simulations start from an initial state of the network. This is the state of all nodes at the begin of the simulation.

General Properties of Boolean Networks:

Fixed topology (doesn’t change with time)
Dynamic (states evolve over time, updates happen at discrete time steps)
Synchronous (update of all states occurs at the same time)
Node States: Deterministic (based on rules), discrete (binary)
Gate Function: Boolean (rules which calculate the update for the state, return discrete new state)
Flow: Information

For one dimensional input of a given node in a boolean network the possible unary boolean operators are

IDENTITY ([0]->[0], [1]->[1])
INVERSE ([0]->[1], [1]->[0])
ZERO ([0]->[0], [1]->[0])
ONE ([0]->[1], [1]->[1])

For two dimensional inputs possible logical operations (rules) are for instance

AND ([1,1]->[1], [1,0]->[0], [0,1]->[1], [0,0]->[0])
OR
XOR
NOR
…

An overview over the truth tables (boolean rules) for unary and binary operations can be found here https://en.wikipedia.org/wiki/Truth_table

Example 1¶

Within this task we will simulate a boolean network by applying the rules repeatedly starting from an intial state, thereby updating the state vector [X1, X2].

Write a computer program which simulates the simple boolean networks consisting of the two nodes X1 and X2 with the initial state [X1, X2](0) = [0, 1]. The boolean rules for updating X1 based on the input from X2, and for updating X2 based on the input of X1 are the unary INVERSE rule. Simulate the model for 20 steps. What is the final state of the boolean network?
What are the possible trajectories of the boolean network, i.e. which sequence of states are possible? (hint: simulate the network for all possible initial states)

Simple solution¶

translate problem into code (just follow the problem description)
use what you know about the problem domain
boolean states, discrete time evolution, synchronous updates

from pprint import pprint
N = 20  # number of time steps
states = [[False, True]]  # initial state
for k in range(N):
    # get state of last step
    x = states[k]
    print(f'{k:<3} : {x}')

    # update state by applying rules
    x_new = [not x[1], not x[0]]

    # store new state
    states.append(x_new)

print('-' * 80)
print(states)

 : [False, True]
 : [False, True]
 : [False, True]
 : [False, True]
 : [False, True]
 : [False, True]
 : [False, True]
 : [False, True]
 : [False, True]
 : [False, True]
: [False, True]
: [False, True]
: [False, True]
: [False, True]
: [False, True]
: [False, True]
: [False, True]
: [False, True]
: [False, True]
: [False, True]
--------------------------------------------------------------------------------
[[False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True], [False, True]]

Analyse trajectories¶

Now analyse all possible states of the network. For this we have to start the network from all possible initial states. * define recurring code as functions * generalize solution so it can be applied to a broader application field

state_init = [
    [True, True],
    [True, False],
    [False, True],
    [False, False],
]

def f_example1(x):
    """Rule for single input which is inversed."""
    assert len(x) == 2
    return [not x[1], not x[0]]

def simulate(x0, f_rules, steps=10):
    """ Simulates the boolean network from initial state by applying given rules."""
    states = [x0]
    for k in range(steps):
        # synchronous updates
        x = states[k]
        states.append(f_rules(x))
    return states

# run network from all initial states
for x0 in state_init:
    states = simulate(x0, f_rules=f_example1)
    pprint(states)
    print('-' * 40)

[[True, True],
 [False, False],
 [True, True],
 [False, False],
 [True, True],
 [False, False],
 [True, True],
 [False, False],
 [True, True],
 [False, False],
 [True, True]]
----------------------------------------
[[True, False],
 [True, False],
 [True, False],
 [True, False],
 [True, False],
 [True, False],
 [True, False],
 [True, False],
 [True, False],
 [True, False],
 [True, False]]
----------------------------------------
[[False, True],
 [False, True],
 [False, True],
 [False, True],
 [False, True],
 [False, True],
 [False, True],
 [False, True],
 [False, True],
 [False, True],
 [False, True]]
----------------------------------------
[[False, False],
 [True, True],
 [False, False],
 [True, True],
 [False, False],
 [True, True],
 [False, False],
 [True, True],
 [False, False],
 [True, True],
 [False, False]]
----------------------------------------

Improve solution¶

use appropriate data structures (appending to a list is not very efficient; data structure which simplifies analysis)
plot results

%matplotlib inline

import numpy as np
from matplotlib import pylab as plt

ndstate_init = [
    np.array([True, True]),
    np.array([True, False]),
    np.array([False, True]),
    np.array([False, False]),
]

def f_example1(x):
    """Inverse of given state."""
    return np.array([not x[1], not x[0]])


def ndsimulate(x0, f_rules, steps=10):
    """ Simulates the boolean network from initial state by applying given rules."""
    states = np.zeros(shape=((steps+1), x0.size), dtype=bool)

    print("-" * 40)
    pprint("x0 = {}".format(x0.astype(np.int)))
    states[0, :] = x0
    for k in range(steps):
        x = states[k]
        states[k+1, :] = f_rules(states[k, :])

    # pprint(states.astype(np.int))
    return states

def plot_states(states, figsize=(5,3), ylabel="time step"):
    """Plot the states."""
    Nt, Nx = states.shape
    fig = plt.figure(figsize=figsize)
    plt.imshow(states.astype(np.double), cmap="binary")
    plt.colorbar()
    plt.ylabel(ylabel)
    plt.xlabel("state")
    ax = plt.gca()
    ax.set_xticks(range(Nx))
    ax.set_xticklabels(['x{}'.format(k) for k in range(Nx)])
    plt.show()

for x0 in ndstate_init:
    states = ndsimulate(x0, f_rules=f_example1)
    plot_states(states)

----------------------------------------
'x0 = [1 1]'

----------------------------------------
'x0 = [1 0]'

----------------------------------------
'x0 = [0 1]'

----------------------------------------
'x0 = [0 0]'

Example 2¶

Simulate the following more complex boolean network consisting of 5 nodes (reuse the code from task 1)
The update rules are given by

X1 = NOT(X4)
X5 = IDENTIY(X4)
X2 = OR(X1, X5)
X3 = OR(X1, X5)
X4 = XOR(X3, X2)

What are the possible trajectories of the boolean network, i.e. which final states (or cycles of states) are reached? (hint: simulate the network for all possible initial states)

*Automatize* * if you have to do it once, you have to do it 1000 times

states_init = [
    [0,0,0,0,0],
    [1,0,0,0,0],
    [0,1,0,0,0],
    ...
]

states_init = np.linspace(0, 31, num=32, dtype=np.uint8)  # (32,)
states_init = np.reshape(states_init, (32,1))
ndstates_init = np.unpackbits(states_init, axis=1)
ndstates_init = ndstates_init[:, 3:]
# print(ndstates_init)
plot_states(ndstates_init, figsize=(10,10), ylabel="init state")

def f_task2(x):
    """
    X0 = INVERSE(X3)
    X4 = IDENTIY(X3)
    X1 = OR(X0, X4)
    X2 = OR(X0, X4)
    X3 = XOR(X2, X1)
    """
    y = np.zeros_like(x)
    y[0] = np.invert(x[3])
    y[4] = x[3]
    y[1] = x[0] or x[4]
    y[2] = x[0] or x[4]

    # xor hack
    y[3] = x[2] or x[1]
    if (x[2] and x[1]):
        y[3] = False

    return y

for x0 in ndstates_init:
    states = ndsimulate(x0, f_rules=f_task2)
    plot_states(states)

----------------------------------------
'x0 = [0 0 0 0 0]'

----------------------------------------
'x0 = [0 0 0 0 1]'

----------------------------------------
'x0 = [0 0 0 1 0]'

----------------------------------------
'x0 = [0 0 0 1 1]'

----------------------------------------
'x0 = [0 0 1 0 0]'

----------------------------------------
'x0 = [0 0 1 0 1]'

----------------------------------------
'x0 = [0 0 1 1 0]'

----------------------------------------
'x0 = [0 0 1 1 1]'

----------------------------------------
'x0 = [0 1 0 0 0]'

----------------------------------------
'x0 = [0 1 0 0 1]'

----------------------------------------
'x0 = [0 1 0 1 0]'

----------------------------------------
'x0 = [0 1 0 1 1]'

----------------------------------------
'x0 = [0 1 1 0 0]'

----------------------------------------
'x0 = [0 1 1 0 1]'

----------------------------------------
'x0 = [0 1 1 1 0]'

----------------------------------------
'x0 = [0 1 1 1 1]'

----------------------------------------
'x0 = [1 0 0 0 0]'

----------------------------------------
'x0 = [1 0 0 0 1]'

----------------------------------------
'x0 = [1 0 0 1 0]'

----------------------------------------
'x0 = [1 0 0 1 1]'

----------------------------------------
'x0 = [1 0 1 0 0]'

----------------------------------------
'x0 = [1 0 1 0 1]'

----------------------------------------
'x0 = [1 0 1 1 0]'

----------------------------------------
'x0 = [1 0 1 1 1]'

----------------------------------------
'x0 = [1 1 0 0 0]'

----------------------------------------
'x0 = [1 1 0 0 1]'

----------------------------------------
'x0 = [1 1 0 1 0]'

----------------------------------------
'x0 = [1 1 0 1 1]'

----------------------------------------
'x0 = [1 1 1 0 0]'

----------------------------------------
'x0 = [1 1 1 0 1]'

----------------------------------------
'x0 = [1 1 1 1 0]'

----------------------------------------
'x0 = [1 1 1 1 1]'

### Trajectory graph
# TODO: see https://plot.ly/python/network-graphs/

def ndsimulate(x0, f_rules, steps=10):
    """ Simulates the boolean network from initial state by applying given rules."""
    states = np.zeros(shape=((steps+1), x0.size), dtype=bool)

    print("-" * 40)
    pprint("x0 = {}".format(x0.astype(np.int)))
    states[0, :] = x0
    for k in range(steps):
        x = states[k]
        states[k+1, :] = f_rules(states[k, :])

    # pprint(states.astype(np.int))
    return states

03 Cellular automata¶

lecture slides

What are cellular automata?

boolean network
spatial pattern of nodes
local interactions, only nearest neighbors in rules
all nodes have same rules

\([X0][X1][X2][X3]...\)

Simplest case: 1-dimension¶

every node has 3 neighbors (left, center, right)
circular boundary conditions
example rules

\(000 \rightarrow 0\)
\(001 \rightarrow 1\)
\(010 \rightarrow 0\)
\(011 \rightarrow 1\)
\(100 \rightarrow 1\)
\(101 \rightarrow 0\)
\(110 \rightarrow 1\)
\(111 \rightarrow 0\)

Example
By applying the rules the next time step is calculated. For instance for
\([0][0][0][1][0]\)
\(\downarrow\)
\([0][0][1][0][1]\)

Such simple rules can result in complex patterns.

Time evolution of cellular automaton with 101 states and the rules from above. The code is provided in the examples.

Insights: local interactions can lead to global patterns → Pattern formation

2D automata¶

The neighborhoods can be extended to 2 dimension.

Famous example: Conway’s Game of life

References¶

Game of Life, Wikipedia; https://en.wikipedia.org/wiki/Conway%27s_Game_of_Life
A Brief History of Cellular Automata, Palash Sarkar, https://www.cs.ucf.edu/~dcm/Teaching/COT4810-Spring2011/Literature/CellularAutomata.pdf

Cellular automata code¶

Cellular automata in a nutshell¶

A cellular automaton is a discrete model studied in computer science, mathematics, physics, complexity science, theoretical biology and microstructure modeling.

A cellular automaton consists of a regular grid of cells, each in one of a finite number of states, such as on and off.
For each cell, a set of cells called its neighborhood is defined relative to the specified cell.
An initial state (time t = 0) is selected by assigning a state for each cell.
A new generation is created (advancing t by 1), according to some fixed rule (generally, a mathematical function) that determines the new state of each cell in terms of the current state of the cell and the states of the cells in its neighborhood.
Typically, the rule for updating the state of cells is the same for each cell and does not change over time, and is applied to the whole grid simultaneously.

For more information see https://en.wikipedia.org/wiki/Cellular_automaton.

A more in depth introduction with hints how to solve the task is given in https://natureofcode.com/book/chapter-7-cellular-automata/

Example: 1-dim cellular automaton¶

Build and simulate the simple cellular automaton with the following characteristics:

Grid: We will use the simplest possible grid, which is one-dimensional: a line of cells.
States: The simplest set of states (beyond having only one state) are the two possible states per cell: 0 or 1.
Neighborhood: The simplest neighborhood in one dimension for any given cell would be the cell itself and its two adjacent neighbors: one to the left and one to the right.
Rules: Define how a cell is updated based on its neighborhood. The simplest rules are identical rules for every cell.

For the update rules we need to define an outcome (new state value 0 or 1) for a cell based on its current neighborhood. The following rules are applied:

neighborhood (with cell in the center) -> new state of cell
-> 0
-> 1
-> 0
-> 1
-> 1
-> 0
-> 1
-> 0

the one dimensional grid contains 101 cells
the initial state of all cells is 0, with exception of the cell in the middle of the grid which starts with state 1

Cellular automaton as a special boolean network¶

reuse our simulator

%matplotlib inline
from matplotlib import pyplot as plt
import numpy as np
from pprint import pprint

def ndsimulate(x0, f_rules, steps=10):
    """ Simulates the boolean network from initial state by applying given rules."""
    states = np.zeros(shape=((steps+1), x0.size), dtype=bool)

    print("-" * 40)
    pprint("x0 = {}".format(x0.astype(np.int)))
    states[0, :] = x0
    for k in range(steps):
        x = states[k]
        states[k+1, :] = f_rules(states[k, :])

    # pprint(states.astype(np.int))
    return states

def plot_states(states, figsize=(5,3), ylabel="time step"):
    """Plot the states."""
    Nt, Nx = states.shape
    fig = plt.figure(figsize=figsize)
    plt.imshow(states.astype(np.double), cmap="binary")
    # plt.colorbar()
    plt.ylabel(ylabel)
    plt.xlabel("state")
    ax = plt.gca()
    ax.set_xticks(range(Nx))
    #ax.set_xticklabels(['x{}'.format(k) for k in range(Nx)])
    ax.set_xticklabels([''.format(k) for k in range(Nx)])
    plt.show()
    return fig

def f_automaton(x):
    """ New state based on neighborhood (cell in center)
    000 -> 0  [0]
    001 -> 1  [1]
    010 -> 0  [2]
    011 -> 1  [3]
    100 -> 1  [4]
    101 -> 0  [5]
    110 -> 1  [6]
    111 -> 0  [7]
    """
    Nx = x.size
    y = np.zeros_like(x)
    for k in range(Nx):

        s = np.zeros(shape=(3,))
        # get the neighborhood
        if k==0:
            s[0] = x[-1]
            s[1] = x[0]
            s[2] = x[1]
        elif k==(Nx-1):
            s[0] = x[Nx-2]
            s[1] = x[Nx-1]
            s[2] = x[0]
        else:
            s = x[(k-1):(k+2)]

        s = ''.join(s.astype(np.uint8).astype(str))

        # update based on neighborhood
        if s == '000':
            y[k] = 0
        elif s == '001':
            y[k] = 1
        elif s == '010':
            y[k] = 0
        elif s == '011':
            y[k] = 1
        elif s == '100':
            y[k] = 1
        elif s == '101':
            y[k] = 0
        elif s == '110':
            y[k] = 1
        elif s == '111':
            y[k] = 0
    return y

# initial condition
Nx = 101  # 101
x0 = np.zeros(Nx, dtype=bool)
x0[int((Nx-1)/2 + 1)] = 1

states = ndsimulate(x0, f_rules=f_automaton, steps=100)
f = plot_states(states, figsize=(10,10))
f.savefig("./images/cellular_automaton.png", dpi=150, bbox_inches="tight")

----------------------------------------
('x0 = [0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 '
 '0 0n'
 ' 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0n'
 ' 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0]')

Create animation¶

In the following we animate the cellular automaton over time. Let the Game of Life begin.

# Create animation
Nt, Nx = states.shape
filenames = []
for k in range(Nt):
    filename = "./results/automaton/a_{:04}.png".format(k)
    # print(filename)

    fig = plt.figure(figsize=(10,4))
    data = states[k,:].astype(np.double)
    data = data.reshape((1, Nx))

    plt.imshow(data, cmap="binary")
    plt.title("time: {}".format(k))
    # plt.ylabel("time: {}".format(k))
    # plt.xlabel("state")
    ax = plt.gca()
    ax.set_xticks([])
    ax.set_xticklabels([])
    ax.set_yticks([])
    ax.set_yticklabels([])

    fig.savefig(filename, bbox_inches="tight")
    plt.close()
    filenames.append(filename)

import imageio

def create_gif(output_file, filenames, duration):
    images = []
    for filename in filenames:
        images.append(imageio.imread(filename))
    imageio.mimsave(output_file, images, duration=duration)

create_gif('./images/automaton.gif', filenames, duration=0.2)

04 Finite difference equations¶

(Lineare und nicht-lineare Abbildungen)

discrete time
rules for update of states
also called: maps

\(x_{t+1} = f(x_{t})\)

Linear map (1D)¶

(Abbildung) First we look at the simplest case of maps, the linear map in 1 dimension

\(x_{t+1} = f(x_{t}) = R \cdot x_{t}\)

From a given initial state we can simulate the time evolution:
\(x_{0}\) (initial condition)
\(x_{1} = R \cdot x_{0}\)
\(x_{2} = R \cdot x_{1} = R^2 \cdot x_{0}\)
\(x_{3} = R \cdot x_{2} = \cdots = R^3 \cdot x_{0}\)
\(\cdots\)

We get a time series of states (trajectory in 1 dimensional state space).

steady state
An important question for dynamical systems are the steady states. Steady states of a map are defined via:
\(\bar{x}_{t+1} = \bar{x}_{t}\)
In case of the linear map this results in
\(R \cdot \bar{x} = \bar{x}\)
\(\bar{x} = 0\)

system behavior

Depending on the value of \(R\) different system behavior is observed in the linear map

\(R > 1\) : growth
\(R = 1\) : steady state (for all x)
\(0 < R < 1\) : decay
\(-1 < R < 0\) : alternating decay
\(R = -1\): periodic cycle
\(R < -1\): alternating growth

We can see the different possible modes in the following figure.

Simple linear map \(x_{t+1} = R \cdot x_{t}\)

graphical solution (web method)
An important tool for the analysis of 1 dimensional maps is the graphical analysis.
One plots the map function (\((x_{t}, f(x_{t})) = (x_{t}, x_{t+1})\) combined with the identity line.

Graphical solution of linear map.

Nonlinear maps¶

(Nichtlineare Abbildung)

The linear map
\(x_{t+1} = R \cdot x_{t}\)
is for \(R > 1\) a simple model of exponential growth. But in reality resources are limited.

logistic map
A better description of growth processes with limitations is the logistic map, which
has an additional term restricting growth.
\(x_{t+1} = R \cdot x_{t} \cdot (1-x_{t})\)
\(0 \leq R \leq 4\)
The map is a function
\([0, 1] \rightarrow [0,1]\)

Example simulation

We will run an example starting from \(x_{0}=0.5\) (initial condition) with \(R=1.5\).

\(x_{0} = 0.5\)
\(x_{1} = \frac{3}{2} \cdot \frac{1}{2} \cdot(1 - \frac{1}{2})=\frac{3}{8}\)
\(x_{2} = \frac{3}{2} \cdot \frac{3}{8} \cdot(1-\frac{3}{8})=0.352\)
\(x_{3} = \cdots = 0.342\)
\(x_{4} = \cdots = 0.3375\)
\(\cdots\)

steady state
We calculate the steady state via
\(\bar{x}_{t+1} = \bar{x}_{t}\)
\(R \cdot \bar{x} \cdot(1-\bar{x}) = \bar{x}\)
\(R - R \cdot \bar{x} = 1\)
Resulting in
\(\bar{x}_{1} = 1-\frac{1}{R}\)
\(\bar{x}_{2} = 0\)

For our example (R=1.5) we get the steady state

\(\bar{x}_{2} = 1-\frac{2}{3} = \frac{1}{3}\)

Graphical solution of logistic map

The steady states can be seen graphically in the web plot

logistic map is a parabel
crossings of map function \(f\) with union line
corresponds to \(x_{t+1} = f(x_{t}) = x_{t}\)

Steady state analysis
We have found that the fix points / steady states in the system are
\(\bar{x}_{1} = 1-\frac{1}{R}\)
\(\bar{x}_{2} = 0\)

An important question is about stability of this fix points? The stability can be calculated by evaluating the derivative in the fix point

References¶

Finite difference equations code¶

Finite difference equations (also known as maps) are simple time-discrete dynamical systems. In every time step the rules (mathematical functions) are applied which give the updated state for the next time point.

discrete time
rules which update state(s)

\[x_{t+1} = f(x_{t})\]

Simulator for maps¶

To be able to analyze maps, we first have to write a simulator which allows to simulate the time evolution from a given initial state \(x0\). The simulator looks very similar to the boolean networks, only that we now can have any state (float) not just binary state (bool). Again we iterate over a loop (simulation steps) and in every loop we apply the rules f. Maps are like boolean networks discrete in time and update states via rules/functions.

%matplotlib inline

from matplotlib import pyplot as plt
import numpy as np
import pandas as pd
from pprint import pprint

def map_simulate(x0, f_rules, steps=10, print_results=True):
    """ simulates map. """
    states = np.zeros(shape=((steps+1), x0.size), dtype=float)


    pprint("x0 = {}".format(x0.astype(np.float)))
    states[0, :] = x0
    for k in range(steps):
        x = states[k]
        states[k+1, :] = f_rules(states[k, :])

    # convert to pandas data frame
    names = [f"S{k}" for k in range(x0.size)]
    index = [f"x{k}" for k in range(steps+1)]
    df = pd.DataFrame(states, columns=names, index=index)
    # add time column
    df["time"] = range(steps+1)

    if print_results:
        print(df)
        print("-" * 40)
    return df

Linear map¶

We can use our simulator to run the the linear map example from the lecture. We use a function generator which creates us our map function for a given R parameter.

def f_linear_factory(R=1.0):
    """x(t+1) = R * x"""
    print(f"Creating f_linear: 'x(t+1) = {R} * x'")

    def f_linear(x, R=R):
        """ Linear map. """
        x_new = R * x
        return x_new

    return f_linear

Now we run the map starting from 1.0 with different R values

df1 = map_simulate(x0=np.array([1.0]), f_rules=f_linear_factory(R=0.8), steps=10)

Creating f_linear: 'x(t+1) = 0.8 * x'
'x0 = [1.]'
           S0  time
x0   1.000000     0
x1   0.800000     1
x2   0.640000     2
x3   0.512000     3
x4   0.409600     4
x5   0.327680     5
x6   0.262144     6
x7   0.209715     7
x8   0.167772     8
x9   0.134218     9
x10  0.107374    10
----------------------------------------

For R values in 0 < R < 1 our state is decaying towards zero, but for R values R>1.0 we see exponential growth

df2 = map_simulate(x0 = np.array([1.0]), f_rules=f_linear_factory(R=1.5))

Creating f_linear: 'x(t+1) = 1.5 * x'
'x0 = [1.]'
            S0  time
x0    1.000000     0
x1    1.500000     1
x2    2.250000     2
x3    3.375000     3
x4    5.062500     4
x5    7.593750     5
x6   11.390625     6
x7   17.085938     7
x8   25.628906     8
x9   38.443359     9
x10  57.665039    10
----------------------------------------

Our simulator also works for multiple states:

# this works also for maps with multiple state variables
df2 = map_simulate(x0 = np.array([1.0, 2.0, 3.0]), f_rules=f_linear_factory(R=-0.8))

Creating f_linear: 'x(t+1) = -0.8 * x'
'x0 = [1. 2. 3.]'
           S0        S1        S2  time
x0   1.000000  2.000000  3.000000     0
x1  -0.800000 -1.600000 -2.400000     1
x2   0.640000  1.280000  1.920000     2
x3  -0.512000 -1.024000 -1.536000     3
x4   0.409600  0.819200  1.228800     4
x5  -0.327680 -0.655360 -0.983040     5
x6   0.262144  0.524288  0.786432     6
x7  -0.209715 -0.419430 -0.629146     7
x8   0.167772  0.335544  0.503316     8
x9  -0.134218 -0.268435 -0.402653     9
x10  0.107374  0.214748  0.322123    10
----------------------------------------

# simulate the various R values
R_values = [-2.0, -1.0, -0.5, 0.0, 0.5, 1.0, 2.0]
results = []
for R in R_values:
    results.append(
        map_simulate(x0 = np.array([1.0]), f_rules=f_linear_factory(R=R))
    )

# plot results
f, axes = plt.subplots(nrows=1, ncols=len(R_values), figsize=(20, 3))
f.subplots_adjust(wspace=0.5)
for k, R in enumerate(R_values):
    ax = axes[k]
    df = results[k]
    ax.plot(df.time, df.S0, 'o', color="black")
    ax.set_title(f"R={R}")
    ax.set_ylabel("state")
    ax.set_xlabel("time")

plt.show()
f.savefig("./images/linear_map.png", bbox_inches="tight", dpi=150)

Creating f_linear: 'x(t+1) = -2.0 * x'
'x0 = [1.]'
         S0  time
x0      1.0     0
x1     -2.0     1
x2      4.0     2
x3     -8.0     3
x4     16.0     4
x5    -32.0     5
x6     64.0     6
x7   -128.0     7
x8    256.0     8
x9   -512.0     9
x10  1024.0    10
----------------------------------------
Creating f_linear: 'x(t+1) = -1.0 * x'
'x0 = [1.]'
      S0  time
x0   1.0     0
x1  -1.0     1
x2   1.0     2
x3  -1.0     3
x4   1.0     4
x5  -1.0     5
x6   1.0     6
x7  -1.0     7
x8   1.0     8
x9  -1.0     9
x10  1.0    10
----------------------------------------
Creating f_linear: 'x(t+1) = -0.5 * x'
'x0 = [1.]'
           S0  time
x0   1.000000     0
x1  -0.500000     1
x2   0.250000     2
x3  -0.125000     3
x4   0.062500     4
x5  -0.031250     5
x6   0.015625     6
x7  -0.007812     7
x8   0.003906     8
x9  -0.001953     9
x10  0.000977    10
----------------------------------------
Creating f_linear: 'x(t+1) = 0.0 * x'
'x0 = [1.]'
      S0  time
x0   1.0     0
x1   0.0     1
x2   0.0     2
x3   0.0     3
x4   0.0     4
x5   0.0     5
x6   0.0     6
x7   0.0     7
x8   0.0     8
x9   0.0     9
x10  0.0    10
----------------------------------------
Creating f_linear: 'x(t+1) = 0.5 * x'
'x0 = [1.]'
           S0  time
x0   1.000000     0
x1   0.500000     1
x2   0.250000     2
x3   0.125000     3
x4   0.062500     4
x5   0.031250     5
x6   0.015625     6
x7   0.007812     7
x8   0.003906     8
x9   0.001953     9
x10  0.000977    10
----------------------------------------
Creating f_linear: 'x(t+1) = 1.0 * x'
'x0 = [1.]'
      S0  time
x0   1.0     0
x1   1.0     1
x2   1.0     2
x3   1.0     3
x4   1.0     4
x5   1.0     5
x6   1.0     6
x7   1.0     7
x8   1.0     8
x9   1.0     9
x10  1.0    10
----------------------------------------
Creating f_linear: 'x(t+1) = 2.0 * x'
'x0 = [1.]'
         S0  time
x0      1.0     0
x1      2.0     1
x2      4.0     2
x3      8.0     3
x4     16.0     4
x5     32.0     5
x6     64.0     6
x7    128.0     7
x8    256.0     8
x9    512.0     9
x10  1024.0    10
----------------------------------------

Web plot¶

We can analyze the behavior of maps visually by using web plots. These plots show the time evolution from a given initial state for 1-dimensional maps.

def web_plot(x0, f_rules, steps=10):
    """Web plot for given map."""

    # get time series values
    df = map_simulate(x0, f_rules, steps=steps)
    x_series = df.S0.values

    xvec = np.linspace(0, max(1, max(x_series)), num=40)
    f, ax = plt.subplots(nrows=1, ncols=1, figsize=(7, 7))
    ax.plot(xvec, f_rules(xvec), label="map")   # plot map
    ax.plot(xvec, xvec, color="darkgrey", label="union line")  # union line

    x_web = []
    y_web = []
    for k in range(len(x_series)):
        if k==0:
            x_web.append(x_series[0])
            y_web.append(0)
        else:
            x_web.append(x_series[k-1])
            y_web.append(x_series[k])

            x_web.append(x_series[k])
            y_web.append(x_series[k])
    ax.set_title(f"x0={x0}, {f_rules.__doc__}")
    ax.plot(x_web, y_web, 'o-', color="black", label="timeseries")
    ax.legend()
    ax.set_xlabel("x(t)")
    ax.set_ylabel("x(t+1)")

    return f

f = web_plot(x0=np.array([0.1]), f_rules=f_linear_factory(R=1.2))
plt.show()
f.savefig("./images/web_plot_linear.png", dpi=150, bbox_inches="tight")

Creating f_linear: 'x(t+1) = 1.2 * x'
'x0 = [0.1]'
           S0  time
x0   0.100000     0
x1   0.120000     1
x2   0.144000     2
x3   0.172800     3
x4   0.207360     4
x5   0.248832     5
x6   0.298598     6
x7   0.358318     7
x8   0.429982     8
x9   0.515978     9
x10  0.619174    10
----------------------------------------

Logistic map¶

In the following we will look at a non-linear 1-dimensional map in more detail, the famous logistic map.

Again we define a function factory which gives us our logistic map for a defined R.

def f_logistic_factory(R=1.0):

    def f_logistic(x, R=R):
        """R * x * (1-x)"""
        return R * x * (1-x)

    return f_logistic

df1 = map_simulate(x0 = np.array([0.5]), f_rules=f_logistic_factory(R=1.5), steps=10)

'x0 = [0.5]'
           S0  time
x0   0.500000     0
x1   0.375000     1
x2   0.351562     2
x3   0.341949     3
x4   0.337530     4
x5   0.335405     5
x6   0.334363     6
x7   0.333847     7
x8   0.333590     8
x9   0.333461     9
x10  0.333397    10
----------------------------------------

We found that for R=1.5 the steady state is 1/3. We can check this by starting from the steady state value.

# start in steady state
df1 = map_simulate(x0 = np.array([1.0/3.0]), f_rules=f_logistic_factory(R=1.5))

'x0 = [0.33333333]'
           S0  time
x0   0.333333     0
x1   0.333333     1
x2   0.333333     2
x3   0.333333     3
x4   0.333333     4
x5   0.333333     5
x6   0.333333     6
x7   0.333333     7
x8   0.333333     8
x9   0.333333     9
x10  0.333333    10
----------------------------------------

f = web_plot(x0=np.array([0.5]), f_rules=f_logistic_factory(R=1.5), steps=10)
plt.show()
# f.savefig("./images/web_plot_logistic.png", dpi=150, bbox_inches="tight")

'x0 = [0.5]'
           S0  time
x0   0.500000     0
x1   0.375000     1
x2   0.351562     2
x3   0.341949     3
x4   0.337530     4
x5   0.335405     5
x6   0.334363     6
x7   0.333847     7
x8   0.333590     8
x9   0.333461     9
x10  0.333397    10
----------------------------------------

For R>3 we see interesting behavior of the logistic map.

f = web_plot(x0=np.array([0.5]), f_rules=f_logistic_factory(R=3.71), steps=20)
plt.show()

'x0 = [0.5]'
           S0  time
x0   0.500000     0
x1   0.927500     1
x2   0.249474     2
x3   0.694649     3
x4   0.786935     4
x5   0.622050     5
x6   0.872235     6
x7   0.413445     7
x8   0.899706     8
x9   0.334773     9
x10  0.826217    10
x11  0.532690    11
x12  0.923535    12
x13  0.261992    13
x14  0.717337    14
x15  0.752257    15
x16  0.691420    16
x17  0.791559    17
x18  0.612124    18
x19  0.880858    19
x20  0.389353    20
----------------------------------------

05 Ordinary differential equations (ODE)¶

Ordinary differential equations (ODE) code¶

Euler method¶

We will mainly use ordinary differential equations of the form.

Here \(\vec{x}\) is a vector of state variables at time \(t\). The parameters of the system are represented by the vector \(\vec{p}\).

In one dimension, the system is written as

And the time-invariant steady states are

The stability of the steady state is determined by the derivative:

The simplest way to solve the equation numerically is the Euler integration

We obtain

Starting from an initial value \(x_0\) at time \(t=0\) the solution can now be determined for later time points.

It is of importance to consider the error of the method. The Euler method introduces an error of \({\cal O}(\Delta t^2)\) per integration step. To obtain the solution \(x(t)\) at a time \(t=T\), \(N=T/\Delta t\) integration steps have to be performed. The total error is therefore of the order \({\cal O}(T \Delta t)\) and decreases with decreasing \(\Delta t\). Euler integration is a first-order method. The method is rarely used in real life (too inefficient).

Example Euler Method¶

We now solve a simple example system with the Euler Method

For \(k>0\) the equation has a stable fix-point at \(x=0\).

The analytical solution at time \(t\) is

We now write a simple function that compares the numerical integration of the simple system with the (known) analytical solution.

%matplotlib inline

import numpy as np
from matplotlib import pyplot as plt

def EulerIntegrator(f_dydt, y0, t_span, N):
    """ The function integrates the simple
    system dx/dt = -k x to a time T using the
    Euler method (N Steps) and initial condition x0.

    param f_dydt: ode system as f(y,t) which returns dy/dt
    param y0: initial values
    param t_span: 2-tuple of floats, interval of integration
    param N: number of time points

    usage: x = SimpleEuler(f, y0, [t_start, t_end], N)
    """
    k = 1 # set parameter k

    # some parameters
    T = float(t_span[1] - t_span[0])
    dt = T/N
    time_vec = np.linspace(t_span[0], t_span[1], num=N)
    x = [float(y0)]

    # integration
    y_vec = []
    for k, t in enumerate(time_vec):
        if k == 0:
            y = y0
        else:
            y = y + dt * f_dydt(y,t)
        y_vec.append(y)

    return y_vec, time_vec


def exponential_decay(y, t):
    """ Linear 1 dimensional ODE"""
    dydt = -0.5 * y
    return dydt

y0 = 10.0

y, t = EulerIntegrator(exponential_decay, y0=y0, t_span=[0,10], N=10)

# plot Euler and exact solution
fig, ax = plt.subplots(nrows=1, ncols=1, figsize=(5,5))

ax.plot(t, y, 'ko-', markersize=8, label='Euler method')
ax.plot(t, y0*np.exp(-0.5*t),'r-',label='analytical solution')

ax.set_xlabel('time t')
ax.set_ylabel('x(t)')
ax.legend(loc='upper right')
plt.show()

Numerical integration in python¶

The module scipy.integrate offers a variety of build-in functions for numerical integration. We will mainly solve_ivp (formerly odeint) for numerical integration.

from scipy.integrate import solve_ivp

help(solve_ivp)

Help on function solve_ivp in module scipy.integrate._ivp.ivp:

solve_ivp(fun, t_span, y0, method='RK45', t_eval=None, dense_output=False, events=None, vectorized=False, args=None, **options)
    Solve an initial value problem for a system of ODEs.

    This function numerically integrates a system of ordinary differential
    equations given an initial value::

        dy / dt = f(t, y)
        y(t0) = y0

    Here t is a one-dimensional independent variable (time), y(t) is an
    n-dimensional vector-valued function (state), and an n-dimensional
    vector-valued function f(t, y) determines the differential equations.
    The goal is to find y(t) approximately satisfying the differential
    equations, given an initial value y(t0)=y0.

    Some of the solvers support integration in the complex domain, but note
    that for stiff ODE solvers, the right-hand side must be
    complex-differentiable (satisfy Cauchy-Riemann equations [11]_).
    To solve a problem in the complex domain, pass y0 with a complex data type.
    Another option always available is to rewrite your problem for real and
    imaginary parts separately.

    Parameters
    ----------
    fun : callable
        Right-hand side of the system. The calling signature is fun(t, y).
        Here t is a scalar, and there are two options for the ndarray y:
        It can either have shape (n,); then fun must return array_like with
        shape (n,). Alternatively it can have shape (n, k); then fun
        must return an array_like with shape (n, k), i.e. each column
        corresponds to a single column in y. The choice between the two
        options is determined by vectorized argument (see below). The
        vectorized implementation allows a faster approximation of the Jacobian
        by finite differences (required for stiff solvers).
    t_span : 2-tuple of floats
        Interval of integration (t0, tf). The solver starts with t=t0 and
        integrates until it reaches t=tf.
    y0 : array_like, shape (n,)
        Initial state. For problems in the complex domain, pass y0 with a
        complex data type (even if the initial value is purely real).
    method : string or OdeSolver, optional
        Integration method to use:

            * 'RK45' (default): Explicit Runge-Kutta method of order 5(4) [1]_.
              The error is controlled assuming accuracy of the fourth-order
              method, but steps are taken using the fifth-order accurate
              formula (local extrapolation is done). A quartic interpolation
              polynomial is used for the dense output [2]_. Can be applied in
              the complex domain.
            * 'RK23': Explicit Runge-Kutta method of order 3(2) [3]_. The error
              is controlled assuming accuracy of the second-order method, but
              steps are taken using the third-order accurate formula (local
              extrapolation is done). A cubic Hermite polynomial is used for the
              dense output. Can be applied in the complex domain.
            * 'DOP853': Explicit Runge-Kutta method of order 8 [13]_.
              Python implementation of the "DOP853" algorithm originally
              written in Fortran [14]_. A 7-th order interpolation polynomial
              accurate to 7-th order is used for the dense output.
              Can be applied in the complex domain.
            * 'Radau': Implicit Runge-Kutta method of the Radau IIA family of
              order 5 [4]_. The error is controlled with a third-order accurate
              embedded formula. A cubic polynomial which satisfies the
              collocation conditions is used for the dense output.
            * 'BDF': Implicit multi-step variable-order (1 to 5) method based
              on a backward differentiation formula for the derivative
              approximation [5]_. The implementation follows the one described
              in [6]_. A quasi-constant step scheme is used and accuracy is
              enhanced using the NDF modification. Can be applied in the
              complex domain.
            * 'LSODA': Adams/BDF method with automatic stiffness detection and
              switching [7]_, [8]_. This is a wrapper of the Fortran solver
              from ODEPACK.

        Explicit Runge-Kutta methods ('RK23', 'RK45', 'DOP853') should be used
        for non-stiff problems and implicit methods ('Radau', 'BDF') for
        stiff problems [9]_. Among Runge-Kutta methods, 'DOP853' is recommended
        for solving with high precision (low values of rtol and atol).

        If not sure, first try to run 'RK45'. If it makes unusually many
        iterations, diverges, or fails, your problem is likely to be stiff and
        you should use 'Radau' or 'BDF'. 'LSODA' can also be a good universal
        choice, but it might be somewhat less convenient to work with as it
        wraps old Fortran code.

        You can also pass an arbitrary class derived from OdeSolver which
        implements the solver.
    t_eval : array_like or None, optional
        Times at which to store the computed solution, must be sorted and lie
        within t_span. If None (default), use points selected by the solver.
    dense_output : bool, optional
        Whether to compute a continuous solution. Default is False.
    events : callable, or list of callables, optional
        Events to track. If None (default), no events will be tracked.
        Each event occurs at the zeros of a continuous function of time and
        state. Each function must have the signature event(t, y) and return
        a float. The solver will find an accurate value of t at which
        event(t, y(t)) = 0 using a root-finding algorithm. By default, all
        zeros will be found. The solver looks for a sign change over each step,
        so if multiple zero crossings occur within one step, events may be
        missed. Additionally each event function might have the following
        attributes:

            terminal: bool, optional
                Whether to terminate integration if this event occurs.
                Implicitly False if not assigned.
            direction: float, optional
                Direction of a zero crossing. If direction is positive,
                event will only trigger when going from negative to positive,
                and vice versa if direction is negative. If 0, then either
                direction will trigger event. Implicitly 0 if not assigned.

        You can assign attributes like event.terminal = True to any
        function in Python.
    vectorized : bool, optional
        Whether fun is implemented in a vectorized fashion. Default is False.
    args : tuple, optional
        Additional arguments to pass to the user-defined functions.  If given,
        the additional arguments are passed to all user-defined functions.
        So if, for example, fun has the signature fun(t, y, a, b, c),
        then jac (if given) and any event functions must have the same
        signature, and args must be a tuple of length 3.
    options
        Options passed to a chosen solver. All options available for already
        implemented solvers are listed below.
    first_step : float or None, optional
        Initial step size. Default is None which means that the algorithm
        should choose.
    max_step : float, optional
        Maximum allowed step size. Default is np.inf, i.e. the step size is not
        bounded and determined solely by the solver.
    rtol, atol : float or array_like, optional
        Relative and absolute tolerances. The solver keeps the local error
        estimates less than atol + rtol * abs(y). Here rtol controls a
        relative accuracy (number of correct digits). But if a component of y
        is approximately below atol, the error only needs to fall within
        the same atol threshold, and the number of correct digits is not
        guaranteed. If components of y have different scales, it might be
        beneficial to set different atol values for different components by
        passing array_like with shape (n,) for atol. Default values are
        1e-3 for rtol and 1e-6 for atol.
    jac : array_like, sparse_matrix, callable or None, optional
        Jacobian matrix of the right-hand side of the system with respect
        to y, required by the 'Radau', 'BDF' and 'LSODA' method. The
        Jacobian matrix has shape (n, n) and its element (i, j) is equal to
        d f_i / d y_j.  There are three ways to define the Jacobian:

            * If array_like or sparse_matrix, the Jacobian is assumed to
              be constant. Not supported by 'LSODA'.
            * If callable, the Jacobian is assumed to depend on both
              t and y; it will be called as jac(t, y) as necessary.
              For 'Radau' and 'BDF' methods, the return value might be a
              sparse matrix.
            * If None (default), the Jacobian will be approximated by
              finite differences.

        It is generally recommended to provide the Jacobian rather than
        relying on a finite-difference approximation.
    jac_sparsity : array_like, sparse matrix or None, optional
        Defines a sparsity structure of the Jacobian matrix for a finite-
        difference approximation. Its shape must be (n, n). This argument
        is ignored if jac is not None. If the Jacobian has only few
        non-zero elements in each row, providing the sparsity structure
        will greatly speed up the computations [10]_. A zero entry means that
        a corresponding element in the Jacobian is always zero. If None
        (default), the Jacobian is assumed to be dense.
        Not supported by 'LSODA', see lband and uband instead.
    lband, uband : int or None, optional
        Parameters defining the bandwidth of the Jacobian for the 'LSODA'
        method, i.e., jac[i, j] != 0 only for i - lband <= j <= i + uband.
        Default is None. Setting these requires your jac routine to return the
        Jacobian in the packed format: the returned array must have n
        columns and uband + lband + 1 rows in which Jacobian diagonals are
        written. Specifically jac_packed[uband + i - j , j] = jac[i, j].
        The same format is used in scipy.linalg.solve_banded (check for an
        illustration).  These parameters can be also used with jac=None to
        reduce the number of Jacobian elements estimated by finite differences.
    min_step : float, optional
        The minimum allowed step size for 'LSODA' method.
        By default min_step is zero.

    Returns
    -------
    Bunch object with the following fields defined:
    t : ndarray, shape (n_points,)
        Time points.
    y : ndarray, shape (n, n_points)
        Values of the solution at t.
    sol : OdeSolution or None
        Found solution as OdeSolution instance; None if dense_output was
        set to False.
    t_events : list of ndarray or None
        Contains for each event type a list of arrays at which an event of
        that type event was detected. None if events was None.
    y_events : list of ndarray or None
        For each value of t_events, the corresponding value of the solution.
        None if events was None.
    nfev : int
        Number of evaluations of the right-hand side.
    njev : int
        Number of evaluations of the Jacobian.
    nlu : int
        Number of LU decompositions.
    status : int
        Reason for algorithm termination:

            * -1: Integration step failed.
            *  0: The solver successfully reached the end of tspan.
            *  1: A termination event occurred.

    message : string
        Human-readable description of the termination reason.
    success : bool
        True if the solver reached the interval end or a termination event
        occurred (status >= 0).

    References
    ----------
    .. [1] J. R. Dormand, P. J. Prince, "A family of embedded Runge-Kutta
           formulae", Journal of Computational and Applied Mathematics, Vol. 6,
           No. 1, pp. 19-26, 1980.
    .. [2] L. W. Shampine, "Some Practical Runge-Kutta Formulas", Mathematics
           of Computation,, Vol. 46, No. 173, pp. 135-150, 1986.
    .. [3] P. Bogacki, L.F. Shampine, "A 3(2) Pair of Runge-Kutta Formulas",
           Appl. Math. Lett. Vol. 2, No. 4. pp. 321-325, 1989.
    .. [4] E. Hairer, G. Wanner, "Solving Ordinary Differential Equations II:
           Stiff and Differential-Algebraic Problems", Sec. IV.8.
    .. [5] Backward Differentiation Formula
            on Wikipedia.
    .. [6] L. F. Shampine, M. W. Reichelt, "THE MATLAB ODE SUITE", SIAM J. SCI.
           COMPUTE., Vol. 18, No. 1, pp. 1-22, January 1997.
    .. [7] A. C. Hindmarsh, "ODEPACK, A Systematized Collection of ODE
           Solvers," IMACS Transactions on Scientific Computation, Vol 1.,
           pp. 55-64, 1983.
    .. [8] L. Petzold, "Automatic selection of methods for solving stiff and
           nonstiff systems of ordinary differential equations", SIAM Journal
           on Scientific and Statistical Computing, Vol. 4, No. 1, pp. 136-148,
           1983.
    .. [9] Stiff equation on
           Wikipedia.
    .. [10] A. Curtis, M. J. D. Powell, and J. Reid, "On the estimation of
            sparse Jacobian matrices", Journal of the Institute of Mathematics
            and its Applications, 13, pp. 117-120, 1974.
    .. [11] Cauchy-Riemann equations on
             Wikipedia.
    .. [12] Lotka-Volterra equations
            on Wikipedia.
    .. [13] E. Hairer, S. P. Norsett G. Wanner, "Solving Ordinary Differential
            Equations I: Nonstiff Problems", Sec. II.
    .. [14] Page with original Fortran code of DOP853.

    Examples
    --------
    Basic exponential decay showing automatically chosen time points.

    >>> from scipy.integrate import solve_ivp
    >>> def exponential_decay(t, y): return -0.5 * y
    >>> sol = solve_ivp(exponential_decay, [0, 10], [2, 4, 8])
    >>> print(sol.t)
    [ 0.          0.11487653  1.26364188  3.06061781  4.81611105  6.57445806
      8.33328988 10.        ]
    >>> print(sol.y)
    [[2.         1.88836035 1.06327177 0.43319312 0.18017253 0.07483045
      0.03107158 0.01350781]
     [4.         3.7767207  2.12654355 0.86638624 0.36034507 0.14966091
      0.06214316 0.02701561]
     [8.         7.5534414  4.25308709 1.73277247 0.72069014 0.29932181
      0.12428631 0.05403123]]

    Specifying points where the solution is desired.

    >>> sol = solve_ivp(exponential_decay, [0, 10], [2, 4, 8],
    ...                 t_eval=[0, 1, 2, 4, 10])
    >>> print(sol.t)
    [ 0  1  2  4 10]
    >>> print(sol.y)
    [[2.         1.21305369 0.73534021 0.27066736 0.01350938]
     [4.         2.42610739 1.47068043 0.54133472 0.02701876]
     [8.         4.85221478 2.94136085 1.08266944 0.05403753]]

    Cannon fired upward with terminal event upon impact. The terminal and
    direction fields of an event are applied by monkey patching a function.
    Here y[0] is position and y[1] is velocity. The projectile starts
    at position 0 with velocity +10. Note that the integration never reaches
    t=100 because the event is terminal.

    >>> def upward_cannon(t, y): return [y[1], -0.5]
    >>> def hit_ground(t, y): return y[0]
    >>> hit_ground.terminal = True
    >>> hit_ground.direction = -1
    >>> sol = solve_ivp(upward_cannon, [0, 100], [0, 10], events=hit_ground)
    >>> print(sol.t_events)
    [array([40.])]
    >>> print(sol.t)
    [0.00000000e+00 9.99900010e-05 1.09989001e-03 1.10988901e-02
     1.11088891e-01 1.11098890e+00 1.11099890e+01 4.00000000e+01]

    Use dense_output and events to find position, which is 100, at the apex
    of the cannonball's trajectory. Apex is not defined as terminal, so both
    apex and hit_ground are found. There is no information at t=20, so the sol
    attribute is used to evaluate the solution. The sol attribute is returned
    by setting dense_output=True. Alternatively, the y_events attribute
    can be used to access the solution at the time of the event.

    >>> def apex(t, y): return y[1]
    >>> sol = solve_ivp(upward_cannon, [0, 100], [0, 10],
    ...                 events=(hit_ground, apex), dense_output=True)
    >>> print(sol.t_events)
    [array([40.]), array([20.])]
    >>> print(sol.t)
    [0.00000000e+00 9.99900010e-05 1.09989001e-03 1.10988901e-02
     1.11088891e-01 1.11098890e+00 1.11099890e+01 4.00000000e+01]
    >>> print(sol.sol(sol.t_events[1][0]))
    [100.   0.]
    >>> print(sol.y_events)
    [array([[-5.68434189e-14, -1.00000000e+01]]), array([[1.00000000e+02, 1.77635684e-15]])]

    As an example of a system with additional parameters, we'll implement
    the Lotka-Volterra equations [12]_.

    >>> def lotkavolterra(t, z, a, b, c, d):
    ...     x, y = z
    ...     return [a*x - b*x*y, -c*y + d*x*y]
    ...

    We pass in the parameter values a=1.5, b=1, c=3 and d=1 with the args
    argument.

    >>> sol = solve_ivp(lotkavolterra, [0, 15], [10, 5], args=(1.5, 1, 3, 1),
    ...                 dense_output=True)

    Compute a dense solution and plot it.

    >>> t = np.linspace(0, 15, 300)
    >>> z = sol.sol(t)
    >>> import matplotlib.pyplot as plt
    >>> plt.plot(t, z.T)
    >>> plt.xlabel('t')
    >>> plt.legend(['x', 'y'], shadow=True)
    >>> plt.title('Lotka-Volterra System')
    >>> plt.show()

We first consider a simple linear ODE of the form

where \(c\) and \(k\) are parameters. The steady state \(x^0\) of the system can be straightforwardly calculated

To solve the system numerically, we must implement the function \(f(x,t) = c - k \cdot x\) into a user-defined {:raw-latex:`tt `python} function.

def exponential_growth(t, y):
    """
    The function implements the simple linear
    ODE dydt = k*y
    """
    return 2.0 * y

To integrate the system numerically, we need to specify the initial condition \(x^0 = x(t=0)\) and a timespan.

from scipy.integrate import solve_ivp
import numpy as np

# solve the ODE
y0 = 1.1
sol = solve_ivp(fun=exponential_growth, y0=np.array([y0]), t_span=[0, 3])

# plot both solutions
fig, ax = plt.subplots(nrows=1, ncols=1, figsize=(5,5))

ax.plot(sol.t, sol.y[0], 'ko-', markersize=8, label='Euler method')
ax.plot(sol.t, y0*np.exp(2.0*sol.t),'r-',label='analytical solution')
ax.set_xlabel('time t')
ax.set_ylabel('y(t)')
ax.legend(loc='upper left')
plt.show()

The Lotka-Volterra System¶

We want to implement the two-dimensional Lotka-Volterra System. A suitable function is

def lotka_volterra(t, x):
    """
    Implements the Lotka-Volterra System x is a two-dimensional vector
    """

    # define parameters
    X = x[0]
    Y = x[1]

    a = 1
    b = 2
    g = 1.5
    d = 2

    dxdt = a*X - b*X*Y
    dydt = g*X*Y - d*Y

    # the function returns the vector [fx, fy]
    return [dxdt, dydt]

First we have a look at state variables over time, i.e. we are looking at the oscillations of x and y through time.

The isoclines can be plotted as follows

import pandas as pd

# parameters for lotka volterra
a = 1
b = 2
g = 1.5
d = 2

# solve the ODE
y0 = [1, 1]
sol = solve_ivp(lotka_volterra, y0=y0, t_span=[0, 50], t_eval=np.linspace(0,50, num=1001))
# store solution in dataframe
s = pd.DataFrame(np.transpose(sol.y), columns=['x', 'y'])
s['time'] = sol.t

# plot solution
fig, (ax1, ax2) = plt.subplots(nrows=1, ncols=2, figsize=(10,5))

# plot timecourse
ax1.plot(s.time, s.x, label='x')
ax1.plot(s.time, s.y, label='y')

ax1.set_xlabel('time')
ax1.set_ylabel('states')
ax1.legend(loc='upper left')

# plot state space with nullklines

ax2.plot([d/g, d/g],[0, 3*a/b],'r-', label="fy=0")
ax2.plot([0, 2*d/g],[a/b, a/b],'b-', label="fx=0")
ax2.plot(s.x, s.y, 'k', alpha=0.8)
ax2.legend()
plt.show()

We can also have a more detailed look on the phase plane. A suitable method are quiver plots (help(plt.quiver).

# solve the ODE
y0 = [1.0, 1.0]
sol = solve_ivp(lotka_volterra, y0=y0, t_span=[0, 50], t_eval=np.linspace(0,50, num=1001))
# store solution in dataframe
s = pd.DataFrame(np.transpose(sol.y), columns=['x', 'y'])
s['time'] = sol.t

x = np.arange(0.1,3,0.1); y = np.arange(0.1,3,0.1)
[xg,yg] = np.meshgrid(x,y)
n = np.size(x); m = np.size(x)
u = np.zeros([n,m])
v = np.zeros([n,m])

for i in range(n):
    for j in range(m):
        df = lotka_volterra(1, [xg[i,j],yg[i,j]])
        df = df/np.linalg.norm(df)
        u[i,j] = df[0]
        v[i,j] = df[1]

fig, ax = plt.subplots(nrows=1, ncols=1, figsize=(10,10))

h = ax.quiver(xg,yg,u,v,0.5, headwidth=5)
ax.plot(s.x, s.y, 'k-', alpha=0.8)
ax.plot([d/g, d/g],[0, 3*a/b],'r-')
ax.plot([0, 2*d/g],[a/b, a/b],'r-')
ax.set_ylim(0, 1.5)
ax.set_xlabel("x")
ax.set_ylabel("y")

plt.show()

06 Models of metabolism¶

lecture notes

07 Stoichiometric matrix¶

lecture notes

08 Constraint-based analysis (CBA)¶

Metabolic network reconstruction¶

Contain:

all metabolic reactions in an organism
genes that encode each enzyme
semi-automatic bottom-up methods have been developed (see Thiele2010)
manual refinement (e.g. removal dead-ends)

Flux balance analysis (FBA)¶

Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network, in particular in genome-scale metabolic networks.

Unknown fluxes are estimated using optimality principles. That is, the flux vector \(v^0\) is assumed to be such that a given objective function is a maximized (such as ATP production of biomass formation).

FBA is based on steady state assumption

\[N \cdot v^0 = 0\]

\(v^0\) is a vector of reaction rates
\(v^0\) is an element of the right nullspace (kernel) of the stoichiometric matrix.
\(v^0\) is typically underdetermined (fewer constraints than unknown fluxes, the number of unknown fluxes is \(r - rank(N)\) )
no need for kinetic information

FBA steps

derive mass balance equations
build up stoichiometric matrix \(N\)
apply constraints to limit feasible solution space
maximize/minize an objective function to find an optimal solution

The most common objective is the biomass objective function (BOF), i.e., growth. Alternatively energy based functions are often used.

Optimization problem

\[\begin{split}\max_{v^0} \; c^T \cdot v \\ s.t. \; N \cdot v^0 = 0 \\ \alpha_i \leq v_i^0 \leq \beta_i\end{split}\]

Often a special biomass function is added to the model

\[\max_{v^0} v_{bio}\]

Solving LP problems

FBA is a linear programming (LP) problem which can be solved using the simplex algorithm.

A system of linear inequalities defines a polytope as a feasible region. The simplex algorithm begins at a starting vertex and moves along the edges of the polytope until it reaches the vertex of the optimal solution.

Solvers

GUROBI
CPLEX
glpk (GNU Linear Programming toolkit)

Non-uniquness of solution

The optimal solution is typically not unique. Typical steps of analysis are either Flux variability analysis, Flux sampling, or running FBA variants with additional constraints like geometric FBA or parsimonious FBA.

Flux variability analysis (FVA)

FBA will not give always give unique solution, because multiple flux states can achieve the same optimum. FVA (or flux variability analysis) finds the ranges of each metabolic flux at the optimum.

Parsimonious FBA (pFBA)

Parsimonious FBA finds a flux distribution which gives the optimal growth rate, but minimizes the total sum of flux. For more details on pFBA, see Lewis2010

Geometric FBA (pFBA)

Geometric FBA finds a unique optimal flux distribution which is central to the range of possible fluxes.

Flux sampling

sampling of flux cone to evaluate possible solution space

Simulating deletions

In addition to species and reactions genes (protein products) are logically connected to reactions. A typical analysis are gene deletions, knocking out genes by setting corresponding reaction fluxes to zero.

Software for constraint-based analysis (CBA)

Many tools exist for performing FBA analysis, e.g.,

COBRA toolbox (Matlab, see Heirendt2019), The COnstraint-Based Reconstruction and Analysis Toolbox
cobrapy (python, see Ebrahim2013)
Escher-FBA (web app, see Rowe2010)

Elementary flux modes (EFM)¶

Alternative analysis method using steady-state assumption \(N \cdot v^0 = 0\)

Enumeration of possible pathways.
A flux mode is a set of reactions that can give rise to a steady state flux vector \(v^0\). An elementary flux mode is a flux mode where no reaction can be removed (=zero flux) and the resulting reactions can still be a flux mode.
The set of EFMs is unique for a given stoichiometry.
The number of EFMs is typically (much) higher then the dimension of the nullspace.

References¶

Heirendt, Laurent, et al. “Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v. 3.0.” Nature protocols 14.3 (2019): 639.
Orth, Jeffrey D., Ines Thiele, and Bernhard Ø. Palsson. “What is flux balance analysis?.” Nature biotechnology 28.3 (2010): 245.
Lewis, Nathan E., et al. “Omic data from evolved E. coli are consistent with computed optimal growth from genome‐scale models.” Molecular systems biology 6.1 (2010).
Ebrahim, Ali, et al. “COBRApy: constraints-based reconstruction and analysis for python.” BMC systems biology 7.1 (2013): 74.
Rowe, Elliot, Bernhard O. Palsson, and Zachary A. King. “Escher-FBA: a web application for interactive flux balance analysis.” BMC systems biology 12.1 (2018): 84.
Thiele, Ines, and Bernhard Ø. Palsson. “A protocol for generating a high-quality genome-scale metabolic reconstruction.” Nature protocols 5.1 (2010): 93.
Schellenberger, Jan, et al. “Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2. 0.” Nature protocols 6.9 (2011): 1290.
Lotz, Katrin, et al. “Elementary flux modes, flux balance analysis, and their application to plant metabolism.” Plant Metabolism. Humana Press, Totowa, NJ, 2014. 231-252.
Megchelenbrink, Wout, Martijn Huynen, and Elena Marchiori. “optGpSampler: an improved tool for uniformly sampling the solution-space of genome-scale metabolic networks.” PloS one 9.2 (2014): e86587.
Wikipedia Simplex Algorithm; https://en.wikipedia.org/wiki/Simplex_algorithm

Constraint-based analysis (CBA) code¶

We will analyse contraint-based models of the form

using cobrapy.

Information in this tutorial is based on https://cobrapy.readthedocs.io/en/latest/

%matplotlib inline

1. Working with metabolic models¶

1.1 Loading and inspecting model¶

To begin with, cobrapy comes with a “textbook” model of E. coli core metabolism. To load the test model use

import cobra
import cobra.test
model = cobra.test.create_test_model("textbook")

The reactions, metabolites, and genes attributes of the cobrapy model are a special type of list called a cobra.DictList, and each one is made up of cobra.Reaction, cobra.Metabolite and cobra.Gene objects respectively.

print(len(model.reactions))
print(len(model.metabolites))
print(len(model.genes))

95
72
137

When using Jupyter notebook this type of information is rendered as a table.

model

Name	e_coli_core
Memory address	0x07fac4a9cb290
Number of metabolites	72
Number of reactions	95
Number of groups	0
Objective expression	1.0Biomass_Ecoli_core - 1.0Biomass_Ecoli_core_reverse_2cdba
Compartments	cytosol, extracellular

Just like a regular list, objects in the DictList can be retrieved by index. For example, to get the 30th reaction in the model (at index 29 because of 0-indexing):

model.reactions[29]

Reaction identifier	EX_glu__L_e
Name	L-Glutamate exchange
Memory address	0x07facb0d14610
Stoichiometry	glu__L_e --> L-Glutamate -->
GPR
Lower bound	0.0
Upper bound	1000.0

Additionally, items can be retrieved by their id using the DictList.get_by_id() function. For example, to get the cytosolic atp metabolite object (the id is “atp_c”), we can do the following:

model.metabolites.get_by_id("atp_c")

Metabolite identifier	atp_c
Name	ATP
Memory address	0x07fac4a737850
Formula	C10H12N5O13P3
Compartment	c
In 13 reaction(s)	PGK, ACKr, ADK1, PFK, PPS, ATPM, SUCOAS, Biomass_Ecoli_core, GLNS, PYK, ATPS4r, PPCK, GLNabc

1.2 Reactions¶

We will consider the reaction glucose 6-phosphate isomerase, which interconverts glucose 6-phosphate and fructose 6-phosphate. The reaction id for this reaction in our test model is PGI.

pgi = model.reactions.get_by_id("PGI")
pgi

Reaction identifier	PGI
Name	glucose-6-phosphate isomerase
Memory address	0x07facb0cfa7d0
Stoichiometry	g6p_c <=> f6p_c D-Glucose 6-phosphate <=> D-Fructose 6-phosphate
GPR	b4025
Lower bound	-1000.0
Upper bound	1000.0

We can also ensure the reaction is mass balanced. This function will return elements which violate mass balance. If it comes back empty, then the reaction is mass balanced.

pgi.check_mass_balance()

{}

1.3 Metabolites¶

We will consider cytosolic atp as our metabolite, which has the id “atp_c” in our test model.

atp = model.metabolites.get_by_id("atp_c")
atp

Metabolite identifier	atp_c
Name	ATP
Memory address	0x07fac4a737850
Formula	C10H12N5O13P3
Compartment	c
In 13 reaction(s)	PGK, ACKr, ADK1, PFK, PPS, ATPM, SUCOAS, Biomass_Ecoli_core, GLNS, PYK, ATPS4r, PPCK, GLNabc

1.4 Genes¶

The gene_reaction_rule is a boolean representation of the gene requirements for this reaction to be active as described in Schellenberger2011.

The GPR is stored as the gene_reaction_rule for a Reaction object as a string.

gpr = pgi.gene_reaction_rule
gpr

'b4025'

Corresponding gene objects also exist. These objects are tracked by the reactions itself, as well as by the model

pgi.genes

frozenset({<Gene b4025 at 0x7facb0d45090>})

pgi_gene = model.genes.get_by_id("b4025")
pgi_gene

Gene identifier	b4025
Name	pgi
Memory address	0x07facb0d45090
Functional	True
In 1 reaction(s)	PGI

Each gene keeps track of the reactions it catalyzes

pgi_gene.reactions

frozenset({<Reaction PGI at 0x7facb0cfa7d0>})

1.5 Export as SBML & Visualization¶

The model can be exported to standard exchange formats, e.g., Systems Biology Markup Language (SBML) and be analyzed in other tools like for instance Cytoscape with cy3sbml

from cobra.io import write_sbml_model
write_sbml_model(model, "./models/e_coli_core.xml")

For instance after loading the model with cy3sbml we can get an overview over the metabolic network with the associated gene-product rules. Note the typical hairball structure of biological networks due to highly connected nodes (cofactor metabolites).

2. FBA simulations¶

Simulations using flux balance analysis can be solved using Model.optimize(). This will maximize or minimize (maximizing is the default) flux through the objective reactions.

import cobra.test
model = cobra.test.create_test_model("textbook")
model

Name	e_coli_core
Memory address	0x07facb0cfafd0
Number of metabolites	72
Number of reactions	95
Number of groups	0
Objective expression	1.0Biomass_Ecoli_core - 1.0Biomass_Ecoli_core_reverse_2cdba
Compartments	cytosol, extracellular

2.1. Running FBA¶

solution = model.optimize()
print(solution)

<Solution 0.874 at 0x7facb0be84d0>

The Model.optimize() function will return a Solution object. A solution object has several attributes:

objective_value: the objective value
status: the status from the linear programming solver
fluxes: a pandas series with flux indexed by reaction identifier. The flux for a reaction variable is the difference of the primal values for the forward and reverse reaction variables.
shadow_prices: a pandas series with shadow price indexed by the metabolite identifier.

For example, after the last call to model.optimize(), if the optimization succeeds it’s status will be optimal. In case the model is infeasible an error is raised.

2.2. Analyzing FBA solutions¶

Models solved using FBA can be further analyzed by using summary methods, which output printed text to give a quick representation of model behavior. Calling the summary method on the entire model displays information on the input and output behavior of the model, along with the optimized objective.

model.summary()

	IN_FLUXES		OUT_FLUXES		OBJECTIVES
	ID	FLUX	ID	FLUX	ID	FLUX
0	o2_e	21.799493	h2o_e	29.175827	Biomass_Ecoli_core	0.873922
1	glc__D_e	10.000000	co2_e	22.809833	NaN	NaN
2	nh4_e	4.765319	h_e	17.530865	NaN	NaN
3	pi_e	3.214895	NaN	NaN	NaN	NaN

In addition, the input-output behavior of individual metabolites can also be inspected using summary methods. For instance, the following commands can be used to examine the overall redox balance of the model

model.metabolites.nadh_c.summary()

		PERCENT	FLUX	REACTION_STRING
RXN_STAT	ID
PRODUCING	GAPD	41.582168	16.023526	g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c
	PDH	24.088820	9.282533	coa_c + nad_c + pyr_c --> accoa_c + co2_c + na...
	AKGDH	13.142408	5.064376	akg_c + coa_c + nad_c --> co2_c + nadh_c + suc...
	MDH	13.142408	5.064376	mal__L_c + nad_c <=> h_c + nadh_c + oaa_c
	Biomass_Ecoli_core	8.044196	3.099800	1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0...
CONSUMING	NADH16	100.000000	38.534610	4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + ...

Or to get a sense of the main energy production and consumption reactions

model.metabolites.atp_c.summary()

		PERCENT	FLUX	REACTION_STRING
RXN_STAT	ID
PRODUCING	ATPS4r	66.579799	45.514010	adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0...
	PGK	23.439885	16.023526	3pg_c + atp_c <=> 13dpg_c + adp_c
	SUCOAS	7.408381	5.064376	atp_c + coa_c + succ_c <=> adp_c + pi_c + succ...
	PYK	2.571936	1.758177	adp_c + h_c + pep_c --> atp_c + pyr_c
CONSUMING	Biomass_Ecoli_core	76.461640	52.269245	1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0...
	ATPM	12.273243	8.390000	atp_c + h2o_c --> adp_c + h_c + pi_c
	PFK	10.938227	7.477382	atp_c + f6p_c --> adp_c + fdp_c + h_c

2.3. Changing objectives¶

The objective function is determined from the objective_coefficient attribute of the objective reaction(s). Generally, a “biomass” function which describes the composition of metabolites which make up a cell is used.

biomass_rxn = model.reactions.get_by_id("Biomass_Ecoli_core")
biomass_rxn

Reaction identifier	Biomass_Ecoli_core
Name	Biomass Objective Function with GAM
Memory address	0x07facb0c110d0
Stoichiometry	1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c ... 1.496 3-Phospho-D-glycerate + 3.7478 Acetyl-CoA + 59.81 ATP + 0.361 D-Erythrose 4-phosphate + 0.0709 D-Fructose 6-phosphate + 0.129 Glyceraldehyde 3-phosphate + 0.205 D-Glucose 6-phosphate + 0.2557...
GPR
Lower bound	0.0
Upper bound	1000.0

Currently in the model, there is only one reaction in the objective (the biomass reaction), with an linear coefficient of 1.

from cobra.util.solver import linear_reaction_coefficients
linear_reaction_coefficients(model)

{<Reaction Biomass_Ecoli_core at 0x7facb0c110d0>: 1.0}

The objective function can be changed by assigning Model.objective, which can be a reaction object (or just it’s name), or a dict of {Reaction: objective_coefficient}.

# change the objective to ATPM
model.objective = "ATPM"

# The upper bound should be 1000, so that we get
# the actual optimal value
model.reactions.get_by_id("ATPM").upper_bound = 1000.
linear_reaction_coefficients(model)

{<Reaction ATPM at 0x7facb0c11990>: 1.0}

model.optimize().objective_value

174.99999999999966

model.summary()

	IN_FLUXES		OUT_FLUXES		OBJECTIVES
	ID	FLUX	ID	FLUX	ID	FLUX
0	o2_e	60.0	co2_e	60.0	ATPM	175.0
1	glc__D_e	10.0	h2o_e	60.0	NaN	NaN

model.metabolites.atp_c.summary()

		PERCENT	FLUX	REACTION_STRING
RXN_STAT	ID
PRODUCING	ATPS4r	72.972973	135.0	adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0...
	SUCOAS	10.810811	20.0	atp_c + coa_c + succ_c <=> adp_c + pi_c + succ...
	PGK	10.810811	20.0	3pg_c + atp_c <=> 13dpg_c + adp_c
	PYK	5.405405	10.0	adp_c + h_c + pep_c --> atp_c + pyr_c
CONSUMING	ATPM	94.594595	175.0	atp_c + h2o_c --> adp_c + h_c + pi_c
CONSUMING	PFK	5.405405	10.0	atp_c + f6p_c --> adp_c + fdp_c + h_c

3 Flux Variability Analysis (FVA)¶

FBA will not give always give unique solution, because multiple flux states can achieve the same optimum. FVA (or flux variability analysis) finds the ranges of each metabolic flux at the optimum.

from cobra.flux_analysis import flux_variability_analysis
flux_variability_analysis(model, model.reactions[:10])

	minimum	maximum
ACALD	-5.247085e-14	0.000000e+00
ACALDt	-5.247085e-14	0.000000e+00
ACKr	-8.024953e-14	0.000000e+00
ACONTa	2.000000e+01	2.000000e+01
ACONTb	2.000000e+01	2.000000e+01
ACt2r	-8.024953e-14	0.000000e+00
ADK1	0.000000e+00	3.410605e-13
AKGDH	2.000000e+01	2.000000e+01
AKGt2r	-3.172656e-14	0.000000e+00
ALCD2x	-4.547474e-14	0.000000e+00

Setting parameter fraction_of_optimium=0.90 would give the flux ranges for reactions at 90% optimality.

cobra.flux_analysis.flux_variability_analysis(
    model, model.reactions[:10], fraction_of_optimum=0.9)

	minimum	maximum
ACALD	-2.692308	0.0
ACALDt	-2.692308	0.0
ACKr	-4.117647	0.0
ACONTa	8.461538	20.0
ACONTb	8.461538	20.0
ACt2r	-4.117647	0.0
ADK1	0.000000	17.5
AKGDH	2.500000	20.0
AKGt2r	-1.489362	0.0
ALCD2x	-2.333333	0.0

3.1. Running FVA in summary methods¶

Flux variability analysis can also be embedded in calls to summary methods. For instance, the expected variability in substrate consumption and product formation can be quickly found by

model.optimize()
model.summary(fva=0.95)

	IN_FLUXES				OUT_FLUXES				OBJECTIVES
	ID	FLUX	FLUX_MIN	FLUX_MAX	ID	FLUX	FLUX_MIN	FLUX_MAX	ID	FLUX
0	o2_e	60.0	55.882353	60.000000	h2o_e	60.0	54.166667	60.000000	ATPM	175.0
1	glc__D_e	10.0	9.500000	10.000000	co2_e	60.0	54.166667	60.000000	NaN	NaN
2	nh4_e	-0.0	-0.000000	0.673077	h_e	0.0	0.000000	5.833333	NaN	NaN
3	NaN	NaN	NaN	NaN	for_e	0.0	0.000000	5.833333	NaN	NaN
4	NaN	NaN	NaN	NaN	ac_e	0.0	0.000000	2.058824	NaN	NaN
5	NaN	NaN	NaN	NaN	acald_e	0.0	0.000000	1.346154	NaN	NaN
6	NaN	NaN	NaN	NaN	pyr_e	0.0	0.000000	1.346154	NaN	NaN
7	NaN	NaN	NaN	NaN	etoh_e	0.0	0.000000	1.166667	NaN	NaN
8	NaN	NaN	NaN	NaN	lac__D_e	0.0	0.000000	1.129032	NaN	NaN
9	NaN	NaN	NaN	NaN	succ_e	0.0	0.000000	0.875000	NaN	NaN
10	NaN	NaN	NaN	NaN	akg_e	0.0	0.000000	0.744681	NaN	NaN
11	NaN	NaN	NaN	NaN	glu__L_e	0.0	0.000000	0.673077	NaN	NaN

4 Flux sampling¶

The easiest way to get started with flux sampling is using the sample function in the flux_analysis submodule. sample takes at least two arguments: a cobra model and the number of samples you want to generate.

This samples from the flux cone of possible solutions (see Megchelenbrink2014 for details).

from cobra.test import create_test_model
from cobra.sampling import sample

model = create_test_model("textbook")
s = sample(model, 500)
s.head()

	ACALD	ACALDt	ACKr	ACONTa	ACONTb	ACt2r	ADK1	AKGDH	AKGt2r	ALCD2x	...	RPI	SUCCt2_2	SUCCt3	SUCDi	SUCOAS	TALA	THD2	TKT1	TKT2	TPI
0	-0.279405	-0.204919	-0.495190	11.843064	11.843064	-0.495190	42.164976	9.972375	-0.027105	-0.074487	...	-0.547864	1.638816	3.633646	491.572336	-9.972375	0.538130	3.697968	0.538130	0.534215	9.159104
1	-0.493738	-0.186165	-3.729782	5.419629	5.419629	-3.729782	17.895967	3.137708	-0.422005	-0.307573	...	-7.013742	14.738326	15.027930	903.123183	-3.137708	7.006810	16.375670	7.006810	7.004023	2.801040
2	-2.918138	-0.047177	-5.604668	4.184706	4.184706	-5.604668	21.380668	3.457323	-0.032278	-2.870962	...	-2.137431	18.409834	19.089707	851.886851	-3.457323	2.133926	2.890324	2.133926	2.132516	7.635461
3	-1.210218	-0.108791	-4.188558	5.325057	5.325057	-4.188558	4.512811	1.853503	-0.703495	-1.101427	...	-3.141216	0.985120	1.207118	891.174008	-1.853503	3.108748	4.295533	3.108748	3.095691	6.291233
4	-2.144321	-0.133900	-2.748090	5.946703	5.946703	-2.748090	11.061729	4.668504	-0.052671	-2.010421	...	-4.326408	9.847510	11.487255	963.492028	-4.668504	4.312598	5.354727	4.312598	4.307044	5.605263

5 rows × 95 columns

import altair as alt
p1 = alt.Chart(s).mark_tick().encode(
    x='PGI:Q',
)
p2 = alt.Chart(s).mark_bar().encode(
    alt.X('PGI:Q', bin=True),
    y='count()'
)
p1 & p2

5. Simulating deletions¶

import pandas as pd
import cobra.test
from cobra.flux_analysis import (
    single_gene_deletion, single_reaction_deletion, double_gene_deletion,
    double_reaction_deletion)

model = cobra.test.create_test_model("textbook")

5.1. Single gene and reaction knockouts¶

A commonly asked question when analyzing metabolic models is what will happen if a certain reaction was not allowed to have any flux at all. This can tested using cobrapy by

print('complete model: ', model.optimize())
with model:
    model.reactions.PFK.knock_out()
    print('pfk knocked out: ', model.optimize())

complete model:  <Solution 0.874 at 0x7fac34eeec50>
pfk knocked out:  <Solution 0.704 at 0x7fac34eee550>

For evaluating genetic manipulation strategies, it is more interesting to examine what happens if given genes are knocked out as doing so can affect no reactions in case of redundancy, or more reactions if gene when is participating in more than one reaction.

print('complete model: ', model.optimize())
with model:
    model.genes.b1723.knock_out()
    print('pfkA knocked out: ', model.optimize())
    model.genes.b3916.knock_out()
    print('pfkB knocked out: ', model.optimize())

complete model:  <Solution 0.874 at 0x7fac34ed0d10>
pfkA knocked out:  <Solution 0.874 at 0x7fac34ed0350>
pfkB knocked out:  <Solution 0.704 at 0x7fac34ed0390>

5.2 Single deletions¶

Perform all single gene deletions on a model

deletion_results = single_gene_deletion(model)

These can also be done for only a subset of genes

single_gene_deletion(model, model.genes[:20])

	growth	status
ids
(b1478)	0.873922	optimal
(b0474)	0.873922	optimal
(b0118)	0.873922	optimal
(b2587)	0.873922	optimal
(b1849)	0.873922	optimal
(b0726)	0.858307	optimal
(b1276)	0.873922	optimal
(b0356)	0.873922	optimal
(b0727)	0.858307	optimal
(b3115)	0.873922	optimal
(b3736)	0.374230	optimal
(b2296)	0.873922	optimal
(b0116)	0.782351	optimal
(b0351)	0.873922	optimal
(b1241)	0.873922	optimal
(b3733)	0.374230	optimal
(b3732)	0.374230	optimal
(b3734)	0.374230	optimal
(s0001)	0.211141	optimal
(b3735)	0.374230	optimal

5.3 Double deletions¶

Double deletions run in a similar way. Passing in return_frame=True will cause them to format the results as a pandas.DataFrame.

double_gene_deletion(
    model, model.genes[-5:], return_frame=True).round(4)

	growth	status
ids
(b0008)	0.8739	optimal
(b3919, b2464)	0.7040	optimal
(b2465, b2464)	0.8739	optimal
(b0008, b2935)	0.8739	optimal
(b3919, b2465)	0.7040	optimal
(b2465, b2935)	0.8739	optimal
(b2465)	0.8739	optimal
(b3919)	0.7040	optimal
(b2935)	0.8739	optimal
(b0008, b2464)	0.8739	optimal
(b3919, b2935)	0.7040	optimal
(b2464)	0.8739	optimal
(b0008, b3919)	0.7040	optimal
(b2464, b2935)	0.8739	optimal
(b0008, b2465)	0.8739	optimal

09 Sensitivity analysis¶

Review kinetic models of metabolism

System of reactions with rate laws \(v_k(\vec{x}, \vec{p}) = f(\vec{x}, \vec{p})\) (\(k \in {1, ..., N_r}\)) which depend on metabolites \(x_i\) (\(i \in {1, ..., N_m}\)) and parameters \(p_m\) (\(i \in {1, ..., N_p})\)
Stochiometric matrix \(N \in I\!R(N_m, N_r)\)
Time evolution of \(\vec{x}(t)\) via system of ordinary differential equations from initial state \(\vec{x}_0\) via

\[\frac{d}{dt} \vec{x} = N \cdot \vec{v}\]

Steady state via

\[N \cdot \vec{v} = 0\]

Stability can be analysed using Jacobian matrix \(J = N \frac{d\vec{v}}{d\vec{x}}\)

Sensitivity¶

A sensitivity quantifies how changes in a parameter or state variable affect results.

A key concept is hereby the sensitivity of a function \(y = f(x)\) with respect to a parameter \(x\) defined as derivative

\[\lim_{\Delta x \to 0} \frac{\Delta f(x)}{\Delta x} = \frac{df(x)}{dx}\]

This sensitivity depends on the absolute value of the parameter: absolute sensitivity

Logarithmic sensitivity

Often the relative sensitivity or logarithmic sensitivity, which scales the sensitivity according to a given reference parameter \(x^0\).

\[\frac{d \left( \frac{f(x)}{f(x^0)} \right)}{d \left( \frac{x}{x^0} \right)} = \frac{x^0}{f(x^0)} \cdot \frac{df(x)}{dx} = \frac{d \ln f(x)}{d \ln x}\]

An advantage is that logarithmic sensitivities are unit-less. But can be undefined for certain parameter/value combinations.

Example

For instance we can calculate the sensitivity of a Michaelis-Menten rate equation \(v(x)\) on the metabolite concentrations x at a concentration \(x^0\)

\[v(x) = \frac{V_{m}\cdot x}{K_m + x}\]

\[\frac{d \ln v(x)}{d \ln x} = \frac{x^0}{v(x^0)} \cdot \frac{dv}{dx}|_{X^0}\]

\[\frac{dv}{dx} = \frac{V_m \cdot (K_m+x) - V_m \cdot x}{(K_m + x)^2} = \frac{V_m \cdot K_m}{(K_m + x)^2}\]

\[\frac{d \ln v(x)}{d \ln x} = \frac{x^0}{\frac{V_m \cdot x^0}{K_m + x0}} \cdot \frac{V_m \cdot K_m}{(K_m + x)^2}= \frac{K_m}{K_m + x^0} = \frac{1}{1 + \frac{x^0}{K_m}} \in [0, 1)\]

The logarithmic sensitivities have an intuitive interpretation as the kinetic order of a reaction. For a Michaelis-Menten function, the logarithmic sensititivity with respect to the substrates ranges from

linear regime

\(x^0 \ll K_m \Rightarrow \frac{\partial \ln v}{\partial \ln x} \to 1\) (substrate concentration small compared to \(K_m\))

Compare to \(\frac{V_m \cdot x}{K_m + x} \to_{x << K_m} \frac{V_m}{K_m} \cdot x\)

saturation

\(x^0 \gg K_m \Rightarrow \frac{\partial \ln v}{\partial \ln x} \to 0\) (saturation, substrate concentration large compared to \(K_m\))

Metabolic Control Analysis (MCA)¶

In metabolic networks the steady state variables, that is the fluxes and metabolite concentrations, depend on the value of parameters such as enzyme concentrations, kinetic constants (like Michelis-Menten constants).
The effect of perturbations depends the place of the perturbation.
MCA considers how a perturbation propagates through a metabolic network. Typically: how a change in enzyme concentration (or other parameter) affects the steady state with respect to metabolite concentrations and flux values.
framework for studying the relationship between steady-state properties of a network of biochemical reactions and the properties of the individual reactions
tool for analysis of control and regulation
originally developed for metabolic networks, MCA has found application in signaling pathways, gene expression models, and hierarchical models
metabolic networks are complex systems

MCA is conceptionally similar to classic sensitivity or control theory (from engineering).

The relations between steady state variables and kinetic parameters are usually nonlinear. MCA analyses small parameter changes around steady state.

Two distinct type of coefficients:

elasticity coefficients are local coefficients pertaining to individual reactions. They can be calculated in any given state.
control coefficients and response coefficients are global quantities. They refer to a given steady state of the entire system.

Elasticities¶

An elasticity coefficient quantifies the sensitivity of a reaction rate to the change of a concentration or a parameter while all other arguments of the kinetic law are kept fixed.

In MCA, the partial derivative of a reaction rate with respect to its substrate is called \(\epsilon\)-elasticity

\[\epsilon^{v}_{x} = \frac{\partial v}{\partial x}\]

More general, the sensitivity of the rate \(v_k\) of a reaction to the change of the concentration \(x_i\) of a metabolite is calculated by

\[\epsilon^{v_k}_{x_i} = \frac{\partial v_k}{\partial x_i}\]

The corresponding scaled elasticities are

\[\epsilon^v_x = \frac{x}{v} \frac{\partial v}{\partial x} = \frac{\partial \ln v}{\partial \ln x}\]

\[\epsilon^{v_k}_{x_i} = \frac{x_i}{v_k} \frac{\partial v_k}{\partial x_i} = \frac{\partial \ln v_k(x_i)}{\partial \ln x_i}\]

A set of reactions and a set of metabolites results in an elasticity matrix \(\epsilon\). Note that the Jacobian matrix is \(J = N \cdot \epsilon\).

Examples

What are the logarithmic (normalized/scaled) sensitivities of the following functions with respect to the variable \(x\)

\[v(x) = \frac{V_m \cdot x}{K_m + x} \Rightarrow \frac{\partial \ln v(x)}{\partial \ln x} = \frac{1}{1 + \frac{x^0}{K_m}} \in [0, 1)\]

\[v(x) = k \cdot x \Rightarrow \frac{\partial \ln v(x)}{\partial \ln x} = 1\]

\[v(x) = k \cdot x^n \Rightarrow \frac{\partial \ln v(x)}{\partial \ln x} = n\]

\[v(x) = \frac{V_m \cdot x^n}{K_m^n + x^n} \Rightarrow \frac{\partial \ln v(x)}{\partial \ln x} = n \cdot \left(\frac{1}{1 + \frac{x_0^n}{K_m^n}}\right) \in (0, 1]\]

\[v(x) = \frac{Vv_m}{1 + \frac{1}{x^n/K_i^n}}\]

The \(\pi\)-elasticity is defined with respect to parameters \(p_m\) like kinetic constants, concentrations of enzymes, or concentrations of external metabolites

\[\pi^{v_k}_{p_m} = \frac{p}{v} \frac{\partial v}{\partial p} = \frac{\partial \ln v_k}{\partial \ln p_m}\]

Control coefficients¶

A control coefficient measures the relative steady state change in a system variable, e.g. pathway flux \(J_k\) or metabolite concentration \(x_i\). The two main control coefficients are the flux and concentration control coefficients.

Control coefficients are defined in a stable steady state of the metabolic system, characterized by steady state \(x^{ss}\) concentrations and fluxes \(\vec{J}\).

Any sufficiently small perturbation of an individual reaction rate \(v_k \to v_k + \Delta v_k\) drives the system to a new steady state in close proximity with \(\vec{J} \to \vec{J} + \Delta \vec{J}\) and \(\vec{x^{ss}} \to \vec{x^{ss}} + \Delta \vec{x^{ss}}\).

A measure of the change of fluxes and concentrations are the control coefficients.

Flux control coefficients

The flux control coefficient for the control of rate \(v_k\) over flux \(J_j\) is defined as

\[C^j_k = \frac{v_k}{J_j} \cdot \frac{\partial J_j}{\partial v_k}\]

The flux control coefficient quantifies the control that a certain reaction \(v_k\) exerts on the steady state flux \(J_j\).

The rate change \(\Delta v_k\) is caused by the change of a parameter \(p_k\), that has direct effect solely on \(v_k\)

\[C^j_k = \frac{v_k}{J_j} \cdot \frac{\frac{\partial J_j}{\partial p_k}}{\frac{\partial v_k}{\partial p_k}}\]

Such a parameter might be the enzyme concentration, a kinetic constant, or the concentration of a specific inhibitor or activator.

Concentration control coefficient

The concentration control coefficients specify how the steady state concentrations change due to a perturbation of a parameter (typically an enzyme concentration) that effects one or more fluxes.

\[C^i_k = \frac{v_k}{x^{ss}_i} \cdot \frac{\partial x^{ss}_i}{\partial v_k}\]

Response coefficients¶

The steady state is determined by the values of the parameters.
The response coefficients express the direct dependency of steady state variables on parameters.

Flux response coefficient

Response of steady state flux to parameter perturbations

\[R^j_m = \frac{p_m}{J_j}\cdot \frac{\partial J_j}{\partial p_m}\]

Concentration response coefficient

Response of steady state concentration to parameter perturbation

\[R^i_m = \frac{p_m}{x^{ss}_i}\cdot \frac{\partial x^{ss}_i}{\partial p_m}\]

Theorems of MCA¶

Summation Theorems

The summation theorems make a statement about the total control over a certain steady-state flux or concentration.

The flux control coefficients fulfill

\[\sum_{k=1}^r C_{v_k}^{J_j} = 1\]

That means that all enzymatic reactions can share the control over this flux.

The concentration control coefficients fulfill

\[\sum_{k=1}^r C_{v_k}^{S_i} = 0\]

The control coefficients of a metabolic network for one steady-state concentration are balanced. Enzyme can share control, but some exert negative control while others exert positive control.

Connectivity Theorems

Flux control coefficients and elasticities are related by

\[\sum_{k=1}^r C_{v_k}^{J_j} \epsilon^{v_k}_{x_i} = 0\]

The sum runs over all rates \(v_k\) for any flux \(J_j\)

The connectivity theorem between concentration control coefficients and elasticities is

\[\sum_{k=1}^r C^{x_h}_{v_k} \epsilon^{v_k}_{x_i} = - \delta_{hi}\]

\[\delta_{hi} = 0, if h \neq i, 1 otherwise\]

Again, the sum runs over all rates \(v_k\), while \(x_h\) and \(x_i\) are the concentrations of two fixed metabolites.

References & further reading¶

https://en.wikipedia.org/wiki/Metabolic_control_analysis
Klipp et al, Systems Biology - A textbook, chapter 4.2 - Metabolic control analysis
Reder, C. “Metabolic control theory: a structural approach.” Journal of theoretical biology vol. 135,2 (1988): 175-201. doi:10.1016/s0022-5193(88)80073-0
Kacser, H, and J A Burns. “The control of flux.” Symposia of the Society for Experimental Biology vol. 27 (1973): 65-104.
Heinrich, R, and T A Rapoport. “A linear steady-state treatment of enzymatic chains. General properties, control and effector strength.” European journal of biochemistry vol. 42,1 (1974): 89-95. doi:10.1111/j.1432-1033.1974.tb03318.x

10 Stochastic processes¶

lecture notes

Traditional approach:

deterministic systems, described by ODE rate equations
Only approximation: large molecule numbers, well stirred compartments & bulk reactions

Stochastic approach:

master equation: evolution of probability distribution
Gillespie algorithm: individual stochastic trajectories

Stochastic processes code¶

Gillespie Algorithm¶

By solving the master equation the time evolution of the probability distribution can be calculated.
Unfortunately, the master equation is very difficult to solve, either numerically or analytically.
In most cases, we therefore do not aim to solve the master equation. Rather a trajectory of individual transitions that is consistent with the master equation is simulated.

The most well known algorithm was proposed by D. Gillespie:

The system is in \(x\) at time \(t\)
Estimate probabilities \(w_i\) for all feasible transitions from this state \(x → x´\)
Estimate the time \(\Delta t\) until which the transition happens
Estimate which transition happens. The probability for an individual transition is proportional to \(w_i\).
Update the state \(x\) and time \(t\): \(t → t + \Delta t\)

"""
Stochastic simulation of gene expression using Gillespie.
"""
import numpy as np
import pandas as pd
from matplotlib import pyplot as plt

def stochastic(tend: float=100, omega: float=1, b: float=5.0, info: bool=True) -> pd.DataFrame:
    """
    The parameters are b, dp, dm and the mean number of proteins A0.
    omega is a system size parameter (volume). In the case of omega=1, the concentration
    corresponds to the number of molecules

    :param tend: end time of simulation
    :param omega: system size parameter
    :Param b: burst size, average number of proteins per mRNA

    :return: stochastic gillespie timecourse
    """

    # parameter
    A0 = 100.0  # steady state value of protein

    dm = 2.0
    dp = 0.2
    kp = b * dm
    km = A0 * dp/b

    M0 = km/dm  # steady state value of mRNA
    if info:
        print("[M0]={}; [A0]={}".format(M0, A0))

    # initial conditions
    M = 0
    A = 0

    # simulation
    t = 0  # [min]
    ix = 0
    res = []
    while t<tend:
        res.append([t, M/omega, A/omega])
        ix = ix + 1

        # calculate the rates for all transitions
        w1 = omega * km  # transcription (M,A) -> (M+1, A)
        w2 = dm * M      # decay mRNA    (M,A) -> (M-1, A)
        w3 = kp * M      # translation   (M,A) -> (M, A+1)
        w4 = dp * A      # decay protein (M,A) -> (M, A-1)

        rate = w1 + w2 + w3 + w4

        # estimate time
        eps1 = 1-np.random.random()  # np.random: Uniformly distributed floats over [0, 1)
        dt = -np.log(eps1)/rate
        t = t + dt

        # which transition was selected
        rate_rand = rate * np.random.random()
        if rate_rand < w1:
            M = M + 1  # transcription
        elif rate_rand < w1 + w2:
            M = M - 1  # decay mRNA
        elif rate_rand < w1 + w2 + w3:
            A = A + 1  # translation
        elif rate_rand < w1 + w2 + w3 + w4:
            A = A - 1  # decay protein

    return pd.DataFrame(res, columns=["time", "M", "A"])

def plot_results(dfs, omega, b, **kwargs):
    """ Helper function for plotting.

    :param df:
    :return:
    """
    fig, (ax1, ax2) = plt.subplots(nrows=1, ncols=2, figsize=(10,5))

    ax1.set_title("M (mRNA), omega={}, b={}".format(omega, b))
    ax1.set_ylabel("# mRNA")
    ax2.set_title("A (protein), omega={}, b={}".format(omega, b))
    ax2.set_ylabel("# protein")

    if not isinstance(dfs, list):
        dfs = [dfs]
    for df in dfs:
        ax1.plot(df.time, df.M, color="blue", **kwargs)
        ax2.plot(df.time, df.A, color="red", **kwargs)

    for ax in (ax1, ax2):
        ax.set_xlabel("time [min]")
    plt.show()

Single trajectories¶

df = stochastic(tend=500, omega=1, b=5.0)
plot_results(df, omega=1, b=5.0)

[M0]=2.0; [A0]=100.0

Effect of system size¶

Now we change the system size parameter \(\Omega\).

dfs_omega = []
for omega in [1, 5, 10, 25]:
    df = stochastic(500, omega=omega, b=5.0)
    plot_results(df, omega=omega, b=5.0)
    dfs_omega.append(df)

[M0]=2.0; [A0]=100.0

[M0]=2.0; [A0]=100.0

[M0]=2.0; [A0]=100.0

[M0]=2.0; [A0]=100.0

Effect of the burst size¶

The next step is looking at the burst size of the system, i.e., how many proteins are translated per mRNA.

df_b = []
for b in [1, 5, 40]:
    df = stochastic(500, omega=10, b=b)
    plot_results(df, omega=10, b=b)

[M0]=10.0; [A0]=100.0

[M0]=2.0; [A0]=100.0

[M0]=0.25; [A0]=100.0

Sampling trajectories from master equation¶

omega = 1
b = 40.0
dfs = []
for k in range(100):
    df = stochastic(100, omega=omega, b=b, info=False)
    dfs.append(df)
plot_results(dfs, omega=omega, b=b, alpha=0.3)

_images/10_stochastic_processes_10_0.png

omega = 1
b = 1.0
dfs = []
for k in range(100):
    df = stochastic(100, omega=omega, b=b, info=False)
    dfs.append(df)
plot_results(dfs, omega=omega, b=b)

_images/10_stochastic_processes_11_0.png

11 Signaling¶

Previously metabolism

\[\frac{d}{dt} \vec{x} = N \cdot \vec{v}\]

describing mass flow and metabolic flux

Signaling¶

In signal transduction we focus on information transfer from input signal (internal or external) to output, i.e. cellular response.

General principle of activation of response regulator \(R\) by signal \(S\): signal binds to receptors activating a signal transduction cascade/path which ultimately results in a cellular response.

Main biological steps

receptor binding
complex formation
protein modification (phosphorylation & dephosphorylation)
activation of gene transcription

Typical signals are: growth hormones, pheromones, heat, osmotic pressure, oxidative stress or substances.

Phosphorylation cycle¶

One of the most important signaling motives are protein phosphorylation cycles, i.e., a post-translational modification of a protein in which an amino acid residue is phosphorylated by a protein kinase, and dephosphorylated by a protein phosphatase.

Phosphorylation is a very common mechanism for regulating the activity of enzymes and is the most common post-translational modification. Other modifications are for instance glycosylation, acetylation or lipidation and can be modelled in a very similar manner.

Phosphorylation changes the structural conformation of the protein, the phosphorylated protein has a modified function (e.g. phosphorylation may activate or deactivate a protein)

Important examples are two-component signaling systems and mitogen-activated protein kinase (MAPK or MAP kinase) systems (as well as many others, e.g., phosphorylation of enzymes).

Simple models follow mass-action kinetics. For example the following simple phosphorylation cycle where the kinase activity represents the signal \(S\), and the activity of the phosphatase is assumed to be constant (and included in the rate constant \(k_2\).)

\[v_1 = k_1 \cdot S \cdot R\]

\[v_2 = k_2 \cdot R_p\]

\[\frac{dR_p}{dt} = v_1 - v_2 = k_1 \cdot S \cdot R - k_2 \cdot R_p.\]

\[\frac{dR}{dt} = -v_1 + v_2 = -\frac{dR}{dt}\]

The system exhibits mass conservation \(R_p + R = R^T\), where \(R^T\) denotes the amount of total protein.

\[\frac{d (R + R_p)}{dt} = 0\]

Steady state

Steady state of the system is given by

\[\frac{dR_p}{dt} = k_1 \cdot S \cdot R - k_2 \cdot R_p = k1 \cdot S \cdot (R^T - R_p) - k_2 \cdot R_p = 0\]

\[R_p^0 = R^T \cdot \frac{S}{S + \frac{k_2}{k_1}}\]

\[R^0 = R^T - R_p^0 = R^T \cdot \left(1- \frac{S}{S + \frac{k_2}{k_1}} \right)\]

which is a Michaelis-Menten like response

Note that the dependence on the kinase activity (signal) is hyperbolic, whereas the dependence on total protein is linear.

Sensitivity of steady state

Dependency on signal

\[\frac{\partial R_p^0}{\partial S} |_{S^*} = \frac{R^T(S+\frac{k_2}{k_1}) - R^T \cdot S}{\left(S + \frac{k_2}{k_1}\right)^2}|_{S^*} = \frac{ \frac{k_2}{k_1} \cdot R^T}{ \left(S^* + \frac{k_2}{k_1}\right)^2}\]

\[\frac{\partial \ln R_p^0}{\partial ln S} |_{S^*} = \frac{S}{R_p^0}\cdot \frac{\partial R_p^0}{\partial S}|_{S^*} = \frac{S^*}{R^T \cdot \left(1- \frac{S^*}{S^* + \frac{k_2}{k_1}}\right)} \cdot \frac{\frac{k_2}{k_1} R^T}{\left(S^* + \frac{k_2}{k_1} \right)^2} = \frac{\frac{k_2}{k_1}}{S^* + \frac{k_2}{k_1}} = \frac{1}{1 + \frac{S^*}{\frac{k_2}{k_1}}}\]

Dependency on total response regulator

\[\frac{\partial R_p^0}{\partial R^T} |_{R^T*} = \frac{S}{S+\frac{k_2}{k_1}} = \frac{1}{1 + \frac{k_2/k_1}{S}}\]

Two-component system¶

A two-component regulatory system serves as a basic stimulus-response coupling mechanism to allow organisms to sense and respond to changes in many different environmental conditions.

Two-component signaling systems typically consist of

(membrane-bound) histidine kinase (HK) that senses a specific environmental stimulus (typically homodimeric transmembrane proteins containing a histidine phosphotransfer domain and an ATP binding domain)
corresponding response regulator that mediates the cellular response, mostly through differential expression of target genes (may consist only of receiver domain, but mostly receiver and output domain, often involved in DNA binding)
two-component systems serve as a basic stimulus-response coupling mechanism to allow organism to sense and response to changes in many different environmental conditions.
overall level of phosphorylated response regulator ultimately controls its activity
many HKs are bifunctional and possess phosphatase activity against response regulator
most common in bacteria

Important examples

bacterial chemotaxis
E.coli osmoregulation (EnvZ/OmpR)
B.subtilis sporulation

The chemistry of 2-component system involves
Autophosphorylation: HK-His + ATP <-> HK-His-P + ADP
Phosphotransfer: HK-His-P + RR-Asp <-> HK-His + RR-Asp-P
Dephosphorylation: RR-Asp-P + H20 <-> RR-Asp + Pi

Robustness of two-component systems

The cellular environment fluctuates and protein expression is stochastic. Cells evolved mechanisms to cope with such fluctuations. A well known example is the robustness of (some) two-component systems with respect to fluctuations in the total amounts of proteins.

To model a two-component system (using mass-action kinetics), we consider the dynamics of the histidine kinase \(H\) and the response regulator \(R\). Both exist in phosphorylated and unphosphorylated form. The ODEs are

mass action kinetics
\(H\): histidine kinase
\(R\): response regulator

\[v_1 = k_1 \cdot S \cdot H\]

\[v_2 = k_2 \cdot R \cdot H_p\]

\[v_3 = k_3 \cdot R_p\]

\[\frac{dH_p}{dt} = v_1 - v_2 = k_1 \cdot S \cdot H - k_2 \cdot R \cdot H_p\]

\[\frac{dR_p}{dt} = v_2 - v_3 = k_2 \cdot R \cdot H_p - k_3 \cdot R_p\]

mass conservation: \(H + H_p = H^T\) and \(R + R_p = R^T\)

\[\frac{dH_p}{dt} = k_1 \cdot S \cdot (H^T - H_p) - k_2 \cdot (R^T-R_p) \cdot H_p = k_1 \cdot S \cdot H^T - (k_1 \cdot S + k_2 \cdot R^T)\cdot H^T + k_2 \cdot R_p \cdot H_p\]

\[\frac{dR_p}{dt} = k_2 \cdot (R^T - R_p) - k_3 \cdot R_p = k_2 \cdot R^T - (k_2 + k_3) \cdot R_p\]

steady state solution can be calculated, but lengthy quadratic equation.

In many 2 component systems, the (unphosphorylated) sensor kinase also acts as a phosphatase for the response regulator. This results in redundancy in the system: the phosphorylated form activates the response regulator, the unphosphorylated form deactivates the response regulator.

A possible reason was to prevent residual (auto- or unspecific) activation of the response regulator. The equations, however, show that the effect is more profound.

At steady state we know that \(v1 = v3\). Hence, if the dephosphorylation reaction is

\[v_3 = k_3 \cdot R_p \cdot H\]

the steady state solution for the response regulator is

\[R_p^0 = \frac{k_1}{k_3} \cdot S\]

The resulting expression is independent of the expression of the proteins \(R\) and \(H\). This is often termed perfect adaption or integral feedback.

Ultra-sensitivity¶

An ultrasensitive response describes a response that is more sensitive to changes in input than the hyperbolic Michaelis-Menten response.

Ultrasensitivity was first (heuristically) described by A. Hill in 1910 to describe the sigmoidal O2 binding curve of haemoglobin. The hill equation is

\[y = \frac{k_p \cdot L^n}{K_A^n + L^n}\]

\(y\) denotes some output (such as the fractional binding), \(L\) the concentration of a ligand, \(k_p\) a proportionality constant, \(K_A\) the half-saturation constant, and \(n\) the Hill coefficient.

Increasing n results in steeper sigmoidal response.

What is the logarithmic sensitivity of the output with respect to the ligand concentration?

\[\frac{\partial \ln y}{\partial \ln L} |_{L^*} = \frac{L}{y} \cdot \frac{\partial y}{\partial L} |_{L^*}\]

A mechanistic model for ultrasensitivity was proposed by Goldbeter and Koshland, the Goldbeter-Koshland switch. The switch arises if the reactions in a protein phosphorylation cycle are close to saturation. Similar to equation

\[\frac{dR_p}{dt} = v1 - v2 = \frac{k1 \cdot S \cdot R}{K_{m1} + R} - \frac{k2 \cdot R_p}{K_{m2} + R_p}\]

The solution provides the Goldbeter-Koshland function, a sigmoidal response curve in steady state.

To calculate the steady-state solution \(R_p^0 = f(S)\) is straight-forward but lengthy. It is much simpler to calculate the inverse function \(S = g(R_p^0)\) and plot this function.

There are now several other known mechanisms that result in ultrasensitivity (see articles by Ferrel and Ha).

References & further reading¶

https://en.wikipedia.org/wiki/Post-translational_modification
https://en.wikipedia.org/wiki/Two-component_regulatory_system
https://en.wikipedia.org/wiki/Goldbeter%E2%80%93Koshland_kinetics
Stock, Ann M., Victoria L. Robinson, and Paul N. Goudreau. “Two-component signal transduction.” Annual review of biochemistry 69.1 (2000): 183-215.
Klipp et al, Systems Biology - A textbook, chapter 12.2 - Signaling pathways
Batchelor, Eric, and Mark Goulian. “Robustness and the cycle of phosphorylation and dephosphorylation in a two-component regulatory system.” Proceedings of the National Academy of Sciences 100.2 (2003): 691-696.
Ferrell Jr, James E., and Sang Hoon Ha. “Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity.” Trends in biochemical sciences 39.10 (2014): 496-503.
Ferrell, James E., and Sang Hoon Ha. “Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback.” Trends in biochemical sciences 39.11 (2014): 556-569.
Ferrell Jr, James E., and Sang Hoon Ha. “Ultrasensitivity part III: cascades, bistable switches, and oscillators.” Trends in biochemical sciences 39.12 (2014): 612-618.

Signaling code¶

In the following we will implement and analyse the simple signaling motives from the lecture - phosphorylation cycle - two-component system

In addition we will have a look at a real world example. A MAP kinase model.

We will use tellurium to encode the model, i.e., the ODEs and for simulation. For documentation see https://tellurium.readthedocs.io/en/latest/notebooks.html#modeling-case-studies

%matplotlib inline

1. Building ODE models¶

1.1 Modeling in a nutshell¶

Basic steps: - write down the players (species Si) in your system - write down the processes vi which influence your species and the stoichiometry (number of species consumed/produced via the process) - write down mathematical equations for the processes - equations define the rates of the processes, defining how fast the process changes the species

Processes - require stoichiometry and rate law (kinetics)

\[v1: S1 \rightarrow S2\]

\[v1 = k1 \cdot S1\]

System of ordinary differential equations (ODEs)

The result is a list of mathematical equations (differential equations) * can be solved with numerical methods * results in time courses, i.e., the time-dependent

\[\frac{dS1}{dt} = -v1 = -k1 \cdot S1\]

\[\frac{dS2}{dt} = v1 = k1 \cdot S1\]

Main types of equations * Mass-Action kinetics * Michaelis-Menten Kinetics (irreversible & reversible) * Hill equations (cooperativity) * (Non-)Competitive Inhibition

1.2 Model definition¶

import tellurium as te
import pandas as pd

---------------------------------------------------------------------------

ModuleNotFoundError                       Traceback (most recent call last)

<ipython-input-2-8d1c52be6743> in <module>
----> 1 import tellurium as te
      2 import pandas as pd


ModuleNotFoundError: No module named 'tellurium'

# model definition
model = te.loada(f"""
model example1()
  // compartments and species
  species S1, S2;

  // processes
  v1: S1 -> S2; k1*S1;

  // initial conditions
  S1 = 10.0;

  // parameters
  k1 = 0.1;
end
""")
print(te.sbmlToAntimony(model.getSBML()))

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-3-b51a36b51f47> in <module>
      1 # model definition
----> 2 model = te.loada(f"""
      3 model example1()
      4   // compartments and species
      5   species S1, S2;


NameError: name 'te' is not defined

1.3 simulation¶

model.reset()
s = model.simulate(start=0, end=100, steps=100)
model.plot(s)
s = pd.DataFrame(s, columns=s.colnames)
display(s)

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-4-748f20177d7d> in <module>
----> 1 model.reset()
      2 s = model.simulate(start=0, end=100, steps=100)
      3 model.plot(s)
      4 s = pd.DataFrame(s, columns=s.colnames)
      5 display(s)


NameError: name 'model' is not defined

2. Phosphorylation cycle¶

One of the most important signaling motives are protein phosphorylation cycles, i.e., a post-translational modification of a protein in which an amino acid residue is phosphorylated by a protein kinase, and dephosphorylated by a protein phosphatase.

Simple models follow mass-action kinetics. For example the following simple phosphorylation cycle where the kinase activity represents the signal \(S\), and the activity of the phosphatase is assumed to be constant (and included in the rate constant \(k_2\))

The system exhibits mass conservation \(R_p + R = R^T\), where \(R^T\) denotes the amount of total protein.

2.1 Build model phosphorylation cycle¶

import tellurium as te
import pandas as pd
from IPython.display import display, HTML

---------------------------------------------------------------------------

ModuleNotFoundError                       Traceback (most recent call last)

<ipython-input-5-68a3a525987d> in <module>
----> 1 import tellurium as te
      2 import pandas as pd
      3 from IPython.display import display, HTML


ModuleNotFoundError: No module named 'tellurium'

model_pcycle = te.loada(f"""
model pcycle()
  // compartments and species
  species R, Rp;

  // reactions
  v1: R -> Rp; k1*S*R;
  v2: Rp -> R; k2*Rp;

  // initial conditions
  R = 10.0; Rp = 0.0;

  // parameters
  k1 = 0.1; k2 = 0.1;
  S = 1.0;
end
""")

# print(te.sbmlToAntimony(model_pcycle.getSBML()))
s = model_pcycle.simulate(start=0, end=50, steps=200)
model_pcycle.plot(s)

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-6-0e52bacfcfb1> in <module>
----> 1 model_pcycle = te.loada(f"""
      2 model pcycle()
      3   // compartments and species
      4   species R, Rp;
      5


NameError: name 'te' is not defined

2.2 Check mass balance¶

to check the mass balance we add an assignment rule to the model
to be able to access the variables in the results we Rt to the selections

model_pcycle = te.loada(f"""
model pcycle()
  // compartments and species
  species R, Rp;

  // reactions
  v1: R -> Rp; k1*S*R;
  v2: Rp -> R; k2*Rp;

  // initial conditions
  R = 10.0; Rp = 0.0;

  // parameters
  k1 = 0.1; k2 = 0.1;
  S = 1.0;

  // rules
  Rt := R + Rp
end
""")

# print(te.sbmlToAntimony(model_pcycle.getSBML()))

selections = ["time", "R", "Rp", "S", "Rt"]

s = model_pcycle.simulate(start=0, end=50, steps=200, selections=selections)
model_pcycle.plot(s)
s = pd.DataFrame(s, columns=s.colnames)
display(s)

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-7-a4374d7c48b1> in <module>
----> 1 model_pcycle = te.loada(f"""
      2 model pcycle()
      3   // compartments and species
      4   species R, Rp;
      5


NameError: name 'te' is not defined

2.3 Parameter scan¶

A typical task in a simulation study is to scan parameters and check the influence of parameters on the model.

In the following we will change the parameter of the kinase k1

import numpy as np
from matplotlib import pyplot as plt

model.resetToOrigin()
k1_vec = np.linspace(0, 1, num=21)
# k1_vec = np.logspace(-10, 1, num=21)

# run parameter scan
results = []
for k1 in k1_vec:
    # print(k1)
    model_pcycle.reset()
    model_pcycle["k1"] = k1
    s = model_pcycle.simulate(start=0, end=50, steps=200)
    s = pd.DataFrame(s, columns=s.colnames)
    results.append(s)

# create plot
f, ax = plt.subplots()
kwargs = {"alpha": 0.8}
for k, s in enumerate(results):
    ax.plot(s.time, s.R, color="blue", **kwargs)
    ax.plot(s.time, s.Rp, color="darkorange", **kwargs)
    ax.plot(s.time, s.Rt, color="red", **kwargs)

ax.set_xlabel("time")
ax.set_ylabel("amount")

plt.show()

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-9-bc393d3f761e> in <module>
----> 1 model.resetToOrigin()
      2 k1_vec = np.linspace(0, 1, num=21)
      3 # k1_vec = np.logspace(-10, 1, num=21)
      4
      5 # run parameter scan


NameError: name 'model' is not defined

Important things - numerical simulations (with floating point values and certain accuracy) - steady state concentration depend on the \(k_1\) parameter - the higher the phosphorylation rate the faster the steady state is reached - mass balance is conserved for changing of parameters

Often one is interested in changes in steady state (or other system properties with parameters). - for instance how do the steady state values of R and Rp change with \(k_1\)

# collect steady state values
R_ss = np.zeros_like(k1_vec)
Rp_ss = np.zeros_like(k1_vec)
Rt_ss = np.zeros_like(k1_vec)

for k, s in enumerate(results):
    R_ss[k] = s.R.values[-1]
    Rp_ss[k] = s.Rp.values[-1]
    Rt_ss[k] = s.Rt.values[-1]

f, ax = plt.subplots()
kwargs = {"marker": "s"}
ax.plot(k1_vec, R_ss, color="blue", **kwargs)
ax.plot(k1_vec, Rp_ss, color="darkorange", **kwargs)
ax.plot(k1_vec, Rt_ss, color="red", **kwargs)
ax.set_xlabel("k1")
ax.set_ylabel("amount")
# ax.set_xscale("log")
plt.show()

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-10-2eec67600bbe> in <module>
      1 # collect steady state values
----> 2 R_ss = np.zeros_like(k1_vec)
      3 Rp_ss = np.zeros_like(k1_vec)
      4 Rt_ss = np.zeros_like(k1_vec)
      5


NameError: name 'k1_vec' is not defined

2.4 Steady state (dependency on signal)¶

Steady state of the system is given by

Note that the dependence on the kinase activity (signal) is hyperbolic, whereas the dependence on total protein is linear.

In the following we compare the analytical solution against the numerical solution (vs actual steady state simulation).

# make sure the model is reset
model_pcycle.resetToOrigin()
# print model (to check parameter values)
print(te.sbmlToAntimony(model_pcycle.getSBML()))

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-11-e479a66a6a9f> in <module>
      1 # make sure the model is reset
----> 2 model_pcycle.resetToOrigin()
      3 # print model (to check parameter values)
      4 print(te.sbmlToAntimony(model_pcycle.getSBML()))


NameError: name 'model_pcycle' is not defined

S_vec = np.linspace(0, 10, num=21)
# S_vec = np.logspace(-3, 3, num=100)

R_ss = np.zeros_like(S_vec)
Rp_ss = np.zeros_like(S_vec)
Rt_ss = np.zeros_like(S_vec)

# run parameter scan
results = []
for k, S in enumerate(S_vec):
    model_pcycle.reset()
    model_pcycle["S"] = S
    s = model_pcycle.simulate(start=0, end=50, steps=100)
    s = pd.DataFrame(s, columns=s.colnames)

    # store results
    results.append(s)

    # collect steady state values
    R_ss[k] = s.R.values[-1]
    Rp_ss[k] = s.Rp.values[-1]
    Rt_ss[k] = s.Rt.values[-1]

f, ax = plt.subplots()
kwargs = {"marker": "s", "alpha": 0.8}

ax.plot(S_vec, R_ss, color="blue", label="R_ss", **kwargs)
ax.plot(S_vec, Rp_ss, color="darkorange", label="Rp_ss", **kwargs)
ax.plot(S_vec, Rt_ss, color="red", label="Rt_ss", **kwargs)

# analytical solution
Rp_ssf = model_pcycle.Rt * (1-S_vec/(S_vec + model_pcycle.k2/model_pcycle.k1))
ax.plot(S_vec, Rp_ssf, "-k", label="Rp_ss exact", linewidth="2")

ax.legend()
ax.set_xlabel("S")
ax.set_ylabel("amount")
# ax.set_xscale("log")
plt.show()

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-12-4f1ffbc467d7> in <module>
      9 results = []
     10 for k, S in enumerate(S_vec):
---> 11     model_pcycle.reset()
     12     model_pcycle["S"] = S
     13     s = model_pcycle.simulate(start=0, end=50, steps=100)


NameError: name 'model_pcycle' is not defined

2.5 Steady state sensitivity (signal)¶

Steady state of the system is given by

Dependency on signal

S_vec = np.linspace(0, 10, num=21)
# S_vec = np.logspace(-3, 3, num=100)

dR_dRt = np.zeros_like(S_vec)
dRp_dRt = np.zeros_like(S_vec)
ln_dR_dRt = np.zeros_like(S_vec)
ln_dRp_dRt = np.zeros_like(S_vec)

# change
delta = 0.1  # increase parameter 1%

# run parameter scan
results = []
for k, S in enumerate(S_vec):
    # complete reset
    model_pcycle.resetToOrigin()
    model_pcycle["S"] = S
    s = model_pcycle.simulate(start=0, end=50, steps=100)
    s = pd.DataFrame(s, columns=s.colnames)

    # collect steady state values
    R_ss = s.R.values[-1]
    Rp_ss = s.Rp.values[-1]

    # calculate sensitivity (right sided)
    model_pcycle.resetToOrigin()

    # small parameter change delta S (only one-sided sensitivity)
    model_pcycle["S"] = S * (1 + delta)
    s = model_pcycle.simulate(start=0, end=50, steps=100)
    s = pd.DataFrame(s, columns=s.colnames)

    # collect steady state values
    R_ss_delta = s.R.values[-1]
    Rp_ss_delta = s.Rp.values[-1]


    # dR/dRt ~ (R(S+delta S)-R(Rt))/(delta*S)
    dR_dRt[k] = (R_ss_delta-R_ss)/(S*delta)
    dRp_dRt[k] = (Rp_ss_delta-Rp_ss)/(S*delta)

    # log sensitivities
    ln_dR_dRt[k] = S/R_ss * dR_dRt[k]
    ln_dRp_dRt[k] = S/Rp_ss * dRp_dRt[k]

# plot the sensitivities
f, (ax1, ax2) = plt.subplots(ncols=2, nrows=1, figsize=(10, 5))
f.subplots_adjust(wspace=0.3)
kwargs = {"marker": "s", "alpha": 0.8}

ax1.set_ylabel("dR(p)/dS")
ax1.plot(S_vec, dR_dRt, color="blue", label="dR/dS", **kwargs)
ax1.plot(S_vec, dRp_dRt, color="darkorange", label="dRp/dS", **kwargs)

ax2.set_ylabel("dlnR(p)/dlnS")
ax2.plot(S_vec, ln_dR_dRt, color="blue", label="dlnR/dlnS", **kwargs)
ax2.plot(S_vec, ln_dRp_dRt, color="darkorange", label="dRp/dS", **kwargs)

# analytical solutions
Rp_ssf = model_pcycle.k2/model_pcycle.k1 * model_pcycle.Rt/((S_vec + (model_pcycle.k2/model_pcycle.k1))**2)
ax1.plot(S_vec, Rp_ssf, "-k", label="dRp_dRt exact", linewidth="2")

Rp_ssf = model_pcycle.k2/model_pcycle.k1/(S_vec + (model_pcycle.k2/model_pcycle.k1))
ax2.plot(S_vec, Rp_ssf, "-k", label="dRp_dRt exact", linewidth="2")

for ax in (ax1, ax2):
    ax.legend()
    ax.set_xlabel("S")
    # ax.set_xscale("log")
plt.show()

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-13-b660ac94f742> in <module>
     14 for k, S in enumerate(S_vec):
     15     # complete reset
---> 16     model_pcycle.resetToOrigin()
     17     model_pcycle["S"] = S
     18     s = model_pcycle.simulate(start=0, end=50, steps=100)


NameError: name 'model_pcycle' is not defined

3. Two-component system¶

Two-component signaling systems typically consist of - (membrane-bound) histidine kinase (HK) that senses a specific environmental stimulus (typically homodimeric transmembrane proteins containing a histidine phosphotransfer domain and an ATP binding domain)

mass action kinetics
\(H\): histidine kinase
\(R\): response regulator

mass conservation: \(H + H_p = H^T\) and \(R + R_p = R^T\)

model_twocomp = te.loada(f"""
model pcycle()
  v1: H -> Hp; k1*S*H;
  v2: Hp + R -> H + Rp; k2*R*Hp;
  v3: Rp -> R; k3 * Rp;

  // species
  species H, Hp, R, Rp;

  // initial values
  H = 10.0; Hp = 0.0;
  R = 10.0; Rp = 0.0;

  // parameters
  S = 1.0;
  k1 = 0.1; k2 = 0.1; k3 = 0.1;

  // rules
  Ht := H + Hp
  Rt := R + Rp
end
""")
model_twocomp.selections = ["time", "H", "Hp", "R", "Rp"]
model_twocomp.simulate(start=0, end=100, steps=200)
model_twocomp.plot()

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-14-d8866ae53e1f> in <module>
----> 1 model_twocomp = te.loada(f"""
      2 model pcycle()
      3   v1: H -> Hp; k1*S*H;
      4   v2: Hp + R -> H + Rp; k2*R*Hp;
      5   v3: Rp -> R; k3 * Rp;


NameError: name 'te' is not defined

Steady state solution can be calculated, but lengthy quadratic equation.

# S_vec = np.linspace(0, 10, num=21)
S_vec = np.logspace(-3, 3, num=100)

H_ss = np.zeros_like(S_vec)
Hp_ss = np.zeros_like(S_vec)
R_ss = np.zeros_like(S_vec)
Rp_ss = np.zeros_like(S_vec)

# run parameter scan
results = []
for k, S in enumerate(S_vec):
    model_twocomp.reset()
    model_twocomp["S"] = S
    s = model_twocomp.simulate(start=0, end=500, steps=100)
    s = pd.DataFrame(s, columns=s.colnames)

    # store results
    results.append(s)

    # collect steady state values
    R_ss[k] = s.R.values[-1]
    Rp_ss[k] = s.Rp.values[-1]
    H_ss[k] = s.H.values[-1]
    Hp_ss[k] = s.Hp.values[-1]

f, ax = plt.subplots()
kwargs = {"marker": "s", "alpha": 0.8}
ax.plot(S_vec, H_ss, color="blue", label="H_ss", **kwargs)
ax.plot(S_vec, Hp_ss, color="darkorange", label="Hp_ss", **kwargs)
ax.plot(S_vec, R_ss, color="darkgreen", label="R_ss", **kwargs)
ax.plot(S_vec, Rp_ss, color="red", label="Rp_ss", **kwargs)
ax.legend()
ax.set_xlabel("S")
ax.set_ylabel("amount")
ax.set_xscale("log")
plt.show()

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-15-c00e474149a9> in <module>
     10 results = []
     11 for k, S in enumerate(S_vec):
---> 12     model_twocomp.reset()
     13     model_twocomp["S"] = S
     14     s = model_twocomp.simulate(start=0, end=500, steps=100)


NameError: name 'model_twocomp' is not defined

3.2 Perfect adaption¶

model_tcperfect = te.loada(f"""
model pcycle()
  v1: H -> Hp; k1*S*H;
  v2: Hp + R -> H + Rp; k2*R*Hp;
  v3: Rp -> R; k3 * Rp * H;

  // initial values
  H = 10.0; Hp = 0.0;
  R = 10.0; Rp = 0.0;

  // parameters
  S = 1.0;
  k1 = 0.1; k2 = 0.1; k3 = 0.1;

  // rules
  Ht := H + Hp
  Rt := R + Rp
end
""")
model_tcperfect.selections = ["time", "H", "Hp", "R", "Rp"]
model_tcperfect.simulate(start=0, end=50, steps=200)
model_tcperfect.plot()

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-16-8ed5631fdc32> in <module>
----> 1 model_tcperfect = te.loada(f"""
      2 model pcycle()
      3   v1: H -> Hp; k1*S*H;
      4   v2: Hp + R -> H + Rp; k2*R*Hp;
      5   v3: Rp -> R; k3 * Rp * H;


NameError: name 'te' is not defined

She steady state solution for the response regulator is

The resulting expression is independent of the expression of the proteins :math:R and :math:H. This is often termed perfect adaption or integral feedback.

S_vec = np.linspace(0, 10, num=100)
# S_vec = np.logspace(-3, 3, num=100)

H_ss = np.zeros_like(S_vec)
Hp_ss = np.zeros_like(S_vec)
R_ss = np.zeros_like(S_vec)
Rp_ss = np.zeros_like(S_vec)

# run parameter scan
results = []
for k, S in enumerate(S_vec):
    model_tcperfect.reset()
    model_tcperfect["Hp"] = 20
    model_tcperfect["Rp"] = 150
    model_tcperfect["S"] = S
    s = model_tcperfect.simulate(start=0, end=500, steps=100)
    s = pd.DataFrame(s, columns=s.colnames)

    # collect steady state values
    R_ss[k] = s.R.values[-1]
    Rp_ss[k] = s.Rp.values[-1]
    H_ss[k] = s.H.values[-1]
    Hp_ss[k] = s.Hp.values[-1]

f, ax = plt.subplots()
kwargs = {"marker": "s", "alpha": 0.8}
ax.plot(S_vec, H_ss, color="blue", label="H_ss", **kwargs)
ax.plot(S_vec, Hp_ss, color="darkorange", label="Hp_ss", **kwargs)
ax.plot(S_vec, R_ss, color="darkgreen", label="R_ss", **kwargs)
ax.plot(S_vec, Rp_ss, color="red", label="Rp_ss", **kwargs)

# analytical solution
Rp_ssf = model_tcperfect.k1/model_tcperfect.k3 * S_vec
ax.plot(S_vec, Rp_ssf, "-k", label="dRp_dRt exact", linewidth="2")

ax.legend()
ax.set_xlabel("S")
ax.set_ylabel("amount")
# ax.set_xscale("log")
plt.show()

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-17-266b2cc18fe9> in <module>
     10 results = []
     11 for k, S in enumerate(S_vec):
---> 12     model_tcperfect.reset()
     13     model_tcperfect["Hp"] = 20
     14     model_tcperfect["Rp"] = 150


NameError: name 'model_tcperfect' is not defined

4. MAPK (real-world example)¶

Kholodenko2000 - Ultrasensitivity and negative feedback bring oscillations in MAPK cascade¶

This model is described in the article:
Negative feedback and ultrasensitivity can bring about oscillations
in the mitogen-activated protein kinase cascades.
Kholodenko BN
Eur. J. Biochem. 2000; 267(6):1583-8
http://identifiers.org/pubmed/10712587

Abstract:

Functional organization of signal transduction into protein phosphorylation cascades, such as the mitogen-activated protein kinase (MAPK) cascades, greatly enhances the sensitivity of cellular targets to external stimuli. The sensitivity increases multiplicatively with the number of cascade levels, so that a tiny change in a stimulus results in a large change in the response, the phenomenon referred to as ultrasensitivity. In a variety of cell types, the MAPK cascades are imbedded in long feedback loops, positive or negative, depending on whether the terminal kinase stimulates or inhibits the activation of the initial level. Here we demonstrate that a negative feedback loop combined with intrinsic ultrasensitivity of the MAPK cascade can bring about sustained oscillations in MAPK phosphorylation. Based on recent kinetic data on the MAPK cascades, we predict that the period of oscillations can range from minutes to hours. The phosphorylation level can vary between the base level and almost 100% of the total protein. The oscillations of the phosphorylation cascades and slow protein diffusion in the cytoplasm can lead to intracellular waves of phospho-proteins.

https://www.ebi.ac.uk/biomodels-main/BIOMD0000000010

import tellurium as te

# Load model from biomodels (may not work with https).
r = te.loadSBMLModel("https://www.ebi.ac.uk/biomodels-main/download?mid=BIOMD0000000010")
result = r.simulate(start=0, end=3000, steps=3000)
r.plot(result)

---------------------------------------------------------------------------

ModuleNotFoundError                       Traceback (most recent call last)

<ipython-input-18-9a85773b2df0> in <module>
----> 1 import tellurium as te
      2
      3 # Load model from biomodels (may not work with https).
      4 r = te.loadSBMLModel("https://www.ebi.ac.uk/biomodels-main/download?mid=BIOMD0000000010")
      5 result = r.simulate(start=0, end=3000, steps=3000)


ModuleNotFoundError: No module named 'tellurium'

print(te.sbmlToAntimony(r.getSBML()))

---------------------------------------------------------------------------

NameError                                 Traceback (most recent call last)

<ipython-input-19-4cfabc9f32e0> in <module>
----> 1 print(te.sbmlToAntimony(r.getSBML()))

NameError: name 'te' is not defined

12 Standard formats¶

lecture slides

13 Parameter fitting¶

lecture notes

Parameter fitting code¶

import numpy as np
from matplotlib import pyplot as plt

# global settings for plots
plt.rcParams.update({
    'axes.labelsize': 'large',
    'axes.labelweight': 'bold',
    'axes.titlesize': 'medium',
    'axes.titleweight': 'bold',
    'legend.fontsize': 'small',
    'xtick.labelsize': 'large',
    'ytick.labelsize': 'large',
    'figure.facecolor': '1.00'
})

1. Particle Swarm Optimization (PSO)¶

Particle swarm optimization solves a problem by - having a population of candidate solutions, here dubbed particles - moving these particles around in the search-space according to simple mathematical formulae over the particle’s position and velocity. - Each particle’s movement is influenced by its local best known position, but is also guided toward the best known positions in the search-space, which are updated as better positions are found by other particles.

https://en.wikipedia.org/wiki/Particle_swarm_optimization

PSO is a metaheuristic: makes few or no assumptions about the problem being optimized
can search very large spaces of candidate solutions.
However, metaheuristics such as PSO do not guarantee an optimal solution is ever found.
PSO does not use the gradient of the problem being optimized, which means PSO does not require that the optimization problem be differentiable as is required by classic optimization methods such as gradient descent and quasi-newton methods.

2. Steepest descent (gradient descent)¶

In the following example we apply the gradient descent algorithm to find a local minima in a 1 dimensional function:

Function \(F{(x)}=x^{4}-3x^{3}+2\),

with derivative \(F'{(x)}=4x^{3}-9x^{2}\)

and second derivative \(F''{(x)}=12x^{2}-18x\)

https://en.wikipedia.org/wiki/Gradient_descent

2.1 Analytical solution¶

We can easily calculate the minima analytically via \(F(x)=0\) as \(x_1=0\) and \(x_2=9/4=2.25\).

\(F''{(x_2)} = 12 \cdot (9/4)^2 - 18 \cdot 9/4 =20.25> 0\)

# calculate functions
x = np.linspace(-3, 4, num=100)
F = np.power(x, 4) - 3*np.power(x, 3) +2
Fdx = 4*np.power(x, 3) - 9*np.power(x, 2)
Fdx2 = 12*np.power(x, 2) - 18*x

# figure
fig, (ax1, ax2, ax3) = plt.subplots(nrows=1, ncols=3, figsize=(15,5))
fig.subplots_adjust(wspace=0.3)

ax1.set_title("$F(x)= x^4 -3x^3 +2$")
ax1.set_ylabel("F(x)")
ax2.set_title("$F'(x)= 4x^3 -9x^2$")
ax2.set_ylabel("F'(x)")
ax3.set_title("$F''(x)= 12x^2 -18x$")
ax3.set_ylabel("F''(x)")

ax1.plot(x, F, color="black", label="F(x)")
ax2.plot(x, Fdx, color="blue", label="F'(x)")
ax3.plot(x, Fdx2, color="darkorange", label="F''(x)")
for ax in (ax1, ax2, ax3):
    ax.axhline(0, color="gray")
    ax.axvline(0, color="gray", linestyle="--")
    ax.axvline(9/4, color="gray", linestyle="--")

for ax in (ax1, ax2, ax3):
    ax.set_xlabel("x [-]")

plt.show()

2.2 Numerical calculation¶

Now we implement a simple gradient descent algorithm to find the minimas numerically

x_new = 6.0  # The algorithm starts at x=6
gamma = 0.01  # step size multiplier
precision = 0.00001  # stop criteria
max_iters = 10000  # maximum number of iterations (stop criteria)

# definition of functions
fun = lambda x: np.power(x,4) - 3*np.power(x,3) + 2
df = lambda x: 4 * np.power(x,3) - 9 * np.power(x, 2)

# running algorithm
k = 0  # iteration counter
previous_step_size = 1
x_vals = [x_new]
print(f"Start, {x_new}")
while previous_step_size > precision and k < max_iters:
    x_old = x_new

    # update with stepsize and gradient
    x_new -= gamma * df(x_old)

    # calculate precision (change)
    previous_step_size = abs(x_new - x_old)

    # update counters
    k += 1
    print(f"Step {k}, {x_new}")
    x_vals.append(x_new)

print("The local minimum occurs at", x_new)

Start, 6.0
Step 1, 0.5999999999999996
Step 2, 0.6237599999999996
Step 3, 0.6490692731402646
Step 4, 0.6760475763767438
Step 5, 0.704821965498881
Step 6, 0.7355261366038248
Step 7, 0.7682992721113444
Step 8, 0.8032842278686305
Step 9, 0.840624861847519
Step 10, 0.8804622684298664
Step 11, 0.9229296507309586
Step 12, 0.9681455460305634
Step 13, 1.016205130521792
Step 14, 1.067169389942697
Step 15, 1.1210520795330405
Step 16, 1.1778046421472836
Step 17, 1.237299637824332
Step 18, 1.2993137782331108
Step 19, 1.3635123370474889
Step 20, 1.429437442158506
Step 21, 1.4965033788967752
Step 22, 1.5640022802344904
Step 23, 1.6311231270849003
Step 24, 1.6969855549473505
Step 25, 1.7606875094969714
Step 26, 1.821362659674955
Step 27, 1.8782404675959476
Step 28, 1.930700009196379
Step 29, 1.9783089472809865
Step 30, 2.0208417065692057
Step 31, 2.0582751831448975
Step 32, 2.090764845528107
Step 33, 2.118607415721545
Step 34, 2.1421976265432066
Step 35, 2.1619858762300224
Step 36, 2.178441640823547
Step 37, 2.1920251576443675
Step 38, 2.203167862727841
Step 39, 2.2122606942724694
Step 40, 2.2196486877629633
Step 41, 2.2256301304909205
Step 42, 2.2304587076907274
Step 43, 2.234347382687595
Step 44, 2.2374730902946083
Step 45, 2.239981621916576
Step 46, 2.2419923174775156
Step 47, 2.243602351591089
Step 48, 2.2448905184851697
Step 49, 2.2459204946033684
Step 50, 2.2467436015363202
Step 51, 2.2474011148628947
Step 52, 2.2479261740485823
Step 53, 2.2483453500247714
Step 54, 2.2486799240099864
Step 55, 2.2489469258218673
Step 56, 2.2491599737759116
Step 57, 2.2493299520940697
Step 58, 2.249465555993498
Step 59, 2.24957372949745
Step 60, 2.249660016570137
Step 61, 2.2497288424102844
Step 62, 2.24978373858824
Step 63, 2.2498275231061067
Step 64, 2.249862444322635
Step 65, 2.249890295941524
Step 66, 2.2499125088471215
Step 67, 2.24993022442776
Step 68, 2.249944353104799
Step 69, 2.2499556210437
Step 70, 2.2499646074278457
The local minimum occurs at 2.2499646074278457

x_vals = np.array(x_vals)
x_range = np.arange(0,7,0.1)

from matplotlib import pyplot as plt
f, (ax1, ax2) = plt.subplots(nrows=1, ncols=2, figsize=(10,5))

ax1.plot(x_range, fun(x_range), '-', color="blue", label="f")
ax1.plot(x_vals, fun(x_vals), 'o--', color="black")
ax2.plot(x_range, df(x_range), '-', color="blue", label="df")
ax2.plot(x_vals, df(x_vals), 'o--', color="black", label="df")
ax2.set_xlim(0, 3.0)
ax2.set_ylim(-10, 10)

(-10, 10)

Gradient descent has problems with pathological functions (zig-zag behavior) The “Zig-Zagging” nature of the method is also evident below, where the gradient descent method is applied to \(F\left(x,y\right)=\sin \left({\frac {1}{2}}x^{2}-{\frac {1}{4}}y^{2}+3\right)\cos \left(2x+1-e^{y}\right)\).

3. Model fitting¶

Multiple tools for parameter fitting in models exist. Most of these tools can work with models in SBML description. Examples are - COPASI (http://copasi.org/, http://copasi.org/Support/User_Manual/Tasks/Parameter_Estimation/) - data2dynamics (https://github.com/Data2Dynamics/d2d) - pyPESTO (with AMICI) (https://pypesto.readthedocs.io) - AMICI (https://github.com/ICB-DCM/AMICI)

In the following we are running some example parameter fits with pyPESTO and AMICI.

For installation of AMICI the following is required

sudo apt-get install libatlas-base-dev
sudo apt-get install libhdf5-dev libhdf5-serial-dev

3.1 Example model (conversion reaction)¶

For our example we use a simple model with a single reversible conversion reaction with mass-action kinetics

R1: A <-> B; v = R1_k1 * A - R1_k2*B

The model is available as SBML model which we will use in the following for simulation and parameter fitting.

# sbml file we want to import
sbml_file = './fitting/model_conversion_reaction.xml'

# convert to human readable description
import antimony
antimony.loadSBMLFile(sbml_file)
astr = antimony.getAntimonyString("model_conversion_reaction")
print(astr)

// Created by libAntimony v2.11.0
model *model_conversion_reaction()

  // Compartments and Species:
  compartment compartment_;
  species A in compartment_, B in compartment_;

  // Reactions:
  R1: A -> B; compartment_*(R1_k1*A - R1_k2*B);

  // Species initializations:
  A = 1;
  A has substance_per_volume;
  B = 0;
  B has substance_per_volume;

  // Compartment initializations:
  compartment_ = 1;
  compartment_ has volume;

  // Variable initializations:
  R1_k1 = 0.3;
  R1_k2 = 0.5;

  // Other declarations:
  const compartment_;

  // Unit definitions:
  unit length = metre;
  unit area = metre^2;
  unit volume = 1e-3 litre;
  unit time_unit = time_unit;
  unit substance = 1e-3 mole;
  unit extent = substance;
  unit substance_per_volume = 1e-3 mole / 1e-3 litre;

  // Display Names:
  time_unit is "time";
end

model_conversion_reaction is "New Model"

# run a simulation with roadrunner
import roadrunner
model = roadrunner.RoadRunner(sbml_file)
s = model.simulate(start=0, end=100, steps=200)
model.plot(s)

[[<matplotlib.lines.Line2D at 0x7ff3e12e3b10>],
 [<matplotlib.lines.Line2D at 0x7ff3e12e3090>]]

3.2 Compile AMICI model¶

Parameter fitting is numerically very expensive so the model is compiled to C++ code with AMICI.

import importlib
import os
import sys
import numpy as np
import amici
import amici.plotting
import pypesto


# name of the model that will also be the name of the python module
model_name = 'model_conversion_reaction'
# directory to which the generated model code is written
model_output_dir = 'tmp/' + model_name

# import sbml model, compile and generate amici module
sbml_importer = amici.SbmlImporter(sbml_file)

sbml_importer.sbml2amici(model_name,
                         model_output_dir,
                         verbose=False)

running build_ext
building 'model_conversion_reaction._model_conversion_reaction' extension
swigging swig/model_conversion_reaction.i to swig/model_conversion_reaction_wrap.cpp
swig -python -c++ -modern -outdir model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/swig -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -o swig/model_conversion_reaction_wrap.cpp swig/model_conversion_reaction.i
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c swig/model_conversion_reaction_wrap.cpp -o build/temp.linux-x86_64-3.7/swig/model_conversion_reaction_wrap.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dydx.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dydx.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dydp.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dydp.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dwdx_colptrs.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdx_colptrs.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_total_cl.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_total_cl.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dxdotdp_explicit.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdp_explicit.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dwdp_rowvals.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdp_rowvals.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_x_solver.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_x_solver.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_JDiag.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_JDiag.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_w.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_w.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dxdotdw.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdw.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dwdp_colptrs.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdp_colptrs.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c wrapfunctions.cpp -o build/temp.linux-x86_64-3.7/wrapfunctions.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_JB.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_JB.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_Jy.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_Jy.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_x0.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_x0.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dwdx.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdx.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dxdotdw_rowvals.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdw_rowvals.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dJydsigmay.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dJydsigmay.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dJydy.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dJydy.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dxdotdp_explicit_rowvals.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdp_explicit_rowvals.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_sx0_fixedParameters.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_sx0_fixedParameters.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_x0_fixedParameters.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_x0_fixedParameters.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_xdot.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_xdot.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_JSparseB_colptrs.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparseB_colptrs.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dwdx_rowvals.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdx_rowvals.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_sigmay.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_sigmay.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dxdotdp_explicit_colptrs.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdp_explicit_colptrs.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_JSparse_rowvals.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparse_rowvals.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_y.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_y.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_J.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_J.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_JSparseB.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparseB.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dsigmaydp.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dsigmaydp.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_sx0.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_sx0.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dxdotdp_implicit_rowvals.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdp_implicit_rowvals.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_JSparse.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparse.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dxdotdw_colptrs.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdw_colptrs.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_JSparseB_rowvals.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparseB_rowvals.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dJydy_rowvals.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dJydy_rowvals.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dxdotdp_implicit_colptrs.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdp_implicit_colptrs.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_JSparse_colptrs.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparse_colptrs.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_x_rdata.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_x_rdata.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dJydy_colptrs.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dJydy_colptrs.o -std=c++11
x86_64-linux-gnu-gcc -pthread -Wno-unused-result -Wsign-compare -DNDEBUG -g -fwrapv -O2 -Wall -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -fPIC -I/home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/gsl -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/sundials/include -I/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/ThirdParty/SuiteSparse/include -I/usr/include/openmpi -I/usr/include/hdf5/openmpi -I/usr/include/python3.7m -I/home/mkoenig/envs/mcp/include/python3.7m -c model_conversion_reaction_dwdp.cpp -o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdp.o -std=c++11
x86_64-linux-gnu-g++ -pthread -shared -Wl,-O1 -Wl,-Bsymbolic-functions -Wl,-Bsymbolic-functions -Wl,-z,relro -Wl,-Bsymbolic-functions -Wl,-z,relro -g -fdebug-prefix-map=/build/python3.7-WA8NgD/python3.7-3.7.6=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 build/temp.linux-x86_64-3.7/swig/model_conversion_reaction_wrap.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dydx.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dydp.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdx_colptrs.o build/temp.linux-x86_64-3.7/model_conversion_reaction_total_cl.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdp_explicit.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdp_rowvals.o build/temp.linux-x86_64-3.7/model_conversion_reaction_x_solver.o build/temp.linux-x86_64-3.7/model_conversion_reaction_JDiag.o build/temp.linux-x86_64-3.7/model_conversion_reaction_w.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdw.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdp_colptrs.o build/temp.linux-x86_64-3.7/wrapfunctions.o build/temp.linux-x86_64-3.7/model_conversion_reaction_JB.o build/temp.linux-x86_64-3.7/model_conversion_reaction_Jy.o build/temp.linux-x86_64-3.7/model_conversion_reaction_x0.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdx.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdw_rowvals.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dJydsigmay.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dJydy.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdp_explicit_rowvals.o build/temp.linux-x86_64-3.7/model_conversion_reaction_sx0_fixedParameters.o build/temp.linux-x86_64-3.7/model_conversion_reaction_x0_fixedParameters.o build/temp.linux-x86_64-3.7/model_conversion_reaction_xdot.o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparseB_colptrs.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdx_rowvals.o build/temp.linux-x86_64-3.7/model_conversion_reaction_sigmay.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdp_explicit_colptrs.o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparse_rowvals.o build/temp.linux-x86_64-3.7/model_conversion_reaction_y.o build/temp.linux-x86_64-3.7/model_conversion_reaction_J.o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparseB.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dsigmaydp.o build/temp.linux-x86_64-3.7/model_conversion_reaction_sx0.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdp_implicit_rowvals.o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparse.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdw_colptrs.o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparseB_rowvals.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dJydy_rowvals.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dxdotdp_implicit_colptrs.o build/temp.linux-x86_64-3.7/model_conversion_reaction_JSparse_colptrs.o build/temp.linux-x86_64-3.7/model_conversion_reaction_x_rdata.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dJydy_colptrs.o build/temp.linux-x86_64-3.7/model_conversion_reaction_dwdp.o -L/usr/lib/x86_64-linux-gnu/hdf5/openmpi -L/usr/lib/openmpi/lib -L/home/mkoenig/envs/mcp/lib/python3.7/site-packages/amici/libs -lamici -lsundials -lsuitesparse -lcblas -lhdf5_hl_cpp -lhdf5_hl -lhdf5_cpp -lhdf5 -o /home/mkoenig/git/mcp/docs/notebooks/tmp/model_conversion_reaction/model_conversion_reaction/_model_conversion_reaction.cpython-37m-x86_64-linux-gnu.so

3.3 Load AMICI model¶

We now load the model and run an example simulation

# load amici module (the usual starting point later for the analysis)
sys.path.insert(0, os.path.abspath(model_output_dir))
model_module = importlib.import_module(model_name)
model = model_module.getModel()
model.requireSensitivitiesForAllParameters()
model.setTimepoints(amici.DoubleVector(np.linspace(0, 10, 11)))
model.setParameterScale(amici.ParameterScaling_log10)
model.setParameters(amici.DoubleVector([-0.3,-0.7]))
solver = model.getSolver()
solver.setSensitivityMethod(amici.SensitivityMethod_forward)
solver.setSensitivityOrder(amici.SensitivityOrder_first)

# run example simulation with amici
rdata = amici.runAmiciSimulation(model, solver, None)
print(rdata)
amici.plotting.plotStateTrajectories(rdata)

<amici.numpy.ReturnDataView object at 0x7ff36b42f510>

3.3 Load Experimental data¶

In addition to the model we require experimental data for model fitting.

# define experimental data, artificial data
edata = amici.ExpData(rdata, 0.8, 0.0)

3.4 Optimization (parameter fitting)¶

# ??pypesto.AmiciObjective

# create objective function from amici model
# pesto.AmiciObjective is derived from pesto.Objective,
# the general pesto objective function class
# get the optimizer trace
objective_options = pypesto.ObjectiveOptions(trace_record=True, trace_save_iter=1)

objective = pypesto.AmiciObjective(model, solver, edatas=[edata], max_sensi_order=1,
                                  options=objective_options)

# create optimizer object which contains all information for doing the optimization
# optimizer = pypesto.ScipyOptimizer(method='ls_trf')
optimizer = pypesto.ScipyOptimizer(method='TNC')
# optimizer = pypesto.ScipyOptimizer(method='L-BFGS-B')
# optimizer = pypesto.ScipyOptimizer(method='dogleg')



#optimizer.solver = 'bfgs|meigo'
# if select meigo -> also set default values in solver_options
#optimizer.options = {'maxiter': 1000, 'disp': True} # = pesto.default_options_meigo()
#optimizer.startpoints = []
#optimizer.startpoint_method = 'lhs|uniform|something|function'
#optimizer.n_starts = 100

# see PestoOptions.m for more required options here
# returns OptimizationResult, see parameters.MS for what to return
# list of final optim results foreach multistart, times, hess, grad,
# flags, meta information (which optimizer -> optimizer.get_repr())

# create problem object containing all information on the problem to be solved
problem = pypesto.Problem(objective=objective,
                          lb=[-2,-2], ub=[2,2])

# maybe lb, ub = inf
# other constraints: kwargs, class pesto.Constraints
# constraints on pams, states, esp. pesto.AmiciConstraints (e.g. pam1 + pam2<= const)
# if optimizer cannot handle -> error
# maybe also scaling / transformation of parameters encoded here

# do the optimization
result = pypesto.minimize(problem=problem,
                          optimizer=optimizer,
                          n_starts=10)  # type: pypesto.Result.OptimizeResult
# optimize is a function since it does not need an internal memory,
# just takes input and returns output in the form of a Result object
# 'result' parameter: e.g. some results from somewhere -> pick best start points

# optimization results
result.optimize_result.as_dataframe()

	x	fval	grad	hess	n_fval	n_grad	x0	fval0	trace	exitflag	time	message
0	[1.240593738364695, 0.8524102279096418]	18.272588	[-5.946573534175279e-09, 6.3074264082892035e-09]	None	32	32	[0.31872281423493076, 1.774281155735614]	25.409341	time n_fval n_grad n_hess n_res n_sres...	1	0.351414	Converged (\|f_n-f_(n-1)\| ~= 0)
1	[1.2916461745377459, 0.9034626632086132]	18.272588	[-2.6842875946011517e-10, -4.621958510966866e-11]	None	36	36	[0.45872042834570825, -0.16319850334747477]	18.426206	time n_fval n_grad n_hess n_res n_sres...	1	0.395395	Converged (\|f_n-f_(n-1)\| ~= 0)
2	[1.987819240686852, 1.5996357293541672]	18.272588	[-1.1872761526346859e-11, 2.7857625721764903e-11]	None	10	10	[1.889808236461624, 1.6976467335950565]	18.431448	time n_fval n_grad n_hess n_res n_sres...	1	0.110502	Converged (\|f_n-f_(n-1)\| ~= 0)
3	[1.4887174760999564, 1.1005339647467896]	18.272588	[6.968283430495492e-11, -1.4448026760045995e-10]	None	12	12	[1.5429522809109333, 1.0462991598998004]	18.309582	time n_fval n_grad n_hess n_res n_sres...	1	0.132435	Converged (\|f_n-f_(n-1)\| ~= 0)
4	[1.1800687225918949, 0.7918852112340071]	18.272588	[-3.553474703221968e-09, -1.806187423019605e-09]	None	52	52	[-1.3633216196865523, 0.3148458412777626]	25.497545	time n_fval n_grad n_hess n_res n_sre...	1	0.568169	Converged (\|f_n-f_(n-1)\| ~= 0)
5	[1.1329092021013247, 0.7447255923199679]	18.272588	[1.8634388278067394e-07, -2.2735375979024686e-07]	None	10	10	[1.1066280457099054, 0.7710067141715182]	18.282790	time n_fval n_grad n_hess n_res n_sres...	1	0.110795	Converged (\|f_n-f_(n-1)\| ~= 0)
6	[1.1108673059515404, 0.7226801620718648]	18.272588	[2.5484667328533038e-05, -2.557808617546579e-05]	None	47	47	[-0.6011283950028239, 0.9316754580399342]	25.522714	time n_fval n_grad n_hess n_res n_sres...	1	0.530817	Converged (\|f_n-f_(n-1)\| ~= 0)
7	[0.9892982784716362, 0.6011145066526753]	18.272588	[-2.021036107023119e-06, -3.645212221633074e-06]	None	48	48	[1.143728024175115, -1.2191376083395697]	19.550679	time n_fval n_grad n_hess n_res n_sres...	1	0.527696	Converged (\|f_n-f_(n-1)\| ~= 0)
8	[0.9833201436429737, 0.5951289099005517]	18.272588	[4.972946391938184e-05, -5.647505510047428e-05]	None	57	57	[-1.4801860908669124, -0.9052564726889085]	19.605299	time n_fval n_grad n_hess n_res n_sre...	1	0.624599	Converged (\|f_n-f_(n-1)\| ~= 0)
9	[0.9373972619991663, 0.5492022513634875]	18.272588	[6.487871389783481e-05, -8.853615399245409e-05]	None	16	16	[1.3950467302866691, 0.091431438514892]	19.195009	time n_fval n_grad n_hess n_res n_sres...	1	0.176672	Converged (\|f_n-f_(n-1)\| ~= 0)

3.5 Visualize¶

# waterfall, parameter space, scatter plots, fits to data
# different functions for different plotting types
import pypesto.visualize

pypesto.visualize.waterfall(result)
pypesto.visualize.parameters(result)

<matplotlib.axes._subplots.AxesSubplot at 0x7ff3d4a91f50>

traces = result.optimize_result.get_for_key('trace')
# print(traces)

pypesto.visualize.optimizer_history(result)

<matplotlib.axes._subplots.AxesSubplot at 0x7ff3d4968a10>

pypesto.visualize.profiles(result)

---------------------------------------------------------------------------

IndexError                                Traceback (most recent call last)

<ipython-input-16-c8009df95224> in <module>
----> 1 pypesto.visualize.profiles(result)


~/git/pyPESTO/pypesto/visualize/profiles.py in profiles(results, ax, profile_indices, size, reference, colors, legends, profile_list_id)
     60         for result in results:
     61             tmp_indices = [ind for ind in range(len(
---> 62                 result.profile_result.list[profile_list_id]))]
     63             profile_indices = list(set().union(profile_indices, tmp_indices))
     64


IndexError: list index out of range

14 Biological databases¶

lecture notes

Biological databases code¶

Many data bases provide programatic access via so called webservices. We can easily query such databases uses libraries like request.

import requests

UniprotKB¶

For instance we can For instance a few example gathering data for glucokinase. http://www.uniprot.org/uniprot/P35557

https://www.ebi.ac.uk/proteins/api/doc/

r = requests.get('https://www.ebi.ac.uk/proteins/api/proteins/P35557')

r.status_code

json = r.json()
# json
print(json)

{'accession': 'P35557', 'id': 'HXK4_HUMAN', 'proteinExistence': 'Evidence at protein level', 'info': {'type': 'Swiss-Prot', 'created': '1994-06-01', 'modified': '2019-12-11', 'version': 211}, 'organism': {'taxonomy': 9606, 'names': [{'type': 'scientific', 'value': 'Homo sapiens'}, {'type': 'common', 'value': 'Human'}], 'lineage': ['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata', 'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Primates', 'Haplorrhini', 'Catarrhini', 'Hominidae', 'Homo']}, 'secondaryAccession': ['A4D2J2', 'A4D2J3', 'Q05810'], 'protein': {'recommendedName': {'fullName': {'value': 'Hexokinase-4', 'evidences': [{'code': 'ECO:0000305'}]}, 'shortName': [{'value': 'HK4', 'evidences': [{'code': 'ECO:0000305'}]}], 'ecNumber': [{'value': '2.7.1.1', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '11916951', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/11916951', 'alternativeUrl': 'https://europepmc.org/abstract/MED/11916951'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15277402', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15277402', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15277402'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17082186', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17082186', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17082186'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '18322640', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/18322640', 'alternativeUrl': 'https://europepmc.org/abstract/MED/18322640'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19146401', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/19146401', 'alternativeUrl': 'https://europepmc.org/abstract/MED/19146401'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '25015100', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/25015100', 'alternativeUrl': 'https://europepmc.org/abstract/MED/25015100'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8325892', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8325892', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8325892'}}]}]}, 'alternativeName': [{'fullName': {'value': 'Glucokinase', 'evidences': [{'code': 'ECO:0000303', 'source': {'name': 'PubMed', 'id': '1354840', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/1354840', 'alternativeUrl': 'https://europepmc.org/abstract/MED/1354840'}}]}}, {'fullName': {'value': 'Hexokinase type IV', 'evidences': [{'code': 'ECO:0000250', 'source': {'name': 'UniProtKB', 'id': 'P17712', 'url': 'https://www.uniprot.org/uniprot/P17712'}}]}, 'shortName': [{'value': 'HK IV', 'evidences': [{'code': 'ECO:0000250', 'source': {'name': 'UniProtKB', 'id': 'P17712', 'url': 'https://www.uniprot.org/uniprot/P17712'}}]}]}, {'fullName': {'value': 'Hexokinase-D', 'evidences': [{'code': 'ECO:0000250', 'source': {'name': 'UniProtKB', 'id': 'P17712', 'url': 'https://www.uniprot.org/uniprot/P17712'}}]}}]}, 'gene': [{'name': {'value': 'GCK', 'evidences': [{'code': 'ECO:0000303', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}, {'code': 'ECO:0000312', 'source': {'name': 'HGNC', 'id': 'HGNC:4195', 'url': 'https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:4195'}}]}}], 'comments': [{'type': 'FUNCTION', 'text': [{'value': 'Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:7742312, PubMed:11916951, PubMed:15277402, PubMed:17082186, PubMed:18322640, PubMed:19146401, PubMed:25015100, PubMed:8325892). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:18322640, PubMed:25015100, PubMed:8325892, PubMed:11916951, PubMed:15277402). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (By similarity). In pancreas, plays an important role in modulating insulin secretion (By similarity). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (PubMed:8878425). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:7742312)', 'evidences': [{'code': 'ECO:0000250', 'source': {'name': 'UniProtKB', 'id': 'P17712', 'url': 'https://www.uniprot.org/uniprot/P17712'}}, {'code': 'ECO:0000250', 'source': {'name': 'UniProtKB', 'id': 'P52792', 'url': 'https://www.uniprot.org/uniprot/P52792'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '11916951', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/11916951', 'alternativeUrl': 'https://europepmc.org/abstract/MED/11916951'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15277402', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15277402', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15277402'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17082186', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17082186', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17082186'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '18322640', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/18322640', 'alternativeUrl': 'https://europepmc.org/abstract/MED/18322640'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19146401', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/19146401', 'alternativeUrl': 'https://europepmc.org/abstract/MED/19146401'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '25015100', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/25015100', 'alternativeUrl': 'https://europepmc.org/abstract/MED/25015100'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '7742312', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/7742312', 'alternativeUrl': 'https://europepmc.org/abstract/MED/7742312'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8325892', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8325892', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8325892'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8878425', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8878425', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8878425'}}]}]}, {'type': 'CATALYTIC_ACTIVITY', 'reaction': {'name': 'ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+)', 'dbReferences': [{'type': 'Rhea', 'id': 'RHEA:22740'}, {'type': 'ChEBI', 'id': 'CHEBI:4194'}, {'type': 'ChEBI', 'id': 'CHEBI:15378'}, {'type': 'ChEBI', 'id': 'CHEBI:30616'}, {'type': 'ChEBI', 'id': 'CHEBI:61567'}, {'type': 'ChEBI', 'id': 'CHEBI:456216'}], 'ecNumber': '2.7.1.1', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '11916951', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/11916951', 'alternativeUrl': 'https://europepmc.org/abstract/MED/11916951'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15277402', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15277402', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15277402'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17082186', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17082186', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17082186'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '18322640', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/18322640', 'alternativeUrl': 'https://europepmc.org/abstract/MED/18322640'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19146401', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/19146401', 'alternativeUrl': 'https://europepmc.org/abstract/MED/19146401'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '25015100', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/25015100', 'alternativeUrl': 'https://europepmc.org/abstract/MED/25015100'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8325892', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8325892', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8325892'}}]}, 'physiologicalReactions': [{'direction': 'left-to-right', 'dbReference': {'type': 'Rhea', 'id': 'RHEA:22741'}, 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '11916951', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/11916951', 'alternativeUrl': 'https://europepmc.org/abstract/MED/11916951'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15277402', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15277402', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15277402'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17082186', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17082186', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17082186'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '18322640', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/18322640', 'alternativeUrl': 'https://europepmc.org/abstract/MED/18322640'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19146401', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/19146401', 'alternativeUrl': 'https://europepmc.org/abstract/MED/19146401'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '25015100', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/25015100', 'alternativeUrl': 'https://europepmc.org/abstract/MED/25015100'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8325892', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8325892', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8325892'}}]}]}, {'type': 'CATALYTIC_ACTIVITY', 'reaction': {'name': 'ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+)', 'dbReferences': [{'type': 'Rhea', 'id': 'RHEA:16125'}, {'type': 'ChEBI', 'id': 'CHEBI:15378'}, {'type': 'ChEBI', 'id': 'CHEBI:30616'}, {'type': 'ChEBI', 'id': 'CHEBI:37721'}, {'type': 'ChEBI', 'id': 'CHEBI:61527'}, {'type': 'ChEBI', 'id': 'CHEBI:456216'}], 'ecNumber': '2.7.1.1', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '7742312', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/7742312', 'alternativeUrl': 'https://europepmc.org/abstract/MED/7742312'}}]}, 'physiologicalReactions': [{'direction': 'left-to-right', 'dbReference': {'type': 'Rhea', 'id': 'RHEA:16126'}, 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '7742312', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/7742312', 'alternativeUrl': 'https://europepmc.org/abstract/MED/7742312'}}]}]}, {'type': 'CATALYTIC_ACTIVITY', 'reaction': {'name': 'ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)', 'dbReferences': [{'type': 'Rhea', 'id': 'RHEA:17825'}, {'type': 'ChEBI', 'id': 'CHEBI:4167'}, {'type': 'ChEBI', 'id': 'CHEBI:15378'}, {'type': 'ChEBI', 'id': 'CHEBI:30616'}, {'type': 'ChEBI', 'id': 'CHEBI:61548'}, {'type': 'ChEBI', 'id': 'CHEBI:456216'}], 'ecNumber': '2.7.1.1', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '7742312', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/7742312', 'alternativeUrl': 'https://europepmc.org/abstract/MED/7742312'}}]}, 'physiologicalReactions': [{'direction': 'left-to-right', 'dbReference': {'type': 'Rhea', 'id': 'RHEA:17826'}, 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '7742312', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/7742312', 'alternativeUrl': 'https://europepmc.org/abstract/MED/7742312'}}]}]}, {'type': 'CATALYTIC_ACTIVITY', 'reaction': {'name': 'ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+)', 'dbReferences': [{'type': 'Rhea', 'id': 'RHEA:11028'}, {'type': 'ChEBI', 'id': 'CHEBI:4208'}, {'type': 'ChEBI', 'id': 'CHEBI:15378'}, {'type': 'ChEBI', 'id': 'CHEBI:30616'}, {'type': 'ChEBI', 'id': 'CHEBI:58735'}, {'type': 'ChEBI', 'id': 'CHEBI:456216'}], 'ecNumber': '2.7.1.1', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '7742312', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/7742312', 'alternativeUrl': 'https://europepmc.org/abstract/MED/7742312'}}]}, 'physiologicalReactions': [{'direction': 'left-to-right', 'dbReference': {'type': 'Rhea', 'id': 'RHEA:11029'}, 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '7742312', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/7742312', 'alternativeUrl': 'https://europepmc.org/abstract/MED/7742312'}}]}]}, {'type': 'ACTIVITY_REGULATION', 'text': [{'value': 'Subject to allosteric regulation (PubMed:15016359). Low glucose and high fructose-6-phosphate triggers association with the inhibitor GCKR followed by sequestration in the nucleus (PubMed:10456334)', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '10456334', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/10456334', 'alternativeUrl': 'https://europepmc.org/abstract/MED/10456334'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15016359', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15016359', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15016359'}}]}]}, {'type': 'PATHWAY', 'text': [{'value': 'Carbohydrate metabolism; hexose metabolism', 'evidences': [{'code': 'ECO:0000305', 'source': {'name': 'PubMed', 'id': '7742312', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/7742312', 'alternativeUrl': 'https://europepmc.org/abstract/MED/7742312'}}]}]}, {'type': 'PATHWAY', 'text': [{'value': 'Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4', 'evidences': [{'code': 'ECO:0000305', 'source': {'name': 'PubMed', 'id': '7742312', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/7742312', 'alternativeUrl': 'https://europepmc.org/abstract/MED/7742312'}}]}]}, {'type': 'SUBUNIT', 'text': [{'value': 'Monomer (PubMed:15016359, PubMed:19362831, PubMed:23957911). Interacts with MIDN; the interaction occurs preferentially at low glucose levels and results in inhibition of hexokinase activity (PubMed:24187134). Interacts with GCKR; leading to sequestration in the nucleus (PubMed:10456334)', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '10456334', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/10456334', 'alternativeUrl': 'https://europepmc.org/abstract/MED/10456334'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15016359', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15016359', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15016359'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19362831', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/19362831', 'alternativeUrl': 'https://europepmc.org/abstract/MED/19362831'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '23957911', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/23957911', 'alternativeUrl': 'https://europepmc.org/abstract/MED/23957911'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '24187134', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/24187134', 'alternativeUrl': 'https://europepmc.org/abstract/MED/24187134'}}]}]}, {'type': 'INTERACTION', 'interactions': [{'interactionType': 'BINARY', 'id': 'Q14397', 'gene': 'GCKR', 'interactor1': 'EBI-709928', 'interactor2': 'EBI-709948', 'organismDiffer': False, 'experiments': 2}, {'interactionType': 'BINARY', 'id': 'P16118', 'gene': 'PFKFB1', 'interactor1': 'EBI-709928', 'interactor2': 'EBI-709807', 'organismDiffer': False, 'experiments': 2}]}, {'type': 'SUBCELLULAR_LOCATION', 'locations': [{'location': {'value': 'Cytoplasm', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '10456334', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/10456334', 'alternativeUrl': 'https://europepmc.org/abstract/MED/10456334'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '24187134', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/24187134', 'alternativeUrl': 'https://europepmc.org/abstract/MED/24187134'}}]}}, {'location': {'value': 'Nucleus', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '10456334', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/10456334', 'alternativeUrl': 'https://europepmc.org/abstract/MED/10456334'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '24187134', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/24187134', 'alternativeUrl': 'https://europepmc.org/abstract/MED/24187134'}}]}}, {'location': {'value': 'Mitochondrion', 'evidences': [{'code': 'ECO:0000250', 'source': {'name': 'UniProtKB', 'id': 'P17712', 'url': 'https://www.uniprot.org/uniprot/P17712'}}]}}], 'text': [{'value': 'Under low glucose concentrations, GCK associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '10456334', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/10456334', 'alternativeUrl': 'https://europepmc.org/abstract/MED/10456334'}}]}]}, {'type': 'ALTERNATIVE_PRODUCTS', 'comment': [{'value': 'A number of isoforms are produced by alternative promoter usage. The use of alternative promoters apparently enables the type IV hexokinase gene to be regulated by insulin in the liver and glucose in the beta cell. This may constitute an important feedback loop for maintaining glucose homeostasis.', 'evidences': [{'code': 'ECO:0000305', 'source': {'name': 'PubMed', 'id': '1871135', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/1871135', 'alternativeUrl': 'https://europepmc.org/abstract/MED/1871135'}}]}], 'event': ['Alternative splicing'], 'isoforms': [{'ids': ['P35557-1'], 'name': {'value': '1'}, 'sequenceStatus': 'displayed'}, {'ids': ['P35557-2'], 'name': {'value': '2'}, 'sequenceStatus': 'described', 'sequence': ['VSP_002074']}, {'ids': ['P35557-3'], 'name': {'value': '3'}, 'sequenceStatus': 'described', 'sequence': ['VSP_002075']}]}, {'type': 'DISEASE', 'diseaseId': 'Maturity-onset diabetes of the young 2', 'acronym': 'MODY2', 'dbReference': {'type': 'MIM', 'id': '125851'}, 'description': {'value': 'A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '10588527', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/10588527', 'alternativeUrl': 'https://europepmc.org/abstract/MED/10588527'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '10694920', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/10694920', 'alternativeUrl': 'https://europepmc.org/abstract/MED/10694920'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '11106831', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/11106831', 'alternativeUrl': 'https://europepmc.org/abstract/MED/11106831'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '11372010', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/11372010', 'alternativeUrl': 'https://europepmc.org/abstract/MED/11372010'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '1303265', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/1303265', 'alternativeUrl': 'https://europepmc.org/abstract/MED/1303265'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '1464666', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/1464666', 'alternativeUrl': 'https://europepmc.org/abstract/MED/1464666'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '1502186', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/1502186', 'alternativeUrl': 'https://europepmc.org/abstract/MED/1502186'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '16965331', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/16965331', 'alternativeUrl': 'https://europepmc.org/abstract/MED/16965331'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '18322640', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/18322640', 'alternativeUrl': 'https://europepmc.org/abstract/MED/18322640'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19884385', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/19884385', 'alternativeUrl': 'https://europepmc.org/abstract/MED/19884385'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '22611063', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/22611063', 'alternativeUrl': 'https://europepmc.org/abstract/MED/22611063'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '25015100', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/25015100', 'alternativeUrl': 'https://europepmc.org/abstract/MED/25015100'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8168652', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8168652', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8168652'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8325892', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8325892', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8325892'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8446612', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8446612', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8446612'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8495817', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8495817', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8495817'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8878425', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8878425', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8878425'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '9049484', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/9049484', 'alternativeUrl': 'https://europepmc.org/abstract/MED/9049484'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '9662401', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/9662401', 'alternativeUrl': 'https://europepmc.org/abstract/MED/9662401'}}]}, 'text': [{'value': 'The disease is caused by mutations affecting the gene represented in this entry'}]}, {'type': 'DISEASE', 'diseaseId': 'Familial hyperinsulinemic hypoglycemia 3', 'acronym': 'HHF3', 'dbReference': {'type': 'MIM', 'id': '602485'}, 'description': {'value': 'Most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '11916951', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/11916951', 'alternativeUrl': 'https://europepmc.org/abstract/MED/11916951'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '12941786', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/12941786', 'alternativeUrl': 'https://europepmc.org/abstract/MED/12941786'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15277402', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15277402', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15277402'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17082186', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17082186', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17082186'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19884385', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/19884385', 'alternativeUrl': 'https://europepmc.org/abstract/MED/19884385'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '20375417', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/20375417', 'alternativeUrl': 'https://europepmc.org/abstract/MED/20375417'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '28247534', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/28247534', 'alternativeUrl': 'https://europepmc.org/abstract/MED/28247534'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '9435328', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/9435328', 'alternativeUrl': 'https://europepmc.org/abstract/MED/9435328'}}]}, 'text': [{'value': 'The disease is caused by mutations affecting the gene represented in this entry'}]}, {'type': 'DISEASE', 'diseaseId': 'Diabetes mellitus, non-insulin-dependent', 'acronym': 'NIDDM', 'dbReference': {'type': 'MIM', 'id': '125853'}, 'description': {'value': "A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.", 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '1360036', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/1360036', 'alternativeUrl': 'https://europepmc.org/abstract/MED/1360036'}}]}, 'text': [{'value': 'Disease susceptibility is associated with variations affecting the gene represented in this entry'}]}, {'type': 'DISEASE', 'diseaseId': 'Diabetes mellitus, permanent neonatal', 'acronym': 'PNDM', 'dbReference': {'type': 'MIM', 'id': '606176'}, 'description': {'value': 'A rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '11372010', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/11372010', 'alternativeUrl': 'https://europepmc.org/abstract/MED/11372010'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '25015100', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/25015100', 'alternativeUrl': 'https://europepmc.org/abstract/MED/25015100'}}]}, 'text': [{'value': 'The disease is caused by mutations affecting the gene represented in this entry'}]}, {'type': 'SIMILARITY', 'text': [{'value': 'Belongs to the hexokinase family', 'evidences': [{'code': 'ECO:0000255', 'source': {'name': 'PROSITE-ProRule', 'id': 'PRU01084', 'url': 'https://prosite.expasy.org/unirule/PRU01084'}}, {'code': 'ECO:0000305'}]}]}, {'type': 'SEQUENCE_CAUTION', 'conflictType': 'ERRONEOUS_PREDICTION', 'sequence': 'AAA67541.1', 'evidences': [{'code': 'ECO:0000305'}]}, {'type': 'SEQUENCE_CAUTION', 'conflictType': 'ERRONEOUS_PREDICTION', 'sequence': 'AAA67542.1', 'evidences': [{'code': 'ECO:0000305'}]}, {'type': 'WEBRESOURCE', 'name': 'Wikipedia', 'url': 'https://en.wikipedia.org/wiki/Glucokinase', 'text': 'Glucokinase entry'}], 'features': [{'type': 'CHAIN', 'category': 'MOLECULE_PROCESSING', 'ftId': 'PRO_0000197593', 'description': 'Hexokinase-4', 'begin': '1', 'end': '465', 'molecule': ''}, {'type': 'DOMAIN', 'category': 'DOMAINS_AND_SITES', 'description': 'Hexokinase', 'begin': '10', 'end': '454', 'molecule': '', 'evidences': [{'code': 'ECO:0000255', 'source': {'name': 'PROSITE-ProRule', 'id': 'PRU01084', 'url': 'https://prosite.expasy.org/unirule/PRU01084'}}]}, {'type': 'NP_BIND', 'category': 'DOMAINS_AND_SITES', 'description': 'ATP', 'begin': '78', 'end': '83', 'molecule': '', 'evidences': [{'code': 'ECO:0000250', 'source': {'name': 'UniProtKB', 'id': 'P19367', 'url': 'https://www.uniprot.org/uniprot/P19367'}}]}, {'type': 'NP_BIND', 'category': 'DOMAINS_AND_SITES', 'description': 'ATP', 'begin': '295', 'end': '296', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3FGU', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3FGU'}}, {'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3ID8', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3ID8'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '22101819', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/22101819', 'alternativeUrl': 'https://europepmc.org/abstract/MED/22101819'}}]}, {'type': 'NP_BIND', 'category': 'DOMAINS_AND_SITES', 'description': 'ATP', 'begin': '332', 'end': '336', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3FGU', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3FGU'}}, {'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3ID8', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3ID8'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '22101819', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/22101819', 'alternativeUrl': 'https://europepmc.org/abstract/MED/22101819'}}]}, {'type': 'NP_BIND', 'category': 'DOMAINS_AND_SITES', 'description': 'ATP', 'begin': '411', 'end': '415', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3FGU', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3FGU'}}, {'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3ID8', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3ID8'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '22101819', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/22101819', 'alternativeUrl': 'https://europepmc.org/abstract/MED/22101819'}}]}, {'type': 'REGION', 'category': 'DOMAINS_AND_SITES', 'description': 'Hexokinase small subdomain', 'begin': '67', 'end': '203', 'molecule': '', 'evidences': [{'code': 'ECO:0000255', 'source': {'name': 'PROSITE-ProRule', 'id': 'PRU01084', 'url': 'https://prosite.expasy.org/unirule/PRU01084'}}]}, {'type': 'REGION', 'category': 'DOMAINS_AND_SITES', 'description': 'Substrate binding', 'begin': '151', 'end': '152', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15016359', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15016359', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15016359'}}]}, {'type': 'REGION', 'category': 'DOMAINS_AND_SITES', 'description': 'Substrate binding', 'begin': '168', 'end': '169', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15016359', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15016359', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15016359'}}]}, {'type': 'REGION', 'category': 'DOMAINS_AND_SITES', 'description': 'Hexokinase large subdomain', 'begin': '204', 'end': '443', 'molecule': '', 'evidences': [{'code': 'ECO:0000255', 'source': {'name': 'PROSITE-ProRule', 'id': 'PRU01084', 'url': 'https://prosite.expasy.org/unirule/PRU01084'}}]}, {'type': 'REGION', 'category': 'DOMAINS_AND_SITES', 'description': 'Substrate binding', 'begin': '204', 'end': '205', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15016359', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15016359', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15016359'}}]}, {'type': 'BINDING', 'category': 'DOMAINS_AND_SITES', 'description': 'ATP', 'begin': '228', 'end': '228', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3FGU', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3FGU'}}, {'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3ID8', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3ID8'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '22101819', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/22101819', 'alternativeUrl': 'https://europepmc.org/abstract/MED/22101819'}}]}, {'type': 'BINDING', 'category': 'DOMAINS_AND_SITES', 'description': 'Substrate', 'begin': '231', 'end': '231', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15016359', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15016359', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15016359'}}]}, {'type': 'BINDING', 'category': 'DOMAINS_AND_SITES', 'description': 'Substrate', 'begin': '256', 'end': '256', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15016359', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15016359', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15016359'}}]}, {'type': 'BINDING', 'category': 'DOMAINS_AND_SITES', 'description': 'Substrate', 'begin': '290', 'end': '290', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '15016359', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15016359', 'alternativeUrl': 'https://europepmc.org/abstract/MED/15016359'}}]}, {'type': 'VAR_SEQ', 'category': 'VARIANTS', 'ftId': 'VSP_002074', 'begin': '1', 'end': '15', 'molecule': '', 'evidences': [{'code': 'ECO:0000303', 'source': {'name': 'PubMed', 'id': '14702039', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/14702039', 'alternativeUrl': 'https://europepmc.org/abstract/MED/14702039'}}]}, {'type': 'VAR_SEQ', 'category': 'VARIANTS', 'ftId': 'VSP_002075', 'begin': '1', 'end': '15', 'molecule': '', 'evidences': [{'code': 'ECO:0000305'}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_003692', 'description': 'in dbSNP:rs202091228', 'alternativeSequence': 'N', 'begin': '4', 'end': '4', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8325892', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8325892', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8325892'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_010583', 'description': 'in dbSNP:rs116093166', 'alternativeSequence': 'T', 'begin': '11', 'end': '11', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8454109', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8454109', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8454109'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079430', 'description': 'in MODY2', 'alternativeSequence': 'E', 'begin': '16', 'end': '16', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079431', 'description': 'in MODY2', 'alternativeSequence': 'N', 'begin': '19', 'end': '19', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079432', 'description': 'in MODY2', 'alternativeSequence': 'P', 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'https://europepmc.org/abstract/MED/17573900'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_003701', 'description': 'in MODY2', 'alternativeSequence': 'A', 'begin': '203', 'end': '203', 'molecule': ''}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079455', 'description': 'in MODY2; dbSNP:rs1441649062', 'alternativeSequence': 'M', 'begin': '206', 'end': '206', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_010590', 'description': 'in MODY2', 'alternativeSequence': 'M', 'begin': '209', 'end': '209', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8168652', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8168652', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8168652'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_012351', 'description': 'in MODY2 and PNDM; dbSNP:rs80356654', 'alternativeSequence': 'K', 'begin': '210', 'end': '210', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '11372010', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/11372010', 'alternativeUrl': 'https://europepmc.org/abstract/MED/11372010'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_010591', 'description': 'in MODY2; dbSNP:rs80356654', 'alternativeSequence': 'T', 'begin': '210', 'end': '210', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '9049484', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/9049484', 'alternativeUrl': 'https://europepmc.org/abstract/MED/9049484'}}]}, {'type': 'VARIANT', 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'https://europepmc.org/abstract/MED/10694920'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_078251', 'description': 'in MODY2', 'alternativeSequence': 'S', 'begin': '223', 'end': '223', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '16965331', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/16965331', 'alternativeUrl': 'https://europepmc.org/abstract/MED/16965331'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079457', 'description': 'in MODY2', 'alternativeSequence': 'R', 'begin': '224', 'end': '224', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}]}, 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unknown pathological significance', 'alternativeSequence': 'H', 'begin': '231', 'end': '231', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '16965331', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/16965331', 'alternativeUrl': 'https://europepmc.org/abstract/MED/16965331'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079459', 'description': 'in MODY2; loss of glucokinase activity; loss of affinity for glucose; loss of affinity for ATP', 'alternativeSequence': 'R', 'begin': '233', 'end': '233', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '18322640', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/18322640', 'alternativeUrl': 'https://europepmc.org/abstract/MED/18322640'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079460', 'description': 'in MODY2', 'alternativeSequence': '', 'begin': '234', 'end': '465', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_081975', 'description': 'in MODY2', 'alternativeSequence': '', 'begin': '248', 'end': '465', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '9049484', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/9049484', 'alternativeUrl': 'https://europepmc.org/abstract/MED/9049484'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_075224', 'description': 'in MODY2; associated in cis with M-225; highly decreased glucokinase activity; loss of glucokinase activity when associated with M-225; dbSNP:rs759421263', 'alternativeSequence': 'K', 'begin': 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'https://europepmc.org/abstract/MED/21604084'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_081976', 'description': 'in MODY2', 'alternativeSequence': '', 'begin': '360', 'end': '465', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '9049484', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/9049484', 'alternativeUrl': 'https://europepmc.org/abstract/MED/9049484'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_010596', 'description': 'in MODY2; dbSNP:rs1057521092', 'alternativeSequence': 'M', 'begin': '367', 'end': '367', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '9049484', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/9049484', 'alternativeUrl': 'https://europepmc.org/abstract/MED/9049484'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079466', 'description': 'in MODY2; dbSNP:rs193922264', 'alternativeSequence': 'H', 'begin': '377', 'end': '377', 'molecule': '', 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'PubMed', 'id': '25015100', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/25015100', 'alternativeUrl': 'https://europepmc.org/abstract/MED/25015100'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079471', 'description': 'in MODY2', 'alternativeSequence': '', 'begin': '399', 'end': '465', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079472', 'description': 'in MODY2', 'alternativeSequence': 'F', 'begin': '411', 'end': '411', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_003714', 'description': 'in MODY2; 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'alternativeSequence': 'L', 'begin': '441', 'end': '441', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '25015100', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/25015100', 'alternativeUrl': 'https://europepmc.org/abstract/MED/25015100'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_078256', 'description': 'in MODY2; decreased affinity for glucose', 'alternativeSequence': 'W', 'begin': '441', 'end': '441', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '16965331', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/16965331', 'alternativeUrl': 'https://europepmc.org/abstract/MED/16965331'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17573900', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17573900', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17573900'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19884385', 'url': 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'16965331', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/16965331', 'alternativeUrl': 'https://europepmc.org/abstract/MED/16965331'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079476', 'description': 'in PNDM; decreased stability; increased glucokinase activity; increased affinity for glucose; dbSNP:rs193922282', 'alternativeSequence': 'T', 'begin': '449', 'end': '449', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '25015100', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/25015100', 'alternativeUrl': 'https://europepmc.org/abstract/MED/25015100'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_003715', 'description': 'in HHF3; increased glucokinase activity based on measure of catalytic efficiency; increased affinity for glucose; decreased inhibition by GCKR; no effect on affinity for ATP; dbSNP:rs104894012', 'alternativeSequence': 'M', 'begin': '455', 'end': '455', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17082186', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17082186', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17082186'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '9435328', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/9435328', 'alternativeUrl': 'https://europepmc.org/abstract/MED/9435328'}}]}, {'type': 'VARIANT', 'category': 'VARIANTS', 'ftId': 'VAR_079477', 'description': 'in HHF3; increased glucokinase activity based on measure of catalytic efficiency; increased affinity for glucose; loss of inhibition by GCKR; no effect on affinity for ATP; dbSNP:rs104894014', 'alternativeSequence': 'V', 'begin': '456', 'end': '456', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '11916951', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/11916951', 'alternativeUrl': 'https://europepmc.org/abstract/MED/11916951'}}, {'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17082186', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17082186', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17082186'}}]}, {'type': 'MUTAGEN', 'category': 'MUTAGENESIS', 'description': 'Increased glucokinase activity based on measure of catalytic efficiency. 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Increased affinity for glucose.', 'alternativeSequence': 'V', 'begin': '197', 'end': '197', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19146401', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/19146401', 'alternativeUrl': 'https://europepmc.org/abstract/MED/19146401'}}]}, {'type': 'MUTAGEN', 'category': 'MUTAGENESIS', 'description': 'Increased glucokinase activity based on measure of catalytic efficiency. Increased affinity for glucose.', 'alternativeSequence': 'F', 'begin': '211', 'end': '211', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19146401', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/19146401', 'alternativeUrl': 'https://europepmc.org/abstract/MED/19146401'}}]}, {'type': 'MUTAGEN', 'category': 'MUTAGENESIS', 'description': 'Increased glucokinase activity based on measure of catalytic efficiency. Increased affinity for glucose. No effect on affinity for ATP.', 'alternativeSequence': 'A', 'begin': '214', 'end': '214', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17082186', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17082186', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17082186'}}]}, {'type': 'MUTAGEN', 'category': 'MUTAGENESIS', 'description': 'Increased glucokinase activity based on measure of catalytic efficiency. Increased affinity for glucose. Loss of inhibition by GCKR. No effect on affinity for ATP.', 'alternativeSequence': 'A', 'begin': '215', 'end': '215', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '17082186', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/17082186', 'alternativeUrl': 'https://europepmc.org/abstract/MED/17082186'}}]}, {'type': 'MUTAGEN', 'category': 'MUTAGENESIS', 'description': 'Inactive enzyme with no glucokinase activity.', 'alternativeSequence': 'A', 'begin': '256', 'end': '256', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8325892', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8325892', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8325892'}}]}, {'type': 'MUTAGEN', 'category': 'MUTAGENESIS', 'description': 'Small change in glucokinase activity.', 'alternativeSequence': 'A', 'begin': '414', 'end': '414', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '8325892', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/8325892', 'alternativeUrl': 'https://europepmc.org/abstract/MED/8325892'}}]}, {'type': 'MUTAGEN', 'category': 'MUTAGENESIS', 'description': 'Increased glucokinase activity based on measure of catalytic efficiency. Increased affinity for glucose.', 'alternativeSequence': 'A', 'begin': '453', 'end': '453', 'molecule': '', 'evidences': [{'code': 'ECO:0000269', 'source': {'name': 'PubMed', 'id': '19146401', 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/19146401', 'alternativeUrl': 'https://europepmc.org/abstract/MED/19146401'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '12', 'end': '20', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '21', 'end': '23', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '27', 'end': '45', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'TURN', 'category': 'STRUCTURAL', 'begin': '47', 'end': '52', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '58', 'end': '65', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'TURN', 'category': 'STRUCTURAL', 'begin': '66', 'end': '68', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '4LC9', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/4LC9'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '72', 'end': '92', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '95', 'end': '97', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3H1V', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3H1V'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '99', 'end': '109', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '112', 'end': '115', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '116', 'end': '118', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '119', 'end': '136', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '140', 'end': '142', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '145', 'end': '150', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '154', 'end': '158', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '161', 'end': '164', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '181', 'end': '192', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '198', 'end': '203', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '205', 'end': '214', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '220', 'end': '237', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '238', 'end': '240', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '248', 'end': '254', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '257', 'end': '259', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'TURN', 'category': 'STRUCTURAL', 'begin': '260', 'end': '263', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '264', 'end': '266', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '4MLH', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/4MLH'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '267', 'end': '269', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '272', 'end': '280', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '281', 'end': '283', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '288', 'end': '291', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '295', 'end': '311', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '316', 'end': '318', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'TURN', 'category': 'STRUCTURAL', 'begin': '322', 'end': '325', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '332', 'end': '339', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '340', 'end': '342', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3QIC', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3QIC'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '343', 'end': '345', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '4ISE', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/4ISE'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '346', 'end': '354', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'HELIX', 'category': 'STRUCTURAL', 'begin': '361', 'end': '396', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'STRAND', 'category': 'STRUCTURAL', 'begin': '400', 'end': '409', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 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'category': 'STRUCTURAL', 'begin': '444', 'end': '456', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3F9M', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3F9M'}}]}, {'type': 'TURN', 'category': 'STRUCTURAL', 'begin': '457', 'end': '459', 'molecule': '', 'evidences': [{'code': 'ECO:0000244', 'source': {'name': 'PDB', 'id': '3H1V', 'url': 'https://www.ebi.ac.uk/pdbe-srv/view/entry/3H1V'}}]}], 'dbReferences': [{'type': 'EMBL', 'id': 'M88011', 'properties': {'molecule type': 'mRNA', 'protein sequence ID': 'AAA51824.1'}}, {'type': 'EMBL', 'id': 'M69051', 'properties': {'molecule type': 'mRNA', 'protein sequence ID': 'AAB59563.1', 'status': 'ALT_SEQ'}}, {'type': 'EMBL', 'id': 'M90298', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAA67541.1', 'status': 'ALT_SEQ'}}, {'type': 'EMBL', 'id': 'M90298', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAA67542.1', 'status': 'ALT_SEQ'}}, {'type': 'EMBL', 'id': 'M90299', 'properties': {'molecule type': 'mRNA', 'protein sequence ID': 'AAA52562.1'}}, {'type': 'EMBL', 'id': 'AF041022', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97680.1'}}, {'type': 'EMBL', 'id': 'AF041012', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97680.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041015', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97680.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041016', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97680.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041017', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97680.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041018', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97680.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041019', 'properties': {'molecule type': 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ID': 'AAB97681.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041018', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97681.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041019', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97681.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041020', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97681.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041021', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97681.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041022', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97682.1'}}, {'type': 'EMBL', 'id': 'AF041014', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97682.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041015', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97682.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041016', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97682.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041017', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97682.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041018', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97682.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041019', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97682.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041020', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97682.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AF041021', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'AAB97682.1', 'status': 'JOINED'}}, {'type': 'EMBL', 'id': 'AK122876', 'properties': {'molecule type': 'mRNA', 'protein sequence ID': 'BAG53774.1'}}, {'type': 'EMBL', 'id': 'CH236960', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'EAL23765.1'}}, {'type': 'EMBL', 'id': 'CH236960', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'EAL23766.1'}}, {'type': 'EMBL', 'id': 'CH471128', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'EAW61114.1'}}, {'type': 'EMBL', 'id': 'CH471128', 'properties': {'molecule type': 'Genomic_DNA', 'protein sequence ID': 'EAW61116.1'}}, {'type': 'EMBL', 'id': 'BC001890', 'properties': {'molecule type': 'mRNA', 'protein sequence ID': 'AAH01890.1'}}, {'type': 'CCDS', 'id': 'CCDS5479.1', 'isoform': 'P35557-1'}, {'type': 'CCDS', 'id': 'CCDS5480.1', 'isoform': 'P35557-2'}, {'type': 'CCDS', 'id': 'CCDS5481.1', 'isoform': 'P35557-3'}, {'type': 'PIR', 'id': 'A46157', 'properties': {'entry name': 'A46157'}}, {'type': 'PIR', 'id': 'B46157', 'properties': {'entry name': 'B46157'}}, {'type': 'PIR', 'id': 'C46157', 'properties': {'entry name': 'C46157'}}, {'type': 'RefSeq', 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Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.', 'authors': ['Takeda J.', 'Gidh-Jain M.', 'Xu L.Z.', 'Froguel P.', 'Velho G.', 'Vaxillaire M.', 'Cohen D.', 'Shimada F.', 'Makino H.', 'Nishi S.', 'Stoffel M.', 'Vionnet N.', 'St Charles R.', 'Harrison R.W.', 'Weber I.T.', 'Bell G.I.', 'Pilkis S.J.'], 'publication': {'journalName': 'J. Biol. Chem.'}, 'location': {'volume': '268', 'firstPage': '15200', 'lastPage': '15204'}, 'dbReferences': [{'type': 'PubMed', 'id': '8325892'}]}, 'scope': ['VARIANT ASN-4', 'VARIANTS MODY2 LYS-70; PRO-131; THR-188; ARG-257 AND GLU-414', 'MUTAGENESIS OF GLU-177; GLU-256 AND LYS-414', 'CATALYTIC ACTIVITY', 'FUNCTION']}, {'citation': {'type': 'journal article', 'publicationDate': '1993', 'title': 'Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.', 'authors': ['Gidh-Jain M.', 'Takeda J.', 'Xu L.Z.', 'Lange A.J.', 'Vionnet N.', 'Stoffel M.', 'Froguel P.', 'Velho G.', 'Sun D.', 'Cohen D.', 'Patel P.', 'Lo Y.-M.D.', 'Hattersley A.T.', 'Luthman H.', 'Wedell A.', 'St Charles R.', 'Harrison R.W.', 'Weber I.T.', 'Bell G.I.', 'Pilkis S.J.'], 'publication': {'journalName': 'Proc. Natl. Acad. Sci. U.S.A.'}, 'location': {'volume': '90', 'firstPage': '1932', 'lastPage': '1936'}, 'dbReferences': [{'type': 'PubMed', 'id': '8446612'}, {'type': 'DOI', 'id': '10.1073/pnas.90.5.1932'}]}, 'scope': ['CHARACTERIZATION OF VARIANTS MODY2']}, {'citation': {'type': 'journal article', 'publicationDate': '1994', 'title': 'Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique.', 'authors': ['Hager J.', 'Blanche H.', 'Sun F.', 'Vionnet N.', 'Vaxillaire M.', 'Poller W.', 'Cohen D.', 'Czernichow P.', 'Velho G.', 'Robert J.-J.', 'Cohen N.', 'Froguel P.'], 'publication': {'journalName': 'Diabetes'}, 'location': {'volume': '43', 'firstPage': '730', 'lastPage': '733'}, 'dbReferences': [{'type': 'PubMed', 'id': '8168652'}, {'type': 'DOI', 'id': '10.2337/diab.43.5.730'}]}, 'scope': ['VARIANTS MODY2 TRP-36; MET-209 AND GLU-261']}, {'citation': {'type': 'journal article', 'publicationDate': '1997', 'title': 'Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.', 'authors': ['Velho G.', 'Blanche H.', 'Vaxillaire M.', 'Bellanne-Chantelot C.', 'Pardini V.C.', 'Timsit J.', 'Passa P.', 'Deschamps I.', 'Robert J.-J.', 'Weber I.T.', 'Marotta D.', 'Pilkis S.J.', 'Lipkind G.M.', 'Bell G.I.', 'Froguel P.'], 'publication': {'journalName': 'Diabetologia'}, 'location': {'volume': '40', 'firstPage': '217', 'lastPage': '224'}, 'dbReferences': [{'type': 'PubMed', 'id': '9049484'}, {'type': 'DOI', 'id': '10.1007/s001250050666'}]}, 'scope': ['VARIANTS MODY2 SER-53; ALA-80; ARG-137; PRO-168; 186-ARG--GLN-465 DEL; THR-210; ARG-213; MET-226; 248-GLU--GLN-465 DEL; ARG-261; LEU-336; 360-SER--GLN-465 DEL AND MET-367']}, {'citation': {'type': 'journal article', 'publicationDate': '1998', 'title': 'Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY).', 'authors': ['Guazzini B.', 'Gaffi D.', 'Mainieri D.', 'Multari G.', 'Cordera R.', 'Bertolini S.', 'Pozza G.', 'Meschi F.', 'Barbetti F.'], 'publication': {'journalName': 'Hum. Mutat.'}, 'location': {'volume': '12', 'firstPage': '136', 'lastPage': '136'}, 'dbReferences': [{'type': 'PubMed', 'id': '10694920'}, {'type': 'DOI', 'id': '10.1002/(SICI)1098-1004(1998)12:2<136::AID-HUMU13>3.3.CO;2-M'}]}, 'scope': ['VARIANTS MODY2 SER-80; LYS-221 AND CYS-227']}, {'citation': {'type': 'journal article', 'publicationDate': '1998', 'title': 'Mutations in the glucokinase gene of the fetus result in reduced birth weight.', 'authors': ['Hattersley A.T.', 'Beards F.', 'Ballantyne E.', 'Appleton M.', 'Harvey R.', 'Ellard S.'], 'publication': {'journalName': 'Nat. Genet.'}, 'location': {'volume': '19', 'firstPage': '268', 'lastPage': '270'}, 'dbReferences': [{'type': 'PubMed', 'id': '9662401'}, {'type': 'DOI', 'id': '10.1038/953'}]}, 'scope': ['VARIANTS MODY2 HIS-108; SER-150; THR-259; ARG-299; TYR-382; THR-384 AND CYS-392']}, {'citation': {'type': 'journal article', 'publicationDate': '1998', 'title': 'Familial hyperinsulinism caused by an activating glucokinase mutation.', 'authors': ['Glaser B.', 'Kesavan P.', 'Heyman M.', 'Davis E.', 'Cuesta A.', 'Buchs A.', 'Stanley C.A.', 'Thornton P.S.', 'Permutt M.A.', 'Matschinsky F.M.', 'Herold K.C.'], 'publication': {'journalName': 'N. Engl. J. Med.'}, 'location': {'volume': '338', 'firstPage': '226', 'lastPage': '230'}, 'dbReferences': [{'type': 'PubMed', 'id': '9435328'}, {'type': 'DOI', 'id': '10.1056/nejm199801223380404'}]}, 'scope': ['VARIANT HHF3 MET-455']}, {'citation': {'type': 'journal article', 'publicationDate': '1999', 'title': 'Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY.', 'authors': ['Ng M.C.Y.', 'Cockburn B.N.', 'Lindner T.H.', 'Yeung V.T.F.', 'Chow C.-C.', 'So W.-Y.', 'Li J.K.Y.', 'Lo Y.M.D.', 'Lee Z.S.K.', 'Cockram C.S.', 'Critchley J.A.J.H.', 'Bell G.I.', 'Chan J.C.N.'], 'publication': {'journalName': 'Diabet. Med.'}, 'location': {'volume': '16', 'firstPage': '956', 'lastPage': '963'}, 'dbReferences': [{'type': 'PubMed', 'id': '10588527'}, {'type': 'DOI', 'id': '10.1046/j.1464-5491.1999.00188.x'}]}, 'scope': ['VARIANTS MODY2 THR-110; ASP-119 AND VAL-385']}, {'citation': {'type': 'journal article', 'publicationDate': '2000', 'title': 'Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus.', 'authors': ['Nam J.H.', 'Lee H.C.', 'Kim Y.H.', 'Cha B.S.', 'Song Y.D.', 'Lim S.K.', 'Kim K.R.', 'Huh K.B.'], 'publication': {'journalName': 'Diabetes Res. Clin. Pract.'}, 'location': {'volume': '50', 'firstPage': '169', 'lastPage': '176'}, 'dbReferences': [{'type': 'PubMed', 'id': '11106831'}, {'type': 'DOI', 'id': '10.1016/s0168-8227(00)00191-1'}]}, 'scope': ['VARIANT MODY2 PRO-164']}, {'citation': {'type': 'journal article', 'publicationDate': '2001', 'title': 'Neonatal diabetes mellitus due to complete glucokinase deficiency.', 'authors': ['Njoelstad P.R.', 'Soevik O.', 'Cuesta-Munoz A.', 'Bjoerkhaug L.', 'Massa O.', 'Barbetti F.', 'Undlien D.E.', 'Shiota C.', 'Magnuson M.A.', 'Molven A.', 'Matschinsky F.M.', 'Bell G.I.'], 'publication': {'journalName': 'N. Engl. J. Med.'}, 'location': {'volume': '344', 'firstPage': '1588', 'lastPage': '1592'}, 'dbReferences': [{'type': 'PubMed', 'id': '11372010'}, {'type': 'DOI', 'id': '10.1056/nejm200105243442104'}]}, 'scope': ['INVOLVEMENT IN PNDM', 'INVOLVEMENT IN MODY2', 'VARIANTS MODY2 LYS-210 AND MET-228', 'VARIANTS PNDM LYS-210 AND MET-228']}, {'citation': {'type': 'journal article', 'publicationDate': '2002', 'title': 'The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.', 'authors': ['Christesen H.B.', 'Jacobsen B.B.', 'Odili S.', 'Buettger C.', 'Cuesta-Munoz A.', 'Hansen T.', 'Brusgaard K.', 'Massa O.', 'Magnuson M.A.', 'Shiota C.', 'Matschinsky F.M.', 'Barbetti F.'], 'publication': {'journalName': 'Diabetes'}, 'location': {'volume': '51', 'firstPage': '1240', 'lastPage': '1246'}, 'dbReferences': [{'type': 'PubMed', 'id': '11916951'}, {'type': 'DOI', 'id': '10.2337/diabetes.51.4.1240'}]}, 'scope': ['VARIANT HHF3 VAL-456', 'CHARACTERIZATION OF VARIANT HHF3 VAL-456', 'FUNCTION', 'CATALYTIC ACTIVITY']}, {'citation': {'type': 'journal article', 'publicationDate': '2003', 'title': 'Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.', 'authors': ['Gloyn A.L.', 'Noordam K.', 'Willemsen M.A.', 'Ellard S.', 'Lam W.W.', 'Campbell I.W.', 'Midgley P.', 'Shiota C.', 'Buettger C.', 'Magnuson M.A.', 'Matschinsky F.M.', 'Hattersley A.T.'], 'publication': {'journalName': 'Diabetes'}, 'location': {'volume': '52', 'firstPage': '2433', 'lastPage': '2440'}, 'dbReferences': [{'type': 'PubMed', 'id': '12941786'}, {'type': 'DOI', 'id': '10.2337/diabetes.52.9.2433'}]}, 'scope': ['VARIANT HHF3 ILE-65', 'CHARACTERIZATION OF VARIANT HHF3 ILE-65']}, {'citation': {'type': 'journal article', 'publicationDate': '2004', 'title': 'Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.', 'authors': ['Cuesta-Munoz A.L.', 'Huopio H.', 'Otonkoski T.', 'Gomez-Zumaquero J.M.', 'Naentoe-Salonen K.', 'Rahier J.', 'Lopez-Enriquez S.', 'Garcia-Gimeno M.A.', 'Sanz P.', 'Soriguer F.C.', 'Laakso M.'], 'publication': {'journalName': 'Diabetes'}, 'location': {'volume': '53', 'firstPage': '2164', 'lastPage': '2168'}, 'dbReferences': [{'type': 'PubMed', 'id': '15277402'}, {'type': 'DOI', 'id': '10.2337/diabetes.53.8.2164'}]}, 'scope': ['VARIANT HHF3 CYS-214', 'CHARACTERIZATION OF VARIANT HHF3 CYS-214', 'FUNCTION', 'CATALYTIC ACTIVITY']}, {'citation': {'type': 'journal article', 'publicationDate': '2006', 'title': 'Identification of novel and recurrent glucokinase mutations in Belgian and Luxembourg maturity onset diabetes of the young patients.', 'authors': ['Vits L.', 'Beckers D.', 'Craen M.', 'de Beaufort C.', 'Vanfleteren E.', 'Dahan K.', 'Nollet A.', 'Vanhaverbeke G.', 'Imschoot S.V.', 'Bourguignon J.P.', 'Beauloye V.', 'Storm K.', 'Massa G.', 'Giri M.', 'Nobels F.', 'De Schepper J.', 'Rooman R.', 'Van den Bruel A.', 'Mathieu C.', 'Wuyts W.'], 'publication': {'journalName': 'Clin. Genet.'}, 'location': {'volume': '70', 'firstPage': '355', 'lastPage': '359'}, 'dbReferences': [{'type': 'PubMed', 'id': '16965331'}, {'type': 'DOI', 'id': '10.1111/j.1399-0004.2006.00686.x'}]}, 'scope': ['VARIANTS MODY2 TRP-36; TYR-129; LEU-152; VAL-188; TRP-191; ARG-202; SER-223; MET-226; HIS-231; PHE-315; THR-378; PHE-434; TRP-441 AND GLN-447']}, {'citation': {'type': 'journal article', 'publicationDate': '2006', 'title': 'Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.', 'authors': ['Heredia V.V.', 'Carlson T.J.', 'Garcia E.', 'Sun S.'], 'publication': {'journalName': 'J. Biol. Chem.'}, 'location': {'volume': '281', 'firstPage': '40201', 'lastPage': '40207'}, 'dbReferences': [{'type': 'PubMed', 'id': '17082186'}, {'type': 'DOI', 'id': '10.1074/jbc.m607987200'}]}, 'scope': ['CHARACTERIZATION OF VARIANTS HHF3 ILE-65; CYS-214; MET-455 AND VAL-456', 'MUTAGENESIS OF TYR-214 AND TYR-215', 'FUNCTION', 'CATALYTIC ACTIVITY']}, {'citation': {'type': 'journal article', 'publicationDate': '2007', 'title': 'Mutations in GCK and HNF-1alpha explain the majority of cases with clinical diagnosis of MODY in Spain.', 'authors': ['Estalella I.', 'Rica I.', 'Perez de Nanclares G.', 'Bilbao J.R.', 'Vazquez J.A.', 'San Pedro J.I.', 'Busturia M.A.', 'Castano L.'], 'consortiums': ['Spanish MODY Group'], 'publication': {'journalName': 'Clin. Endocrinol. (Oxf.)'}, 'location': {'volume': '67', 'firstPage': '538', 'lastPage': '546'}, 'dbReferences': [{'type': 'PubMed', 'id': '17573900'}, {'type': 'DOI', 'id': '10.1111/j.1365-2265.2007.02921.x'}]}, 'scope': ['VARIANTS MODY2 GLU-16; ASN-19; PRO-20; TRP-36; SER-43; SER-44; 61-TYR--GLN-465 DEL; SER-61; LYS-70; ARG-72; PRO-77; GLU-78; ASP-80; ILE-82; HIS-108; PRO-116; LEU-182; 186-ARG--GLN-465 DEL; TYR-187; TRP-191; LEU-200; THR-202; MET-206; MET-209; SER-223; ARG-224; SER-227; MET-228; ARG-233; 234-TYR--GLN-465 DEL; GLY-252; ALA-255; LYS-256; ARG-261; LYS-265; LYS-298; TRP-308; HIS-377; VAL-379; LEU-383; 399-GLU--GLN-465 DEL; PHE-411; PRO-416; GLU-420 AND TRP-441']}, {'citation': {'type': 'journal article', 'publicationDate': '2008', 'title': 'Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.', 'authors': ['Estalella I.', 'Garcia-Gimeno M.A.', 'Marina A.', 'Castano L.', 'Sanz P.'], 'publication': {'journalName': 'J. Hum. Genet.'}, 'location': {'volume': '53', 'firstPage': '460', 'lastPage': '466'}, 'dbReferences': [{'type': 'PubMed', 'id': '18322640'}, {'type': 'DOI', 'id': '10.1007/s10038-008-0271-5'}]}, 'scope': ['CHARACTERIZATION OF VARIANTS MODY2 SER-61; LEU-182; ARG-233; LYS-265; VAL-379 AND GLU-420', 'FUNCTION', 'CATALYTIC ACTIVITY']}, {'citation': {'type': 'journal article', 'publicationDate': '2009', 'title': 'Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene.', 'authors': ['Barbetti F.', 'Cobo-Vuilleumier N.', 'Dionisi-Vici C.', 'Toni S.', 'Ciampalini P.', 'Massa O.', 'Rodriguez-Bada P.', 'Colombo C.', 'Lenzi L.', 'Garcia-Gimeno M.A.', 'Bermudez-Silva F.J.', 'Rodriguez de Fonseca F.', 'Banin P.', 'Aledo J.C.', 'Baixeras E.', 'Sanz P.', 'Cuesta-Munoz A.L.'], 'publication': {'journalName': 'Mol. Endocrinol.'}, 'location': {'volume': '23', 'firstPage': '1983', 'lastPage': '1989'}, 'dbReferences': [{'type': 'PubMed', 'id': '19884385'}, {'type': 'DOI', 'id': '10.1210/me.2009-0094'}]}, 'scope': ['VARIANT MODY2 TRP-441', 'CHARACTERIZATION OF VARIANT MODY2 TRP-441', 'VARIANT HHF3 LYS-442', 'CHARACTERIZATION OF VARIANT HHF3 LYS-442']}, {'citation': {'type': 'journal article', 'publicationDate': '2010', 'title': 'Large islets, beta-cell proliferation, and a glucokinase mutation.', 'authors': ['Kassem S.', 'Bhandari S.', 'Rodriguez-Bada P.', 'Motaghedi R.', 'Heyman M.', 'Garcia-Gimeno M.A.', 'Cobo-Vuilleumier N.', 'Sanz P.', 'Maclaren N.K.', 'Rahier J.', 'Glaser B.', 'Cuesta-Munoz A.L.'], 'publication': {'journalName': 'N. Engl. J. Med.'}, 'location': {'volume': '362', 'firstPage': '1348', 'lastPage': '1350'}, 'dbReferences': [{'type': 'PubMed', 'id': '20375417'}, {'type': 'DOI', 'id': '10.1056/nejmc0909845'}]}, 'scope': ['VARIANT HHF3 LEU-91', 'CHARACTERIZATION OF VARIANT HHF3 LEU-91']}, {'citation': {'type': 'journal article', 'publicationDate': '2010', 'authors': ['Kassem S.', 'Bhandari S.', 'Rodriguez-Bada P.', 'Motaghedi R.', 'Heyman M.', 'Garcia-Gimeno M.A.', 'Cobo-Vuilleumier N.', 'Sanz P.', 'Maclaren N.K.', 'Rahier J.', 'Glaser B.', 'Cuesta-Munoz A.L.'], 'publication': {'journalName': 'N. Engl. J. Med.'}, 'location': {'volume': '363', 'firstPage': '2178', 'lastPage': '2178'}}, 'scope': ['ERRATUM']}, {'citation': {'type': 'journal article', 'publicationDate': '2011', 'title': 'The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY.', 'authors': ['Steele A.M.', 'Tribble N.D.', 'Caswell R.', 'Wensley K.J.', 'Hattersley A.T.', 'Gloyn A.L.', 'Ellard S.'], 'publication': {'journalName': 'Diabetologia'}, 'location': {'volume': '54', 'firstPage': '2202', 'lastPage': '2205'}, 'dbReferences': [{'type': 'PubMed', 'id': '21604084'}, {'type': 'DOI', 'id': '10.1007/s00125-011-2194-5'}]}, 'scope': ['VARIANT PRO-342']}, {'citation': {'type': 'journal article', 'publicationDate': '2012', 'title': 'Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterization of compound heterozygous and double mutations inherited in cis.', 'authors': ['Beer N.L.', 'Osbak K.K.', 'van de Bunt M.', 'Tribble N.D.', 'Steele A.M.', 'Wensley K.J.', 'Edghill E.L.', 'Colcough K.', 'Barrett A.', 'Valentinova L.', 'Rundle J.K.', 'Raimondo A.', 'Grimsby J.', 'Ellard S.', 'Gloyn A.L.'], 'publication': {'journalName': 'Diabetes Care'}, 'location': {'volume': '35', 'firstPage': '1482', 'lastPage': '1484'}, 'dbReferences': [{'type': 'PubMed', 'id': '22611063'}, {'type': 'DOI', 'id': '10.2337/dc11-2420'}]}, 'scope': ['VARIANTS MODY2 HIS-43; ASP-68; ASN-217; MET-225; LYS-248; ARG-261 AND ARG-261', 'CHARACTERIZATION OF VARIANTS MODY2 HIS-43; ASP-68; ASN-217; MET-225; LYS-248; ARG-261 AND ARG-261']}, {'citation': {'type': 'journal article', 'publicationDate': '2014', 'title': 'Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability.', 'authors': ['Raimondo A.', 'Chakera A.J.', 'Thomsen S.K.', 'Colclough K.', 'Barrett A.', 'De Franco E.', 'Chatelas A.', 'Demirbilek H.', 'Akcay T.', 'Alawneh H.', 'Flanagan S.E.', 'Van De Bunt M.', 'Hattersley A.T.', 'Gloyn A.L.', 'Ellard S.'], 'consortiums': ['International NDM Consortium'], 'publication': {'journalName': 'Hum. Mol. Genet.'}, 'location': {'volume': '23', 'firstPage': '6432', 'lastPage': '6440'}, 'dbReferences': [{'type': 'PubMed', 'id': '25015100'}, {'type': 'DOI', 'id': '10.1093/hmg/ddu360'}]}, 'scope': ['VARIANTS PNDM LYS-40; CYS-43; ASP-50; ARG-72; THR-151; PRO-164; ALA-168; ARG-169; ARG-261; THR-393; LEU-397; LEU-441 AND THR-449', 'CHARACTERIZATION OF VARIANTS PNDM LYS-40; CYS-43; ASP-50; ARG-72; ALA-168; ARG-261; THR-393; LEU-397; LEU-441 AND THR-449', 'VARIANTS MODY2 ASN-160 AND MET-226', 'CHARACTERIZATION OF VARIANT MODY2 ASN-160 AND MET-226', 'FUNCTION', 'CATALYTIC ACTIVITY']}, {'citation': {'type': 'journal article', 'publicationDate': '2017', 'title': 'Heterogeneity in phenotype of hyperinsulinism caused by activating glucokinase mutations: a novel mutation and its functional characterization.', 'authors': ['Martinez R.', 'Gutierrez-Nogues A.', 'Fernandez-Ramos C.', 'Velayos T.', 'Vela A.', 'Navas M.A.', 'Castano L.'], 'consortiums': ['Spanish Congenital Hyperinsulinism Group'], 'publication': {'journalName': 'Clin. Endocrinol. (Oxf.)'}, 'location': {'volume': '86', 'firstPage': '778', 'lastPage': '783'}, 'dbReferences': [{'type': 'PubMed', 'id': '28247534'}, {'type': 'DOI', 'id': '10.1111/cen.13318'}]}, 'scope': ['VARIANTS HHF3 ILE-65; LEU-91; CYS-99 AND LYS-442', 'CHARACTERIZATION OF VARIANT HHF3 CYS-99']}], 'sequence': {'version': 1, 'length': 465, 'mass': 52191, 'modified': '1994-06-01', 'sequence': 'MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ'}}

json['organism']

{'taxonomy': 9606,
 'names': [{'type': 'scientific', 'value': 'Homo sapiens'},
  {'type': 'common', 'value': 'Human'}],
 'lineage': ['Eukaryota',
  'Metazoa',
  'Chordata',
  'Craniata',
  'Vertebrata',
  'Euteleostomi',
  'Mammalia',
  'Eutheria',
  'Euarchontoglires',
  'Primates',
  'Haplorrhini',
  'Catarrhini',
  'Hominidae',
  'Homo']}

import pandas as pd
df = pd.DataFrame(json['dbReferences'])

df

	type	id	properties	isoform	evidences
0	EMBL	M88011	{'molecule type': 'mRNA', 'protein sequence ID...	NaN	NaN
1	EMBL	M69051	{'molecule type': 'mRNA', 'protein sequence ID...	NaN	NaN
2	EMBL	M90298	{'molecule type': 'Genomic_DNA', 'protein sequ...	NaN	NaN
3	EMBL	M90298	{'molecule type': 'Genomic_DNA', 'protein sequ...	NaN	NaN
4	EMBL	M90299	{'molecule type': 'mRNA', 'protein sequence ID...	NaN	NaN
...	...	...	...	...	...
236	PANTHER	PTHR19443:SF3	{'match status': '1', 'entry name': 'PTHR19443...	NaN	NaN
237	Pfam	PF00349	{'match status': '1', 'entry name': 'Hexokinas...	NaN	NaN
238	Pfam	PF03727	{'match status': '1', 'entry name': 'Hexokinas...	NaN	NaN
239	PROSITE	PS00378	{'match status': '1', 'entry name': 'HEXOKINAS...	NaN	NaN
240	PROSITE	PS51748	{'match status': '1', 'entry name': 'HEXOKINAS...	NaN	NaN

241 rows × 5 columns

df.type.unique()

array(['EMBL', 'CCDS', 'PIR', 'RefSeq', 'PDB', 'PDBsum', 'SMR', 'BioGrid',
       'IntAct', 'STRING', 'BindingDB', 'ChEMBL', 'DrugBank',
       'GuidetoPHARMACOLOGY', 'iPTMnet', 'PhosphoSitePlus', 'BioMuta',
       'DMDM', 'jPOST', 'MassIVE', 'PaxDb', 'PeptideAtlas', 'PRIDE',
       'ProteomicsDB', 'DNASU', 'Ensembl', 'GeneID', 'KEGG', 'UCSC',
       'CTD', 'DisGeNET', 'EuPathDB', 'GeneCards', 'GeneReviews', 'HGNC',
       'HPA', 'MalaCards', 'MIM', 'neXtProt', 'OpenTargets', 'Orphanet',
       'PharmGKB', 'eggNOG', 'GeneTree', 'HOGENOM', 'InParanoid', 'KO',
       'OMA', 'OrthoDB', 'PhylomeDB', 'TreeFam', 'BioCyc', 'BRENDA',
       'Reactome', 'SABIO-RK', 'SIGNOR', 'UniPathway', 'ChiTaRS',
       'EvolutionaryTrace', 'GeneWiki', 'GenomeRNAi', 'Pharos', 'PRO',
       'Proteomes', 'RNAct', 'Bgee', 'ExpressionAtlas', 'Genevisible',
       'GO', 'InterPro', 'PANTHER', 'Pfam', 'PROSITE'], dtype=object)

Looking up ontologies with the OLS (ontology lookup service)¶

The Ontology Lookup Service (OLS) is a repository for biomedical ontologies that aims to provide a single point of access to the latest ontology versions. You can browse the ontologies through the website as well as programmatically via the OLS API. OLS is developed and maintained by the Samples, Phenotypes and Ontologies Team (SPOT) at EMBL-EBI.

https://www.ebi.ac.uk/ols/index

https://www.ebi.ac.uk/ols/docs/api

df[df.type=="GO"]

	type	id	properties	isoform	evidences
205	GO	GO:0005623	{'term': 'C:cell', 'source': 'IEA:GOC'}	NaN	NaN
206	GO	GO:0005829	{'term': 'C:cytosol', 'source': 'IDA:HPA'}	NaN	NaN
207	GO	GO:0005739	{'term': 'C:mitochondrion', 'source': 'IEA:Uni...	NaN	NaN
208	GO	GO:0005654	{'term': 'C:nucleoplasm', 'source': 'TAS:React...	NaN	NaN
209	GO	GO:0005524	{'term': 'F:ATP binding', 'source': 'IDA:UniPr...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
210	GO	GO:0008865	{'term': 'F:fructokinase activity', 'source': ...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
211	GO	GO:0004340	{'term': 'F:glucokinase activity', 'source': '...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
212	GO	GO:0005536	{'term': 'F:glucose binding', 'source': 'IDA:U...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
213	GO	GO:0019158	{'term': 'F:mannokinase activity', 'source': '...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
214	GO	GO:0070509	{'term': 'P:calcium ion import', 'source': 'IE...	NaN	NaN
215	GO	GO:0061621	{'term': 'P:canonical glycolysis', 'source': '...	NaN	NaN
216	GO	GO:0001678	{'term': 'P:cellular glucose homeostasis', 'so...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
217	GO	GO:0032869	{'term': 'P:cellular response to insulin stimu...	NaN	NaN
218	GO	GO:0044320	{'term': 'P:cellular response to leptin stimul...	NaN	NaN
219	GO	GO:0051594	{'term': 'P:detection of glucose', 'source': '...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
220	GO	GO:0051156	{'term': 'P:glucose 6-phosphate metabolic proc...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
221	GO	GO:0042593	{'term': 'P:glucose homeostasis', 'source': 'I...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
222	GO	GO:0006096	{'term': 'P:glycolytic process', 'source': 'IB...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
223	GO	GO:0006739	{'term': 'P:NADP metabolic process', 'source':...	NaN	NaN
224	GO	GO:0045721	{'term': 'P:negative regulation of gluconeogen...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
225	GO	GO:0045725	{'term': 'P:positive regulation of glycogen bi...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
226	GO	GO:0032024	{'term': 'P:positive regulation of insulin sec...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
227	GO	GO:0006110	{'term': 'P:regulation of glycolytic process',...	NaN	NaN
228	GO	GO:0050796	{'term': 'P:regulation of insulin secretion', ...	NaN	[{'code': 'ECO:0000269', 'source': {'name': 'P...
229	GO	GO:0043266	{'term': 'P:regulation of potassium ion transp...	NaN	NaN

ols_results = {}
for goid in df[df.type=='GO'].id:
    print(goid)
    query_id = goid.replace(':', '_')
    r = requests.get('http://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252F{}'.format(query_id))
    print(r.url)
    print(r.status_code)
    ols_results[goid] = r.json()

GO:0005623
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0005623
200
GO:0005829
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0005829
200
GO:0005739
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0005739
200
GO:0005654
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0005654
200
GO:0005524
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0005524
200
GO:0008865
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0008865
200
GO:0004340
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0004340
200
GO:0005536
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0005536
200
GO:0019158
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0019158
200
GO:0070509
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0070509
200
GO:0061621
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0061621
200
GO:0001678
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0001678
200
GO:0032869
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0032869
200
GO:0044320
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0044320
200
GO:0051594
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0051594
200
GO:0051156
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0051156
200
GO:0042593
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0042593
200
GO:0006096
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0006096
200
GO:0006739
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0006739
200
GO:0045721
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0045721
200
GO:0045725
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0045725
200
GO:0032024
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0032024
200
GO:0006110
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0006110
200
GO:0050796
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0050796
200
GO:0043266
https://www.ebi.ac.uk/ols/api/ontologies/go/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FGO_0043266
200

ols_results
for key, value in ols_results.items():
    print(key, value['label'])
    print(value['description'][0])
    print()

GO:0005623 cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

GO:0005829 cytosol
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0005739 mitochondrion
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

GO:0005654 nucleoplasm
That part of the nuclear content other than the chromosomes or the nucleolus.

GO:0005524 ATP binding
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

GO:0008865 fructokinase activity
Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate.

GO:0004340 glucokinase activity
Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.

GO:0005536 glucose binding
Interacting selectively and non-covalently with the D- or L-enantiomer of glucose.

GO:0019158 mannokinase activity
Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate.

GO:0070509 calcium ion import
The directed movement of calcium ions into a cell or organelle.

GO:0061621 canonical glycolysis
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the  chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.

GO:0001678 cellular glucose homeostasis
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.

GO:0032869 cellular response to insulin stimulus
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.

GO:0044320 cellular response to leptin stimulus
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.

GO:0051594 detection of glucose
The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal.

GO:0051156 glucose 6-phosphate metabolic process
The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6.

GO:0042593 glucose homeostasis
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.

GO:0006096 glycolytic process
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

GO:0006739 NADP metabolic process
The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.

GO:0045721 negative regulation of gluconeogenesis
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.

GO:0045725 positive regulation of glycogen biosynthetic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.

GO:0032024 positive regulation of insulin secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.

GO:0006110 regulation of glycolytic process
Any process that modulates the frequency, rate or extent of glycolysis.

GO:0050796 regulation of insulin secretion
Any process that modulates the frequency, rate or extent of the regulated release of insulin.

GO:0043266 regulation of potassium ion transport
Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Ensembl information¶

https://rest.ensembl.org/

For instance retrieving the homolog proteins in mouse https://rest.ensembl.org/documentation/info/homology_ensemblgene

df[df.type=="Ensembl"]

	type	id	properties	isoform	evidences
143	Ensembl	ENST00000345378	{'gene ID': 'ENSG00000106633', 'protein sequen...	P35557-2	NaN
144	Ensembl	ENST00000395796	{'gene ID': 'ENSG00000106633', 'protein sequen...	P35557-3	NaN
145	Ensembl	ENST00000403799	{'gene ID': 'ENSG00000106633', 'protein sequen...	P35557-1	NaN
146	Ensembl	ENST00000616242	{'gene ID': 'ENSG00000106633', 'protein sequen...	P35557-3	NaN

for p in df[df.type=="Ensembl"].properties:
    print(p)

{'gene ID': 'ENSG00000106633', 'protein sequence ID': 'ENSP00000223366'}
{'gene ID': 'ENSG00000106633', 'protein sequence ID': 'ENSP00000379142'}
{'gene ID': 'ENSG00000106633', 'protein sequence ID': 'ENSP00000384247'}
{'gene ID': 'ENSG00000106633', 'protein sequence ID': 'ENSP00000482149'}

from pprint import pprint
r = requests.get('https://rest.ensembl.org/homology/id/ENSG00000106633?content-type=application/json')
entries = r.json()
data = entries['data'][0]
for homology in data['homologies']:
    pprint(homology)

{'dn_ds': 0.26749,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 96.5665,
            'perc_pos': 96.9957,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'LEDSRARTSPSQW---QEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13M3D450M',
            'id': 'ENSPPAG00000030131',
            'perc_id': 97.1922,
            'perc_pos': 97.6242,
            'protein_id': 'ENSPPAP00000014005',
            'species': 'pan_paniscus',
            'taxon_id': 9597},
 'taxonomy_level': 'Homininae',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.05357,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 99.7854,
            'perc_pos': 100,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGKASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSPTRG00000019140',
            'perc_id': 99.7854,
            'perc_pos': 100,
            'protein_id': 'ENSPTRP00000043519',
            'species': 'pan_troglodytes',
            'taxon_id': 9598},
 'taxonomy_level': 'Homininae',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02535,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 99.7854,
            'perc_pos': 100,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKEQFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSGGOG00000001501',
            'perc_id': 99.7854,
            'perc_pos': 100,
            'protein_id': 'ENSGGOP00000001483',
            'species': 'gorilla_gorilla',
            'taxon_id': 9595},
 'taxonomy_level': 'Homininae',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.11468,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 97.2103,
            'perc_pos': 97.6395,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEAAKE--KVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13M2D451M',
            'id': 'ENSPPYG00000017596',
            'perc_id': 97.6293,
            'perc_pos': 98.0603,
            'protein_id': 'ENSPPYP00000019722',
            'species': 'pongo_abelii',
            'taxon_id': 9601},
 'taxonomy_level': 'Hominidae',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.31115,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQA--QTALT-L--VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS-EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEML--FDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVE-SDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '10M2D5MDM2D54MD53M2D217MD126M',
            'id': 'ENSG00000106633',
            'perc_id': 82.4034,
            'perc_pos': 82.8326,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MA-----MDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSV-------LTLGSSG--PALGHSGEGNCGQ--VPVGGLPASTPPCQMVTMACIFQLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVER------------------------C--------SVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M5D69M7D7M2D13M2D242M24DM8D93M',
            'id': 'ENSNLEG00000028208',
            'perc_id': 89.9297,
            'perc_pos': 90.3981,
            'protein_id': 'ENSNLEP00000027462',
            'species': 'nomascus_leucogenys',
            'taxon_id': 61853},
 'taxonomy_level': 'Hominoidea',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03364,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 98.927,
            'perc_pos': 99.3562,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDAMRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDIMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCQITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSCANG00000013002',
            'perc_id': 98.927,
            'perc_pos': 99.3562,
            'protein_id': 'ENSCANP00000003917',
            'species': 'colobus_angolensis_palliatus',
            'taxon_id': 336983},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.0156,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 99.5708,
            'perc_pos': 99.5708,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDATRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSMMUG00000002427',
            'perc_id': 99.5708,
            'perc_pos': 99.5708,
            'protein_id': 'ENSMMUP00000051138',
            'species': 'macaca_mulatta',
            'taxon_id': 9544},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02248,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 99.3562,
            'perc_pos': 99.5708,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDATRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKEQFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSCSAG00000015587',
            'perc_id': 99.3562,
            'perc_pos': 99.5708,
            'protein_id': 'ENSCSAP00000011672',
            'species': 'chlorocebus_sabaeus',
            'taxon_id': 60711},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.12778,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMD--VTRSQAQTALT------------LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '4M2D11M12D451M',
            'id': 'ENSG00000106633',
            'perc_id': 96.7811,
            'perc_pos': 97.2103,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MQPGWVRGKFGASAWVQTPPWPVVLWAWGRVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '480M',
            'id': 'ENSMFAG00000043774',
            'perc_id': 93.9583,
            'perc_pos': 94.375,
            'protein_id': 'ENSMFAP00000024627',
            'species': 'macaca_fascicularis',
            'taxon_id': 9541},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.01442,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 99.5708,
            'perc_pos': 99.5708,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDATRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSMLEG00000039475',
            'perc_id': 99.5708,
            'perc_pos': 99.5708,
            'protein_id': 'ENSMLEP00000030794',
            'species': 'mandrillus_leucophaeus',
            'taxon_id': 9568},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.04137,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 98.7124,
            'perc_pos': 98.927,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDAMMSQAQRALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDIMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSRROG00000035669',
            'perc_id': 98.7124,
            'perc_pos': 98.927,
            'protein_id': 'ENSRROP00000023696',
            'species': 'rhinopithecus_roxellana',
            'taxon_id': 61622},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.12013,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMD--VTRSQAQTALT------------LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '4M2D11M12D451M',
            'id': 'ENSG00000106633',
            'perc_id': 96.5665,
            'perc_pos': 96.9957,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MQPGWVRGKFGASAWVQTSPWPVVLWAWGRVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASELLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '480M',
            'id': 'ENSPANG00000021695',
            'perc_id': 93.75,
            'perc_pos': 94.1667,
            'protein_id': 'ENSPANP00000041169',
            'species': 'papio_anubis',
            'taxon_id': 9555},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.0234,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 99.3562,
            'perc_pos': 99.5708,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDATRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLLLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSMNEG00000036780',
            'perc_id': 99.3562,
            'perc_pos': 99.5708,
            'protein_id': 'ENSMNEP00000026883',
            'species': 'macaca_nemestrina',
            'taxon_id': 9545},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.124,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMD--VTRSQAQTALT------------LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '4M2D11M12D451M',
            'id': 'ENSG00000106633',
            'perc_id': 96.7811,
            'perc_pos': 97.2103,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MQPGWVRGKFGASAWVQTPPWPVVLWAWGRVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '480M',
            'id': 'ENSCATG00000038208',
            'perc_id': 93.9583,
            'perc_pos': 94.375,
            'protein_id': 'ENSCATP00000030077',
            'species': 'cercocebus_atys',
            'taxon_id': 9531},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.04335,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 98.927,
            'perc_pos': 99.1416,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MVMDATRSQAQRALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDIMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSRBIG00000034645',
            'perc_id': 98.927,
            'perc_pos': 99.1416,
            'protein_id': 'ENSRBIP00000021383',
            'species': 'rhinopithecus_bieti',
            'taxon_id': 61621},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03103,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 98.927,
            'perc_pos': 99.1416,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDAMRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDIMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGH',
            'cigar_line': '466M',
            'id': 'ENSPTEG00000003496',
            'perc_id': 98.927,
            'perc_pos': 99.1416,
            'protein_id': 'ENSPTEP00000002966',
            'species': 'piliocolobus_tephrosceles',
            'taxon_id': 591936},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.0201,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 99.3562,
            'perc_pos': 99.3562,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDATRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASELLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSTGEG00000012839',
            'perc_id': 99.3562,
            'perc_pos': 99.3562,
            'protein_id': 'ENSTGEP00000015909',
            'species': 'theropithecus_gelada',
            'taxon_id': 9565},
 'taxonomy_level': 'Catarrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.06281,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MD-VTRSQA----QTALT-----LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M2D2MD6M4D5M5D451M',
            'id': 'ENSG00000106633',
            'perc_id': 97.2103,
            'perc_pos': 97.4249,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MWVPDDIPPRSPAYPLPSLAAPIPLPMQVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKASMLGQ',
            'cigar_line': '478M',
            'id': 'ENSCJAG00000008025',
            'perc_id': 94.7699,
            'perc_pos': 94.9791,
            'protein_id': 'ENSCJAP00000014864',
            'species': 'callithrix_jacchus',
            'taxon_id': 9483},
 'taxonomy_level': 'Simiiformes',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02766,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 98.4979,
            'perc_pos': 99.1416,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDVTKNQDQTVLTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKDRFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKASMLGQ',
            'cigar_line': '466M',
            'id': 'ENSSBOG00000000143',
            'perc_id': 98.4979,
            'perc_pos': 99.1416,
            'protein_id': 'ENSSBOP00000000162',
            'species': 'saimiri_boliviensis_boliviensis',
            'taxon_id': 39432},
 'taxonomy_level': 'Simiiformes',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02241,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 98.7124,
            'perc_pos': 99.1416,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDVTKNQDQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRLLTPSCEITFIESEEGSGRGAALVSAVACKKASMLGQ',
            'cigar_line': '466M',
            'id': 'ENSCCAG00000027953',
            'perc_id': 98.7124,
            'perc_pos': 99.1416,
            'protein_id': 'ENSCCAP00000020417',
            'species': 'cebus_capucinus',
            'taxon_id': 1737458},
 'taxonomy_level': 'Simiiformes',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02031,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 98.927,
            'perc_pos': 99.3562,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDVTKNQHQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKASMLGQ',
            'cigar_line': '466M',
            'id': 'ENSANAG00000028532',
            'perc_id': 98.927,
            'perc_pos': 99.3562,
            'protein_id': 'ENSANAP00000021505',
            'species': 'aotus_nancymaae',
            'taxon_id': 37293},
 'taxonomy_level': 'Simiiformes',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.04134,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-MA-MDVTRSQAQTALTL-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': 'D2MD14MD450M',
            'id': 'ENSG00000106633',
            'perc_id': 95.7082,
            'perc_pos': 96.5665,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'SLGN--RVRLQLKKKKKLWVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEGGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRERRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLSQ',
            'cigar_line': '4M2D463M',
            'id': 'ENSTSYG00000007022',
            'perc_id': 95.5032,
            'perc_pos': 96.3597,
            'protein_id': 'ENSTSYP00000006413',
            'species': 'carlito_syrichta',
            'taxon_id': 1868482},
 'taxonomy_level': 'Haplorrhini',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02851,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMD--VTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '4M2D462M',
            'id': 'ENSG00000106633',
            'perc_id': 96.3519,
            'perc_pos': 97.8541,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAVDATRSKS--QTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLADENLLFHGEASEQLRTRGAFETRFVSQVESDSGDCKQIHNILSTLGLRPSAADCDIVRRVCESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '10M2D456M',
            'id': 'ENSPCOG00000021845',
            'perc_id': 96.3519,
            'perc_pos': 97.8541,
            'protein_id': 'ENSPCOP00000019771',
            'species': 'propithecus_coquereli',
            'taxon_id': 379532},
 'taxonomy_level': 'Primates',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03799,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MD--VTRSQA--QTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M2D2M2D6M2D456M',
            'id': 'ENSG00000106633',
            'perc_id': 95.0644,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MATRLACQDRRAGMDPPTRPVQVEQILAEFQLQEEDLKKVMRRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLADENLLFHGEASEQLRTRGAFETRFVSQVESDSGDCKQIHNILSTLGLRPSVADCDIVRRVCESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '472M',
            'id': 'ENSMICG00000013503',
            'perc_id': 93.8559,
            'perc_pos': 95.1271,
            'protein_id': 'ENSMICP00000043190',
            'species': 'microcebus_murinus',
            'taxon_id': 30608},
 'taxonomy_level': 'Primates',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.01515,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 97.4249,
            'perc_pos': 98.927,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAVDTTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFQGEASEQLRTRGAFETRFVSQVESDSGDYKQIHNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEEVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIQSEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSOGAG00000013533',
            'perc_id': 97.4249,
            'perc_pos': 98.927,
            'protein_id': 'ENSOGAP00000019975',
            'species': 'otolemur_garnettii',
            'taxon_id': 30611},
 'taxonomy_level': 'Primates',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.04091,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMD--VTRSQA--------------QTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '4M2D6M14D456M',
            'id': 'ENSG00000106633',
            'perc_id': 94.6352,
            'perc_pos': 96.1373,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MILSCCSRKKGCFCSCSRSAPVPHIPRRAQLEVEQILAEFQLQEEDLKKVMRRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLADENLLFHGEASEQLRTRGAFETRFVSQVESDSGDCKQIHNILSTLGLRPSAADCDIVRRVCESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '482M',
            'id': 'ENSPSMG00000016706',
            'perc_id': 91.4938,
            'perc_pos': 92.9461,
            'protein_id': 'ENSPSMP00000023640',
            'species': 'prolemur_simus',
            'taxon_id': 1328070},
 'taxonomy_level': 'Primates',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVM-------RITVGVDGSV--YKLH-PSF--KERFHASVR------------------------RLTPS--------CEITFIE----------------SEEGSG---------------------------RGAALV----SAVACKKACMLGQ---------------------------------',
            'cigar_line': '403M7D10M2D4MD3M2D9M24D5M8D7M16D6M27D6M4D13M33D',
            'id': 'ENSG00000106633',
            'perc_id': 78.7554,
            'perc_pos': 84.9785,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDNRARMEATKKEK-AEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKQQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSVNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFV-----DPGDRKQIHNILSTLGLRPSATDCDIVRPLLQ--FSRWAALVLAGVASRRSRHRDSNAPAYLGWNAVPGRKWITQDFAVPHWTLWLPAWPGKEVFPGPGLGRGPQDPAIAWTLWGPPCRGRHLQKLGQTDQGPRGMRAAVTWVGVFLPVAWETWDPWKRAQQHGSASQAAGVPRRPFPSHSPSPGWLVVLAWLRGPPLGDLLGPPSALRQGGVLGSYTGPERCSQQHPAHLRGPPQTRLLSSSGHPCST',
            'cigar_line': '15MD320M5D32M2D215M',
            'id': 'ENSFDAG00000015691',
            'perc_id': 63.0584,
            'perc_pos': 68.0412,
            'protein_id': 'ENSFDAP00000007096',
            'species': 'fukomys_damarensis',
            'taxon_id': 885580},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02237,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 85.4077,
            'perc_pos': 86.6953,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDEARSRAQAALTLAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQL----------------------------------------------------DPGDRKQIHNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSLDMMRITVGVDGSVYKLHPSFKERFHASVRRLTPRCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '289M52D125M',
            'id': 'ENSCPOG00000005392',
            'perc_id': 96.1353,
            'perc_pos': 97.5845,
            'protein_id': 'ENSCPOP00000029488',
            'species': 'cavia_porcellus',
            'taxon_id': 10141},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03003,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 95.0644,
            'perc_pos': 96.5665,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEAAKKDKVAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSVNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDPGDRKQIHNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSQDVMRITVGVDGSVYKLHPSFKERFHASVRRLAPRCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSODEG00000014198',
            'perc_id': 95.0644,
            'perc_pos': 96.5665,
            'protein_id': 'ENSODEP00000019248',
            'species': 'octodon_degus',
            'taxon_id': 10160},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.01979,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': 'D466M',
            'id': 'ENSG00000106633',
            'perc_id': 96.7811,
            'perc_pos': 98.0687,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'RDAMESMRSLTQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHXSVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '467M',
            'id': 'ENSUPAG00010021047',
            'perc_id': 96.5739,
            'perc_pos': 97.8587,
            'protein_id': 'ENSUPAP00010026635',
            'species': 'urocitellus_parryii',
            'taxon_id': 9999},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 95.279,
            'perc_pos': 97.2103,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRTRMEATKK-EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGDAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDTGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIQSEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'ENSMOCG00000007909',
            'perc_id': 95.4839,
            'perc_pos': 97.4194,
            'protein_id': 'ENSMOCP00000008006',
            'species': 'microtus_ochrogaster',
            'taxon_id': 79684},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03266,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 93.9914,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDNRARMEATKKEKVAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSVNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDPGDRKQIHNILSTLGLRPSPTDCDLVRRACESVSTRAAHMCSAGLAGVINRMRESRSQDVLRITVGVDGSVYKLHPSFKEQFHSSVRRLAPRCEITFIESEEGSGRGAALVSAVACKKACMLG-',
            'cigar_line': '465MD',
            'id': 'ENSHGLG00100010467',
            'perc_id': 94.1936,
            'perc_pos': 96.5591,
            'protein_id': 'ENSHGLP00100014157',
            'species': 'heterocephalus_glaber_male',
            'taxon_id': 10181},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 96.3519,
            'perc_pos': 97.8541,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDEARSRAQAALTLAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRECEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSVNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDPGDRKQIHNILSTLGLRPSTADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSQDVMRITVGVDGSVYKLHPSFKERFHASVRRLAPRCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSCLAG00000004771',
            'perc_id': 96.3519,
            'perc_pos': 97.8541,
            'protein_id': 'ENSCLAP00000006767',
            'species': 'chinchilla_lanigera',
            'taxon_id': 34839},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 93.5622,
            'perc_pos': 96.1373,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEATKK-EKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'ENSMUSG00000041798',
            'perc_id': 93.7634,
            'perc_pos': 96.3441,
            'protein_id': 'ENSMUSP00000099984',
            'species': 'mus_musculus',
            'taxon_id': 10090},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 84.3348,
            'perc_pos': 85.6223,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MTMDATSGQAQSTATLVEQILAEFQLQEEDLKKVMRRMQKEMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEVGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQLKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDSGDRKQTYNILSTLGLRPSAADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRCVDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGH',
            'cigar_line': '466M',
            'id': 'ENSOPRG00000001902',
            'perc_id': 84.3348,
            'perc_pos': 85.6223,
            'protein_id': 'ENSOPRP00000001752',
            'species': 'ochotona_princeps',
            'taxon_id': 9978},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03266,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 93.9914,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDNRARMEATKKEKVAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSVNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDPGDRKQIHNILSTLGLRPSPTDCDLVRRACESVSTRAAHMCSAGLAGVINRMRESRSQDVLRITVGVDGSVYKLHPSFKEQFHSSVRRLAPRCEITFIESEEGSGRGAALVSAVACKKACMLG-',
            'cigar_line': '465MD',
            'id': 'ENSHGLG00000019150',
            'perc_id': 94.1936,
            'perc_pos': 96.5591,
            'protein_id': 'ENSHGLP00000026925',
            'species': 'heterocephalus_glaber_female',
            'taxon_id': 10181},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT---LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRL-ETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15M3D33MD418M',
            'id': 'ENSG00000106633',
            'perc_id': 84.7639,
            'perc_pos': 87.5536,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-NLDTIQ--------HTW-FSQLL----------QKVMTQ----TDRSYHLSHSHQD------PLK---------VGDFLSLDLGGTNFRVMLVKVGEGDAC-WSVKTEHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDAGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': 'D6M8D3MD5M10D6M4D13M6D3M9D27MD367M',
            'id': 'ENSMAUG00000003438',
            'perc_id': 91.8605,
            'perc_pos': 94.8837,
            'protein_id': 'ENSMAUP00000003252',
            'species': 'mesocricetus_auratus',
            'taxon_id': 10036},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 94.8498,
            'perc_pos': 96.9957,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPDDRTRMEAAKK-EKVEQILAEFQLREEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGDAGQWSVKTKQQMYSIPQDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'ENSCGRG00000017741',
            'perc_id': 95.0538,
            'perc_pos': 97.2043,
            'protein_id': 'ENSCGRP00000024471',
            'species': 'cricetulus_griseus_crigri',
            'taxon_id': 10029},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03593,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTL--VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVR---------------------RLTPSCEITFIESEEGSG--RGAALVSAVACKKACMLGQ',
            'cigar_line': '16M2D413M21D18M2D19M',
            'id': 'ENSG00000106633',
            'perc_id': 89.2704,
            'perc_pos': 91.2017,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'LLDRGARMEP------RGVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPR----------LQGETAEAGVGVDIQKTSEMF--LPS--------QEVAGNW-GAALVSPVACKKACMLGQ',
            'cigar_line': '10M6D405M10D21M2D3M8D7MD18M',
            'id': 'ENSSDAG00000015099',
            'perc_id': 89.6552,
            'perc_pos': 91.5948,
            'protein_id': 'ENSSDAP00000016725',
            'species': 'spermophilus_dauricus',
            'taxon_id': 99837},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.01939,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': 'D466M',
            'id': 'ENSG00000106633',
            'perc_id': 96.7811,
            'perc_pos': 98.2833,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'RGAMEYMRSLTQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIQSEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '467M',
            'id': 'ENSSTOG00000002740',
            'perc_id': 96.5739,
            'perc_pos': 98.0728,
            'protein_id': 'ENSSTOP00000002448',
            'species': 'ictidomys_tridecemlineatus',
            'taxon_id': 43179},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT--LVEQIL---------------------AEFQLQEEDLKKVMRRMQKEMDR-----GLRLETHEEASVKMLPTYVRST------------------PEGS----EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15M2D6M21D23M5D22M18D4M4D396M',
            'id': 'ENSG00000106633',
            'perc_id': 85.4077,
            'perc_pos': 88.8412,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDTTR--------CG--AQLLTLGTNKCTNACSLLCRAGTHNGHMNPRCRTEQAAATQL--PTCRVQLLLNYHVEGRAD------PGRVPAAGGRPEEGDEPDAEGDGPWPEAGDPRGEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ',
            'cigar_line': '7M8D2M2D42M2D18M6D429M',
            'id': 'ENSRNOG00000061527',
            'perc_id': 79.9197,
            'perc_pos': 83.1325,
            'protein_id': 'ENSRNOP00000068656',
            'species': 'rattus_norvegicus',
            'taxon_id': 10116},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.01508,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 97.4249,
            'perc_pos': 98.2833,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MATDATRSQAQTALTLAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSMNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDLGDRKQIHNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSDORG00000016392',
            'perc_id': 97.4249,
            'perc_pos': 98.2833,
            'protein_id': 'ENSDORP00000026422',
            'species': 'dipodomys_ordii',
            'taxon_id': 10020},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 94.8498,
            'perc_pos': 96.9957,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPDDRTRMEAAKK-EKVEQILAEFQLREEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGDAGQWSVKTKQQMYSIPQDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'ENSCGRG00001009989',
            'perc_id': 95.0538,
            'perc_pos': 97.2043,
            'protein_id': 'ENSCGRP00001007607',
            'species': 'cricetulus_griseus_chok1gshd',
            'taxon_id': 10029},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02112,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 96.5665,
            'perc_pos': 98.4979,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MATDPTKNRDQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSVNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRQSRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEISFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSCCNG00000017006',
            'perc_id': 96.5665,
            'perc_pos': 98.4979,
            'protein_id': 'ENSCCNP00000016778',
            'species': 'castor_canadensis',
            'taxon_id': 51338},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.01839,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 69.5279,
            'perc_pos': 70.3863,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDEARSRAQAALTLAEQILAEFQLQEEDLKKVMQRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSVNPGQQL----------------------------------------------------------------------------------------------------------------------------------FKERFHASVRRLTPRCEITFIESEEGSGRGAALVSAVACKKACMQGQ',
            'cigar_line': '289M130D47M',
            'id': 'ENSCAPG00000016334',
            'perc_id': 96.4286,
            'perc_pos': 97.619,
            'protein_id': 'ENSCAPP00000016450',
            'species': 'cavia_aperea',
            'taxon_id': 37548},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.06422,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLH-PSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '417MD49M',
            'id': 'ENSG00000106633',
            'perc_id': 47.8541,
            'perc_pos': 49.1416,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MTMEATRRQAQTATSLVEQILAEFQLHEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQLKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APTCRTPF-----WLGPE-------------------HRVL---------',
            'cigar_line': '229M188D8M5D5M19D4M9D',
            'id': 'ENSOCUG00000001018',
            'perc_id': 90.6504,
            'perc_pos': 93.0894,
            'protein_id': 'ENSOCUP00000032410',
            'species': 'oryctolagus_cuniculus',
            'taxon_id': 9986},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02169,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 95.4936,
            'perc_pos': 98.0687,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MATDATRTRAHSSLTLAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSVNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEKLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSITDCDIVRHACESVSTRAAHMCSAGLAGVINRMRESRSEEVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSNGAG00000022694',
            'perc_id': 95.4936,
            'perc_pos': 98.0687,
            'protein_id': 'ENSNGAP00000024422',
            'species': 'nannospalax_galili',
            'taxon_id': 1026970},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02043,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-----------------------------MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '29D466M',
            'id': 'ENSG00000106633',
            'perc_id': 96.9957,
            'perc_pos': 98.4979,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPQLQLHPRPQQAEASPPSKNTSFLCPWRDAVESMRSQTQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '495M',
            'id': 'ENSMMMG00000012459',
            'perc_id': 91.3131,
            'perc_pos': 92.7273,
            'protein_id': 'ENSMMMP00000013989',
            'species': 'marmota_marmota_marmota',
            'taxon_id': 9994},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02922,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 94.6352,
            'perc_pos': 97.4249,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAVDTTRRGAQSL-TLVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQIRNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'ENSMSIG00000019231',
            'perc_id': 94.8387,
            'perc_pos': 97.6344,
            'protein_id': 'ENSMSIP00000022689',
            'species': 'mus_spicilegus',
            'taxon_id': 10103},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.01949,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 96.5665,
            'perc_pos': 98.0687,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDATGSSAQSALILVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHKEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEEEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSAADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSJJAG00000020695',
            'perc_id': 96.5665,
            'perc_pos': 98.0687,
            'protein_id': 'ENSJJAP00000019855',
            'species': 'jaculus_jaculus',
            'taxon_id': 51337},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 93.5622,
            'perc_pos': 96.1373,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEATKK-EKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQIRNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'MGP_SPRETEiJ_G0016905',
            'perc_id': 93.7634,
            'perc_pos': 96.3441,
            'protein_id': 'MGP_SPRETEiJ_P0026897',
            'species': 'mus_spretus',
            'taxon_id': 10096},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 94.206,
            'perc_pos': 96.1373,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEATKK-EKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQIRNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'MGP_CAROLIEiJ_G0016063',
            'perc_id': 94.4086,
            'perc_pos': 96.3441,
            'protein_id': 'MGP_CAROLIEiJ_P0025564',
            'species': 'mus_caroli',
            'taxon_id': 10089},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 94.206,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEATKK-EKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQIHNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'MGP_PahariEiJ_G0016828',
            'perc_id': 94.4086,
            'perc_pos': 96.5591,
            'protein_id': 'MGP_PahariEiJ_P0030387',
            'species': 'mus_pahari',
            'taxon_id': 10093},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 94.8498,
            'perc_pos': 96.9957,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPDDRTRMEAAKK-EKVEQILAEFQLREEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGDAGQWSVKTKQQMYSIPQDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'ENSCGRG00015004254',
            'perc_id': 95.0538,
            'perc_pos': 97.2043,
            'protein_id': 'ENSCGRP00015005508',
            'species': 'cricetulus_griseus_picr',
            'taxon_id': 10029},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 95.0644,
            'perc_pos': 96.7811,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'RLDDRARMEAAKK-EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEATVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'ENSMUGG00000023356',
            'perc_id': 95.2688,
            'perc_pos': 96.9893,
            'protein_id': 'ENSMUGP00000028156',
            'species': 'meriones_unguiculatus',
            'taxon_id': 10047},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 95.279,
            'perc_pos': 96.9957,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRIRMEAPKK-EKVEQILAEFQLREEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13MD452M',
            'id': 'ENSPEMG00000001040',
            'perc_id': 95.4839,
            'perc_pos': 97.2043,
            'protein_id': 'ENSPEMP00000001352',
            'species': 'peromyscus_maniculatus_bairdii',
            'taxon_id': 230844},
 'taxonomy_level': 'Euarchontoglires',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03408,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '----------------MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '16D466M',
            'id': 'ENSG00000106633',
            'perc_id': 92.0601,
            'perc_pos': 94.4206,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'CVGPCESGHPGPGPTRLLH--------RPAQ-AEQILADFQLQEADLKKVMRRMQTEMARGLRLQTHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGAEGQWSVTTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPFCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '19M8D4MD450M',
            'id': 'ENSMPUG00000018201',
            'perc_id': 90.6977,
            'perc_pos': 93.0233,
            'protein_id': 'ENSMPUP00000018089',
            'species': 'mustela_putorius_furo',
            'taxon_id': 9669},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03495,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 93.9914,
            'perc_pos': 96.1373,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'TAMDAMRGQTHTALNLAEQILADFQLQEADLKKVMWRMQKEMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPTATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHTIVRKLTPSCEITFIESEEGSGRGAALVSAVACKKACMQGQ',
            'cigar_line': '466M',
            'id': 'ENSSSUG00005002920',
            'perc_id': 93.9914,
            'perc_pos': 96.1373,
            'protein_id': 'ENSSSUP00005004538',
            'species': 'suricata_suricatta',
            'taxon_id': 37032},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.04253,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA---MD--VTRSQA---------------QTALT-------------------------------LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVE-------------------------------------------SDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M3D2M2D6M15D5M31D325M43D126M',
            'id': 'ENSG00000106633',
            'perc_id': 93.3476,
            'perc_pos': 96.5665,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MILPQGESNSTRALLGTWKHAEEPGSQPSAPTASTLARAPQHHGSLPKLMAQLAWPAPAPPEAGRHTAEQILADFQMQEADLKKVMRRMQREMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHEMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVERRARVAHVRAETPGVEARRPAHCWCLAESDALPSGARAPSALPGDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '560M',
            'id': 'ENSCAFG00040023667',
            'perc_id': 77.6786,
            'perc_pos': 80.3571,
            'protein_id': 'ENSCAFP00040038568',
            'species': 'canis_lupus_familiarisgreatdane',
            'taxon_id': 9615},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02957,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 94.8498,
            'perc_pos': 96.7811,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMTATRIQAQPASNLAEQILADFQLQEADLKKVMRRMQKEMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVTTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDAMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSUAMG00000004714',
            'perc_id': 94.8498,
            'perc_pos': 96.7811,
            'protein_id': 'ENSUAMP00000005276',
            'species': 'ursus_americanus',
            'taxon_id': 9643},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-------------------------------MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '31D466M',
            'id': 'ENSG00000106633',
            'perc_id': 83.2618,
            'perc_pos': 85.4077,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'PLVGRSLGYFCLGSPLGNTEGFQLPRRAAVQMLDDRARMEIAKKEK-VEQILAEFQLQDEDLKKVMRRMQKEMDRGLRLETHKEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAARMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '46MD450M',
            'id': 'ENSTTRG00000006046',
            'perc_id': 78.2258,
            'perc_pos': 80.2419,
            'protein_id': 'ENSTTRP00000005718',
            'species': 'tursiops_truncatus',
            'taxon_id': 9739},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGT-GCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '229MD237M',
            'id': 'ENSG00000106633',
            'perc_id': 43.9914,
            'perc_pos': 45.7082,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-------------------------MQEADLKKVMRRMQREMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHEMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGKDSCPA--------------------------------------------------------------------LSRGLCLPL-----------SSVLRSKG-----------------------------------------------------------------------------------------------------------------------------------------',
            'cigar_line': '25D209M68D9M11D8M137D',
            'id': 'ENSCAFG00000002944',
            'perc_id': 90.708,
            'perc_pos': 94.2478,
            'protein_id': 'ENSCAFP00000004364',
            'species': 'canis_familiaris',
            'taxon_id': 9615},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03697,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMD--VTRSQAQTALT----LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '4M2D11M4D451M',
            'id': 'ENSG00000106633',
            'perc_id': 92.7039,
            'perc_pos': 95.7082,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----GGDDRAWI-----WGAQLAEQILADFQMQEADLKKVMRRMQREMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHEMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '4D8M5D455M',
            'id': 'ENSCAFG00020016524',
            'perc_id': 93.3045,
            'perc_pos': 96.3283,
            'protein_id': 'ENSCAFP00020020949',
            'species': 'canis_lupus_dingo',
            'taxon_id': 286419},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.0891,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '------------------------------MAMDVTRSQAQTALT--L--VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVR-----------------------------------------------RLTPS----------CEITFIE--SEEGSG---RGAALV---------------------------------SAVACKKACMLGQ----------------------------------------------------------------',
            'cigar_line': '30D15M2DM2D413M47D5M10D7M2D6M3D6M33D13M64D',
            'id': 'ENSG00000106633',
            'perc_id': 87.1245,
            'perc_pos': 90.1288,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MVPPPPTTCGLPKLRKKGQISLLPPDSNSGHFHPQACMEDCRQESEFLRRAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPRPAERRGPGARPRPPSRPSEALPMSFPCSSKPRSKSSRKPSAASTRTVMASSASQTFERPTPSWVSAPLSHRPCAAQARTQCCRAVAGSLMRGPASCRSLPLPVLPFLLTAPSSSHTPPPSHLPPPPPPELPLTCSQSGEGGEGGWKGTEAGPYSGTLKLPVSISLPARTPREGECSRRGAGCHAAGREGAHQLHRLPHVVRGEAQR',
            'cigar_line': '659M',
            'id': 'ENSSSCG00000016751',
            'perc_id': 61.6085,
            'perc_pos': 63.7329,
            'protein_id': 'ENSSSCP00000048940',
            'species': 'sus_scrofa',
            'taxon_id': 9823},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.0437,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 92.0601,
            'perc_pos': 95.4936,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPDDRARMENAKKEK-AEQILAEFRLQDEDLKKVMRRMQMEMDRGLRLETHEKASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYVSECISDFLEKHHMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMHNVELVEGEEGRMCVNTEWGAFGDAGELDEFLLEYDRMVDESSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSRLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIQSEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15MD450M',
            'id': 'ENSRFEG00010020533',
            'perc_id': 92.2581,
            'perc_pos': 95.6989,
            'protein_id': 'ENSRFEP00010031126',
            'species': 'rhinolophus_ferrumequinum',
            'taxon_id': 59479},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.04777,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 92.7039,
            'perc_pos': 94.8498,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMDVTKKEK-AEQILADFQLQEADLKKVMRRMQTEMARGLRLQTHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGAEGQWSVTTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPFCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '15MD450M',
            'id': 'ENSNVIG00000021119',
            'perc_id': 92.9032,
            'perc_pos': 95.0538,
            'protein_id': 'ENSNVIP00000027326',
            'species': 'neovison_vison',
            'taxon_id': 452646},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 53.0043,
            'perc_pos': 54.721,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '------------------------------------------------------------------------------------------------------------------------------------------------------------------GILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLFEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVE---------------------------------------------GLSVVINRMRQSRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFLESEEGSGRGAALVSAVAWKKACMLGQ',
            'cigar_line': '162D178M45D81M',
            'id': 'ENSSARG00000006856',
            'perc_id': 95.3668,
            'perc_pos': 98.4556,
            'protein_id': 'ENSSARP00000006210',
            'species': 'sorex_araneus',
            'taxon_id': 42254},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.04259,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MDVTRSQA-QTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M2D8MD456M',
            'id': 'ENSG00000106633',
            'perc_id': 92.9185,
            'perc_pos': 95.7082,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--DKGDKRRLEHG-----LVRQILAEFQLQEEDLKKVMRRMQEEMDRGLRLETHEEATVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDAGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRLVSQVESDSGDRKQIYNILSTLGLRPSGTDCDIVRRACESVSTRAAHMCSAGLAAVINRMRESRREDVMRITVGVDGSVYKLHPSFKQRFHASVRRLTPNCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '2D11M5D451M',
            'id': 'ENSEASG00005017749',
            'perc_id': 93.7229,
            'perc_pos': 96.5368,
            'protein_id': 'ENSEASP00005026027',
            'species': 'equus_asinus_asinus',
            'taxon_id': 83772},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03351,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2D466M',
            'id': 'ENSG00000106633',
            'perc_id': 94.206,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'VVMEATRSRAQIALN--LAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSAADCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '15M2D451M',
            'id': 'ENSMMSG00000010554',
            'perc_id': 94.206,
            'perc_pos': 96.3519,
            'protein_id': 'ENSMMSP00000014061',
            'species': 'moschus_moschiferus',
            'taxon_id': 68415},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.04217,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT-LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15MD451M',
            'id': 'ENSG00000106633',
            'perc_id': 93.7768,
            'perc_pos': 95.9227,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEISKK--EKAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHKEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTTHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '13M2D452M',
            'id': 'ENSBTAG00000032288',
            'perc_id': 93.9785,
            'perc_pos': 96.129,
            'protein_id': 'ENSBTAP00000043100',
            'species': 'bos_taurus',
            'taxon_id': 9913},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '----MA-----------MDVTRSQA----QTALT------------L--------VEQIL-------------------AEFQLQEEDL--------KKVMR-RMQKEMDR--------------------GLRLETHEEASVKMLPTYVRST----------PEGS------EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYS--IPEDAMTGTAEML-----------FDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVE---------------------------------------S----DTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '4D2M11D8M4D5M12DM8D5M19D10M8D5MD8M20D22M10D4M6D40M2D13M11D217M39DM4D125M',
            'id': 'ENSG00000106633',
            'perc_id': 76.824,
            'perc_pos': 82.8326,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MVPGMAPAGHILAQCPR--GIR---WVTGQLREQAGAVSTQHSASFLCVTPSPSNSRDTLWGGCSCNVCPGGNATHWWGGLERLQKDDEPSGEAGRGRAILRARVSRQESHGSLVLTTPLHAIGVNQGGRDGMGTSQGPSTSGDLGPSAEHSTIPSFVDGPTQQDGGWSSAGPGVGQPGSWRQQSTEIRVMSTAEPLSKVCGWTSSGRDLSWCCPVPGAAAFGRGALRPMACWRCVFQLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVERRARVAHVRAETPGVEARRPAHCWCLAESDALPSGARAPSALPGDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '17M2D3M3D600M',
            'id': 'ENSCAFG00030004946',
            'perc_id': 57.7419,
            'perc_pos': 62.2581,
            'protein_id': 'ENSCAFP00030008087',
            'species': 'canis_lupus_familiarisbasenji',
            'taxon_id': 9615},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03808,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTL----------------VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '16M16D450M',
            'id': 'ENSG00000106633',
            'perc_id': 93.5622,
            'perc_pos': 95.4936,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--MVQTRQEGSLEYLLLCQQAETTLLSPPPPQAEQILADFQLQEADLKKVMWRMQKEMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2D480M',
            'id': 'ENSPPRG00000001844',
            'perc_id': 90.8333,
            'perc_pos': 92.7083,
            'protein_id': 'ENSPPRP00000006363',
            'species': 'panthera_pardus',
            'taxon_id': 9691},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03985,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2D466M',
            'id': 'ENSG00000106633',
            'perc_id': 93.7768,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'VVMEATRSQAQTALN--LAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHKEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTTHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '15M2D451M',
            'id': 'ENSBIXG00000003587',
            'perc_id': 93.7768,
            'perc_pos': 96.3519,
            'protein_id': 'ENSBIXP00000015396',
            'species': 'bos_taurus_hybrid',
            'taxon_id': 30522},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.04195,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT-LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15MD451M',
            'id': 'ENSG00000106633',
            'perc_id': 94.206,
            'perc_pos': 96.1373,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEIAKK--EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSAADCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '13M2D452M',
            'id': 'ENSCHIG00000015555',
            'perc_id': 94.4086,
            'perc_pos': 96.3441,
            'protein_id': 'ENSCHIP00000014563',
            'species': 'capra_hircus',
            'taxon_id': 9925},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02802,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG----------------------------------------------------------------DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '194M64D272M',
            'id': 'ENSG00000106633',
            'perc_id': 88.6266,
            'perc_pos': 91.2017,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------------------------MRRMQEEMDRGLRLETHEEATVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGVRRHLPLPLPWVPLTLPRVQDAGEGLLGVHPGRNPVLPHLAGPAQSRLSRDPQPYHRCLCASWQDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDAGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRLVSQVESDSGDRKQIYNILSTLGLRPSGTDCDIVRRACESVSTRAAHMCSAGLAAVINRMRESRREDVMRITVGVDGSVYKLHPSFKQRFHASVRRLTPNCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '34D496M',
            'id': 'ENSECAG00000022171',
            'perc_id': 83.2661,
            'perc_pos': 85.6855,
            'protein_id': 'ENSECAP00000039470',
            'species': 'equus_caballus',
            'taxon_id': 9796},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.07976,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTL-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG---------------------------------------------DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALV------------SAVACKKACMLGQ--',
            'cigar_line': '16MD178M45D259M12D13M2D',
            'id': 'ENSG00000106633',
            'perc_id': 81.7597,
            'perc_pos': 84.5494,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMDVTKKE--KAEQILADFQMQEADLKKVMRRMQREMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHEMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGVRWPPCPPWEPPAPLAREPGHWLEGPRAPRPRPRPRHCCLLASWQDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGS-----------------------------------------PPTPGPPDREGGGPTCCSSSGGG--PR',
            'cigar_line': '14M2D442M41D23M2D2M',
            'id': 'ENSVVUG00000008505',
            'perc_id': 79.21,
            'perc_pos': 81.9127,
            'protein_id': 'ENSVVUP00000011546',
            'species': 'vulpes_vulpes',
            'taxon_id': 9627},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.0408,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT-LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15MD451M',
            'id': 'ENSG00000106633',
            'perc_id': 94.206,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEIAKK--EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEKLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAARMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAGVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '13M2D452M',
            'id': 'ENSPCTG00005005671',
            'perc_id': 94.4086,
            'perc_pos': 96.5591,
            'protein_id': 'ENSPCTP00005008141',
            'species': 'physeter_catodon',
            'taxon_id': 9755},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.04429,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT-LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15MD451M',
            'id': 'ENSG00000106633',
            'perc_id': 93.9914,
            'perc_pos': 95.9227,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEIAKK--EKAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSAADCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '13M2D452M',
            'id': 'ENSOARG00000015987',
            'perc_id': 94.1936,
            'perc_pos': 96.129,
            'protein_id': 'ENSOARP00000017168',
            'species': 'ovis_aries',
            'taxon_id': 9940},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03985,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2D466M',
            'id': 'ENSG00000106633',
            'perc_id': 93.7768,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'VVMEATRSQAQTALN--LAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHKEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTTHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '15M2D451M',
            'id': 'ENSBIXG00005019239',
            'perc_id': 93.7768,
            'perc_pos': 96.3519,
            'protein_id': 'ENSBIXP00005015369',
            'species': 'bos_indicus_hybrid',
            'taxon_id': 30522},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 91.8455,
            'perc_pos': 93.9914,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------AEQILAEFRLQEEDLKKVMRRMQKEMDRGLRLATHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSLNTKHQMYSIPEDAMTGTAEMLFDYVSECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMHNVELVDGDEGRMCVNTEWGAFGDAGELDEFLLEYDRMVDESSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDEDLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCGAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHP-FKERFHAIVRRLTPSCEITFIQSEEGSGRGAALVSAVARKKACMLGQ',
            'cigar_line': '16D402MD47M',
            'id': 'ENSPVAG00000008079',
            'perc_id': 95.3229,
            'perc_pos': 97.5501,
            'protein_id': 'ENSPVAP00000007630',
            'species': 'pteropus_vampyrus',
            'taxon_id': 132908},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.07247,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 80.4721,
            'perc_pos': 83.9056,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '---------------------AEFHAAGGRLEEGMRRMQKEMDRGL------------LPMRLVCFSLCAEVGIPL-LDLGGTNFR----------EGQWSVKTKHQMSSIPGVSVLGRPHRLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDEDLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRHACESVSTRAARMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKDRFHTSVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '21D25M12D18MD9M10D370M',
            'id': 'ENSCDRG00005009900',
            'perc_id': 88.8626,
            'perc_pos': 92.654,
            'protein_id': 'ENSCDRP00005014290',
            'species': 'camelus_dromedarius',
            'taxon_id': 9838},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTL-------GLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '356M7D110M',
            'id': 'ENSG00000106633',
            'perc_id': 79.1845,
            'perc_pos': 82.8326,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPDDGAGMETAKKEK-AEQILAEFRLQEEDLKKVMRRMQKEMDRGLRLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGHWSVKTKHQMYCIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMHNVELVEGEEGRMCVNTEWGAFGDAGELDEFLLEYDRAVDESSLNPGQQLYEKLIGGKYMGELVRLVLLPLVYEDLLYRAEGSEQLSPPGAFETRFVSHVETCARRRPRIQNVISKVYCLDSEHGRLP---------------SPRAQRGC-------------------VHITMGVDGSVYKLHPIFKERFHASVRRLTPSCEITFIQSEDGSGRGAALVSAVACKKAYMLGQ',
            'cigar_line': '15MD351M15D8M19D64M',
            'id': 'ENSMLUG00000012016',
            'perc_id': 84.2466,
            'perc_pos': 88.1279,
            'protein_id': 'ENSMLUP00000010946',
            'species': 'myotis_lucifugus',
            'taxon_id': 59463},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02809,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 94.8498,
            'perc_pos': 96.5665,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDAMRSQTQMPLNLAEQILADFQLQEADLKKVMWRMQKEMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSFCAG00000014361',
            'perc_id': 94.8498,
            'perc_pos': 96.5665,
            'protein_id': 'ENSFCAP00000013323',
            'species': 'felis_catus',
            'taxon_id': 9685},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03446,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMD-VTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '4MD462M',
            'id': 'ENSG00000106633',
            'perc_id': 69.5279,
            'perc_pos': 71.03,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDIRSQ---TAAPNLAEHILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLKDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAARMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRLLTPSCEITFIE-SEGSGPGAGLVSAVAWK-ACMLGQ',
            'cigar_line': '8M3D431MD17MD6M',
            'id': 'ENSEEUG00000001219',
            'perc_id': 70.1299,
            'perc_pos': 71.645,
            'protein_id': 'ENSEEUP00000001096',
            'species': 'erinaceus_europaeus',
            'taxon_id': 9365},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT---LVEQILAEFQLQEEDLKKVMRRMQKEMDR-GLRLETHEEASVKMLPTYVRSTPEGS-------EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEML-----------FDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGEL-VRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPST-TDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEE--GSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15M3D29MD26M7D53M11D179MD60MD82M2D22M',
            'id': 'ENSG00000106633',
            'perc_id': 54.2918,
            'perc_pos': 57.7253,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDDRARMEA-----TKK----------------EKVMHPFGRLLGSVGC--DRHRQA----LPAPPLREPKADVLLPVAAEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMVSSEGLLCVLQLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMHNVELVEGEEGRMCVNTEWGAFGDSGELDEFLLEYDRL-------------------------PLPLVLPLQADDGLVFK-----------------------QLGGR----------------W---------GES-----------------NR------------------------PS--------LRQLAPL----------SFGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '10M5D3M16D16M2D6M4D237M25D17M23D5M16DM9D3M17D2M24D2M8D7M10D24M',
            'id': 'ENSPTIG00000013711',
            'perc_id': 75.976,
            'perc_pos': 80.7808,
            'protein_id': 'ENSPTIP00000014260',
            'species': 'panthera_tigris_altaica',
            'taxon_id': 74533},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03693,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '---MAMDVTRSQA-----QTALT-----LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '3D10M5D5M5D451M',
            'id': 'ENSG00000106633',
            'perc_id': 93.133,
            'perc_pos': 95.279,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'PPWVG--DARELGHPGPPAHAAAPPTPAQAEQILADFQLQEADLKKVMRRMQKEMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVTTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIASEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '5M2D472M',
            'id': 'ENSAMEG00000017601',
            'perc_id': 90.9853,
            'perc_pos': 93.0818,
            'protein_id': 'ENSAMEP00000018607',
            'species': 'ailuropoda_melanoleuca',
            'taxon_id': 9646},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03836,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2D466M',
            'id': 'ENSG00000106633',
            'perc_id': 93.9914,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'VVMEATRSRAQTALN--LAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHKEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTTHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '15M2D451M',
            'id': 'ENSBMUG00000026269',
            'perc_id': 93.9914,
            'perc_pos': 96.3519,
            'protein_id': 'ENSBMUP00000035334',
            'species': 'bos_mutus',
            'taxon_id': 72004},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03911,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2D466M',
            'id': 'ENSG00000106633',
            'perc_id': 93.9914,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'VVMEATRSRAQTALN--LAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHKEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTTHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '15M2D451M',
            'id': 'ENSBBBG00000004174',
            'perc_id': 93.9914,
            'perc_pos': 96.3519,
            'protein_id': 'ENSBBBP00000022778',
            'species': 'bison_bison_bison',
            'taxon_id': 43346},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02732,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 95.0644,
            'perc_pos': 96.7811,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMDATRSQTQMPLNLAEQILADFQLQEADLKKVMWRMQKEMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSLCNG00005002889',
            'perc_id': 95.0644,
            'perc_pos': 96.7811,
            'protein_id': 'ENSLCNP00005004319',
            'species': 'lynx_canadensis',
            'taxon_id': 61383},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03935,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2D466M',
            'id': 'ENSG00000106633',
            'perc_id': 93.9914,
            'perc_pos': 96.3519,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'VVMEATRSRAQTALN--LAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHKEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTTHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAIVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '15M2D451M',
            'id': 'ENSBGRG00000011827',
            'perc_id': 93.9914,
            'perc_pos': 96.3519,
            'protein_id': 'ENSBGRP00000019086',
            'species': 'bos_grunniens',
            'taxon_id': 30521},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.02906,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 95.9227,
            'perc_pos': 98.4979,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MAMEATRSWARTALNLAEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIRRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLIFHGEASEKLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAARMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSCWAG00000006145',
            'perc_id': 95.9227,
            'perc_pos': 98.4979,
            'protein_id': 'ENSCWAP00000008010',
            'species': 'catagonus_wagneri',
            'taxon_id': 51154},
 'taxonomy_level': 'Boreoeutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.05901,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 90.3433,
            'perc_pos': 93.5622,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'SVSSRPRIQGSRREV-AEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGETGQWSIKTKHQMYSIPDDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGNEGRMCVNTEWGGFGDSGELDEFLLEYDRVVDETSMNPGQQLYEKLIGGKYMGELVRLVLLKLADENLLFHGKTSEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRASATDCDIVRLACESVSTRAAQMCSAGLAGVINRMRESRSEEVMHITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIQSEEGSGRGAALISALSAKVLSVLGL',
            'cigar_line': '15MD450M',
            'id': 'ENSLAFG00000020833',
            'perc_id': 90.5376,
            'perc_pos': 93.7634,
            'protein_id': 'ENSLAFP00000015917',
            'species': 'loxodonta_africana',
            'taxon_id': 9785},
 'taxonomy_level': 'Eutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-----------------------MA--------MDVTRSQA-QTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS-------------------EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEML------------FDYI----SECISDFLDK--HQMKHKKLPLGFTFSFPVR-HEDIDK--GILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVE-------------------------------------------S----DTGDRKQIYNILSTL-------GLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '23D2M8D8MD60M19D53M12D4M4D10M2D19MD6M2D178M43DM4D15M7D110M',
            'id': 'ENSG00000106633',
            'perc_id': 45.0644,
            'perc_pos': 46.5665,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'SWVRRDFGYFCWRGLLESTEGSQLPGLAAIQMLDHRARME-NAKKEK-AEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSXXXXXXXXXXXXXXXXXXX----------------------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYEKLIGGKYMGELVRLVLLKLVDQNLLFHGEASEHLRTRGAFETRFVSQVEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------XXX---------------------------------------------FKDRFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLAQ',
            'cigar_line': '40MD6MD73M40D327M9D3M45D47M',
            'id': 'ENSCHOG00000013302',
            'perc_id': 42.3387,
            'perc_pos': 43.75,
            'protein_id': 'ENSCHOP00000011779',
            'species': 'choloepus_hoffmanni',
            'taxon_id': 9358},
 'taxonomy_level': 'Eutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.03065,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 90.7725,
            'perc_pos': 94.6352,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '------------SLRQVEQILAEFQLQEEDLKKVMRRMQEEMDRGLRLETHEAASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDVMTGTAETLFDYVSECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGNEGRMCVNTEWGAFGDSGELDDFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLLLLKLVDQNLLFHGEASEHLRTRGAFETRFVSQVESDSGDRKQIYNILRTLGLRPSAADCDLVRRACESVSTRAAQMCSAGLAAVLNRMRQSRSEDVMRITVGVDGSVYKLHPSFKDRFHASVRRLTPSCEITFIESQEGSGRGAALVSAVACKKACLLGQ',
            'cigar_line': '12D454M',
            'id': 'ENSDNOG00000015156',
            'perc_id': 93.1718,
            'perc_pos': 97.1366,
            'protein_id': 'ENSDNOP00000011747',
            'species': 'dasypus_novemcinctus',
            'taxon_id': 9361},
 'taxonomy_level': 'Eutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 70.1717,
            'perc_pos': 72.7468,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--------------------------------------------------------------------------------------------------------------------------LLDYVSECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGNEGRMCVNTEWGAFGDAGELDEFLLEYDRVVDETSMNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHGKASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRASATDCDIVRRACESVSTRAAQMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKDRFHASVRRLTPSCEITFIQSEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '122D344M',
            'id': 'ENSETEG00000018598',
            'perc_id': 95.0581,
            'perc_pos': 98.5465,
            'protein_id': 'ENSETEP00000015114',
            'species': 'echinops_telfairi',
            'taxon_id': 9371},
 'taxonomy_level': 'Eutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': 0.05189,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--------------------------MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '26D466M',
            'id': 'ENSG00000106633',
            'perc_id': 91.4163,
            'perc_pos': 94.206,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'RGLGYFCSTDVLESTGSQLTRLAAVQMLDHRARMENA-KEK-AEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGETGQWSIKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEGIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMRSVELVEGNEGRMCVNTEWGGFGDSGELDEFLLEYDRVVDETSINPGQQLYEKLIGGKYMGELVRLVLLKLADENLLFHGKASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRASATDCDIVHRVCESVSTRAAQMCSAGLAGVINRMRESRREEVMRITVGVDGSVYKLHPRFKERFHASVRRLTPGCEITFIESEEGSGRGAALISAVACKKACMLGQ',
            'cigar_line': '37MD3MD450M',
            'id': 'ENSPCAG00000010715',
            'perc_id': 86.9388,
            'perc_pos': 89.5918,
            'protein_id': 'ENSPCAP00000009993',
            'species': 'procavia_capensis',
            'taxon_id': 9813},
 'taxonomy_level': 'Eutheria',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA-MD-VTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2MD2MD462M',
            'id': 'ENSG00000106633',
            'perc_id': 90.9871,
            'perc_pos': 95.279,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--MLDYRARMDSSKKEK-VEQILSEFRLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGDAGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEQLRTRGAFETRFVSQVESDSGDGKQIYNILSTLGLLPSTTDCDIVRMACESVSTRAAQMCSAGLAGVINRMRESRSEEVMRITVGVDGSVYKLHPSFKHRFHATVRQLAPCCDISFIQSEEGSGRGAALVSAVACKKACMLNQ',
            'cigar_line': '2D15MD450M',
            'id': 'ENSPCIG00000009364',
            'perc_id': 91.1828,
            'perc_pos': 95.4839,
            'protein_id': 'ENSPCIP00000044788',
            'species': 'phascolarctos_cinereus',
            'taxon_id': 38626},
 'taxonomy_level': 'Mammalia',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '---------------------------------------------------------------MA---MD-VTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '63D2M3D2MD462M',
            'id': 'ENSG00000106633',
            'perc_id': 90.5579,
            'perc_pos': 95.279,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MTETQKVNQQRQSIPIQTLVSGTIEKGPHSSVEDDLENFCSETERTTGNSHKWTCPWAAHLALEAAQMLDYRARMESSKKEK-VEQILSEFRLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEEEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHHMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGNAGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLMKLVDENLLFNGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLIPSTTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSEEVMRITVGVDGSVYKLHPSFKHRFHATVRQLAPCCDITFIQSEEGSGRGAALVSAVACKKACMLSQ',
            'cigar_line': '82MD450M',
            'id': 'ENSMODG00000016167',
            'perc_id': 79.3233,
            'perc_pos': 83.4586,
            'protein_id': 'ENSMODP00000048190',
            'species': 'monodelphis_domestica',
            'taxon_id': 13616},
 'taxonomy_level': 'Mammalia',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--MA---MDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIE--SEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2D2M3D439M2D25M',
            'id': 'ENSG00000106633',
            'perc_id': 90.9871,
            'perc_pos': 95.279,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'FLRALQRLD----KVKKISQ-VEQILSEFRLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHHMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGDAGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLLPSTTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSEEVMRITVGVDGSVYKLHPSFKHRFHATVRQLAPCCDITFIQSESEEGSGRGAALVSAVACKKACMLSQ',
            'cigar_line': '9M4D7MD452M',
            'id': 'ENSSHAG00000014686',
            'perc_id': 90.5983,
            'perc_pos': 94.8718,
            'protein_id': 'ENSSHAP00000017276',
            'species': 'sarcophilus_harrisii',
            'taxon_id': 9305},
 'taxonomy_level': 'Mammalia',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--------MAMDVTRSQAQTALT----LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS---EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDK--GILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '8D15M4D55M3D92M2D304M',
            'id': 'ENSG00000106633',
            'perc_id': 88.6266,
            'perc_pos': 92.7039,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'LPLPLTIHLL-------------CCLGQVEQILSEFRLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSGPTEVGDFLSLDLGGTNLRVMLVKVGEGEEGQWSVKTKHQLYSIPTDAMTGTAEMLFDYISECISDFLDKHHMKHKKLPLGFTFSFPVRHEDIDKSKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMINDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGAAGELDDFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFGGEASEKLRTRGAFETRFVSQVESDCGDRKQIYNLLSTLGLRPSPADCDIVRLACESVSTRAAQMCSAGLAGVINRMRESRLGELTRITVGVDGSVYKLHPSFKERFHASVRQLAPCCEITFIQSEEGSGRGAALVSAVACKKACMLAQ',
            'cigar_line': '10M13D460M',
            'id': 'ENSOANG00000006506',
            'perc_id': 87.8723,
            'perc_pos': 91.9149,
            'protein_id': 'ENSOANP00000010387',
            'species': 'ornithorhynchus_anatinus',
            'taxon_id': 9258},
 'taxonomy_level': 'Mammalia',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 90.5579,
            'perc_pos': 94.206,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------VEQILSEFRLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGDAGELDEFLLEYDRVVDEASLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEQLRTRGAFETRFVSQVESDSGDGKQIYNILSTLGLLPSMTDCDIVRMACESVSTRAAQMCSAGLAGVINRMRESRSEEVMRITVGVDGSVYKLHPSFKHRFHATVRQLAPCCDITFIQSEEGSGRGAALVSAVACKKACMLNQ',
            'cigar_line': '16D450M',
            'id': 'ENSVURG00010002504',
            'perc_id': 93.7778,
            'perc_pos': 97.5556,
            'protein_id': 'ENSVURP00010003115',
            'species': 'vombatus_ursinus',
            'taxon_id': 29139},
 'taxonomy_level': 'Mammalia',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 65.0215,
            'perc_pos': 68.4549,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--------------------------------------------------------------------------------------------------------------------------LFDYISECISDFLDKHHMKHKKLPLXXXXXXXXXXXXXXXGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGDAGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLLPSTTDCDIVRMACESVSTRAAQMCSAGLAGVINRMRESRSEEVMRITVGVDGSVYKLHPSFKHRFHATVRQLAPCCDITFIQSEEGSGRGAALISAVACKKACMLSQ',
            'cigar_line': '122D344M',
            'id': 'ENSMEUG00000001332',
            'perc_id': 88.0814,
            'perc_pos': 92.7326,
            'protein_id': 'ENSMEUP00000001217',
            'species': 'notamacropus_eugenii',
            'taxon_id': 9315},
 'taxonomy_level': 'Mammalia',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 68.4549,
            'perc_pos': 73.3906,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-----------------------------------------MGTGWR-------------------------------GRGGTGAR------GRGRHGD----------------SSATPPQLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFVSQIESDSGDRKQIYNILTAFELLPSGTDCDIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '41D6M31D8M6D7M16D351M',
            'id': 'ENSAPLG00000023543',
            'perc_id': 85.7527,
            'perc_pos': 91.9355,
            'protein_id': 'ENSAPLP00000030627',
            'species': 'anas_platyrhynchos_platyrhynchos',
            'taxon_id': 8840},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 86.9099,
            'perc_pos': 92.9185,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------VDQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPKDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSGDRKQIYNILTAFELLPSGTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRRLTPGCDITFIQSEEGSGRGAALVSAVACKMACMIGQ',
            'cigar_line': '16D450M',
            'id': 'ENSAHAG00000006122',
            'perc_id': 90,
            'perc_pos': 96.2222,
            'protein_id': 'ENSAHAP00000008274',
            'species': 'apteryx_haastii',
            'taxon_id': 8823},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT---LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS----------------------------------------EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15M3D55M40D396M',
            'id': 'ENSG00000106633',
            'perc_id': 87.1245,
            'perc_pos': 92.7039,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'ML-------------CGVQVEQILSEFHLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSGTVSLPVPCVSPLPLTPSSSMWKAEPTKSPSPSPPLPGFAEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '2M13D494M',
            'id': 'ENSCCEG00000012267',
            'perc_id': 81.8548,
            'perc_pos': 87.0968,
            'protein_id': 'ENSCCEP00000012723',
            'species': 'cyanistes_caeruleus',
            'taxon_id': 156563},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.5536,
            'perc_pos': 93.9914,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRSRMESWRQE-KVEQILSEFRLKEEDLRKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLRLVDENLLFSGQACEKLKTRGAFETRFVSQVESDSGDRKQIYNILTAFGLLPSGSDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSPCLG00000012093',
            'perc_id': 87.7419,
            'perc_pos': 94.1936,
            'protein_id': 'ENSPCLP00000014771',
            'species': 'phasianus_colchicus',
            'taxon_id': 9054},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 86.6953,
            'perc_pos': 92.9185,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------VERILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILTAFELLPSGTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '16D450M',
            'id': 'ENSACCG00020006927',
            'perc_id': 89.7778,
            'perc_pos': 96.2222,
            'protein_id': 'ENSACCP00020010150',
            'species': 'aquila_chrysaetos_chrysaetos',
            'taxon_id': 223781},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.3391,
            'perc_pos': 93.5622,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESGRKE-KVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSTGUG00000003490',
            'perc_id': 87.5269,
            'perc_pos': 93.7634,
            'protein_id': 'ENSTGUP00000003646',
            'species': 'taeniopygia_guttata',
            'taxon_id': 59729},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS--EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '70M2D396M',
            'id': 'ENSG00000106633',
            'perc_id': 86.2661,
            'perc_pos': 93.3476,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMDSSKKE-KVEQILSEFQLREEDLKKVMRRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSAAEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWTVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGNEGRMCVNTEWGAFGASGELDEFLLEYDHVVDETSLNPGQQLYEKIIGGKYMGEIARLVLLKLVNENLLFNGEASEKLKTRGSFETRLISQVESDPGDRKQIYNILTSFGLLPSATDCDIVRMVCERVSTRAAQMCSAGLAGVINRMRDSRSEETLKITVGVDGSVYKLHPSFKDRFHTTVRQLTPGCDITFLQSEEGSGRGAALISAVACKMACMISQ',
            'cigar_line': '14MD453M',
            'id': 'ENSACAG00000011822',
            'perc_id': 86.0814,
            'perc_pos': 93.1478,
            'protein_id': 'ENSACAP00000011676',
            'species': 'anolis_carolinensis',
            'taxon_id': 28377},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.5536,
            'perc_pos': 95.0644,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'LIIDRTRVDL-----KVEQILSEFRLREEDLKKVMRRMQKEMDRGLKLDTHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWTVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIARLVLLKLVNENLLFNGEASEQLKTRGSFETRFISQIESDTGDRKQIYNILTSFGLLPSATDCDVVRMVCESVSTRAAQMCSAGLAGVINRMRDSRSEETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFLQSEEGSGRGAALISAVACKMACMIGQ',
            'cigar_line': '10M5D451M',
            'id': 'ENSPVIG00000018588',
            'perc_id': 88.5033,
            'perc_pos': 96.0954,
            'protein_id': 'ENSPVIP00000024706',
            'species': 'pogona_vitticeps',
            'taxon_id': 103695},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTR-SQA-------QTALT-----LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '7MD3M7D5M5D451M',
            'id': 'ENSG00000106633',
            'perc_id': 86.6953,
            'perc_pos': 93.7768,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--MNEAEALDDPDVEPGGSRKC-RRVAIEVEQILSEFRLQEQDLKKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEKQWNVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDVGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVNENLLFNGEATEKLKTRGSFETRFISQIESDPGDRKQIYNILTSFGLLPSVTDCDIVRMACESVSTRAAQMCSAGLAGVINRMRDSRCEDTLKITVGVDGSVYKLHPSFKDRFHAAVRQLTPDCDITFLQSEEGSGRGAALISAVACKMACMIGQ',
            'cigar_line': '2D20MD456M',
            'id': 'ENSPMRG00000017579',
            'perc_id': 84.8739,
            'perc_pos': 91.8067,
            'protein_id': 'ENSPMRP00000027247',
            'species': 'podarcis_muralis',
            'taxon_id': 64176},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '----------------MAMDVTR-SQA-----QTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '16D7MD3M5D456M',
            'id': 'ENSG00000106633',
            'perc_id': 87.5536,
            'perc_pos': 93.7768,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MWPAERKAPSDSPGLPGPDYVPRLMEAAPGXPARGC-YVDQILSEFRLREEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFVSQIESDSGDRKQIYNILTAFELLPSGTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMIGQ',
            'cigar_line': '36MD451M',
            'id': 'ENSDNVG00000016064',
            'perc_id': 83.7782,
            'perc_pos': 89.7331,
            'protein_id': 'ENSDNVP00000023105',
            'species': 'dromaius_novaehollandiae',
            'taxon_id': 8790},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-------------MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13D466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.1245,
            'perc_pos': 92.9185,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'QLDDRAGRTSVPA---------------LVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '13M15D451M',
            'id': 'ENSEGOG00005018034',
            'perc_id': 87.5,
            'perc_pos': 93.319,
            'protein_id': 'ENSEGOP00005022189',
            'species': 'erythrura_gouldiae',
            'taxon_id': 44316},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.5536,
            'perc_pos': 93.9914,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESGRRE-KVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILTSFELLPSRTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSSHBG00005013652',
            'perc_id': 87.7419,
            'perc_pos': 94.1936,
            'protein_id': 'ENSSHBP00005015615',
            'species': 'strigops_habroptila',
            'taxon_id': 2489341},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 86.6953,
            'perc_pos': 93.3476,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRSRMESWRHE-KVEQILSEFRLKEEDLRKVMQRMQKEMDRGLKLATHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISGCISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHSCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLRLVDENLLFSGQSCEKLKTRGAFETRFVSQVESDSGDRKQIYNILTAFGLLPSGSDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHTTVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSCJPG00005011620',
            'perc_id': 86.8817,
            'perc_pos': 93.5484,
            'protein_id': 'ENSCJPP00005013827',
            'species': 'coturnix_japonica',
            'taxon_id': 93934},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.7682,
            'perc_pos': 94.206,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRSRMESSRQE-KVEQILSEFRLREEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFVSQIESDSGDRKQIYNILTAFELLPSGTDCDIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSABRG00000014872',
            'perc_id': 87.957,
            'perc_pos': 94.4086,
            'protein_id': 'ENSABRP00000017029',
            'species': 'anser_brachyrhynchus',
            'taxon_id': 132585},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLH-------------------------------PSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '417M31D49M',
            'id': 'ENSG00000106633',
            'perc_id': 87.3391,
            'perc_pos': 93.3476,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESSRKE-KVEQILSEFHLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPRWGSPDPNDISILSLHPQSLGPIGDPVFLLPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD482M',
            'id': 'ENSPMJG00000015571',
            'perc_id': 82.0564,
            'perc_pos': 87.7016,
            'protein_id': 'ENSPMJP00000020973',
            'species': 'parus_major',
            'taxon_id': 9157},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQA-----QTALT---------LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '10M5D5M9D451M',
            'id': 'ENSG00000106633',
            'perc_id': 86.4807,
            'perc_pos': 94.4206,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'VLEDKGR---QQPHPSFCE-HFHLWFCIFQVQQILSEFRLQEQDLKKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWTVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGNEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVNENLLFNGEAPEKMKTRGSFETRFISQIESDSGDRKQIYNILTSFGLLPSATDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRDSRSEDILKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFLQSEEGSGRGAALISAVACKMACMMSQ',
            'cigar_line': '7M3D9MD460M',
            'id': 'ENSSMRG00000021806',
            'perc_id': 84.6639,
            'perc_pos': 92.437,
            'protein_id': 'ENSSMRP00000028361',
            'species': 'salvator_merianae',
            'taxon_id': 96440},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '------------MA--MDVTR-SQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '12D2M2D5MD459M',
            'id': 'ENSG00000106633',
            'perc_id': 85.4077,
            'perc_pos': 92.9185,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MFCIHSPETLIGMGSFHEAAKEMKR------SLQILSEFRLREEDLKKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWNVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGASGELEEFLLEYDHVVDETSLNPGQQLYEKIIGGKYLGEIVRLVLLKLVNENLLFNGQATEKLKTRGVFETRFVSQIESDIGDRKQIYNLLTAFELLPSATDCDIVRMACESVSTRAAQMCSAGLAGVINRMRESRSEETLKITVGVDGSVYKLHPSFKDRFHATVRMLTPGCDIIFLQSEEGSGRGAALISAVACKMACMISQ',
            'cigar_line': '25M6D450M',
            'id': 'ENSSPUG00000018858',
            'perc_id': 83.7895,
            'perc_pos': 91.1579,
            'protein_id': 'ENSSPUP00000024619',
            'species': 'sphenodon_punctatus',
            'taxon_id': 8508},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-------------MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13D466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.1245,
            'perc_pos': 92.9185,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'QLDDRAGRTSVPA---------------LVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '13M15D451M',
            'id': 'ENSEGOG00005018025',
            'perc_id': 87.5,
            'perc_pos': 93.319,
            'protein_id': 'ENSEGOP00005022177',
            'species': 'erythrura_gouldiae',
            'taxon_id': 44316},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 34.5494,
            'perc_pos': 35.1931,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--------------------------------------------------------------------------------------------------------------------------LFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------',
            'cigar_line': '122D167M177D',
            'id': 'ENSMGAG00000017169',
            'perc_id': 96.4072,
            'perc_pos': 98.2036,
            'protein_id': 'ENSMGAP00000018534',
            'species': 'meleagris_gallopavo',
            'taxon_id': 9103},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 83.2618,
            'perc_pos': 92.7039,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'ILGSSCKLES------VEEILSEFQLREEDLKKVMRRMQKEMDRGLKLETHEKASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGDDEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLGKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVELLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMENVELVEGNEGRMCVNTEWGAFGESGELDEFLLEYDRVVDETSFNPGQQLFEKIIGGKYIGEIVRLVLLKLVNENLLFNGDASEKLKTRGSFESRFISQIESDAGDCKQIYNILTSFELLPSAMDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRDSRNEERLNITVGVDGSVYKHHPSFKKRFHASVRQLTPGCDITFLQSEEGSGRGAALISAVAYKMACMIAQ',
            'cigar_line': '10M6D450M',
            'id': 'ENSNSUG00000003385',
            'perc_id': 84.3478,
            'perc_pos': 93.913,
            'protein_id': 'ENSNSUP00000004266',
            'species': 'notechis_scutatus',
            'taxon_id': 8663},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.7682,
            'perc_pos': 93.9914,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESGRKE-KVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFVSQIESDSGDRKQIYNILTAFELLPSGTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSCPGG00000001023',
            'perc_id': 87.957,
            'perc_pos': 94.1936,
            'protein_id': 'ENSCPGP00000001294',
            'species': 'calidris_pygmaea',
            'taxon_id': 425635},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQA-------------QTALT-----LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '10M13D5M5D451M',
            'id': 'ENSG00000106633',
            'perc_id': 87.9828,
            'perc_pos': 93.7768,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MRKTRARKGNVGQLFHFSVPYPPATAD-AACSTQVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILRSLELLPSRWDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '27MD456M',
            'id': 'ENSMUNG00000007128',
            'perc_id': 84.8861,
            'perc_pos': 90.4762,
            'protein_id': 'ENSMUNP00000009052',
            'species': 'melopsittacus_undulatus',
            'taxon_id': 13146},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.5536,
            'perc_pos': 93.9914,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRSRMESWRQE-KVEQILSEFRLKEEDLRKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLRLVDENLLFSGQACEKLKTRGAFETRFVSQVESDSGDRKQIYNILTAFGLLPSGSDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSPSTG00000010632',
            'perc_id': 87.7419,
            'perc_pos': 94.1936,
            'protein_id': 'ENSPSTP00000015063',
            'species': 'pavo_cristatus',
            'taxon_id': 9049},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 86.9099,
            'perc_pos': 92.7039,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------VEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '16D450M',
            'id': 'ENSEGOG00005018121',
            'perc_id': 90,
            'perc_pos': 96,
            'protein_id': 'ENSEGOP00005022266',
            'species': 'erythrura_gouldiae',
            'taxon_id': 44316},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.5536,
            'perc_pos': 93.9914,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRSRMESWRQE-KVEQILSEFRLKEEDLRKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLRLVDENLLFSGQACEKLKTRGAFETRFVSQVESDSGDRKQIYNILTAFGLLPSGSDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSGALG00000031359',
            'perc_id': 87.7419,
            'perc_pos': 94.1936,
            'protein_id': 'ENSGALP00000053403',
            'species': 'gallus_gallus',
            'taxon_id': 9031},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 81.7597,
            'perc_pos': 88.6266,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '---------------------------------VMRRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVTTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGHQLYEKMIGGKYMGEIVRLVLLKLVNENLLFHGEASEKLKTRGSFETRFISQIESDADDWKQTYNILTSFELLPSLTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRGEERLKITVGIDGSVYKLHPSFKDQFHATVRQLAPGCDITFLQSEEGSGRGAALISAVACKMACLIGR',
            'cigar_line': '33D433M',
            'id': 'ENSCPBG00000001267',
            'perc_id': 87.9908,
            'perc_pos': 95.3811,
            'protein_id': 'ENSCPBP00000001641',
            'species': 'chrysemys_picta_bellii',
            'taxon_id': 8478},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.7682,
            'perc_pos': 93.9914,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESGRKE-KVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFVSQIESDSGDRKQIYNILTAFELLPSGTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSCPUG00000011377',
            'perc_id': 87.957,
            'perc_pos': 94.1936,
            'protein_id': 'ENSCPUP00000016453',
            'species': 'calidris_pugnax',
            'taxon_id': 198806},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.3391,
            'perc_pos': 93.5622,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESSRKE-KVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSGFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSMVIG00005010064',
            'perc_id': 87.5269,
            'perc_pos': 93.7634,
            'protein_id': 'ENSMVIP00005013923',
            'species': 'manacus_vitellinus',
            'taxon_id': 328815},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MDVTRS--QA-----------QTALT-----L-VEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEE-GQWSVKTKHQMYSIPEDAMTGTAE--MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDK-GILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIV-GTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA------C-MLGQ---',
            'cigar_line': '2M2D6M2D2M11D5M5DMD5MD76MD24M2D41MD65MD234M6DMD4M3D',
            'id': 'ENSG00000106633',
            'perc_id': 27.2532,
            'perc_pos': 28.97,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPFC---CRLLPGAPHVPNPCFPAMT----PSLPP-QVDQILS-EFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGSRRRQ---------------ARLA---LFQLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKV------------------------------KG-------S-------------------------RG-GSR-------------------------------------------------------------------------------------------------------AAQ-----GTSP------------PAA------------------------------------------------------HP--------------------------AS---------------LSSPRP-R----ESF',
            'cigar_line': '4M3D19M4D5MD7MD78M15D4M3D44M30D2M7DM25D2MD3M103D3M5D4M12D3M54D2M26D2M15D6MDM4D3M',
            'id': 'ENSAOWG00000019308',
            'perc_id': 65.8031,
            'perc_pos': 69.9482,
            'protein_id': 'ENSAOWP00000028663',
            'species': 'apteryx_owenii',
            'taxon_id': 8824},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.3391,
            'perc_pos': 93.5622,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESSRKE-KVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSFALG00000000058',
            'perc_id': 87.5269,
            'perc_pos': 93.7634,
            'protein_id': 'ENSFALP00000000065',
            'species': 'ficedula_albicollis',
            'taxon_id': 59894},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.3391,
            'perc_pos': 93.7768,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESGRKE-KVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILTAFELLPSGTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSANIG00000007045',
            'perc_id': 87.5269,
            'perc_pos': 93.9785,
            'protein_id': 'ENSANIP00000010401',
            'species': 'accipiter_nisus',
            'taxon_id': 211598},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA---MDVTR-SQA--------------------------QTALT-------L----VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPST---------TDCDIVRRA-CES-VSTRAAHMCSAGLAGVINRMRESRSEDVM-------RITVGVDGSV-YKLH---PSF----KERFHASVR------------RLTPS----------------------------CEITFIE----SEE--------------------------GSG-------RGAALVSAVACKKACMLGQ',
            'cigar_line': '2M3D5MD3M26D5M7DM4D346M9D9MD3MD29M7D10MD4M3D3M4D9M12D5M28D7M4D3M26D3M7D19M',
            'id': 'ENSG00000106633',
            'perc_id': 74.0343,
            'perc_pos': 82.618,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MDSLLRENSRAMGYVISGWPCENRAGGRETWSFLKVLQLRHLASQIPGPCLTLCCVQVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSXPSTPLPHVPVPCPVLVLSLCGSPVSPHTLSVPVPGFAGTPGYL----SPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKVRGLLGSCGLVGTARWVQDMRMGARWVQGIGTDAP-----',
            'cigar_line': '446M4D155M5D',
            'id': 'ENSZALG00000009426',
            'perc_id': 57.4043,
            'perc_pos': 64.0599,
            'protein_id': 'ENSZALP00000011109',
            'species': 'zonotrichia_albicollis',
            'taxon_id': 44394},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 29.3991,
            'perc_pos': 33.4764,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLRLVDENLLFSGQTCEKLKTRGAFETRFVSQVESDSGDRKQIYNILTAFGLLPSGSDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQS------------------------',
            'cigar_line': '273D169M24D',
            'id': 'ENSMGAG00000016756',
            'perc_id': 81.0651,
            'perc_pos': 92.3077,
            'protein_id': 'ENSMGAP00000018117',
            'species': 'meleagris_gallopavo',
            'taxon_id': 9103},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.7682,
            'perc_pos': 94.206,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRSRMESSRQE-KVEQILSEFRLREEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFVSQIESDSGDRKQIYNILTAFELLPSGTDCDIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD451M',
            'id': 'ENSACDG00005018454',
            'perc_id': 87.957,
            'perc_pos': 94.4086,
            'protein_id': 'ENSACDP00005025513',
            'species': 'anser_cygnoides',
            'taxon_id': 8845},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT-LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15MD451M',
            'id': 'ENSG00000106633',
            'perc_id': 84.5494,
            'perc_pos': 91.4163,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'YLDD-----------C-------EFRLQEEDLKKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEDGQWSVTTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGHQLYEKMIGGKYMGEIVRLVLLKLVNENLLFHGEASEKLKTRGSFETRFVSQIESDADDRKQTYNILTSFELLPSLTDCDIVRMACESVSTRAAQMCSAGLAGVINRMRESRGEERLKITVGIDGSVYKLHPSFKDQFHAIVRQLTPGCDITFLQSEEGSGRGAALISAVACKMACLIGR',
            'cigar_line': '4M11DM7D444M',
            'id': 'ENSCABG00000020100',
            'perc_id': 87.7506,
            'perc_pos': 94.8775,
            'protein_id': 'ENSCABP00000027383',
            'species': 'chelonoidis_abingdonii',
            'taxon_id': 106734},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 84.9785,
            'perc_pos': 92.2747,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------VEQILSEFRLQEEDLKKVMRRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVTTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGHQLYEKMIGGKYMGEIVRLVLLKLVNENLLFHGEASEKLKTRGNFETRFISQIESDADDWKQTYNILTSFELLPSLTDCDIVRMACESVSTRAAQMCSAGLAGVINRMRESRGEERLKITVGIDGSVYKLHPSFKDQFHATVKQLAPGCDITFLQSEEGSGRGAALISAVACKMACLIGR',
            'cigar_line': '16D450M',
            'id': 'ENSTMTG00000002903',
            'perc_id': 88,
            'perc_pos': 95.5556,
            'protein_id': 'ENSTMTP00000003963',
            'species': 'terrapene_carolina_triunguis',
            'taxon_id': 2587831},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 86.9099,
            'perc_pos': 93.3476,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESSRKE-KVDQILSEFRLKEEDLKKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTCGTFETRFVSQIESDSGDRKQIYNILTAFELLPSGTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKERFHATVRQLTPGCDITFLQSEEGSGRGAALISAVACKMACMMGP',
            'cigar_line': '14MD451M',
            'id': 'ENSNPEG00000010375',
            'perc_id': 87.0968,
            'perc_pos': 93.5484,
            'protein_id': 'ENSNPEP00000013902',
            'species': 'nothoprocta_perdicaria',
            'taxon_id': 30464},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '---------MAMDVTRSQA-QTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '9D10MD456M',
            'id': 'ENSG00000106633',
            'perc_id': 84.3348,
            'perc_pos': 90.3433,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MRPKCSKHSWLRGRGT---AGRKT--VEQILSEFRLKEEDLRKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDID-----------KASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLRLVDENLLFSGQACEKLKTRGAFETRFVSQVESDSGDGKQIYNILTAFGLLPSGSDCNIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '16M3D5M2D145M11D294M',
            'id': 'ENSCPIG00010012293',
            'perc_id': 85.4348,
            'perc_pos': 91.5217,
            'protein_id': 'ENSCPIP00010015433',
            'species': 'chrysolophus_pictus',
            'taxon_id': 9089},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.1245,
            'perc_pos': 93.133,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------VEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILTSFELLPSRTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '16D450M',
            'id': 'ENSACOG00000002559',
            'perc_id': 90.2222,
            'perc_pos': 96.4444,
            'protein_id': 'ENSACOP00000003650',
            'species': 'amazona_collaria',
            'taxon_id': 241587},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT--LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGEL--VRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15M2D287M2D164M',
            'id': 'ENSG00000106633',
            'perc_id': 59.2275,
            'perc_pos': 63.7339,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MK--PRRIEA-----LHLVEQILSEFRLQEEDLKTVMRRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVSTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVACPCHLSNLHPVLQKELPPGHCGGSCYPREWGAFGASGELDEFLLEYDRVVDETSLNPGQQLLCAALGGRAGGQAARMRLVLLKLVNENLLFRGEASEKLKTRGSFETRFVSQIE------------------------------------------------------------------------------------------------------------------------------',
            'cigar_line': '2M2D6M5D329M126D',
            'id': 'ENSPSIG00000007130',
            'perc_id': 81.8991,
            'perc_pos': 88.1306,
            'protein_id': 'ENSPSIP00000007857',
            'species': 'pelodiscus_sinensis',
            'taxon_id': 13735},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 86.4807,
            'perc_pos': 92.9185,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------VEQILSEFQLQDEDLKKVMRRMQKEMDRGLKLETHEEASVKMLPTYVCSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEERQWKVKTKHQTYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVNENLLFNGEASEKLKTRGSFETRFISQIESDPGDHKQIYNILTSFGLLPSVTDCDIVRMACESVSTRAAQMCSAGLAGVINRMRDSRSEETLKITVGVDGSVYKLHPSFKDRFHTTVRQLTPGCDITFLQSEEGSGRGAALISAVACKMACMIGQ',
            'cigar_line': '16D450M',
            'id': 'ENSVKKG00000015430',
            'perc_id': 89.5556,
            'perc_pos': 96.2222,
            'protein_id': 'ENSVKKP00000023254',
            'species': 'varanus_komodoensis',
            'taxon_id': 61221},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 81.5451,
            'perc_pos': 86.9099,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------VDQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFVSQIESDSGDRKQIYNILTAFELLPSGTDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDIXXXXXXXXXXXXXXXXXXXXXXXXXXXXX',
            'cigar_line': '16D450M',
            'id': 'ENSSCUG00000014547',
            'perc_id': 84.4444,
            'perc_pos': 90,
            'protein_id': 'ENSSCUP00000019801',
            'species': 'struthio_camelus_australis',
            'taxon_id': 441894},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT---LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '15M3D451M',
            'id': 'ENSG00000106633',
            'perc_id': 85.1931,
            'perc_pos': 92.7039,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLESKQS--------GCFGVEQILSEFRLQEEDLKKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEDGQWSVTTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMENVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGHQLYEKMIGGKYMGEIVRLVLLKMVNENLLFHGEASEKLKTRGSFETRFISQIESDADDRKQTYNILTSFELLPSLTDCDIVRMACESVSTRAAHMCSAGLAGVINRMRESRGEERLKITVGIDGSVYKLHPSFKDQFHVIVRQLTPGCDITFLQSEEGSGRGAALISAVACKMACLIGR',
            'cigar_line': '7M8D454M',
            'id': 'ENSGAGG00000013623',
            'perc_id': 86.1171,
            'perc_pos': 93.7093,
            'protein_id': 'ENSGAGP00000018402',
            'species': 'gopherus_agassizii',
            'taxon_id': 38772},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-------------------------------------------------------------------------------------------------MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '97D466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.3391,
            'perc_pos': 93.5622,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLPLRLRAGTGAGTASLPEGTGTASPGPLGSSDEIRQRKWSIREGRSEGRGTEQRGARRTRSRPGQGTAPGPAPRWGHSGRGGHGSARSPPQPAPAPMLDHRARMESSRKE-KVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '111MD451M',
            'id': 'ENSJHYG00000007973',
            'perc_id': 72.4199,
            'perc_pos': 77.5801,
            'protein_id': 'ENSJHYP00000010150',
            'species': 'junco_hyemalis',
            'taxon_id': 40217},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '---------------------------------------------------------------------MAMDVTRSQA--QTALT--------------------------------------------LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '69D10M2D5M44D451M',
            'id': 'ENSG00000106633',
            'perc_id': 87.1245,
            'perc_pos': 93.7768,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MARSTPCWEWLWDSSGWEVPGHCWNGDGFYTAIQTIQLVDRDGRSPVPTMAPRDTGADRGILQAAPEGALVPHDSAMDSLLSRRITEQQDKSFRGVHVKTGLGEGKLGYFLWFRPLASQIPGPWLTLCCVQVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '581M',
            'id': 'ENSSCAG00000015769',
            'perc_id': 69.8795,
            'perc_pos': 75.2151,
            'protein_id': 'ENSSCAP00000021931',
            'species': 'serinus_canaria',
            'taxon_id': 9135},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-----------------------------------------------------------------------------------------------------MAMDVTRSQA---QTALT-------LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '101D10M3D5M7D451M',
            'id': 'ENSG00000106633',
            'perc_id': 87.7682,
            'perc_pos': 93.7768,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MGGASTVGVAPSFGRGLKCGRGLRCGAGPMGQPHPTEWAPYGAAPSVPRPSTHDPEASPSCGAGTALWGQRRGDILGGHAGWAPRGAPPGTVGPATAAFSPLSRSRGRLSPWDRWRAGGGDQDTEWLVEQILSEFRLKEEDLRKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLRLVDENLLFSGQACEKLKTRGAFETRFVSQVESDSGDRKQIYNILTAFGLLPSGPDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVYKLHPSFKDRFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '577M',
            'id': 'ENSNMEG00000001829',
            'perc_id': 70.8839,
            'perc_pos': 75.7366,
            'protein_id': 'ENSNMEP00000001436',
            'species': 'numida_meleagris',
            'taxon_id': 8996},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 86.6953,
            'perc_pos': 92.9185,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESSRKE-KVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVND---TMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSGFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD191M3D257M',
            'id': 'ENSLCOG00000004279',
            'perc_id': 87.4459,
            'perc_pos': 93.7229,
            'protein_id': 'ENSLCOP00000005771',
            'species': 'lepidothrix_coronata',
            'taxon_id': 321398},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '466M',
            'id': 'ENSG00000106633',
            'perc_id': 83.4764,
            'perc_pos': 93.133,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'ILGSSCKLES------VEEILSEFQLREEDLKKVMRRMQKEMDRGLKLETHEKASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGDDEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVELLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMENVELVEGNEGRMCVNTEWGAFGESGELDEFLLEYDRVVDETSFNPGQQLFEKIIGGKYIGEIVRLVLLKLVNENLLFNGDASEKLKTRGSFESRFISQIESDAGDCKQIYNILTSFELLPSAMDCDIVRMVCESVSTRAAQMCSAGLAGVINRMRDSRNEERLNITVGVDGSVYKHHPSFKKRFHASVRQLTPGCDISFLQSEEGSGRGAALISAVAYKMACMIGQ',
            'cigar_line': '10M6D450M',
            'id': 'ENSPTXG00000010531',
            'perc_id': 84.5652,
            'perc_pos': 94.3478,
            'protein_id': 'ENSPTXP00000015268',
            'species': 'pseudonaja_textilis',
            'taxon_id': 8673},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLH--------------------------------PSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '417M32D49M',
            'id': 'ENSG00000106633',
            'perc_id': 87.5536,
            'perc_pos': 93.5622,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDHRARMESSRKE-KVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPRWGSPGPDGVPVLSPYPPSPDPICDPLFPRLPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '14MD483M',
            'id': 'ENSLSDG00000008020',
            'perc_id': 82.0926,
            'perc_pos': 87.7264,
            'protein_id': 'ENSLSDP00000010987',
            'species': 'lonchura_striata_domestica',
            'taxon_id': 299123},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-------------MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '13D466M',
            'id': 'ENSG00000106633',
            'perc_id': 87.1245,
            'perc_pos': 92.9185,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'QLDDRAGRTSVPA---------------LVEQILSEFRLKEEDLKKVMYRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEMHNVELVEGDEGRMCVNTEWGAFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLKLVDENLLFNGEASEKLKTRGTFETRFMSQIESDSDDRKQIYNILSAFELLPSRTDCEIVRRVCESVSTRAAQMCSAGLAGVINRMRESRSQDTLKITVGVDGSVYKLHPSFKDHFHATVRQLTPGCDITFIQSEEGSGRGAALISAVACKMACMMGQ',
            'cigar_line': '13M15D451M',
            'id': 'ENSEGOG00005018100',
            'perc_id': 87.5,
            'perc_pos': 93.319,
            'protein_id': 'ENSEGOP00005022251',
            'species': 'erythrura_gouldiae',
            'taxon_id': 44316},
 'taxonomy_level': 'Amniota',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTL----VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '16M4D450M',
            'id': 'ENSG00000106633',
            'perc_id': 77.4678,
            'perc_pos': 87.9828,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '------------MEKFEQNEVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPEDAMTGTAEMLFDYIAECISDYLDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNENLIFGGESSEKLKTRGAFDTQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACESVSTRAAVMCSSGLAAILNRMHQSRRGELSRITVGVDGSVYKLHPSFKDKFHATVHKLTSGCEITFIQSEEGSGRGAALISAVAYKMAVLIGH',
            'cigar_line': '12D458M',
            'id': 'ENSXETG00000018141',
            'perc_id': 78.821,
            'perc_pos': 89.5197,
            'protein_id': 'ENSXETP00000050089',
            'species': 'xenopus_tropicalis',
            'taxon_id': 8364},
 'taxonomy_level': 'Tetrapoda',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVE---SDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '340M3D121MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 69.3133,
            'perc_pos': 77.2532,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '---------------------------------------------------------------------TEVGDFLALDLGGTNFRVMLVKVGEDEKGKWKVETKHQMYCIPGDTMTGTAEMLFDYIAQCISDFLDKHNMKEKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIRRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEIRNVDLVEGEEGRMCVNTEWGAFGDSGELEEFRLEYDRMVDEMSLNPGQQLFEKIISGKYMGELVRLVLLKLVNENLLFNGEASGILKTRGSFETRFISQIERTDSDSGDLKQTYNILTTLGLLPSKLDCEIVRLVSESVSTRAALVCAAGLAGVINRMRENRSQESLKITVGVDGSVYKLHPLFKHKFHAMVQELTPRCNITFIQSEEGSGRGAALVSAVARKMASMLCH-',
            'cigar_line': '69D400MD',
            'id': 'ENSLACG00000012891',
            'perc_id': 80.75,
            'perc_pos': 90,
            'protein_id': 'ENSLACP00000014643',
            'species': 'latimeria_chalumnae',
            'taxon_id': 7897},
 'taxonomy_level': 'Sarcopterygii',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.3305,
            'perc_pos': 90.7725,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSSYTGQMGKM--PCSLSSVLETALMVEQILSEFRLKKEQLKEVMKRMMREMDRGLRVETHQESSVKMLPTYVYSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERVWKVETKHQMYSIPEDAMTGTAEMLFDYIAECISDFLDRHHIKHRKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGANGELEEFRLEYDRVVDETSLNPGQQLYEKLISGKYMGELVRLVLLKLVNEELLFNGEASDLLKTRGSFETRYVSQIESDSGDRKQIYNILSTLGVLPSEMDCDIVRLACESVSTRAAHMCGAGLAAVINRMRERRSQEVLKITVGVDGSVYKLHPCFQDRFHKVVRELTPHSDITFIQSEEGSGRGAALISAVACKMAACILTQ',
            'cigar_line': '14M2D464M',
            'id': 'ENSSSAG00000073606',
            'perc_id': 79.2887,
            'perc_pos': 88.4937,
            'protein_id': 'ENSSSAP00000098904',
            'species': 'salmo_salar',
            'taxon_id': 8030},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '10M5D5MDMD450M',
            'id': 'ENSG00000106633',
            'perc_id': 80.6867,
            'perc_pos': 90.3433,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-----MKL--DNKCTSLFQKILQVDQILSEFRLKKQELQEVMRRMQSEMERGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHQMYSIPEDAMTGTAEMLFDYIAECISDFLDKHNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDTGELEDFRLEYDRVVDETSINPGQQLYEKIISGKYMGELVRLVLLKLVNENLLFGGEASDILKMRGSFETKLVSQIESDTGDRKQIYNILTTIGLMPTELECDIVRLACESVSTRAAHMCGAGLAGVINHMRERRKQEMLKITVGVDGSVYKLHPSFQHKFQKAVQDLTPHCDITFIQSEEGSGRGAALISAVACKMACMLNQ',
            'cigar_line': '5D3M2D463M',
            'id': 'ENSECRG00000000329',
            'perc_id': 80.6867,
            'perc_pos': 90.3433,
            'protein_id': 'ENSECRP00000000558',
            'species': 'erpetoichthys_calabaricus',
            'taxon_id': 27687},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 82.618,
            'perc_pos': 90.1288,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCPAAVRKQMMRM--PSAYQSVLEKFLVVDQILSEFLLTKEELKDVMRRMQREMDRGLRLETHDEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMLFDYIAECISDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMHTVELVEGDEGRMCVNTEWGAFGENGELEDFRLEYDRVVDESSLNPGHQLYEKLIGGKYMGELVRLVLMKLVNEGLLFNGEASDMLRTRGSFETRFVSQIESDTGDRKQIYNILSSLGVLPSELDCDIVHLACESVSTRAAHMCAAGLAGVINLMRERRYQDELKITVGVDGSVYKLHPRFKERFHKVVRELTPYCEISFIQSEEGSGRGAALISAVACKKAACLITP',
            'cigar_line': '14M2D464M',
            'id': 'ENSPNAG00000018873',
            'perc_id': 80.5439,
            'perc_pos': 87.8661,
            'protein_id': 'ENSPNAP00000013000',
            'species': 'pygocentrus_nattereri',
            'taxon_id': 42514},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '----------------------------------------------------------------------------------------------------MA--------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '100D2M8D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.0429,
            'perc_pos': 90.1288,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MKTLQNIAASLSFCYLGTLLVNLRLQPKRKKTGMRKPQGRDKTYHCSAAPHVTTAPRDLGRPSESASKTFGFEHKSAAYTHTHTRSGSFNSPSLLKTCTSNVCYSRCRNLLQEVKV--KNRSVWGASTGTKVDQILFEFRLNKEDLKEIMKRMQREMERGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDEASINPGQQLYEKLISGKYMGELVRLVMMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCENVSTRSAHMCAAGLAGVINLMRERRSEEAMKITVGIDGSVYKLHPCFRDRFHKVVRDLTPHSDITFIQSEEGSGRGAALISAVACKMATNLFAD',
            'cigar_line': '116M2D464M',
            'id': 'ENSPNYG00000007097',
            'perc_id': 64.3103,
            'perc_pos': 72.4138,
            'protein_id': 'ENSPNYP00000009382',
            'species': 'pundamilia_nyererei',
            'taxon_id': 303518},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.7597,
            'perc_pos': 90.5579,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCPASLRKQMLRM--PSAYQSVLEKVLMVDQILSEFLMTKEDLKEVMRRMQKEMNRGLRLETHDEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMLFDYIAECISDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMCTVELVEGDEGRMCVNTEWGAFGDCGELEDFRLEYDRVVDESSLNPGRQLYEKLIGGKYMGELVRLVLVKLVNEDLLFNGEASEMLKTKGSFETRFVSQIESDTGDRKQIYNILSSFGVLPSELDCDIVRLACESVSTRAANMCAAGLAGVIDLMRERRSQEELKITVGVDGSVYKLHPHFQERFHKAVWELTPKCEITFVQSEEGSGRGAALISAVACKMAACMISP',
            'cigar_line': '14M2D464M',
            'id': 'ENSAMXG00000034250',
            'perc_id': 79.7071,
            'perc_pos': 88.2845,
            'protein_id': 'ENSAMXP00000035498',
            'species': 'astyanax_mexicanus',
            'taxon_id': 7994},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA---MDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M3D459MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 78.7554,
            'perc_pos': 87.9828,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--SCEDT------SAIKE-VDQILSELNLEKADLEEVMRRLQREMERGLRLETHQEASVKMLPTYVRSSPEGSEVGDFLALDLGGTNFRVMLVKVGEDEETGWKLETKQQMYSIPEDAMTGTAEMLFDYIAERISDFLAKHQLKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYENRNCEVGMIVGTGCNACYMEEMNMVELVEGDEGRMCVNTEWGAFGDNGELEEFRLEYDRKADEMSLNPGQQLFEKIISGKYMGELVRLVLLKLVNEDLLFHGEASEQLRTKGSFETRFVSQIESDCGDRKQIYNVLTTLGLMPSELDCDIVRLVCERVSTRSAHMCAAGLAGIINRMRESRCQELLEITVGIDGSVYKLHPSFQEKFHAVVQELTPGCDITFIQSEEASGRGAALISAVASKMAAT----',
            'cigar_line': '2D5M6D5MD447M4D',
            'id': 'ENSPKIG00000019104',
            'perc_id': 80.3063,
            'perc_pos': 89.7155,
            'protein_id': 'ENSPKIP00000000446',
            'species': 'paramormyrops_kingsleyae',
            'taxon_id': 1676925},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.3305,
            'perc_pos': 88.8412,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCLTSARRQ--GM--LSDFESVLERILMVEQILSEFLLSKEDLEEVMRRMRREMERGLRVETHNEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDTMTGTAEMLFDYIAGCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHSCEVGMIVGTGCNACYMEEMHKVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGHQLYEKLIGGKYMGELVRLVLLKLVNENLLFNGEASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSTLGILPSELDCDVVRLVCESVSTRAAHMCGAGLAGVINLMRERRCQEQLKITVGVDGSVYKLHPHFKERFHKLVWEINPHCEITFIQSEEGSGRGAALISAVACKMATCMLTP',
            'cigar_line': '10M2D2M2D464M',
            'id': 'ENSSRHG00000005457',
            'perc_id': 79.6218,
            'perc_pos': 86.9748,
            'protein_id': 'ENSSRHP00000009584',
            'species': 'sinocyclocheilus_rhinocerous',
            'taxon_id': 307959},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L--VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDM2D445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.8283,
            'perc_pos': 89.0558,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCLTAARQQRLRM--PSSYKSMLETI-HMVDQILSEFQLSKEELKEVMRRMQREMNRGLRVETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVVVGEDEERGWKIETKHRMYSIPEDAMTGTAEMLFDYISECISDFLDKHNIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDIVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNVCYMEEMHSVELVEGEEGRMCVNTEWGAFGGNGELEDFRLEYDRVVDEASLNPGKQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASDMLKTRGSFETRFVSQIESDTGDRKQIYNILSSLGVLPSELDCDIVRLACESVSTRAAQICGAGLAGVINVMRERRCLDELKITVGVDGSVYKLHPWFKERFHKVVWDMTPNCDITFIQSEEGSGRGAALISAVASKMAACTIEP',
            'cigar_line': '14M2D11MD453M',
            'id': 'ENSIPUG00000004068',
            'perc_id': 77.8243,
            'perc_pos': 86.8201,
            'protein_id': 'ENSIPUP00000005853',
            'species': 'ictalurus_punctatus',
            'taxon_id': 7998},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPS-----FKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD403M5D42MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.1159,
            'perc_pos': 89.485,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCLTLARTQ--RI--PSDFESVLERIIMVEQILSEFLLSKEDLEEVMRRMRREMERGLRVETHNEASIKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMLFDYIAGCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHSCEVGMIVGTGCNACYMEEMRKVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGHQLYEKLIGGKYMGELVRLVLLKLVNENLLFNGDASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSTLGILPSELDCDIVRLVCKSVSTRAAHMCGAGLAGVINLMRERRCQEQLKITVGVDGSVYKLHPQKQRWSFKERFHKLVWEMNPDCEITFIQSEEGSGRGAALISAVACKMAACMLTP',
            'cigar_line': '10M2D2M2D469M',
            'id': 'ENSCCRG00020019251',
            'perc_id': 78.5863,
            'perc_pos': 86.6944,
            'protein_id': 'ENSCCRP00020043636',
            'species': 'cyprinus_carpio_hebaored',
            'taxon_id': 7962},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA-------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M7D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.3305,
            'perc_pos': 88.8412,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCISSLGINQNVTM--PCSYSSVVERIQMVEQILSEFRLSKEELKEVMKRMQREMDRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVIVGEDEERSWKVLTKNEMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGDEGRMCVNTEWGAFGENGELEEFRLEYDRVVDEMSINPGHQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEATELLKTRGSFETRFVSQVESDTGDRKQIYNILSTFGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINLMRERRSQEALKITVGVDGSVYKLHPCFRDRFHQIVWDLTPHCEITFIQSEEGSGRGAALISAVACKMAASMLPQ',
            'cigar_line': '15M2D464M',
            'id': 'ENSENLG00000019084',
            'perc_id': 79.1232,
            'perc_pos': 86.4301,
            'protein_id': 'ENSENLP00000044850',
            'species': 'echeneis_naucrates',
            'taxon_id': 173247},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTL-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '16MD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.6137,
            'perc_pos': 89.6996,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '---------------MQVDQILSEFRLNKEDLKEIMKRMRREMERGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDSIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDEASINPGQQLYEKLISGKYMGELVRLVMMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCSAGLAGVINLMRERRSEEAMKITVGIDGSVYKLHPCFRDRFHKVVRDLTPHSDITFIQSEEGSGRGAALISAVACKMATNLFAD',
            'cigar_line': '15D453M',
            'id': 'ENSNBRG00000020875',
            'perc_id': 81.8985,
            'perc_pos': 92.2737,
            'protein_id': 'ENSNBRP00000027357',
            'species': 'neolamprologus_brichardi',
            'taxon_id': 32507},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA----MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M4D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.6137,
            'perc_pos': 90.5579,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLCVRSVQMVKM--PCSYSPAVDKILMAKQILSEFRLKNEELKEVMKRMQREMDRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSWKVETKNQMYSIPEDAMTGTAQMLFDYIAECMSNFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEQGRMCVNTEWGAFGNNGELEEFRLEYDRVVDETSINPGQQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASELLKTGGSLETRYVSQMESDTGDRKQIYNVLSSLGVLPSELDCDIVRLVCESVSTRSAHMCAAGLAGVINLIRERRSEEALKITVGIDGSVYKLHPCFRDRFHKIVRDLTPHCEITFIQSEEGSGRGAALISAVACKMAASILTQ',
            'cigar_line': '12M2D464M',
            'id': 'ENSGACG00000004420',
            'perc_id': 77.9412,
            'perc_pos': 88.6555,
            'protein_id': 'ENSGACP00000005858',
            'species': 'gasterosteus_aculeatus',
            'taxon_id': 69293},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA------QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M6D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.9013,
            'perc_pos': 91.4163,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSSHIDQMVKVK-VPCGYSPVVDKILMVEQILSEFRLKKEELKEVMKRMQREMDRGLSIETHEESSVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGIWKIETNNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDIEMDVVAMVNDTVATMISCYYEDRRCEVGIIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDETSINPGQQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASEQLKTRGSFETRYVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRAAHMCGAGLAGVINLMRERRSQEDLKITVGVDGSVYKLHPCFRDRFHKVVRDLTPRCEITFIQSEEGSGRGAALISAVACKMAACLLTQ',
            'cigar_line': '15MD465M',
            'id': 'ENSSFAG00005009175',
            'perc_id': 78.5417,
            'perc_pos': 88.75,
            'protein_id': 'ENSSFAP00005017657',
            'species': 'salarias_fasciatus',
            'taxon_id': 181472},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.5451,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSSYMGQM-KM--SHGLSHVLETAIMVEQILSEFRLKKEQLKEVMKRMMSEMDRGLRVETHQEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHQMYSIPEDAMTGTAEMLFDYIAECISDFLNIQHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGANGELEEFRLEYDRVVDETSLNPGQQLYEKLISGKYMGELVRLVLVKLVNEELLFKGEASDLLKTRGAFETRYVSQIESDSGDRKQIYNILSTLGVLPSELDCDIVRLACESVSTRAAHMCGAGLAGVINRMRERRSQEALKITVGVDGSVYKLHPCFQHRFHNVVRELTPHCDITFIQSEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '11MD2M2D464M',
            'id': 'ENSELUG00000003857',
            'perc_id': 79.6646,
            'perc_pos': 87.8407,
            'protein_id': 'ENSELUP00000002509',
            'species': 'esox_lucius',
            'taxon_id': 8010},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.1159,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCLTSARRQ--RM--PSDFESVLERILMVDQILSEFLLSKEDLEEVMRRIRREMERGLRVETHDEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMLFDYIASCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRKVELVEGEEGKMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGRQLYEKLIGGKYMGELVRLVLLKLVNENLLFNGEASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSSLGILPSELDCDIVRLVCESVSTRAAHMCGAGLAGVINLMRERRCQEQLKITVGVDGSVYKLHPHFKERFHKLVWEMTPHCEITFIQSEEGSGRGAALISAVACKMAACMLTP',
            'cigar_line': '10M2D2M2D464M',
            'id': 'ENSSGRG00000055500',
            'perc_id': 79.4118,
            'perc_pos': 88.0252,
            'protein_id': 'ENSSGRP00000112926',
            'species': 'sinocyclocheilus_grahami',
            'taxon_id': 75366},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-----------------------------------------------------------------------------MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '77D2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.8283,
            'perc_pos': 90.1288,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MWAFVYVCTSLARWGEVGKGRAIGFGVSSPLHLRIKAAEDCSVVLTLHSLCTHTLGGLTLTKLLKTHASEFFVKPVKMPCVSVQLDQMVKL--PSSYDSVVDKVIAVDQILSEFRLNKEDLKEIMKRMQREMERGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDEASINPGQQLYEKLISGKYMGELVRLVMMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCATGLAGVINLMRERRSEEAMKITVGIDGSVYKLHPCFRDRFHKVVRDLTPHSDITFIQSEEGSGRGAALISAVACKMATNLFAD',
            'cigar_line': '91M2D464M',
            'id': 'ENSACLG00000009790',
            'perc_id': 67.027,
            'perc_pos': 75.6757,
            'protein_id': 'ENSACLP00000014373',
            'species': 'astatotilapia_calliptera',
            'taxon_id': 8154},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-------------MA------------MDVTRSQA---------------------QTALT-----------L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '13D2M12D8M21D5M11DMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.2575,
            'perc_pos': 89.485,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'SSVWSSQISKVTSLPQQQEAACGLDWRRR--RQ--VWVFFYKNRRKQSFCCLSYRESGREKIMNETPFPLQSINVDQILSEFLLSKEDLEEVMRRIRREMERGLRVETHDEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMLFDYIASCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRKVELLEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGRQLYEKLIGGKYMGELVRLVLLKLVNENLLFNGEASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSSLGILPSELDCDIVRLVCESVSTRAAHMCGAGLTGVINLMTERRCQEELKITVGVDGSVYKLHPHFKERFHKLVWEMTPHCEITFIQSEEGSGRGAALISAVACKMAACMLTP',
            'cigar_line': '29M2D2M2D490M',
            'id': 'ENSSRHG00000013620',
            'perc_id': 71.785,
            'perc_pos': 80.0384,
            'protein_id': 'ENSSRHP00000026048',
            'species': 'sinocyclocheilus_rhinocerous',
            'taxon_id': 307959},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '----MA------MDVTRSQA------QTALT-L---VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '4D2M6D8M6D5MDM3D445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.3305,
            'perc_pos': 90.5579,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'AFQSLQTIKSTI----RL--ICNRLSPALNPFLPPQVEQILSEFRLKKEQLKEVMKRMMREMDRGLRVETHQESSVKMLPTYVYSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERVWKVETKHQMYSIPEDAMTGTAEMLFDYIAECISDFLDRHHIKHRKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGANGELEEFRLEYDRVVDETSLNPGQQLYEKLISGKYMGELVRLVLLKLVNEELLFNGEASDLLKTRGSFETRYVSQIESDSGDRKQIYNILSTLGVLPSEMDCDIVRLACESVSTRAAHMCGAGLAAVINRMRERRSQEVLKITVGVDGSVYKLHPCFQDRFHKVVRELTPHCDITFIQSEEGSGRGAALISAVACKMAACILTQ',
            'cigar_line': '12M4D2M2D467M',
            'id': 'ENSSTUG00000026872',
            'perc_id': 78.7942,
            'perc_pos': 87.7339,
            'protein_id': 'ENSSTUP00000064455',
            'species': 'salmo_trutta',
            'taxon_id': 8032},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.9013,
            'perc_pos': 90.3433,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLCVSSYMSQMGKM--PCSLSSVLETVLMVEQILSEFRLKKEQLKEVMKRMMREMDRGLRVETHQEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHQMYSIPEDAMTGTAEMLFDYIAECISDFLNRQHIKHKKLPLGFTFSFPVRHENIDKGILLNWTKGFKASGAEGNNVVELLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGANGELEEFRLEYDRVVDETSLNPGQQLYEKLISGKYMGELVRLVLLKLVNEELLFNGEASDLLKTRGSFETRYVSQIESDSGDRKQIYNILSTLGVLPSELDCDIVRLSCESVSTRAAHMCGAGLAGVINRMRERRSQAVLKITVGIDGSVYKLHPCFQDRFHKVVRELTPHCDITFIQSEEGSGRGAALISAVACKMAACMLTP',
            'cigar_line': '14M2D464M',
            'id': 'ENSHHUG00000005707',
            'perc_id': 78.8703,
            'perc_pos': 88.0753,
            'protein_id': 'ENSHHUP00000009513',
            'species': 'hucho_hucho',
            'taxon_id': 62062},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA-------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M7D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.3305,
            'perc_pos': 90.1288,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSSQLSNQKGKM--PCSYSSVVEKILMVEQILSEFRLNKEELKEVMKRMQREMDRGLHLDTHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVIVGENEERSWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGEFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDETSVNPGQQLYEKVISGKYMGELVRLVLMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINLMRERRSEEALKITVGVDGSVYKLHPCFRDRFHKIVRDLTPHCEITFIQSEEGSGRGAALISAVACKMAASMLTQ',
            'cigar_line': '15M2D464M',
            'id': 'ENSSLDG00000003477',
            'perc_id': 79.1232,
            'perc_pos': 87.6827,
            'protein_id': 'ENSSLDP00000004420',
            'species': 'seriola_lalandi_dorsalis',
            'taxon_id': 1841481},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 78.97,
            'perc_pos': 89.2704,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVISHLDQMVKM--PSNYSSVLDRLLMVEQILSEFRLNKEDLKEIKNRMQCEMNRGLRVETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEDCTWKIETKNQMYSIPEDAMTGTAEMCGCTLSECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDESSINPGQQLYEKLISGKYMGELVRLVLIKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCETVSTRSAHVCGAGLAGVINLMQERRNQDCLKITVGVDGSVYKLHPFFRDRFHKMVRDLTPHCEITFLQSEEGSGRGAALISAVACKMAACIRTQ',
            'cigar_line': '14M2D464M',
            'id': 'ENSATEG00000021372',
            'perc_id': 76.9874,
            'perc_pos': 87.0293,
            'protein_id': 'ENSATEP00000030973',
            'species': 'anabas_testudineus',
            'taxon_id': 64144},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEML-FDYI----SECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD107MD4M4D334MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.9013,
            'perc_pos': 90.1288,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCPASLRKQMLRM--PSAYQSVLEKVLMVDQILSEFLMTKEDLKEVMRRMQKEMNRGLRLETHDEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMVTFIFILKISTNCISDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMCTVELVEGDEGRMCVNTEWGAFGDCGELEDFRLEYDRVVDESSLNPGRQLYEKLIGGKYMGELVRLVLVKLVNEDLLFNGEASEMLKTKGSFETRFVSQIESDTGDRKQIYNILSSFGVLPSELDCDIVRLACESVSTRAANMCAAGLAGVIDLMRERRSQEELKITVGVDGSVYKLHPHFQERFHKAVWELTPKCEITFVQSEEGSGRGAALISAVACKMAACMISP',
            'cigar_line': '14M2D469M',
            'id': 'ENSAMXG00005007433',
            'perc_id': 78.0538,
            'perc_pos': 86.9565,
            'protein_id': 'ENSAMXP00005014392',
            'species': 'astyanax_mexicanus_pachon',
            'taxon_id': 7994},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.6867,
            'perc_pos': 89.6996,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVTSHLGQMVKM--PCSYSSVVDNIFMVEQILSEFRLNKEDLKEVMKRMQREMDRGLRLETHEEASVKMLPTYVCSTPQGSEVGDFLALDLGGTNFRVMLVKVGADEERSWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGNNGELEEFRLEYDRVVDETSINPGRQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASELLKTRGSFETRYVSQIESDAGDRKQIYNILFSLGVLPSDLDCDIVRLVCESVSTRSAHMCGAGLAGVLNLMRERRSQEALNITVGVDGSVYKLHPCFRERFHKIVRDLTPHCEITFIQSEEGSGRGAALISAVACKMAACMLTH',
            'cigar_line': '14M2D464M',
            'id': 'ENSLBEG00000023947',
            'perc_id': 78.6611,
            'perc_pos': 87.4477,
            'protein_id': 'ENSLBEP00000031751',
            'species': 'labrus_bergylta',
            'taxon_id': 56723},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--MA-----MDVTRSQA------------------------------------------------QTALT---------------------L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2D2M5D8M48D5M21DMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.9013,
            'perc_pos': 90.3433,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'GGGVCSLRTDQPVCVCVCVCVCVCVCVCVCVCVCVCFRFPMARWGEFGKGLLAFASGVVGPLHLSIKTAEVLIQCCSRFTDSPLTCSSLPSLQVEQILSEFRLKKEELKEVMKRMQREMDRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEMSWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGNNGELEEFRLEYDRVVDETSINPGQQLYEKLISGKYMGELVRLVLIKLVNEDLLFNGEASELLKTRGSFETRYVSQMESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSSHMCGAGLAAVINRMRERRSQEALKITVGVDGSVYKMHPCFRDRFHQIVSDLTPHCDITFIQSEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '544M',
            'id': 'ENSCGOG00000018589',
            'perc_id': 69.3015,
            'perc_pos': 77.3897,
            'protein_id': 'ENSCGOP00000041763',
            'species': 'cottoperca_gobio',
            'taxon_id': 56716},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '------------------------MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '24D2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.1159,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLLTHIQTLANQRSSYNCLKRLAKMPCLSSARRQ--RT--PSDFESVLERILMVDQILSEFLLSKEDLEEVMRRIRREMERGLRVETHDEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMLFDYIASCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRKVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGHQLYEKLIGGKYMGELVRLVLLKLVNENLLFNGDASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSSLGILPSELDCDIVRLVCESVSTRAAHMCGAGLAGVINLMRERRCQEELKITVGVDGSVYKLHPHFKERFHKLVWEMTPHCEITFIQSEEGSGRGAALISAVACKMAACMLTP',
            'cigar_line': '34M2D2M2D464M',
            'id': 'ENSCCRG00020043480',
            'perc_id': 75.6,
            'perc_pos': 83.8,
            'protein_id': 'ENSCCRP00020095444',
            'species': 'cyprinus_carpio_hebaored',
            'taxon_id': 7962},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.8283,
            'perc_pos': 89.2704,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCITSQLDQMMKL--PGSYSDVVEKICMVEQILSEFRLNKEELEEVMKRMQHEMNRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDSGELEEFRLEYDRVVDETSINPGHQLYEKIISGKYMGELARLVMMKLVNENLLFNGEASEQLKTRGGFETRFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINQMQERRGQDTMKITVGVDGSVYKLHPYFRDRFHQVVRELTPHSEITFLQSEEGSGRGAALISAVACKMASWV---',
            'cigar_line': '14M2D461M3D',
            'id': 'ENSPFOG00000014781',
            'perc_id': 78.3158,
            'perc_pos': 87.5789,
            'protein_id': 'ENSPFOP00000014846',
            'species': 'poecilia_formosa',
            'taxon_id': 48698},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.3305,
            'perc_pos': 90.7725,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSSYTGQMGKM--PCSLSSVLETALMVEQILSEFRLKKEQLKEVMKRMMREMDRGLRVETHKESSVKMLPTYVYSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHQMYSIPEDAMTGTAEMLFDYIAECISDFLDRHHIKHRKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGANGELEEFRLEYDRVVDETSLNTGQQLYEKLISGKYMGELVRLVLLKLVNEELLFNGEASDLLKTRGSFETRYVSQIESDSGDRKQIYNILSTLGMLPSEMDCDIVRLACESVSTRSAHMCGAGLAAVINRMRERRSQEVLKITVGVDGSVYKLHPCFQDRFHKVVRELTPHCDITFIQSEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '14M2D464M',
            'id': 'ENSHHUG00000051102',
            'perc_id': 79.2887,
            'perc_pos': 88.4937,
            'protein_id': 'ENSHHUP00000088445',
            'species': 'hucho_hucho',
            'taxon_id': 62062},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.8283,
            'perc_pos': 88.8412,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVVSEFDQMVKM--PSDYGSVLDRVLMVEQILSEFQLNKEDLTEIMTRMQCEMGRGLRVETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEECTWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDLDMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDESSINPGHQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGDASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDMVRLVCETVSTRSAHLCGAGLAAIINLMRERRSQDALKITVGVDGSVYKLHPHFCDRFHKTVRDLTPRCNITFIRSEEGSGRGAALISAVACKMAAGMLTQ',
            'cigar_line': '14M2D464M',
            'id': 'ENSBSLG00000001762',
            'perc_id': 77.8243,
            'perc_pos': 86.6109,
            'protein_id': 'ENSBSLP00000003209',
            'species': 'betta_splendens',
            'taxon_id': 158456},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.6867,
            'perc_pos': 89.0558,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSTHLDTMGKL--PSSFKAVVKEILMVEQILSEFRLNKEELKEVMKRMQREMDRGLRLESHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGKDEERGFKVETTNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDKGELEEFRLEYDRVVDEFSINPGQQLFEKLISGKYMGELVRLVLMKLVKENLLFNGEASEQLRTRGSFETRFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAQMCGAGLAGVINRMRERRCEEELKITVGVDGSVYKLHPWFRDRFHKVVWDLSPHCEITFIQSEEGSGRGVALISAVACKMAACTTAP',
            'cigar_line': '14M2D464M',
            'id': 'ENSORLG00000002010',
            'perc_id': 78.6611,
            'perc_pos': 86.8201,
            'protein_id': 'ENSORLP00000002505',
            'species': 'oryzias_latipes',
            'taxon_id': 8090},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.4721,
            'perc_pos': 89.0558,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCASSPLDQKATM--PCSFSSVLDEILMVEQILSEFRLKKEELKEIMQRMQCEMDRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGADEERSWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHMKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGGNGELEEFRLEYDRVVDETSINPGQQLYEKVISGKYMGELVRLVLMKLVNEDLLFDGEASELLKTRGSFEARYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLACVINIMRERRGQEALKITVGVDGSVYKLHPCFRDRFHKIVRDLTPHCDITFIQSEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '14M2D464M',
            'id': 'ENSSMAG00000007420',
            'perc_id': 78.4519,
            'perc_pos': 86.8201,
            'protein_id': 'ENSSMAP00000012090',
            'species': 'scophthalmus_maximus',
            'taxon_id': 52904},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M6D8M5D5MDMD450M',
            'id': 'ENSG00000106633',
            'perc_id': 50.6438,
            'perc_pos': 55.5794,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCLTSARRQ--RI--PSDFESVLEKILMVDQILSEFVLSKEELEEVMRRMRREMERGLRVETHDEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMLFDYIAGCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRKVELVEGEEGRMCVNTEWGAFGDHSELEDFRLEYDRVIDETSLNPGHQL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------',
            'cigar_line': '10M2D2M2D286M177D',
            'id': 'ENSDARG00000068006',
            'perc_id': 79.1946,
            'perc_pos': 86.9128,
            'protein_id': 'ENSDARP00000079994',
            'species': 'danio_rerio',
            'taxon_id': 7955},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '461MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 76.3949,
            'perc_pos': 85.8369,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-------------------------------EEVMKRIQHEMNRGLRLETHQEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGEFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEKGRMCVNTEWGAFGDSGELEEFRLEYDRVVDETSINPGHQLYEKIISGKYMGELARLVMMKLVNENLLFNGEASEQLKIRGSFETRFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINQMQEHRGQDTMKITVGVDGSVYKLHPYFRDRFHQVVRELTPHSEITFLQSEEGSGRGAALISAVACKMASWI---',
            'cigar_line': '31D433M3D',
            'id': 'ENSPREG00000010287',
            'perc_id': 82.2171,
            'perc_pos': 92.3788,
            'protein_id': 'ENSPREP00000015264',
            'species': 'poecilia_reticulata',
            'taxon_id': 8081},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '461MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 78.5408,
            'perc_pos': 85.4077,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '----------------------------------MKRMQHEMDRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSWKVETTNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDIEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDESSINPGQQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVHLVCESVSTRSAHMCGAGLAGVINRMRERRCEESLKITVGVDGSVYKLHPCFRDRFHKVVRDLTPHCDITFIQSEEGSGRGAALISAVACKMAAYMLTQ',
            'cigar_line': '34D433M',
            'id': 'ENSAOCG00000006915',
            'perc_id': 84.5266,
            'perc_pos': 91.9169,
            'protein_id': 'ENSAOCP00000021845',
            'species': 'amphiprion_ocellaris',
            'taxon_id': 80972},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTL-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '16MD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.8283,
            'perc_pos': 88.1974,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-----------MLDS-QVEQILSEFILNKEELKEVMKRMQREMDRGLRIETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGADEERSWKVETKTQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHMKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRKVELVEGEEGRMCVNTEWGAFGDSGELEDFRLEYDRVVDESSINPGQQLYEKLISGKYMGELVRLVMMKLVNEGLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSLMGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINQMRERRGQETLKITVGIDGSVYKLHPWFCDRFHKIVRDLTPHCEITFIQSEEGSGRGAALISAVAYKMAVCI---',
            'cigar_line': '11D4MD449M3D',
            'id': 'ENSMALG00000021430',
            'perc_id': 82.1192,
            'perc_pos': 90.7285,
            'protein_id': 'ENSMALP00000031020',
            'species': 'monopterus_albus',
            'taxon_id': 43700},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 75.9657,
            'perc_pos': 85.1931,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCLTFIRKQSMRT--SSSYKSMLEQALMVDQILSELLLTKEELKEVMGRMQQEMKKGLRVETHEGASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDGERGWKVETKHHMYSIPEDAITGTAEMLFDYIAECISDFLDKHGMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIRRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIV----------EMCTVELVEGEEGRMCVNTEWGAFGGNGELEEFRLEYDRVVDELSLNPGQQLYEKMIGGKYMGELVRLVLMKLVNEGLLFNGNTSDMLKTRGSFETRFVSQIESDTGDRKQIYNILSSLSVLPSELDCDIVRLACESVSTRAAHLCGAGLSGILNLMRERRSQEEMKITVGVDG--MKWH--FKERFHKVVRELTPNCDITFIQSEEGSGRGAALISAVACKMAARLIAP',
            'cigar_line': '14M2D224M10D174M2D4M2D48M',
            'id': 'ENSEEEG00000023397',
            'perc_id': 76.2931,
            'perc_pos': 85.5603,
            'protein_id': 'ENSEEEP00000049794',
            'species': 'electrophorus_electricus',
            'taxon_id': 8005},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '--MA---MDVTRSQA---QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2D2M3D8M3D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 75.5365,
            'perc_pos': 83.691,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MRSLCSS-----L--PLV-----VLQVEQILSELRLSKEKLKEVMKRMQREMERGLCLETHQEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDK--------------------VGCVTYAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGALGDNGELEEFRLEYDRVVDETSINPGHQLYEKLISGKYMGELVRLVLVKLVNENLLFNGEASELLKTRGSFETRFVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVSLVCESISTRSAHMCGAGLAGVINLMRERRRQEALAITVGVDGSVYKLHPCFRDRFHKIVRDLTPHCEITFIQSEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '7M5DM2D3M5D149M20D285M',
            'id': 'ENSMMOG00000011665',
            'perc_id': 79.1011,
            'perc_pos': 87.6404,
            'protein_id': 'ENSMMOP00000015293',
            'species': 'mola_mola',
            'taxon_id': 94237},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MDVTRSQAQTALTL-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M2D14MD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.6867,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--MMDKTSRM--------FMEQILSEFRLNKEELKEVMKRMQREMDRGLHLDTHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVIVGENEERSWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGEFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDETSVNPGQQLYEKVISGKYMGELVRLVLMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINLMRERRSQEALKITVGVDGSVYKLHPCFRDRFHKIVRDLTPHCEITFIQSEEGSGRGAALISAVACKMAASMLTQ',
            'cigar_line': '2D8M8D452M',
            'id': 'ENSSDUG00000022756',
            'perc_id': 81.7391,
            'perc_pos': 91.087,
            'protein_id': 'ENSSDUP00000031666',
            'species': 'seriola_dumerili',
            'taxon_id': 41447},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '461MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 78.1116,
            'perc_pos': 85.1931,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-------------------------------KEVMKRMQREMDRGLRLESHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGKDEERGFKVETTNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDKGELEEFRLEYDRVVDEFSINPGQQLFEKLISGKYMGELVRLVLMKLVKENLLFNGEASEQLRTRGSFETRFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAQMCGAGLAGVINRMRERRCEEELKITVGVDGSVYKLHPWFRDRFHKVVWDLSPHCEITFIQSEEGSGRGVALISAVACKMAACTTAP',
            'cigar_line': '31D436M',
            'id': 'ENSORLG00015016492',
            'perc_id': 83.4862,
            'perc_pos': 91.055,
            'protein_id': 'ENSORLP00015031953',
            'species': 'oryzias_latipes_hsok',
            'taxon_id': 8090},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.8283,
            'perc_pos': 90.1288,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSVQLDQMVKL--PSSYDSVVDKVIAVDQILSEFRLNKEDLKEIMKRMQREMERGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDEASINPGQQLYEKLISGKYMGELVRLVMMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCATGLAGVINLMRERRSEEAMKITVGIDGSVYKLHPCFRDRFHKVVRDLTPHSDITFIQSEEGSGRGAALISAVACKMATNLFAD',
            'cigar_line': '14M2D464M',
            'id': 'ENSMZEG00005010696',
            'perc_id': 77.8243,
            'perc_pos': 87.8661,
            'protein_id': 'ENSMZEP00005014233',
            'species': 'maylandia_zebra',
            'taxon_id': 106582},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPS-----FKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD403M5D42MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.1159,
            'perc_pos': 89.485,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCLTLARTQ--RI--PSDFESVLERIIMVEQILSEFLLSKEDLEEVMRRMRREMERGLRVETHNEASIKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMLFDYIAGCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHSCEVGMIVGTGCNACYMEEMRKVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGHQLYEKLIGGKYMGELVRLVLLKLVNENLLFNGDASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSTLGILPSELDCDIVRLVCKSVSTRAAHMCGAGLAGVINLMRERRCQEQLKITVGVDGSVYKLHPQKQRWSFKERFHKLVWEMNPDCEITFIQSEEGSGRGAALISAVACKMAACMLTP',
            'cigar_line': '10M2D2M2D469M',
            'id': 'ENSCCRG00010002931',
            'perc_id': 78.5863,
            'perc_pos': 86.6944,
            'protein_id': 'ENSCCRP00010007118',
            'species': 'cyprinus_carpio_germanmirror',
            'taxon_id': 7962},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.4721,
            'perc_pos': 89.0558,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSTHLDTMGKL--PSSFKAVVKEILMVEQILSEFRLNKEELKEVMKRMQREMDRGLRLESHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGKDEERGFKVETTNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDKGELEEFRLEYDRVVDEFSINPGQQLFEKLISGKYMGELVRLVLMKLVKENLLFNGEASEQLRTRGSFETRFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAQMCGAGLAGVINRMRERRCEEELKITVGVDGSVYKLHPWFRDRFHKVVWDLSPHCKITFIQSEEGSGRGVALISAVACKMAACTTAP',
            'cigar_line': '14M2D464M',
            'id': 'ENSORLG00020006865',
            'perc_id': 78.4519,
            'perc_pos': 86.8201,
            'protein_id': 'ENSORLP00020025100',
            'species': 'oryzias_latipes_hni',
            'taxon_id': 8090},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.6867,
            'perc_pos': 90.5579,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSSHLNQMVKM--PCSYSSVVEKIFMVEQMLSEFRLNKEELKEVMKRMQREMERGLRIETHKEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKNQMYSIPEDAMTGTAEMLFDYIAECISDFLDRHQIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDETSINPGCQLYEKLISGKYMGELVRLVMMKLVNEDLLFNGEASDLLKTRGSFEARFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINLMRERRSQEALKITVGVDGSVYKLHPCFQDRFHKIVRELTPHCEITFIQSEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '14M2D464M',
            'id': 'ENSMMDG00005017499',
            'perc_id': 78.6611,
            'perc_pos': 88.2845,
            'protein_id': 'ENSMMDP00005037721',
            'species': 'myripristis_murdjan',
            'taxon_id': 586833},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA---MDVTRSQA-----QTALTL-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M3D8M5D6MD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 77.0386,
            'perc_pos': 88.412,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--VFD--------PRAADEASSE-RIEEILSKFRLNKEELEEVMNRMQLEMERGLRIETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGKDEDRSWKIETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLGKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGEFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDAASINPGQQLYEKLISGKYMGELVRLVLMKLVNENLLFNGEASEQLKTRGSFETRYVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCEVISTRSSHMCGAGLAAVINRMRERRCQDTLNITVGIDGSVYKLHPYFRDRFHKVVRELTPNCEISFLQSEEGSGRGAALISAVASKMAAAC---',
            'cigar_line': '2D3M8D10MD449M3D',
            'id': 'ENSPMGG00000013033',
            'perc_id': 77.7056,
            'perc_pos': 89.1775,
            'protein_id': 'ENSPMGP00000015897',
            'species': 'periophthalmus_magnuspinnatus',
            'taxon_id': 409849},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALT---L--VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '15M3DM2D445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 77.897,
            'perc_pos': 88.1974,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-----------MLNNRHTINNVDQILSELRLQKDELQEIMKRMRREMDRGLRLETHEVASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGADEERSWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSNFLDQHNIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDIEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMSTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDETSINPGQQLFEKLISGKYMGELVRLVMMKLVNENLLFNGEASEMLKTRGSFETRHVSQVESDSGDRKHIYNILSSMGVLPSELDCDIVGLVCESVSTRSAHMCAAGLAGVINLMRERRGLEALNITVGVDGSVYKMHPCFRDRFHKIVRELTPHCEITFIQSEEGSGRGAALISAVACKMAASMLAR',
            'cigar_line': '11D461M',
            'id': 'ENSHCOG00000006726',
            'perc_id': 78.7419,
            'perc_pos': 89.154,
            'protein_id': 'ENSHCOP00000005117',
            'species': 'hippocampus_comes',
            'taxon_id': 109280},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA---------------------------------------------------MDVTRSQA---------QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEML-FDYI-SECISDFLDK--HQMKHKKLPLGFTFSFPVR-HEDIDK-GILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M51D8M9D5MDMD107MD4MD10M2D19MD6MD299MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 75.5365,
            'perc_pos': 84.5494,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MCGRFCLIGPAHFTRAYHIAGASRCSHISLTPHTHILSKLLRTHTHTHTHVCLDKPVKMPCISPMPCSYSPMIDKILTVEHILSEFRLNKEELKEIMERMQREMKRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGSWKVETKNQMYSIPEDAMTGTAEMVM--HVR------FLGKTPHQAQEASSGLYLLFSCAARGHRQ---GGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDIEMDVVAMVNDTVATMISCYYEDRSCEVGIIVGTGCNACYMEEMRTVELVEGDEGRMCVNTEWGAFGGNGELEDFRLEYDRVVDEISINPGQQLYEKLISGKYMGELVRLVLVKLVNEDLLFNGEASEQLKTRGSFETRYVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHFCSAGLAGVINLMRERRSQEVLKITVGVDGSVYKLHPCFRDRFHKMVWELTPYCEITFIQSEEGSGRGAALISAVACKMAACLLAQ',
            'cigar_line': '186M2D3M6D29M3D306M',
            'id': 'ENSGWIG00000018708',
            'perc_id': 67.1756,
            'perc_pos': 75.1908,
            'protein_id': 'ENSGWIP00000036281',
            'species': 'gouania_willdenowi',
            'taxon_id': 441366},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.3305,
            'perc_pos': 88.8412,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCLTSARRQ--GM--LSDFESVLERILMVEQILSEFLLSKEDLEEVMRRMRREMERGLRVETHNEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDTMTGTAEMLFDYIAGCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHSCEVGMIVGTGCNACYMEEMRKVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGHQLYEKLIGGKYMGELVRLVLLKLVNENLLFNGEASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSTLGILPSELDCDIVRLVCESVSTRAAHMCGAGLAGVINLMRERRCQEQLKITVGVDGSVYKLHPHFKERFHKLVWEINPHCEITFIQSEEGSGRGAALISAVAYKMATCMLTP',
            'cigar_line': '10M2D2M2D464M',
            'id': 'ENSSANG00000033630',
            'perc_id': 79.6218,
            'perc_pos': 86.9748,
            'protein_id': 'ENSSANP00000067683',
            'species': 'sinocyclocheilus_anshuiensis',
            'taxon_id': 1608454},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.1159,
            'perc_pos': 90.3433,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLCVSSFMGQMGKM--PCSLSSVLETVLMVEQILSEFRLKKEQLKEVMKRMMREMDRGLRVETHQEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHQMYSIPEDAMTGTAEMLFDYIAECISDFLNRQHIKHKKLPLGFTFSFPVRHENIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGANGELEEFRLEYDRVVDETSLNPGQQLYEKLISGKYMGELVRLVLLKLVNEELLFNGEASTLLKTRGSFETRYVSQIESESGDRKQIYNILSTLGVLPSELDCDIVRLACESVSTRAAHMCGAGLAGVINRMRERRSQAVLKITVGIDGSVYKLHPCFQDRFHKVVRELTPHCDITFIQSEEGSGRGAALISAVACKMAACMLTP',
            'cigar_line': '14M2D464M',
            'id': 'ENSSTUG00000028305',
            'perc_id': 79.0795,
            'perc_pos': 88.0753,
            'protein_id': 'ENSSTUP00000065430',
            'species': 'salmo_trutta',
            'taxon_id': 8032},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.2575,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSSQLDQMVKM--PCSYSSVVDKIFAVRQILSEFRLNKEELKEVMKRMQREMERGLRVETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDDERSFKVETKNQMYSIPENAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDESSINPGHQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASEMLKTRGSFETRYVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVHLVCESVSTRSAHMCGAGLAGVINQMRERRSQEFLEITVGVDGSVYKLHPCFRDRFHKIVRDLTPHCEINFIQSEEGSGRGAALISAVACKMAACMLNQ',
            'cigar_line': '14M2D464M',
            'id': 'ENSLCRG00005011103',
            'perc_id': 78.2427,
            'perc_pos': 87.6569,
            'protein_id': 'ENSLCRP00005028319',
            'species': 'larimichthys_crocea',
            'taxon_id': 215358},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '----MA---------------------------------------MDVTRSQA-----QTALT-----------------------------------------L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '4D2M39D8M5D5M41DMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.1159,
            'perc_pos': 90.5579,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MSDFLPCDCELTPVFTRRLLHVVREETLGEELIVDIQILLCFVLLKNMVVC--GNFVAELGGELGGCLWSVESPLCFFPIVFCCQVVQENMFFVQPLTCLPLLLLQVEQILSEFRLNKEDLKEIMERMQHEMDRGLRIETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVIVGEDEERSWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILINWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDETSINPGHQLYEKVISGKYMGELVRLVLMKLVNEDLLFNGEASEQLKTRGSFETRFVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINRMRERRCQEALKITVGVDGSVYKLHPCFRDKFHKIVRDLTPHCEITFIQSEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '51M2D504M',
            'id': 'ENSLCAG00010001272',
            'perc_id': 68.1081,
            'perc_pos': 76.036,
            'protein_id': 'ENSLCAP00010002256',
            'species': 'lates_calcarifer',
            'taxon_id': 8187},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.8283,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSTHLDQMVKM--PSSYDSVVDKVIAVDQILSEFRLNKEDLKEIMKRMQCEMERGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDEASINPGHQLYEKLISGKYMGELVRLVMMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCAAGLAGVINLMRERRSEEAMKITVGIDGSVYKLHPCFRDRFHKVVRDLTPHSDITFIQSEEGSGRGAALISAVACKMATNLFAD',
            'cigar_line': '14M2D464M',
            'id': 'ENSONIG00000014301',
            'perc_id': 77.8243,
            'perc_pos': 87.6569,
            'protein_id': 'ENSONIP00000030038',
            'species': 'oreochromis_niloticus',
            'taxon_id': 8128},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ------------------------',
            'cigar_line': '2M6D8M4D5MDMD445MD5M24D',
            'id': 'ENSG00000106633',
            'perc_id': 80.0429,
            'perc_pos': 88.412,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSSHSDQMVMM--PAYISEVDRILQVEQILSVFKLDKKDLSEVMKRMQHEMERGLHLDTHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGSWKVLTKKQMYSIPEDAMTGTAEMLFDYIAECMSHFLDHYHMKHKKLPLGFTFSFPVRHEDIDKGILINWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNVCYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDETSINPGHQLYEKLISGKYMGELVRLVLMKLVNENLLFNGEPSEILKTRGSFDTRFVSQVESDTGDRKQIYNILTSLGVLPSELDCDIVHLVCESVSTRAAHMCGAGLAGVINRMRERRSQEALVITVGVDGSVYKLHPCFRDRFHKIVRDLTPRCEITFLQSEEGSGRGAALISAVACKMAACMLMQSRAEKLQGNQPEGSKTEADDSQQP',
            'cigar_line': '14M2D487M',
            'id': 'ENSTRUG00000016548',
            'perc_id': 74.4511,
            'perc_pos': 82.2355,
            'protein_id': 'ENSTRUP00000042306',
            'species': 'takifugu_rubripes',
            'taxon_id': 31033},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.6137,
            'perc_pos': 89.485,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCISSHFGQMVKM--PGSYDEVVEKIFMVEHILSEFRLNKEELKEVMRRMQHEMSRGLRLETHEEASIKMLPTFVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSFKVETKHQMYSIPEDTMTGTAEMLFDYIAECMSDFLGKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGEFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNVCYMEEMKTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDEASINPGHQLYEKLISGKYMGELVRLVLMKLVNENLLFNGEASELLKTRGSFETRFVSQMESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSALMCGAGLAGVINQMRERRSQDVLKITVGVDGSVYKLHPYFRDRFHKTVRELTPHSEITFIQSEEGSGRGAALISAVACKMAACLLTP',
            'cigar_line': '14M2D464M',
            'id': 'ENSKMAG00000004940',
            'perc_id': 77.6151,
            'perc_pos': 87.2385,
            'protein_id': 'ENSKMAP00000006547',
            'species': 'kryptolebias_marmoratus',
            'taxon_id': 37003},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MDVTRSQA----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M2D8M4D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.3305,
            'perc_pos': 89.6996,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--MSDQTLQG--FEEF-----LPLVEQILSEFRLNKEELKEVMERMQREMDRGLRIETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDRHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDETSINPGHQLYEKLISGKYMGELVRLVLVKLVNEDLLFNGEASEQLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINLMRERRSQEALAITVGVDGSVYKLHPCFRDRFHKIVRDLTPHCEIAFIQSEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '2D8M2D4M5D454M',
            'id': 'ENSSAUG00010023799',
            'perc_id': 81.3305,
            'perc_pos': 89.6996,
            'protein_id': 'ENSSAUP00010058428',
            'species': 'sparus_aurata',
            'taxon_id': 8175},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-----------------------------------------------------------------------------------------------------MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '101D2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.0429,
            'perc_pos': 90.3433,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MKYILRNKVKPFYNFAQRLYLFVCMWAFVYVCTSLARWGEVGKGRAIGFGVSSPLHLRIKAAEDCSVVLTLHSLCTHTLGGLTLTKLLKTHASEFLVKPVKMPCVSVQLDQMVKL--PNSYDSVVDKVIAVDQILSEFRLNKEDLKEIMKRMQREMERGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDEASINPGQQLYEKLISGKYMGELVRLVMMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCAAGLAGVINLMRERRSEEAMKITVGIDGSVYKLHPCFRDRFHKVVRDLTPHSDITFIQSEEGSGRGAALISAVACKMATNLFAD',
            'cigar_line': '115M2D464M',
            'id': 'ENSHBUG00000012698',
            'perc_id': 64.4214,
            'perc_pos': 72.7116,
            'protein_id': 'ENSHBUP00000011080',
            'species': 'haplochromis_burtoni',
            'taxon_id': 8153},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M2D459MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 78.5408,
            'perc_pos': 88.412,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--DLDDI-----------VEHILSEFRLNKGELEEVMKRMQHEMNRGLRLETHETASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGTFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGEFEMDVVAMVNDTVATMVSCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDEASINPGHQLYEKVISGKYMGELVRLVLMKLINENLLFNGEASEQLMTRGSFETCFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINLMRERRGQDTLKITVGVDGSVYKLHPYFRDRFHQVVRELTPHSEITFLQSEEGSGRGAALISAVACKMASWI---',
            'cigar_line': '2D5M11D448M3D',
            'id': 'ENSCVAG00000019648',
            'perc_id': 80.7947,
            'perc_pos': 90.9492,
            'protein_id': 'ENSCVAP00000030822',
            'species': 'cyprinodon_variegatus',
            'taxon_id': 28743},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 78.7554,
            'perc_pos': 89.0558,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCISSQFDQMMKL--SGSYSDVVKKICMVEQILSEFRLNKEELEEVMKRMQHEMNRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFTASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMVSCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEQGRMCVNTEWGAFGDMGELEDFRLEYDRVVDETSINPGHQLYEKIISGKYMGELARLVMMKLVNENLLFNGEASEQLRTRGSFETRFVSQVESDSGDRKQIYNILSSLGVLPTELDCDIVRLVCESVSTRSAHMCGAGLAGVINQMQERRGQDTMKITVGVDGSVYKLHPYFRDRFHQVVRELTPHSEITFLQSEEGSGRGAALISAVACKMESWI---',
            'cigar_line': '14M2D461M3D',
            'id': 'ENSGAFG00000017334',
            'perc_id': 77.2632,
            'perc_pos': 87.3684,
            'protein_id': 'ENSGAFP00000025690',
            'species': 'gambusia_affinis',
            'taxon_id': 33528},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLH---------------------------------PS------F------KERFHASVR-----------------------RLTPS-CEITFIE---SEE--GSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '417M33D2M6DM6D9M23D5MD7M3D3M2D22M',
            'id': 'ENSG00000106633',
            'perc_id': 71.8884,
            'perc_pos': 79.1845,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--------------------------------EVMKRMMREMDRGLRVETHQEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHQMYSIPEDAMTGTAEMLFDYIAECISDFLNRQHIKHKKLPLGFTFSFPVRHENIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGANGELEEFRLEYDRVVDETSLNPGQQLYEKLISGKYMGELVRLVLLKLVNEELLFNGEASALLKTRGSFETRYVSQIESDSGDRKQIYNILSTLGVLPSELDCDIVRLACESVSTRAAHMCGAGLAGVINRMRERRSQAVLKITVGIDGSSFSIKVSLLLLKYDNWVLFPPLAILMGNMASSLPLLPYPTGSSLKPFCANPPPPLSFSLLVSHPITSPPPAPSPYLLFPPPVESWSLGPYR---VHIERERERERE---RERERV-------------',
            'cigar_line': '32D471M3D12M3D6M13D',
            'id': 'ENSSSAG00000069485',
            'perc_id': 68.5072,
            'perc_pos': 75.4601,
            'protein_id': 'ENSSSAP00000088636',
            'species': 'salmo_salar',
            'taxon_id': 8030},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '------------------------MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '24D2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.1159,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLLTHIQTLANQRSSYNCLKRLAKMPCLSSARRQ--RT--PSDFESVLERILMVDQILSEFLLSKEDLEEVMRRIRREMERGLRVETHDEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMLFDYIASCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRKVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGHQLYEKLIGGKYMGELVRLVLLKLVNENLLFNGDASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSSLGILPSELDCDIVRLVCESVSTRAAHMCGAGLAGVINLMRERRCQEELKITVGVDGSVYKLHPHFKERFHKLVWEMTPHCEITFIQSEEGSGRGAALISAVACKMAACMLTP',
            'cigar_line': '34M2D2M2D464M',
            'id': 'ENSCCRG00015014432',
            'perc_id': 75.6,
            'perc_pos': 83.8,
            'protein_id': 'ENSCCRP00015034664',
            'species': 'cyprinus_carpio_huanghe',
            'taxon_id': 7962},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '---------------------------------------------MA----MDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '45D2M4D459MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.1845,
            'perc_pos': 87.7682,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MIFVATSPPPSLEHKNSWASLCTSHTFKFVQINDHHTLVVKRLAKMPCLTS--------------VEQILSEFLLSKEDLEEVMRRMRREMERGLRVETHNEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDTMTGTAEMLFDYIAGCISDFLDKHNLKHKKLPLGFTFSFPEMHFNMD-GILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHSCEVGMIVGTGCNACYMEEMRKVELVEGEEGKMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGHQLYEKLIGGKYMGELVRLVLLKLVNENLLFNSEASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSSLGILPSELDCDVVRLVCESVSTRAAHMCGAGLAGVINLMRERRCQEQLKITVGVDGSVYKLHPHFKERFHKLVWEINPHCEITFIQSEEGSGRGAALISAVACKMATCILTP',
            'cigar_line': '51M14D145MD305M',
            'id': 'ENSSGRG00000021057',
            'perc_id': 73.6527,
            'perc_pos': 81.6367,
            'protein_id': 'ENSSGRP00000038751',
            'species': 'sinocyclocheilus_grahami',
            'taxon_id': 75366},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA----MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M4D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.2575,
            'perc_pos': 89.485,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSTIQILKM--PSSYNAEVDQSLMVEQILSEFRLNKEDLKEVMKRMQLEMDRGLRLETHKEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKNEMYSISEDAMTGTAEMLFDYIAECISDFLGKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDEFSLNPGQQLYEKLISGKYMGELVRLVLIKLVNQDLLFNGDASDLLKTRGGFETRYVSQVESDSGDRKQIYNILSTLGLLPSELDCDIVHLVCESVSTRSAHMCAAGLAAVINVMRERRSQEALKITVGVDGSVYKLHPCFQNRCHEVVRELTPHCDITFIESEEGSGRGAALISAVACKMAACMITQ',
            'cigar_line': '12M2D464M',
            'id': 'ENSGMOG00000007309',
            'perc_id': 78.5714,
            'perc_pos': 87.605,
            'protein_id': 'ENSGMOP00000007811',
            'species': 'gadus_morhua',
            'taxon_id': 8049},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.6137,
            'perc_pos': 88.6266,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSAHSDQMGMI--PAGFGSVVDRILQVEQILSEFKLNTEDLSQVMKRMQREMERGLRLDTHEEASVKMLPTYVCSTPKGSEVGDFLALDLGGTNFRVMLVKVGEDEEGSWKVETQKQMYSIPEDAMTGTAQMLFDYIAECMSHFLDHHHMKHKKLPLGFTFSFPVRHEDIDKGILINWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNVCYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVADEASINPGHQLYEKLISGKYMGELVRLVLMKLVNENLLFNGEASELLKTRGSFDTRFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVHLVCESVSTRAAHMCGAGLAGVINSMRVRRNQEALVITVGVDGSVYKLHPCFRDRFHKIVRDLTPRCEITFLQSEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '14M2D464M',
            'id': 'ENSTNIG00000015932',
            'perc_id': 77.6151,
            'perc_pos': 86.4017,
            'protein_id': 'ENSTNIP00000019018',
            'species': 'tetraodon_nigroviridis',
            'taxon_id': 99883},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '---MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '3D2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.8283,
            'perc_pos': 89.485,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MDKMPCITSQLDQMMKL--PGSYSDVVEKICMVEQILSEFRLNKEELEEVMKRMQHEMNRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDSGELEDFRLEYDRVVDETSINPGHQLYEKIISGKYMGELARLVMMKLVNENLLFNGEASEQLKTRGGFETRFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINQMQERRGQDTMKITVGVDGSVYKLHPYFRDRFHQVVRELTPHSEITFLQSEEGSGRGAALISAVACKMASWI---',
            'cigar_line': '17M2D461M3D',
            'id': 'ENSPMEG00000003262',
            'perc_id': 77.8243,
            'perc_pos': 87.2385,
            'protein_id': 'ENSPMEP00000002213',
            'species': 'poecilia_mexicana',
            'taxon_id': 48701},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.1159,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCLTSARRQ--RM--PSDFESVLERILMVDQILSEFLLSKEDLEEVMRRIRREMERGLRVETHDEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDAMTGTAEMLFDYIASCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRKVELVEGEEGKMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGRQLYEKLIGGKYMGELVRLVLLKLVNENLLFNGEASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSSLGILPSELDCDIVRLVCESVSTRAAHMCGAGLAGVINLMRERRCQEELKITVGVDGSVYKLHPHFKERFHKLVWEMTPHCEITFIQSEEGSGRGAALISAVACKMAACMLTP',
            'cigar_line': '10M2D2M2D464M',
            'id': 'ENSSANG00000030574',
            'perc_id': 79.4118,
            'perc_pos': 88.0252,
            'protein_id': 'ENSSANP00000061360',
            'species': 'sinocyclocheilus_anshuiensis',
            'taxon_id': 1608454},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.9013,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLCVSTYREQPLAM--PCTYKSVLEKVLMVDQILSEFLLKKEELREVMGRMQQEMERGLRLETHNEASIKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEKGWKVETKYYMYSIPEDAMTGTAEMLFDYIAECISDFLDKHQIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGANGELEEFRLEYDRVVDETSLYPGQQLYEKLISGKYMGELVRLVLLKLVNEDLLFNGEASDLLKTRGSFETRFVSQIESDLGDRKQIFNILSTLGVLPSELDCDIVRLACERVSTRAAHMCGAGLAGVINRMRERRSQEALKITVGVDGSVYKLHPRFQERFHKIVRELTPNCDITFIQSEEGSGRGAALISAVACKMAACILTH',
            'cigar_line': '14M2D464M',
            'id': 'ENSCHAG00000012544',
            'perc_id': 78.8703,
            'perc_pos': 87.6569,
            'protein_id': 'ENSCHAP00000025969',
            'species': 'clupea_harengus',
            'taxon_id': 7950},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPS-----FKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD403M5D42MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.9013,
            'perc_pos': 89.2704,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCLTLARTQ--RI--PSDFESVLERIIMVEQILSEFLLSKEDLEEVMRRMRREMERGLRVETHNEASIKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKHHMYSIPEDTMTGTAEMLFDYIAGCISDFLDKHNLKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHSCEVGMIVGTGCNACYMEEMRKVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVIDETSLNPGHQLYEKLIGGKYMGELVRLVLLKLVNENLLFNGDASDLLKTRGAFETRFVSQIESDTGDRKQIYNILSTLGILPSELDCDIVRLVCKSVSTRAAHMCGAGLAGVINLMRERRCQEQLKITVGVDGSVYKLHPQKQRWSFKERFHKLVWEMNPDCEITFIQSEEGSGRGAALISAVACKMAACMLTP',
            'cigar_line': '10M2D2M2D469M',
            'id': 'ENSCCRG00015023495',
            'perc_id': 78.3784,
            'perc_pos': 86.4865,
            'protein_id': 'ENSCCRP00015057470',
            'species': 'cyprinus_carpio_huanghe',
            'taxon_id': 7962},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '---MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '3D2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 78.7554,
            'perc_pos': 89.2704,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MDKMPCISSQLDQMMKL--SGSYSDVVEKICMVEQILSEFRLNKEELEEVTKRMQHEMNRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMVSCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDMGELEDFRLEYDRVVDETSINPGHQLYEKIISGKYMGELARLVMMKLVNENLLFNGKASEQLKTRGSFETRFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINQMQERRGQDTLKITVGVDGSVYKLHPYFRDRFHQVVRELTPHSEITFLQSEEGSGRGAALISAVACKMASWI---',
            'cigar_line': '17M2D461M3D',
            'id': 'ENSXMAG00000010091',
            'perc_id': 76.7782,
            'perc_pos': 87.0293,
            'protein_id': 'ENSXMAP00000029354',
            'species': 'xiphophorus_maculatus',
            'taxon_id': 8083},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '461MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.3991,
            'perc_pos': 86.9099,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--------------------------NKEELKEVMKRMQHEMDRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSWKVETTNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDIEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDESSINPGQQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVHLVCESVSTRSAHMCGAGLAGVINRMRERRCEESLKITVGVDGSVYKLHPCFRDRFHKVVRDLTPHCDITFIQSEEGSGRGAALISAVACKMAAYMLTQ',
            'cigar_line': '26D441M',
            'id': 'ENSAPEG00000016306',
            'perc_id': 83.9002,
            'perc_pos': 91.8367,
            'protein_id': 'ENSAPEP00000022922',
            'species': 'amphiprion_percula',
            'taxon_id': 161767},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.1845,
            'perc_pos': 89.0558,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCISSHLDQLVKL--PASYSDVIEKICTVEHILSEFRLNKEELEEVMKRMQHEMNRGLRLESHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGEFEMDVVAMVNDTVATMVSCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDRGELEEFRLEYDRVVDEASINPGHQLYEKVISGKYMGELVRLVLMKLVNENLLFNGEASEQLMTRGSFETCFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINLMRERRGQDTLKITVGVDGSVYKLHPYFRDRFHQVVRELTPHSEITFLQSEEGSGRGAALISAVACKMASCI---',
            'cigar_line': '14M2D461M3D',
            'id': 'ENSFHEG00000006791',
            'perc_id': 77.6842,
            'perc_pos': 87.3684,
            'protein_id': 'ENSFHEP00000005798',
            'species': 'fundulus_heteroclitus',
            'taxon_id': 8078},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MDVTRSQA--QTALTL-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M2D8M2D6MD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.1159,
            'perc_pos': 89.2704,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--MMDKASRM--FK-----FDVEQILSEFRLNKEELKEVMKRMQREMDRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSWKVETTNQMYSIPEDAMTGTAQMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDESSINPGQQLYEKLISGKYMGELVRLVLMKLVNENLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVHLVCESVSTRSAQMCGAGLAGVINRMRERRCEECLKITVGVDGSVYKLHPCFRDKFHKVVWELTPHCEATFIMSEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '2D8M2D2M5D453M',
            'id': 'ENSSPAG00000008318',
            'perc_id': 81.6415,
            'perc_pos': 89.8488,
            'protein_id': 'ENSSPAP00000010945',
            'species': 'stegastes_partitus',
            'taxon_id': 144197},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.8283,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSAHLDQMVKM--PSSYDSVVDKVIAVDQILSEFRLNKEDLKEIMKRMQCEMERGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEDFRLEYDRVVDEASINPGHQLYEKLISGKYMGELVRLVMMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCAAGLAGVINLMRERRSEEAMKITVGIDGSVYKLHPCFRDRFHKVVRDLTPHSDITFIQSEEGSGRGAALISAVACKMATNLFTD',
            'cigar_line': '14M2D464M',
            'id': 'ENSOABG00000010617',
            'perc_id': 77.8243,
            'perc_pos': 87.6569,
            'protein_id': 'ENSOABP00000022176',
            'species': 'oreochromis_aureus',
            'taxon_id': 47969},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.2575,
            'perc_pos': 88.8412,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCPRSCHNQKMRL--TRRRGSLVEQVLMVDQILSEFRLEKTELEDVMWRLQREMDRGLRSETHKEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEETGWKLETKHQMYSIPEDAMTGTAEMLFDYIAECISDFLAKHQLKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYENRNCEVGMIVGTGCNACYMEEMSMVELVEGDEGRMCVNTEWGAFGDNGELEEYRLEYDRKVDETSLNPGRQLFEKIISGKYMGELVRLVLLKLVNEDLLFHGEASEKLRTRGSFETRFVSQIESDSGDRKQIYNVLTMLGLMPSELDCDIVRLACERVSTRSAHMCGAGLAGIINRMRERRCQEALEITVGVDGSVYKLHPSFQEKFHAVVRELTPGCDITFIHSEEGSGRGAALVSAVACKMAASR---',
            'cigar_line': '14M2D461M3D',
            'id': 'ENSSFOG00015012730',
            'perc_id': 78.7368,
            'perc_pos': 87.1579,
            'protein_id': 'ENSSFOP00015066748',
            'species': 'scleropages_formosus',
            'taxon_id': 113540},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTR------SQA---QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D5M6D3M3D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 78.97,
            'perc_pos': 89.2704,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'LPCPTQKLESWEKCLFVLFL--IGS-VLLRL-QVEQILSEFRLNKEELEEVTKRMQHEMNRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMVSCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDMGELEDFRLEYDRVVDETSINPGHQLYEKIISGKYMGELARLVMMKLVNENLLFNGEASEQLKTRGSFETRFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINQMQERRGQDTLKITVGVDGSVYKLHPYFRDRFHQVVRELTPHSEITFLQSEEGSGRGAALISAVACKMASWI---',
            'cigar_line': '20M2D3MD5MD449M3D',
            'id': 'ENSXCOG00000009335',
            'perc_id': 77.1488,
            'perc_pos': 87.2117,
            'protein_id': 'ENSXCOP00000012352',
            'species': 'xiphophorus_couchianus',
            'taxon_id': 32473},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA---------MDVTRSQA----QTALT--L----VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M9D8M4D5M2DM4D445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.3305,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MVLHIHLAHRIGSHCPLCSSPHN-----GLYFRLKVEEILSEFQLNKEELKEVMKRMQREMDRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGSWKIETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGEFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDESSINPGQQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASEKLKVRGSFETHYVSQVESDSGDRKQIYKILSFLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINLMRERRRQEALKITVGVDGSVYKLHPCFRDRFHKVVRELTPHCEITFIESEEGSGRGAALISAVACKMAACMLTQ',
            'cigar_line': '23M5D458M',
            'id': 'ENSSORG00005008477',
            'perc_id': 78.7942,
            'perc_pos': 87.1102,
            'protein_id': 'ENSSORP00005016766',
            'species': 'sphaeramia_orbicularis',
            'taxon_id': 375764},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.1159,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCISSHLDQMVKM--PNGYGPLADKILMVEQILSEFRRNKEELKEVMKRMQREMERGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSWKVETTNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDIEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDNGELEEFRLEYDRVVDESSINPGHQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASEQLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVHLVCESVSTRSAHMCGAGLAGVINWMRERRCEESLKITVGVDGSVYKLHPCFRDRFHKVVRDLTPHCDITFIQSEEGSGRGAALISAVACKMAAYMLTQ',
            'cigar_line': '14M2D464M',
            'id': 'ENSAPOG00000006075',
            'perc_id': 79.0795,
            'perc_pos': 87.6569,
            'protein_id': 'ENSAPOP00000004456',
            'species': 'acanthochromis_polyacanthus',
            'taxon_id': 80966},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.3305,
            'perc_pos': 89.2704,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSTHLDTM-KL--PSSYKAVVKELLMVEQILSEFRLNKEELKEVMRRMQREMDRGLRLESHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGFKVETTNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDKGELEEFRLEYDRVVDEFSINPGQQLYEKLISGKYMGELVRLVLMKLVNENLLFNGEASEQLRMRGSFETRFVSQVESDTGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAQMCGAGLAGVINRMRERRCEEALKITVGVDGSVYKLHPWFRDRFHKVVWDLSPHCEITFLQSEEGSGRGAALISAVACKMAACTTAP',
            'cigar_line': '11MD2M2D464M',
            'id': 'ENSOMEG00000016412',
            'perc_id': 79.4549,
            'perc_pos': 87.2117,
            'protein_id': 'ENSOMEP00000014845',
            'species': 'oryzias_melastigma',
            'taxon_id': 30732},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA-------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M7D8M5D5MDMD450M',
            'id': 'ENSG00000106633',
            'perc_id': 82.618,
            'perc_pos': 90.9871,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'QPCRVQSRQTEKMRQ--FRRRSSIFEKILRVDQILSEFRLKKEELKEIMRRMQREMDRGLHLETHDEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDDDRGWKVETKYQMYSIPEDAMTGTAEMLFDYISECISDFLDKHNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDTGELEEFRLEYDRVVDETSLNPGQQLYEKIISGKYMGELVRLVLLKLVNENLLFNGEASDILKTRGSFETRFVSQIESDTGDRKQIYNILTTLGVLPSELDCDIVRLACEGVSTRAAHMCGAGLAGVINRMRERRSADTLKITVGVDGSVYKLHPCFQEKFHKVVRELTPRCDITFIQSEEGSGRGAALISAVACKMACMLSQ',
            'cigar_line': '15M2D463M',
            'id': 'ENSLOCG00000015175',
            'perc_id': 80.5439,
            'perc_pos': 88.7029,
            'protein_id': 'ENSLOCP00000018674',
            'species': 'lepisosteus_oculatus',
            'taxon_id': 7918},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA-MDVTRSQA---QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2MD8M3D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 72.5322,
            'perc_pos': 82.4034,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPA--------YSNSIIETFLMIEEILSKFRLNKEELKGVMKRMERELDRGLRIETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGGDEERSWKIETNNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGEFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWG------HLVTTQCVY------------RSRYEKLISGKYMGELVRLVLMKLVNEDLLFNGEAPEQLKTRGSIETRHVSQIESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCECISTRSAHMCAAGLAAVINRMRERRCLDTLQITVGIDGSVYKLHPYFSDRFHKVVRELTPHCDICFLQSEEGSGRGAALISAVASKMADVC---',
            'cigar_line': '3M8D254M6D9M12D178M3D',
            'id': 'ENSNMLG00000003322',
            'perc_id': 76.1261,
            'perc_pos': 86.4865,
            'protein_id': 'ENSNMLP00000004521',
            'species': 'neogobius_melanostomus',
            'taxon_id': 47308},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA-MDVTRSQA-----QTALT-------L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEML------FDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2MD8M5D5M7DMD107M6D338MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.6867,
            'perc_pos': 89.485,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'TKC-----I--FDHFGRTRERHNTLSVRFQVDHILSEFRLDEDDLMEVMRRLQKEMERGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERGWKVETKNGMYSIPEDAMTGTAEMFLPTLLLFDHVAECISDFLGKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKVSGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRRCEVGMIVGTGCNVCYMEEMRTVELVEGEEGRMCVNTEWGAFGDHGELEEFRLEYDRVVDETSVNSGQQLYEKLISGKYMGELVRLVLLKLVSENLLFNGEASEQLRTKGSFDTRYVSQIESDSGDRKHIYNILTTLGLLPSERDCDIVRLACESVSTRAAHMCAAGLAGVINRMRERRSQEDLKITVGVDGSVYKLHPCFQDKFHRVVRDLTPHCDITFLQSEEGSGRGAALVSAVACKMATCMLTQ',
            'cigar_line': '3M5DM2D476M',
            'id': 'ENSSFOG00015019756',
            'perc_id': 78.3333,
            'perc_pos': 86.875,
            'protein_id': 'ENSSFOP00015053268',
            'species': 'scleropages_formosus',
            'taxon_id': 113540},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 81.5451,
            'perc_pos': 90.1288,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSSDLDQMMKI--PCSYSSVVEKILMVEQILSEFRLNKEELKEIMKRMQREMDRGLCLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLAKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHSCEVGMIVGTGCNACYMEEMRTVELVEGDEGRMCVNTEWGAFGNHGELEDFRLEYDRVVDETSINPGYQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSTLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGMINLMRERRSQDFLKITVGVDGSVYKLHPCFRDRFHKIVRDLTPHCEITFIQSEEGSGRGAALISAVACKMAASMLPQ',
            'cigar_line': '14M2D464M',
            'id': 'ENSMAMG00000013140',
            'perc_id': 79.4979,
            'perc_pos': 87.8661,
            'protein_id': 'ENSMAMP00000019572',
            'species': 'mastacembelus_armatus',
            'taxon_id': 205130},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L--------------------------------VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDM32D445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.4721,
            'perc_pos': 89.6996,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCVSSHLDQAFLT--PCKYKTVLERILKVHLFSFSALETKSLNSKIPVPETSLYLRVPKVDQILSEFLLNKEELRDVMKRMQWEMDRGLRLETHDQASIKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEEGCWKVETKHHMYSIPEDAMTGTAEMLFDYIAECISDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGANGELEEFRLEYDRVVDETSLNPGEQLYEKLISGKYMGELVRLVLMKLVNEDLLFNGEASDQLKTRGSFETRFVSQIESDTGDRKQIYNILSTLGVLPSELDCDVVRLACESVSTRAAHMCGAGLAGVINRMRDHRRQEALKITVGIDGSVYKLHPRFQERFHKVVRELTPHCDITFIQSEEGSGRGAALISAVACKMAAVMYP-',
            'cigar_line': '14M2D494MD',
            'id': 'ENSDCDG00000028620',
            'perc_id': 73.8189,
            'perc_pos': 82.2835,
            'protein_id': 'ENSDCDP00000045856',
            'species': 'denticeps_clupeoides',
            'taxon_id': 299321},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 79.6137,
            'perc_pos': 89.485,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCISSQLDEMMKL--PGSYSDVVEKICMVEQILSEFRLNKEELEEVMKRMQHEMNRGLRLETHEEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLVKVGEDEERSFKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGEFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDSGELEEFRLEYDRVVDETSINPGHQLYEKIISGKYMGELARLVMMKLVNENLLFNGEASEQLKTRGGFETRFVSQVESDSGDRKQIYNILSSLGVLPSELDCDIVRLVCESVSTRSAHMCGAGLAGVINQMQERRGQDTMKITVGVDGSVYKLHPYFRDRFHQVVRELTPHSEITFLQSEEGSGRGAALISAVACKMASWV---',
            'cigar_line': '14M2D461M3D',
            'id': 'ENSPLAG00000012267',
            'perc_id': 78.1053,
            'perc_pos': 87.7895,
            'protein_id': 'ENSPLAP00000025315',
            'species': 'poecilia_latipinna',
            'taxon_id': 48699},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MDVTRSQA-----QTALT-L-VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '2M6D8M5D5MDMD445MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 80.6867,
            'perc_pos': 89.9142,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MPCASSRLSQMVRS--PYGYSYTADEIYRVKQILSEFRLTKEELKEVMKRMQQQMDRGLRLETHEEASVKMLPTYVCSTPEGSEVGNFLALDLGGTNFRVMLVIVGEDEERGWKVETKNQMYSIPEDAMTGTAEMLFDYIAECMSDFLDKHHIKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRSCEVGMIVGTGCNACYMEEMRTVELVEGEEGRMCVNTEWGAFGDKGELEDFRLEYDRVVDETSINPGHQLYEKLISGKYMGELVRLVLIKLVNEELLFNGEASELLKTRGSFETRYVSQVESDTGDRKQIYNILSSLGVLPSELDCDVVRLVCESVSTRSAHMCSAGLAGVINRMRERRCQELLKITVGVDGSVYKLHPCFRDRFHKMVWDLTPHCEITFIQSEEGSGRGAALISAVACKMAS-----',
            'cigar_line': '14M2D459M5D',
            'id': 'ENSCSEG00000019959',
            'perc_id': 79.4926,
            'perc_pos': 88.5835,
            'protein_id': 'ENSCSEP00000031227',
            'species': 'cynoglossus_semilaevis',
            'taxon_id': 244447},
 'taxonomy_level': 'Euteleostomi',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MDVTRSQA---QTALT---L----VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M2D8M3D5M3DM4D450M',
            'id': 'ENSG00000106633',
            'perc_id': 61.588,
            'perc_pos': 78.5408,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--VI--DQR---PEG-----ITA-GCMQVEALLEGFALDRSVLEDVMLRLRREMEKGLHVHTNMEASVKMLPTYVRSTPDGSEVGDFLALDLGGTNIRVMVVKTGTDEVGTWKVETKVQVYSIPKDTMTGTAEMLFGFVAECIANFLEKHNMKERKLPLGFTFSFPVKHQDLDKGILMKWTKGFKASGAEGNDIVNLLREAIKKRRDIEMDIVAMVNDTVATMVSCYYEDHNCEIGLIVGTGCNTCYMEEMRNVEMVEGDEGRMCINTEWGAFGDTGELEDLWLEYDRRVDEMSLNPGKQKFEKSISGKYMGELVRLLMLKMVKQGLLFWGKASDALTTWEYFDTRHISLIESDGPELQQTSMVLKNMGMEPTEADCELTWRACNAVSTRASLLCAAGVAAVVTKIRENRGLECLSITVGVDGSLYKQLPHFKQRLRVAVSELAPECKVTFLQSEEGSGRGAALISAVACKMACRTTC',
            'cigar_line': '2D2M2D3M3D3M5D3MD454M',
            'id': 'ENSEBUG00000003343',
            'perc_id': 61.7204,
            'perc_pos': 78.7097,
            'protein_id': 'ENSEBUP00000004897',
            'species': 'eptatretus_burgeri',
            'taxon_id': 7764},
 'taxonomy_level': 'Vertebrata',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MDVTRSQAQTALT-L---VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVES--DTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M2D13MDM3D325M2D125M',
            'id': 'ENSG00000106633',
            'perc_id': 62.0172,
            'perc_pos': 76.6094,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--CV--SGR--------A-GQQVEQLLLEFVLDQQELEEVMHRMRREMERGLRLETHQEASVKMLPTYVRSTPDGSEVGDFLALDLGGTNFRVILVKVGQNEEGEWRVETKNELYCIPEDVMTGTAEMLFDYIAECIANYLDKLNMKHKKLPLGFTFSFPVKHVDLDKGILINWTKGFTATGAEGNNVVELLREAIKRRGDFDMDVVAMVNDTVATMISCYYEDHNTEIGMIVGTGCNTCYMEEMRNVDLVEGDEG-MCINMEWGAFGDSGELEDLRLEYDRKVDETSNNRGQQLFEKIISGKYMGELVRLLVMKLTNQGLLFGGKASEKLQTHFKFETKYVSQIESSDDGAEMKQTLNVLLGLGLQPTEAECRLVRRSCQAVSRRAASLCAAGMAAVVNKIRENRSLEQLEITVGVDGSVYKLHP------------------------------------------------',
            'cigar_line': '2D2M2D3M8DMD237MD169M48D',
            'id': 'ENSPMAG00000003141',
            'perc_id': 70.1456,
            'perc_pos': 86.6505,
            'protein_id': 'ENSPMAP00000003454',
            'species': 'petromyzon_marinus',
            'taxon_id': 7757},
 'taxonomy_level': 'Vertebrata',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTA---------LT-----------------L-VEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPS----------F-KERFHASVRRLTPSCEITFIE-SEEGSGRGAALVSAVACKKA----------C---MLGQ',
            'cigar_line': '13M9D2M17DMD5MD50MD348M10DMD21MD20M10DM3D4M',
            'id': 'ENSG00000106633',
            'perc_id': 49.5708,
            'perc_pos': 68.4549,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-------------ILCIASFRSF-SLPLSMQSAVHVTHCLPLQVEKYLE-PFQLSLEMLQEVSARLRKDLIRGLGKRSHHKAPVKMLPTFVRATPDGTEK-GDFLALDLGGTNFRVLHVRV-EEE-EQRVLKMNSQICAIPKEIMLGTGEQLFDHIAACLGEFLESQKLKGQTLPLGFTFSFPCEQLGIDKSILIRWTKGFNCSGVEGKDVVKLLKEAIHRRGDYDIGTVAMVNDTVGTMMSCGYRDQNCEIGMIVGTGTNACYMEEMKHVKRVEGEDGRMCINTEWGGFGDDGSLNDIVTEFDVEVDKTSINPGIHIFEKMISGMYLGEIVRLVLVKMTKDQLLFKGQMSEALRTPEQFETKLISEIED--GLD-NTKKILTTLGLDWEPVDACVVRLVCDTISSRSARLCAAALATLTNRIRTNRKLDHLKTTVGVDGTVYRKSLNTSLSRLPFSSFSI-ELQKAVCLLAPRCDITFL-VSEDGSGKGAAMVTAVCACFLIPAFILATFP-ISV----',
            'cigar_line': '13D10MD25MD50MD20MD3MD244M2D3MD85MD18MD31MD3M4D',
            'id': 'ENSACIG00000019359',
            'perc_id': 46.9512,
            'perc_pos': 64.8374,
            'protein_id': 'ENSACIP00000025420',
            'species': 'amphilophus_citrinellus',
            'taxon_id': 61819},
 'taxonomy_level': 'Vertebrata',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '----MA--MDVTRSQA------------QTA---------LT--L-VEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVES-DTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSF-KERFHASVRRLTPSCEITFIE-SEEGSGRGAALVSAVACKKA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------C-----------------ML----------------------------------------------GQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------',
            'cigar_line': '4D2M2D8M12D3M9D2M2DMD5MD50MD270MD79MD21MD20M218DM17D2M46D2M175D',
            'id': 'ENSG00000106633',
            'perc_id': 52.7897,
            'perc_pos': 72.5322,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'YNASF-II---SF---FFLYLLYNSFID---TRCSVSICVR-LHLQVETYLE-PFRLSLDKLQEVSARLEKELIRGLGKHTHHRASVKMLPTFVRATPDGTEK-GDFLALDLGGTNFRVLHVRV-VEE-EQKMLKVDSEICAIPQEIMQGTGEQLFNHIATCLSEFLDSQNLKGQTLPLGFTFSFPCEQKEIDKSILIRWTKGFKCSGVEGKDVVKLLKEAIQRRGDYEIGSVAMVNDTVGTMMSCGYRDQSCEIGMIIGTGTNACYMEEMKNVKRVEGEDGQMCINTEWGGFGDDGSLKDILTGFDSVVDEKSINPGVHIFEKMISGMYLGEIVRLVLVRLTEDKLLFNGQTSEALLTQGKFETRFISEIEHQDSGLE-NTQRILTSLGLDWNEVDARVVLLVCDTISSRSARLCAAALATIANRIRVNRGLDHLKTTVGVDGTVYKKHPNFSE-ELQAAVRLLAPECDITFL-VSEDGSGKGAAMVTAVAQRLALQSRLHLQVDKCLEPFRLSRVKLQEVSARLENDLIRGLGTHTHHSAPVKMLPTFVRATPDGTDKGDFLAVDLGGTNLRVLHIRLDGSTQVQIMSQKESAVPEAIMEGTGEELFKFIADCLSDLNLKGRTLPLGFCFSFPCEQKGIDESILISWSKGFKCSGVVGEDVAELLRKAIKDREDYKIGFVAMANDTVGTMMSCGYTDPPCEIGMIIGTGTNACYMEEMKNVERVEGEDGRMCINTEWGGFGDDGSLKDILTGFDSVVDEKSINPGVHIFEKMISGMYLGEIVRLVLVRLTEDKLLFKGQTSEALLTQGKFETRFISEIEHQDSGLENARRILTSLGLDWNEVDARVVLLVCETISSRSACLCAAALATIANHIRVNRGLDHLKTTVGVDGAVYRMHPNFSKKLKDEVPHLAPKCDIKFMVSQDSSGVGAAMVARTGGAWNIILLINIILCTWLPL',
            'cigar_line': '5MD2M3D2M3D12M3D10MD10MD50MD20MD3MD250MD75MD18MD482M',
            'id': 'ENSPRNG00000017241',
            'perc_id': 26.1981,
            'perc_pos': 35.9957,
            'protein_id': 'ENSPRNP00000046755',
            'species': 'parambassis_ranga',
            'taxon_id': 210632},
 'taxonomy_level': 'Vertebrata',
 'type': 'ortholog_one2one'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_PARALOGUES',
 'source': {'align_seq': 'MA--MDVTR----S----QA----QTALT----------LVEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLG--GTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDK-HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYY-EDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSF-KERFHASVRRLTPSCEITFIE-SEEGSGRGAALVSAVACKKA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------C-----------------ML----------------------------------------------GQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------',
            'cigar_line': '2M2D5M4DM4D2M4D5M10D6MD50MD10M2D56MD79MD127MD77MD21MD20M213DM17D2M46D2M165D',
            'id': 'ENSG00000106633',
            'perc_id': 41.6309,
            'perc_pos': 62.6609,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MDSI-----GSSGLRQGEETLSCSE--E-GLPGPSDSSELVQECLQ-QFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQ-GDFVVLELGATGASLRVLWVTL-TGIEGH-RVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQ-PVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRP-CEVGLVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAA-RVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCS-VLQGTVMLLAPECDVSLI-PSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRLAQLTRV',
            'cigar_line': '4M5D16M2DMD17MD50MD22MD6MD38MD82MD127MD75MD18MD467M',
            'id': 'ENSG00000160883',
            'perc_id': 21.0184,
            'perc_pos': 31.636,
            'protein_id': 'ENSP00000292432',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'taxonomy_level': 'Vertebrata',
 'type': 'within_species_paralog'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_PARALOGUES',
 'source': {'align_seq': '----------MA--MDVTRS-QA---QTALTL--VEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSF-KERFHASVRRLTPSCEITFIE-SEEGSGRGAALVSAVACKKA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------C-----------------ML----------------------------------------------GQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------',
            'cigar_line': '10D2M2D6MD2M3D6M2D5MD50MD272MD77MD21MD20M220DM17D2M46D2M165D',
            'id': 'ENSG00000106633',
            'perc_id': 48.7124,
            'perc_pos': 70.6009,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MGQICQRESAT-AA---EKPK-LHLLA--E--SEIDKYLY-AMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEK-GDFIALDLGGSSFRILRVQV-NHEKNQ-NVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLH-NAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSR-RFHKTLRRLVPDSDVRFL-LSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS',
            'cigar_line': '11MD2M3D4MD5M2DM2D8MD50MD20MD6MD247MD75MD18MD474M',
            'id': 'ENSG00000156515',
            'perc_id': 24.6471,
            'perc_pos': 35.722,
            'protein_id': 'ENSP00000494664',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'taxonomy_level': 'Vertebrata',
 'type': 'within_species_paralog'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_PARALOGUES',
 'source': {'align_seq': 'MA--MDVTRS-QA---QTALT-----L--VEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSF-KERFHASVRRLTPSCEITFIE-SEEGSGRGAALVSAVACKKA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------C-----------------ML----------------------------------------------GQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------',
            'cigar_line': '2M2D6MD2M3D5M5DM2D5MD50MD272MD77MD21MD20M220DM17D2M46D2M165D',
            'id': 'ENSG00000106633',
            'perc_id': 53.4335,
            'perc_pos': 74.2489,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'M-IA---SHLL-AYFFT--E-LNHDQVQKVDQYLY-HMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEH-GEFLALDLGGTNFRVLWVKV-TDNGLQ-KVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIR-KAREVLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAK-RLHKTVRRLVPGCDVRFL-RSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQR',
            'cigar_line': 'MD2M3D4MD5M2DMD14MD50MD20MD6MD247MD75MD18MD474M',
            'id': 'ENSG00000159399',
            'perc_id': 27.1538,
            'perc_pos': 37.7317,
            'protein_id': 'ENSP00000290573',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'taxonomy_level': 'Vertebrata',
 'type': 'within_species_paralog'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_PARALOGUES',
 'source': {'align_seq': 'MA--MDVTRS-QA---QTALT-----L--VEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSF-KERFHASVRRLTPSCEITFIE-SEEGSGRGAALVSAVACKKA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------C-----------------ML----------------------------------------------GQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------',
            'cigar_line': '2M2D6MD2M3D5M5DM2D5MD50MD272MD77MD21MD20M219DM17D2M46D2M166D',
            'id': 'ENSG00000106633',
            'perc_id': 48.4979,
            'perc_pos': 69.0987,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'M-FA---VHLM-AFYFS--K-LKEDQIKKVDRFLY-HMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSEN-GEFLSLDLGGSKFRVLKVQV-AEEGKR-HVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLA-NTREILVDLGLEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPK-RLHKVVRKLVPSCDVRFL-LSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIWTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQQAQKEN',
            'cigar_line': 'MD2M3D4MD5M2DMD14MD50MD20MD6MD247MD75MD18MD474M',
            'id': 'ENSG00000156510',
            'perc_id': 24.6456,
            'perc_pos': 35.1145,
            'protein_id': 'ENSP00000346643',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'taxonomy_level': 'Vertebrata',
 'type': 'within_species_paralog'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTA-LT---L-VEQIL-AEFQLQEE--DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYS-IPEDAMTGTAEMLFDYISECISDFLDK-HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFE--MDVVAMVNDTVATMISCYY-EDHQCEVGMIVGTGCNACYMEEMQNV-ELV-EGDEGR----MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQV--ESDT-GDRKQIYNILSTLGLR-PSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVM-RITVGVDGSVYKLHPS-F-KERFHASVRRLTPS-CEITFIE-SEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': '13MD2M3DMD5MD8M2D42MD39MD27MD60M2D19MD26MD3MD6M4D88M2D4MD16MD44MD16MDMD14MD7MD20MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 30.6867,
            'perc_pos': 53.8627,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-------------MKVLPP-EVEEILA-KFRLN--REQLQEISEKVEQQMKMGLAK--TQGSSIAMLPSYVPALPDGTET-GKYVAIDLSGKNLRIMLLTM-NGAG---TTPTHETVNYIVANHVMKGTGDQLFTFIVNCLQRFLQEF-GLVDANLPIGFVFSYPCELLSIRSARLLWWTKGFDIKDCLQRDIVALLEEALEM--NMSTKVSIKAVMNDTVGQLAAAAHKYGPECTIGVVIGYGCNSSYLEKTSRITKFDAKA-RGYDHDNMIVVTEWEEFGKHGELDDILTQFDREVDAASVHKGKQLIDKLCGALYIGEVVRRVLSQLVLDRVLFEGQSCEKLDEDESFPTKYISEILGEE--EGVFKACRRICEELEVEMHGTGDYIIIREVCDVISRRGASIVAAAISALLRHLE-------LSSVKIGVGGALIQFHP-TYHQ-MLKEKLEELTPITMKFELV-PADEGSCQGAALIAAVAERLKL-----',
            'cigar_line': '13D6MD7MD5M2D21M2D22MD20MD4M3D39MD54M2D58MD99M2D54M7D17MD4MD19MD22M5D',
            'id': 'WBGene00022306',
            'perc_id': 31.7073,
            'perc_pos': 55.6541,
            'protein_id': 'Y77E11A.1a.2',
            'species': 'caenorhabditis_elegans',
            'taxon_id': 6239},
 'taxonomy_level': 'Bilateria',
 'type': 'ortholog_one2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQA-QTALT---------L---VEQIL-AEFQLQEEDLK-KVMRRMQKEMDRGLRL-ET-HE---EASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTG---TAEMLFDYISECISDFLDK-H--QMK-----HKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG---DFEMDVVAMVNDTVATMISCYY------EDHQCEVGM-IV----GTGCNACYMEEMQNV-----ELV---EGDEGR--MCVNTEWGAFGDSGELDE-FLLEYDRLVDES-SANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEA----SE-QLRTRGAFETRFVSQVE-SDT-GDRKQIYNILSTLGLR-PST-TDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVM------RITVGVDGSVYKLHPS-FKERFHASVR---RLTPSCEITFIESEEGS-G-RGAALVSAVACKKACMLGQ---------------',
            'cigar_line': '10MD5M9DM3D5MD11MD16MD2MD2M3D19MD47M3D19MDM2D3M5D53M3D22M6D9MD2M4D15M5D3M3D6M2D18MD12MD40M4D2MD17MD3MD16MD3MD41M6D16MD10M3D17MDMD19M15D',
            'id': 'ENSG00000106633',
            'perc_id': 31.1159,
            'perc_pos': 51.073,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'M--------SF---E-NLHKVNAEALEDAVVEICS-SLQVDAAKL-DELTAYFIECMEKGLNNTSVGEEKTVDKGLPMIPTYVTSLPNGTER-GVLLAADLGGTHFRVCSVTL-NGDG---TFDMQQLKSKIPEEYLNDKDVTSEELFSYLGRRTRAFVRKHHPELLKSTGENIKPLKMGFTFSYPVDQTSLSSGTLIRWTKSFKIEDTVGKDVVRLYQEQLDIQGLSM---INVVALTNDTVGTFLSHCYTSGSRPS-SAGEISEPVIGCIFGTGTNGCYMEDIENIKKLPDEL-RTRLLHEGKTQMCINIEWGSFDNE--LKHLSATKYDIDIDQKFSPNPGYHLFEKRISGMYLGELLRNILVDLHARGLILGQYRNYDQLPHRLKTPFQLCSEVLSRIEIDDSTNLRETELSFLQS--LRLPTTFEERKAIQNLVRSITRRSAYLAAVPIAAIL--IKTNA----LNKRYHGEVEIGFDGYVIEYYP-GF----RSMLRHALALSPI----------GTEGERKIHL------RLA-----KDGSGVGAALCALVA',
            'cigar_line': 'M8D2M3DMD19MD9MD46MD20MD4M3D108M3D26MD36MD24M2D98M2D36M2D5M4D22MD2M4D13M10D10M6D3M5D15M',
            'id': 'YDR516C',
            'perc_id': 29,
            'perc_pos': 47.6,
            'protein_id': 'YDR516C',
            'species': 'saccharomyces_cerevisiae',
            'taxon_id': 4932},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQA-QTALT---------L---VEQIL-AEFQLQEEDLK-KVMRRMQKEMDRGLRL-ET-HE---EASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTG---TAEMLFDYISECISDFLDK-H--QMK-----HKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG---DFEMDVVAMVNDTVATMISCYY------EDHQCEVGM-IV----GTGCNACYMEEMQNV-----ELV---EGDEGR--MCVNTEWGAFGDSGELDE-FLLEYDRLVDES-SANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEA----SE-QLRTRGAFETRFVSQVE-SDT-GDRKQIYNILSTLGLR-PST-TDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVM------RITVGVDGSVYKLHPS-FKERFHASVR---RLTPSCEITFIESEEGS-G-RGAALVSAVACKKACMLGQ---------------',
            'cigar_line': '10MD5M9DM3D5MD11MD16MD2MD2M3D19MD47M3D19MDM2D3M5D53M3D22M6D9MD2M4D15M5D3M3D6M2D18MD12MD40M4D2MD17MD3MD16MD3MD41M6D16MD10M3D17MDMD19M15D',
            'id': 'ENSG00000106633',
            'perc_id': 30.4721,
            'perc_pos': 53.0043,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'M--------SF---D-DLHKATERAVIQAVDQICD-DFEVTPEKL-DELTAYFIEQMEKGLAPPKEGHTLASDKGLPMIPAFVTGSPNGTER-GVLLAADLGGTNFRICSVNL-HGDH---TFSMEQMKSKIPDDLLDDENVTSDDLFGFLARRTLAFMKKYHPDEL-AKGKDAKPMKLGFTFSYPVDQTSLNSGTLIRWTKGFRIADTVGKDVVQLYQEQLSAQGMPM---IKVVALTNDTVGTYLSHCYTSDNTDSMTSGEISEPVIGCIFGTGTNGCYMEEINKITKLPQEL-RDKLIKEGKTHMIINVEWGSFDNE--LKHLPTTKYDVVIDQKLSTNPGFHLFEKRVSGMFLGEVLRNILVDLHSQGLLLQQYRSKEQLPRHLTTPFQLSSEVLSHIEIDDSTGLRETELSLLQS--LRLPTTPTERVQIQKLVRAISRRSAYLAAVPLAAIL--IKTNA----LNKRYHGEVEIGCDGSVVEYYP-GF----RSMLRHALALSPL----------GAEGERKVHL------KIA-----KDGSGVGAALCALVA',
            'cigar_line': 'M8D2M3DMD19MD9MD46MD20MD4M3D46MD61M3D63MD24M2D98M2D36M2D5M4D22MD2M4D13M10D10M6D3M5D15M',
            'id': 'YCL040W',
            'perc_id': 28.4,
            'perc_pos': 49.4,
            'protein_id': 'YCL040W',
            'species': 'saccharomyces_cerevisiae',
            'taxon_id': 4932},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-------MA------------MDVTR-SQAQTALT----------------LVEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR----MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GDRKQIYNILSTLGLR-PSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK-ERFHASVR-RLTPSCEITFIE-SEEGSGRGAALVSAVACKKA-CMLGQ---',
            'cigar_line': '7D2M12D5MD8M16D6MD50MD180M4D92MD16MD62MD8MD12MD20MD5M3D',
            'id': 'ENSG00000106633',
            'perc_id': 40.5579,
            'perc_pos': 62.4464,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MRKSTRLLTHSLFGPVFKILF----HN------KTVCGGCNRKMPSLVNTE-IEAAVK-GFLIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKER-GKYLALDLGGSNFRVLLVNL-ISNS---DVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLALGFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLMSCAFYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTSYDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISDVESDAPGEYRNCNKVLSELGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNINE------VAIGIDGSVYRFHPKY-HDMLQYHMKKLLKPGVKFELV-VSEDGSGRGAALVAATAVQA-K-----SKL',
            'cigar_line': '21M4D2M6D18MD6MD50MD20MD4M3D304M6D16MD21MD20MDM5D3M',
            'id': 'FBgn0042710',
            'perc_id': 38.8889,
            'perc_pos': 59.8765,
            'protein_id': 'FBpp0084383',
            'species': 'drosophila_melanogaster',
            'taxon_id': 7227},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': '-MA--MDVTRSQAQTALTLVEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR----MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEA------SEQLRTRGAFETRFVSQVESDT-GDRKQIYNILSTL-GLR-PSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK-ERFHASVR-RLTPSCEITFIE-SEEGSGRGAALVSAVACKKA-CMLGQ',
            'cigar_line': 'D2M2D19MD50MD180M4D70M6D22MD13MD3MD62MD8MD12MD20MD5M',
            'id': 'ENSG00000106633',
            'perc_id': 42.7039,
            'perc_pos': 61.588,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MLDAE--------------VRELMQ-PFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEM-GKYLALDLGGTNFRVLLVSL-KGHH---DATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSCAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFETRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRTSNRR------VIVGMDGSVYRYHPKF-DAYMRQTLQKLVKADKEWDIM-LSEDGSGRGAALVAAVASKT-K-----',
            'cigar_line': '5M14D6MD50MD20MD4M3D311M6D16MD21MD20MDM5D',
            'id': 'FBgn0001187',
            'perc_id': 43.8326,
            'perc_pos': 63.2159,
            'protein_id': 'FBpp0086530',
            'species': 'drosophila_melanogaster',
            'taxon_id': 7227},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA----------------MD-VTR-----S------------QA---------QTA---LT--------------------------L---------VEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR---MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GDRKQIYNILSTLGLR-PSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK-ERFHASVR-RLTPSCEITFIE-SEEGSGRGAALVSAVACKKA---CMLGQ----',
            'cigar_line': '2M16D2MD3M5DM12D2M9D3M3D2M26DM9D5MD50MD180M3D92MD16MD62MD8MD12MD20M3D5M4D',
            'id': 'ENSG00000106633',
            'perc_id': 45.4936,
            'perc_pos': 65.6652,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'MDRELNGAMKSVSINSAQ--LNGHNNGGGLDETDRVGVAQGA-ALSATEKITTTTAAATKSATATTNATTATATTTNLTTHSPQQIALLSAAEKSKMVHELCQ-QLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNER-GKFLALDLGGTNFRVLLIHL-QENN---DFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINKMDEPT------VTVGVDGSVYRFHPKF-HNLMVEKISQLIKPGITFDLM-LSEDGSGRGAALVAAVACRE-DIL-----NGKK',
            'cigar_line': '18M2D22MD60MD50MD20MD4M3D303M6D16MD21MD20MD3M5D4M',
            'id': 'FBgn0001186',
            'perc_id': 39.1867,
            'perc_pos': 56.5619,
            'protein_id': 'FBpp0071296',
            'species': 'drosophila_melanogaster',
            'taxon_id': 7227},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQA----QTA-LT-----L--VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLET-HEEASVKMLP---TYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKR-RGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR--MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GDRKQIYNILSTL----GLRPST-TDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVM-RITVGVDGSVYKLHPS-F-KERFHASVR--RLTPSCEITFIE-SEEGSGRGAALVSAVAC---KKA---CMLGQ------',
            'cigar_line': '10M4D3MD2M5DM2D34MD10M3D11MD121MD59M2D92MD13M4D6MD41MD16MDMD9M2D12MD17M3D3M3D5M6D',
            'id': 'ENSG00000106633',
            'perc_id': 29.8283,
            'perc_pos': 52.7897,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-------M-ANTFN---PE-EDFPEVYKVCK---LFNPSIDDLEKIKNAMDREITMGLSR--D--HHDRSTVPCHLSYVQDLPTGRER-GQFLALEMMPTNCRIMLVKF-SSER---DIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVDKDNLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFP-EISVDVMGIINVGAGSLLALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWAHFGDTGQLDFIRNEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDYIGIQWKLDMVSLIEIVSDPPGVYTKAQEVMDKFRIRH-CK---ERDLAALKYICDTVTNRAAMLVASGVSCLIDRMR-------LPQISIAVDGGIYRLHP-TFST-VLNKYTRLL-ADPNYNFEFV-ITQDSCGVGAAIMAGMAHANKYKTDAK-----LFTMDY',
            'cigar_line': '7DMD5M3D2MD11M3D26M2DM2D23MD20MD4M3D94MD169MD2M3D34M7D17MD4MD9MD10MD27M5D6M',
            'id': 'FBgn0042711',
            'perc_id': 29.8925,
            'perc_pos': 52.9032,
            'protein_id': 'FBpp0084382',
            'species': 'drosophila_melanogaster',
            'taxon_id': 7227},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQAQTALTLVE-Q-IL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEE--GQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDK-HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG--------------------DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVG-----------TGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVES--DTGDRKQIYNILSTL--G-LRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESR-SEDVMRITVGVDGSVYKLHPSF-KERFHASVRRLTPS--CEITFIE-SEEGSGRGAALVSAVACKKA----CMLGQ-',
            'cigar_line': '18MDMD2MD50MD26M2D40MD57M20D34M11D113M2D15M2DMD41MD22MD14M2D7MD20M4D5MD',
            'id': 'ENSG00000106633',
            'perc_id': 48.927,
            'perc_pos': 68.8841,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '------------------IKLTLD-DLHLSNEQLTKIMKKMIKEMHKGLGKDTHDDATVKMIPSYVKSLPDGTER-GSFLALDLGGTNFRVLLVKIKEGDKLDGKPKIEMDSQIYRMPEDVIVGEGEKLFDHIAMCMADFLKRL-DLLDQRLPVGFTFSFPCQQDGLDQATLITWTKGFSAPGVVGKNIVKMLKDAIDRRGVSLELTSCLTIYGQTFKMMHDMDVDIIAVVNDTVGTMTSCAFDDQECMVGLIVGNNLVYLTTFLCTGSNACYMEKMSNIERVDSDKGEMCVNMEWGAFGDDGALSEYRNEYDAHVDENSLNCGKQLYEKMISGMYMGEIVRLVLVKLTDDGLLFGGKGSDALRTRGSFQTSYVSQIESAIPSGMT-AVQNILATLDIGAMR---HDCEIVIQVCRAVSRRAAHLCAAGQWSVVVSI-ALHPEQEVLRMTCGVDGTVYKKHPTFSD-IMSEKVNELCAGADVAVNFA-LSYDGSGKGAALITAVAQRA-INAE-----Q',
            'cigar_line': '18D6MD50MD68MD241MD15M3D32MD28MD20MD20MD4M5DM',
            'id': 'ENSCSAVG00000000629',
            'perc_id': 47.0103,
            'perc_pos': 66.1856,
            'protein_id': 'ENSCSAVP00000001127',
            'species': 'ciona_savignyi',
            'taxon_id': 51511},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA------MD-VTRSQA-QTALT---L--VEQIL--AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGE---EGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR--MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQV-ESDT----GDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDV-MRITVGVDGSVYKLHPSF-KERFHASVRRLTPS--CEITFIE-SEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M6D2MD6MD5M3DM2D5M2D50MD25M3D155M2D88MD4M4D59MD18MD14M2D7MD25M',
            'id': 'ENSG00000106633',
            'perc_id': 39.6996,
            'perc_pos': 60.9442,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'VVVIGICS--IFIKMGSY---Q-PYL-QSLKELLHV-----TDAQLTTVSDRMLQDMTYGLQLSRKSKTQMEMLPSFVDSLPDGSER-GAFIGLDLGGTNLRVLLLTL-SDPVDNGSKPVADIKSESFKVTKDLLEGTSAQLFDFIAEKMASFAHKNGLVGKKLPVGFTFSFPFDQDRINHAILKAWTKAYHIKDGVGDDVVQMLHDAIARQGDLNCEVVAVCNDTVGTLVSGVAEDQNCQIGLIVGTGTNAAYLEKVSNIESVESQGADRWMCVDMEWEYFADTGCLDQFLTEFDKQVDASSPMPGQFIFEKMISGMYMGEIVRSILCKLAKVDNLFAGNISETLATTDAFLSRYVSDITE-EAIAEHGKTEVVTKILSSVGVTPSSEDVVIVQLVCEFVSTRAAHLCAAGVSAIARKIKANHPDENDLVITAGVDGSVYAGHPTFDT-MLEDKTAQLCSAHGVKVQFI-HAKDGSGKGAALIAA-----------',
            'cigar_line': '8M2D8M3DMD3MD9M5D46MD20MD253MD86MD20MD15M11D',
            'id': 'ENSCSAVG00000004672',
            'perc_id': 39.4456,
            'perc_pos': 60.5544,
            'protein_id': 'ENSCSAVP00000007813',
            'species': 'ciona_savignyi',
            'taxon_id': 51511},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQA-QTALT---L--VEQIL--AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGE---EGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR--MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQV-ESDT----GDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDV-MRITVGVDGSVYKLHPSF-KERFHASVRRLTPS--CEITFIE-SEEGSGRGAALVSAVACKKA----CMLGQ----',
            'cigar_line': '10MD5M3DM2D5M2D50MD25M3D155M2D88MD4M4D59MD18MD14M2D7MD20M4D5M4D',
            'id': 'ENSG00000106633',
            'perc_id': 37.5536,
            'perc_pos': 60.0858,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '------KMGSF---Q-PHL-EKLKKLMHI-----NDVQLALISDRMLQDMSIGLQKSTKSNVRMEMLPSYVDSLPDGSER-GAYIGLDLGGTNLRVLLLTL-TDSIDGGAKFDATIKSESYKVPNEKLEGTSAELFDFIAANMVDFAIKNGLEEKMLPVGFTFSFPFDQDRIDHAILKQWTKAYNIKDGVGEDVVQMLRDAIARQGSLKFEVVAVCNDTVGTLVSGVSEDQNCQIGLIVGTGTNAAYLEKVSNIESVNGYKDDRFMCVDMEWEYFADTGALNHFVTEFDKQVDATSPMPGEFIFEKMISGMYLGEIVRLILCQLASVGNIFNEKCLGDLGTTGGFDSRYVSDITE-EAIAGHGETNVVKSILASVGVKASQGDVHTVQLVCEFVSIRAAHLCAAGISAVARKIKANHPEKNDLVVTAGVDGSVYAGHPTFDT-LLEDKTDELCRNHGVKVQFI-RAKDGSGKGAALIAAVLTKV-STLV-----LTTL',
            'cigar_line': '6D5M3DMD3MD9M5D46MD20MD253MD86MD20MD20MD4M5D4M',
            'id': 'ENSCING00000009548',
            'perc_id': 37.155,
            'perc_pos': 59.448,
            'protein_id': 'ENSCINP00000030113',
            'species': 'ciona_intestinalis',
            'taxon_id': 7719},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQA--QTALT-L-VEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR-GDFEMDVVA-MVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELV---EGDEGRMCVNTEWGAFGDS-GELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQV-E-S-DTGDRKQIYNILST-LGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDV--MRITVGVDGSVYKLHPSF-KERFHASVRRLTPSCEITFIE-SEEGSGRGAALVSAVACKKA----CMLGQ--',
            'cigar_line': '10M2D5MDMD5MD50MD122MD9MD43M3D19MD75MDMDMD14MD47M2D18MD21MD20M4D5M2D',
            'id': 'ENSG00000106633',
            'perc_id': 41.8455,
            'perc_pos': 61.1588,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '-------M--LN-----V-KVDHVIE-SLSLSDDHLMRLSSKMSQELVRGLHQSTNDEAEIKMLPSFVTSTPDGSEN-GEFLALDLGGTNFRIILVKI-QSG-DSPKIQMDNQVYAISNELMTGTGTQLFDHMVNCLWDFLVERDMMCQLLPIGFTFSFPTKNLGIKQTILVNWSKGFTATGVVGEDIGQLLNDAINRKFKNFELKIMATVVNDTVGTLVSCAFDHHDTCMGLIVGTGTNMCYMEAQSNIELLNNHKTLEGEMCINTEWGAFGDNSGALDEIKTSYDIDIDRNSPNVGQHIFEKMISGMYMGELARLIIVDLSNKGHLFQSIDSNSLFYKSGFSTAFVSQILHMNDNCSQALGTTDIFKNKYGVTCSDEDMTKLRKICESLSIRAASLCAIGVIAVARKIIEHR----GQRHLVVGVDGSVYRKHPTFKS-LLINTTHRLAPELNIDFQ-LSTDGSGRGAALVAAVESRI-QHIV-----TQ',
            'cigar_line': '7DM2D2M5DMD7MD50MD20MD3MD311M4D22MD18MD20MD4M5D2M',
            'id': 'ENSCING00000018731',
            'perc_id': 42.2994,
            'perc_pos': 61.8221,
            'protein_id': 'ENSCINP00000033264',
            'species': 'ciona_intestinalis',
            'taxon_id': 7719},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MAMDVTRSQA---QTALT---L-------VE-Q-IL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEE--GQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDK-HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVES--DTGDRKQIYNILSTL--G-LRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESR-SEDVMRITVGVDGSVYKLHPSF-KERFHASVRRLTPS--CEITFIE-SEEGSGRGAALVSAVACKKA----CMLGQ-',
            'cigar_line': '10M3D5M3DM7D2MDMD2MD50MD26M2D40MD204M2D15M2DMD41MD22MD14M2D7MD20M4D5MD',
            'id': 'ENSG00000106633',
            'perc_id': 47.6395,
            'perc_pos': 70.1717,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': 'LP---CH-SSFTVTVCRSLCNISKGLGEFLEVKLTLD-ELNLSNQQLTKIMEKMIKEMVKGLGKDTNEDATVKMIPSYVKSLPDGTER-GQFLALDLGGTNFRVLLVKIKEADEINGQPKIEMDSQIYRMPENVITGKGDELFDHIALCMADFLKKL-DLLDHKLPVGFTFSFPCKQDGLDHATLITWTKGFSASNVVGKDIVKMLKTAIDKRGDLDVDIIAVVNDTVGTMTSCAFDDQECMIGLIVGTGSNACYMEKMSNIERLDSNKGGMCINMEWGAFGDDGALSDYRNEYDVHVDENSLNSGKQLYEKMISGMYMGEIVRLVLVKLTEDGLLFGGETSEALKTPGTFQTSYVSQIESAIPSGMT-AVQNILANLGIGAMR---ADCEVVIQVCKAVSRRAAHLCAAGIAAVARKIKANHPDRETLRMTVGVDGTVYKKHPTFSQ-MMSEKVDELCAGAGVDVHFA-LSYDGSGKGAALITAVAQRK-IGSD-----E',
            'cigar_line': '2M3D2MD29MD50MD68MD210MD15M3D61MD20MD20MD4M5DM',
            'id': 'ENSCING00000006724',
            'perc_id': 46.0581,
            'perc_pos': 67.8423,
            'protein_id': 'ENSCINP00000013803',
            'species': 'ciona_intestinalis',
            'taxon_id': 7719},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}
{'dn_ds': None,
 'method_link_type': 'ENSEMBL_ORTHOLOGUES',
 'source': {'align_seq': 'MA--MDVTRSQA--QTALT-L-VEQIL-AEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE-VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR-GDFEMDVVA-MVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELV----EGDEGRMCVNTEWGAFGDS-GELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQV-E-S-DTGDRKQIYNILST-LGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDV--MRITVGVDGSVYKLHPSF-KERFHASVRRLTPSCEITFIE-SEEGSGRGAALVSAVACKKACMLGQ',
            'cigar_line': '2M2D8M2D5MDMD5MD50MD122MD9MD43M4D19MD75MDMDMD14MD47M2D18MD21MD25M',
            'id': 'ENSG00000106633',
            'perc_id': 42.9185,
            'perc_pos': 61.1588,
            'protein_id': 'ENSP00000223366',
            'species': 'homo_sapiens',
            'taxon_id': 9606},
 'target': {'align_seq': '--IY-----I--FV-----L-QVDKVIE-AFTLSDEKLMHLSTKLFEQLFKGLGQATNEEAELKMLPSYVTSTPDGTEH-GDFLALDLGGTNFRIILVKI-TPN-PNSNIQMDNQVYSISHKLMTGTGTKLFDHLVNCLWDFLVERDMMCQLLPIGFTFSFPTRHLGIKKTILVNWSKGFTASGVVGEDIGQLLNDAINRKFKNFELKIMSTVVNDTVGTMVSCAYDHHETCMGLIVGTGTNMCYMESQSNTEMLGDNFRSLEGEMCINTEWGAFGDNSGSLDEVKTSYDIAIDHNSPNQGEHIYEKMISGMYMGELVRRIIVDLSAKGELFQKVDEHSILYDGGFSTAFVSQILQPNIDATMTME----YLRSFGVTANIDDVAKVKKICEAVSVRAAALCAVGVVAVARKIEKNR----GHVRMVVGVDGSVYRKHPTFKN-VLIDTTRRLAPELNIGFE-VSTDGSGRGAALVAAV----------',
            'cigar_line': '2D2M5DM2D2M5DMD7MD50MD20MD3MD261M4D47M4D22MD18MD16M10D',
            'id': 'ENSCSAVG00000011413',
            'perc_id': 44.4444,
            'perc_pos': 63.3333,
            'protein_id': 'ENSCSAVP00000019470',
            'species': 'ciona_savignyi',
            'taxon_id': 51511},
 'taxonomy_level': 'Opisthokonta',
 'type': 'ortholog_many2many'}

Accessing kinetic information from SABIO-RK¶

SABIO-RK is a curated database that contains information about biochemical reactions, their kinetic rate equations with parameters and experimental conditions.

http://sabiork.h-its.org/layouts/content/docuRESTfulWeb/manual.gsp

# http://sabiork.h-its.org/sabioRestWebServices/searchKineticLaws/entryIDs?q=uniProtKB_AC:P35557
r = requests.get('http://sabiork.h-its.org/sabioRestWebServices/searchKineticLaws/entryIDs?q=uniProtKB_AC:P35557')
print(r.url)
print(r.text)

http://sabiork.h-its.org/sabioRestWebServices/searchKineticLaws/entryIDs?q=uniProtKB_AC:P35557
<SabioEntryIDs>
  <SabioEntryID>1569</SabioEntryID>
  <SabioEntryID>1570</SabioEntryID>
  <SabioEntryID>1571</SabioEntryID>
  <SabioEntryID>1572</SabioEntryID>
  <SabioEntryID>1573</SabioEntryID>
  <SabioEntryID>1574</SabioEntryID>
  <SabioEntryID>1575</SabioEntryID>
  <SabioEntryID>1576</SabioEntryID>
  <SabioEntryID>1577</SabioEntryID>
  <SabioEntryID>22015</SabioEntryID>
  <SabioEntryID>22016</SabioEntryID>
  <SabioEntryID>22017</SabioEntryID>
  <SabioEntryID>22018</SabioEntryID>
  <SabioEntryID>22019</SabioEntryID>
  <SabioEntryID>22020</SabioEntryID>
  <SabioEntryID>2580</SabioEntryID>
  <SabioEntryID>2581</SabioEntryID>
  <SabioEntryID>2582</SabioEntryID>
  <SabioEntryID>2583</SabioEntryID>
  <SabioEntryID>2584</SabioEntryID>
  <SabioEntryID>2585</SabioEntryID>
  <SabioEntryID>2586</SabioEntryID>
  <SabioEntryID>2587</SabioEntryID>
  <SabioEntryID>2588</SabioEntryID>
  <SabioEntryID>2589</SabioEntryID>
  <SabioEntryID>2590</SabioEntryID>
  <SabioEntryID>2591</SabioEntryID>
  <SabioEntryID>2916</SabioEntryID>
  <SabioEntryID>2917</SabioEntryID>
  <SabioEntryID>2918</SabioEntryID>
  <SabioEntryID>2919</SabioEntryID>
  <SabioEntryID>2920</SabioEntryID>
  <SabioEntryID>2921</SabioEntryID>
  <SabioEntryID>2922</SabioEntryID>
  <SabioEntryID>2923</SabioEntryID>
  <SabioEntryID>2924</SabioEntryID>
  <SabioEntryID>2925</SabioEntryID>
  <SabioEntryID>2926</SabioEntryID>
  <SabioEntryID>2927</SabioEntryID>
  <SabioEntryID>2928</SabioEntryID>
  <SabioEntryID>2929</SabioEntryID>
  <SabioEntryID>2930</SabioEntryID>
  <SabioEntryID>2931</SabioEntryID>
  <SabioEntryID>2932</SabioEntryID>
  <SabioEntryID>2933</SabioEntryID>
  <SabioEntryID>2934</SabioEntryID>
  <SabioEntryID>2935</SabioEntryID>
  <SabioEntryID>2936</SabioEntryID>
  <SabioEntryID>2937</SabioEntryID>
  <SabioEntryID>2938</SabioEntryID>
  <SabioEntryID>2939</SabioEntryID>
  <SabioEntryID>2940</SabioEntryID>
  <SabioEntryID>2941</SabioEntryID>
  <SabioEntryID>2942</SabioEntryID>
  <SabioEntryID>2943</SabioEntryID>
  <SabioEntryID>2944</SabioEntryID>
  <SabioEntryID>2945</SabioEntryID>
  <SabioEntryID>2946</SabioEntryID>
  <SabioEntryID>2947</SabioEntryID>
  <SabioEntryID>2948</SabioEntryID>
  <SabioEntryID>2949</SabioEntryID>
  <SabioEntryID>2950</SabioEntryID>
  <SabioEntryID>2951</SabioEntryID>
  <SabioEntryID>2952</SabioEntryID>
  <SabioEntryID>2953</SabioEntryID>
  <SabioEntryID>2954</SabioEntryID>
  <SabioEntryID>2955</SabioEntryID>
  <SabioEntryID>2956</SabioEntryID>
  <SabioEntryID>2957</SabioEntryID>
  <SabioEntryID>2958</SabioEntryID>
  <SabioEntryID>2959</SabioEntryID>
  <SabioEntryID>2960</SabioEntryID>
  <SabioEntryID>2961</SabioEntryID>
  <SabioEntryID>2962</SabioEntryID>
  <SabioEntryID>37745</SabioEntryID>
  <SabioEntryID>37746</SabioEntryID>
  <SabioEntryID>37747</SabioEntryID>
  <SabioEntryID>37748</SabioEntryID>
  <SabioEntryID>37749</SabioEntryID>
  <SabioEntryID>37750</SabioEntryID>
  <SabioEntryID>37751</SabioEntryID>
  <SabioEntryID>37752</SabioEntryID>
  <SabioEntryID>37753</SabioEntryID>
  <SabioEntryID>37754</SabioEntryID>
  <SabioEntryID>37755</SabioEntryID>
  <SabioEntryID>37756</SabioEntryID>
  <SabioEntryID>4963</SabioEntryID>
  <SabioEntryID>4964</SabioEntryID>
  <SabioEntryID>4965</SabioEntryID>
  <SabioEntryID>4966</SabioEntryID>
  <SabioEntryID>4967</SabioEntryID>
  <SabioEntryID>4968</SabioEntryID>
  <SabioEntryID>4969</SabioEntryID>
  <SabioEntryID>4970</SabioEntryID>
  <SabioEntryID>4971</SabioEntryID>
  <SabioEntryID>4972</SabioEntryID>
  <SabioEntryID>4973</SabioEntryID>
  <SabioEntryID>4974</SabioEntryID>
  <SabioEntryID>4975</SabioEntryID>
  <SabioEntryID>4976</SabioEntryID>
  <SabioEntryID>4977</SabioEntryID>
  <SabioEntryID>4978</SabioEntryID>
  <SabioEntryID>4979</SabioEntryID>
  <SabioEntryID>4980</SabioEntryID>
  <SabioEntryID>4981</SabioEntryID>
  <SabioEntryID>4982</SabioEntryID>
  <SabioEntryID>4983</SabioEntryID>
  <SabioEntryID>4984</SabioEntryID>
  <SabioEntryID>4985</SabioEntryID>
  <SabioEntryID>4986</SabioEntryID>
  <SabioEntryID>4987</SabioEntryID>
  <SabioEntryID>4988</SabioEntryID>
  <SabioEntryID>4989</SabioEntryID>
  <SabioEntryID>4990</SabioEntryID>
  <SabioEntryID>4991</SabioEntryID>
  <SabioEntryID>4992</SabioEntryID>
  <SabioEntryID>4993</SabioEntryID>
  <SabioEntryID>4994</SabioEntryID>
  <SabioEntryID>8766</SabioEntryID>
  <SabioEntryID>8767</SabioEntryID>
  <SabioEntryID>8768</SabioEntryID>
  <SabioEntryID>8769</SabioEntryID>
  <SabioEntryID>8770</SabioEntryID>
  <SabioEntryID>8771</SabioEntryID>
  <SabioEntryID>8772</SabioEntryID>
  <SabioEntryID>8773</SabioEntryID>
  <SabioEntryID>8774</SabioEntryID>
  <SabioEntryID>8775</SabioEntryID>
  <SabioEntryID>8776</SabioEntryID>
  <SabioEntryID>8777</SabioEntryID>
  <SabioEntryID>8778</SabioEntryID>
  <SabioEntryID>8779</SabioEntryID>
  <SabioEntryID>8780</SabioEntryID>
  <SabioEntryID>8781</SabioEntryID>
  <SabioEntryID>8782</SabioEntryID>
  <SabioEntryID>8783</SabioEntryID>
  <SabioEntryID>8784</SabioEntryID>
  <SabioEntryID>8785</SabioEntryID>
  <SabioEntryID>8786</SabioEntryID>
  <SabioEntryID>8787</SabioEntryID>
  <SabioEntryID>8788</SabioEntryID>
  <SabioEntryID>8789</SabioEntryID>
  <SabioEntryID>8790</SabioEntryID>
  <SabioEntryID>8791</SabioEntryID>
  <SabioEntryID>8792</SabioEntryID>
  <SabioEntryID>8793</SabioEntryID>
  <SabioEntryID>8794</SabioEntryID>
  <SabioEntryID>8795</SabioEntryID>
  <SabioEntryID>8796</SabioEntryID>
  <SabioEntryID>8797</SabioEntryID>
  <SabioEntryID>8798</SabioEntryID>
  <SabioEntryID>8799</SabioEntryID>
  <SabioEntryID>8800</SabioEntryID>
  <SabioEntryID>8801</SabioEntryID>
  <SabioEntryID>8802</SabioEntryID>
  <SabioEntryID>8803</SabioEntryID>
  <SabioEntryID>8804</SabioEntryID>
  <SabioEntryID>8805</SabioEntryID>
  <SabioEntryID>8806</SabioEntryID>
  <SabioEntryID>8807</SabioEntryID>
  <SabioEntryID>8808</SabioEntryID>
  <SabioEntryID>8809</SabioEntryID>
  <SabioEntryID>8810</SabioEntryID>
  <SabioEntryID>8811</SabioEntryID>
  <SabioEntryID>8812</SabioEntryID>
  <SabioEntryID>8813</SabioEntryID>
  <SabioEntryID>8814</SabioEntryID>
  <SabioEntryID>8815</SabioEntryID>
  <SabioEntryID>8816</SabioEntryID>
  <SabioEntryID>8817</SabioEntryID>
</SabioEntryIDs>

Online search http://sabiork.h-its.org/newSearch/index

r = requests.get("http://sabiork.h-its.org/sabioRestWebServices/kineticLaws/8817")
print(r.text)

<?xml version='1.0' encoding='UTF-8' standalone='no'?>
<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" level="3" version="1">
  <model name="SABIOmdl07Feb2020110">
<notes><body xmlns="http://www.w3.org/1999/xhtml">
<p>
This model has been created with the help of the SABIO-RK Database
(http://sabio.h-its.org/)
 (c) 2005-2020 HITS gGmbH http://www.h-its.org

</p><br/>
To cite SABIO-RK Database, please use
"http://www.ncbi.nlm.nih.gov/pubmed/22102587"
<br/>
SABIO-RK - database for biochemical reaction kinetics. Wittig U, Kania R, Golebiewski M, Rey M, Shi L, Jong L, Algaa E, Weidemann A, Sauer-Danzwith H, Mir S, Krebs O, Bittkowski M, Wetsch E, Rojas I, Mueller W. Nucleic Acids Res. 2012;40(Database issue)790-6
</body></notes>
      <listOfFunctionDefinitions>
      <functionDefinition id="KL_8817" sboTerm="SBO:0000192">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> h </ci>
            </bvar>
            <bvar>
              <ci> kcat </ci>
            </bvar>
            <bvar>
              <ci> B </ci>
            </bvar>
            <bvar>
              <ci> K </ci>
            </bvar>
            <bvar>
              <ci> S </ci>
            </bvar>
            <bvar>
              <ci> E </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <apply>
                  <times/>
                  <ci> E </ci>
                  <ci> kcat </ci>
                </apply>
                <apply>
                  <power/>
                  <ci> S </ci>
                  <ci> h </ci>
                </apply>
              </apply>
              <apply>
                <plus/>
                <ci> K </ci>
                <apply>
                  <power/>
                  <ci> S </ci>
                  <ci> h </ci>
                </apply>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
    </listOfFunctionDefinitions>
    <listOfUnitDefinitions>
      <unitDefinition id="swedgeone" name="s^(-1)">
        <listOfUnits>
          <unit scale="0" exponent="-1" multiplier="1" kind="second"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="M" name="M">
        <listOfUnits>
          <unit scale="0" exponent="-1" multiplier="1" kind="litre"/>
          <unit scale="0" exponent="1" multiplier="1" kind="mole"/>
        </listOfUnits>
      </unitDefinition>
    </listOfUnitDefinitions>
    <listOfCompartments>
      <compartment id="compart_Cell" constant="true" name="Cell"/>
    </listOfCompartments>
    <listOfSpecies>
      <species id="SPC_34_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="ATP" metaid="META_SPC_34_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_SPC_34_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:15422"/>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:30616"/>
                  <rdf:li rdf:resource="http://identifiers.org/kegg.compound/C00002"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
      <species id="SPC_1464_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="D-Fructose" metaid="META_SPC_1464_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_SPC_1464_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:15824"/>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:37721"/>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:48095"/>
                  <rdf:li rdf:resource="http://identifiers.org/kegg.compound/C00095"/>
                  <rdf:li rdf:resource="http://identifiers.org/kegg.compound/C10906"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
      <species id="SPC_1374_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="D-Fructose 6-phosphate" metaid="META_SPC_1374_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_SPC_1374_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:15946"/>
                  <rdf:li rdf:resource="http://identifiers.org/kegg.compound/C00085"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
      <species id="SPC_35_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="ADP" metaid="META_SPC_35_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_SPC_35_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:16761"/>
                  <rdf:li rdf:resource="http://identifiers.org/kegg.compound/C00008"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
      <species id="ENZ_46027_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="glucokinase(Enzyme) mutant Glu290Ala" metaid="META_ENZ_46027_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
<sbrk:sabiork xmlns:sbrk="http://sabiork.h-its.org">
<sbrk:modifierType>Modifier-Catalyst</sbrk:modifierType>
</sbrk:sabiork>                  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_ENZ_46027_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/uniprot/P35557"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
    </listOfSpecies>
    <listOfReactions>
      <reaction id="REAC_0" metaid="META_REAC_0" reversible="true" fast="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_REAC_0">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/ec-code/2.7.1.2"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/kegg.reaction/R00760"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:hasTaxon>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/taxonomy/9606"/>
                </rdf:Bag>
              </bqbiol:hasTaxon>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/sabiork.reaction/1116"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:occursIn>
                <rdf:Bag>
                  <rdf:li rdf:resource="http://identifiers.org/bto/BTO:0000783"/>
                </rdf:Bag>
              </bqbiol:occursIn>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference constant="true" species="SPC_34_Cell" sboTerm="SBO:0000015" stoichiometry="1"/>
          <speciesReference constant="true" species="SPC_1464_Cell" sboTerm="SBO:0000015" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="SPC_1374_Cell" sboTerm="SBO:0000011" stoichiometry="1"/>
          <speciesReference constant="true" species="SPC_35_Cell" sboTerm="SBO:0000011" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="ENZ_46027_Cell" sboTerm="SBO:0000460"/>
        </listOfModifiers>
        <kineticLaw metaid="META_KL_8817" sboTerm="SBO:0000192">
          <annotation>
<sbrk:sabiork xmlns:sbrk="http://sabiork.h-its.org">
<sbrk:kineticLawID>8817</sbrk:kineticLawID>
<sbrk:experimentalConditions>
<sbrk:pH>
<sbrk:startValuepH>7.5</sbrk:startValuepH>
</sbrk:pH>
<sbrk:temperature>
<sbrk:startValueTemperature>30.0</sbrk:startValueTemperature>
<sbrk:temperatureUnit>°C</sbrk:temperatureUnit>
</sbrk:temperature>
<sbrk:buffer> 100 mM Tris HCl, 100 mM KCl, 20 mM MgCl2, 0.6 mM phosphoenolpyruvate, 0.6 mM NADH, 1.76 units/ml lactate dehydrogenase, 1.4 units/ml pyruvate kinase</sbrk:buffer>
</sbrk:experimentalConditions>
</sbrk:sabiork>
                      <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
              <rdf:Description rdf:about="#META_KL_8817">
                <bqbiol:isDescribedBy>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/pubmed/7961659"/>
                  </rdf:Bag>
                </bqbiol:isDescribedBy>
                <bqbiol:isDescribedBy>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/sabiork.kineticrecord/8817"/>
                  </rdf:Bag>
                </bqbiol:isDescribedBy>
              </rdf:Description>
            </rdf:RDF>
          </annotation>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <ci> KL_8817 </ci>
              <ci> h_SPC_1464_Cell </ci>
              <ci> kcat </ci>
              <ci> SPC_34_Cell </ci>
              <ci> K_SPC_1464_Cell </ci>
              <ci> SPC_1464_Cell </ci>
              <ci> ENZ_46027_Cell </ci>
            </apply>
          </math>
                  <listOfLocalParameters>
            <localParameter id="h_SPC_1464_Cell" name="h_DFructose" sboTerm="SBO:0000190"/>
            <localParameter id="kcat" name="kcat" value="2.4" sboTerm="SBO:0000025" units="swedgeone"/>
            <localParameter id="K_SPC_1464_Cell" name="K_DFructose" value="2.9" sboTerm="SBO:0000191" units="M"/>
          </listOfLocalParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>

15 Course review¶

lecture notes